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Journal Articles

Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins Alleviates Chronic Graft- Versus -Host-Disease Via Modulating the CXCR5/CXCL13 Axis

Rathan Kumar, Lotus Neidermire-Colley, Charlie Spencer, David Aslaner, Yandi Gao, Simran Surana, Matthew W Gorr, Katiri Snyder, Malith Karunasiri, Loren E Wold, Gideon Bollag, Ben Powell, Hannah Choe, Parvathi Ranganathan
Journal: Blood
Blood (2023) 142 (Supplement 1): 2047.
https://doi.org/10.1182/blood-2023-182354
Published: 2023
Journal Articles

Final Results of a Phase 1b Study of BET Inhibitor PLX2853 in Patients with Relapsed or Refractory Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Alice S. Mims, Melhem Solh, Jennifer N. Saultz, Uma Borate, Naveen Pemmaraju, Gautam Borthakur, Gail J. Roboz, Ben Powell, Bernice Matusow, Jason Halladay, Shireen Vali, Chelsea L. Hope, Madan G. Kundu, Ching Hsu, Paul Watkins, Chao Zhang, Jackie M. Walling, Athanasios C. Tsiatis, Amy E. DeZern
Journal: Blood
Blood (2021) 138 (Supplement 1): 3420.
https://doi.org/10.1182/blood-2021-152040
Published: 2021
Journal Articles

BET Inhibition As a Targeted Epigenetic Approach to Reverse T Cell Dysfunction in Chronic Lymphocytic Leukemia

Audrey L Smith, Alexandria P Eiken, Sydney A Skupa, Dalia Y Moore, Avyakta Kallam, Christopher D'Angelo, Gregory R Bociek, Matthew A. Lunning, Julie M. Vose, Ben Powell, Gideon Bollag, Dalia ElGamal
Journal: Blood
Blood (2021) 138 (Supplement 1): 3715.
https://doi.org/10.1182/blood-2021-153921
Published: 2021
Journal Articles

Co-Targeting BET Bromodomain Proteins and Aberrant Signaling in AML

Benjamin J. Huang, MD, Xinyue Wang, BA, Max Harris, BA, Anica Wandler, PhD, Eugene Hwang, BA, Michael R. Burgess, MD PhD, Qing Li, MD PhD, Paul Severson, PhD, Ben Powell, PhD, Edward A. Kolb, MD, Soheil Meshinchi, MDPhD, Barry S Taylor, PhD, Gideon Bollag, PhD, Kevin M. Shannon, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-142921
Published: 2020
Journal Articles

Phase 1b Study of BET Inhibitor PLX2853 in Patients with Relapsed or Refractory Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Alice S. Mims, MD, Melhem Solh, MD, Uma Borate, Naveen Pemmaraju, MD, Gautam Borthakur, MD, Gail J. Roboz, MD, Ben Powell, PhD, Paul Severson, PhD, Bernice Matusow, Jason Halladay, PhD, Ching Hsu, PhD, Paul Watkins, Chao Zhang, PhD, Jackie M. Walling, PhD MD, Athanasios C. Tsiatis, MD, Amy E. DeZern, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-140138
Published: 2020
Journal Articles

A Novel Combination Regimen of BET and FLT3 Inhibition for FLT3-ITD Acute Myeloid Leukemia

Lauren Lee, Yoshiyuki Hizukuri, Paul Severson, Ben Powell, PhD, Chao Zhang, PhD, Yan Ma, Maiko Narahara, Hiroyuki Sumi, PhD, Gideon Bollag, PhD, Mark J. Levis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1373.
https://doi.org/10.1182/blood-2019-124030
Published: 2019
Journal Articles

Dose Escalation Study of BET Inhibitor PLX2853 in Patients with Relapsed or Refractory Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

Naveen Pemmaraju, MD, Uma Borate, MD, Melhem Solh, MD, Gautam M. Borthakur, MD, Amy E. DeZern, MD, Chao Zhang, PhD, Ben Powell, PhD, Paul Severson, Kerry Inokuchi, Bernice Matusow, Jason Halladay, Ching Hsu, PhD, Paul Watkins, Jackie M. Walling, PhD MD, Athanasios C. Tsiatis, MD, Alice S. Mims, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1391.
https://doi.org/10.1182/blood-2019-127497
Published: 2019
Journal Articles

Bromodomain and Extraterminal (BET) Domain Inhibition with PLX51107 and PLX2853 Improves Survival and Decreases Acute GVHD Severity in Murine Models

Hannah K. Choe, MD, Yandi Gao, MS, Katiri Snyder, BS, Ben Powell, PhD, Gideon Bollag, PhD, Parvathi Ranganathan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4429.
https://doi.org/10.1182/blood-2019-122455
Published: 2019
Journal Articles

Response and Resistance to Bromodomain Inhibition in AML Driven By Hyperactive Ras Signaling

Benjamin Huang, MD, Eugene Hwang, Anica M. Wandler, PhD, Ben Powell, PhD, Gideon Bollag, PhD, Kevin Shannon, MD
Journal: Blood
Blood (2016) 128 (22): 1654.
https://doi.org/10.1182/blood.V128.22.1654.1654
Published: 2016
Journal Articles

Efficacy and Mechanism of Action of the Novel Bromodomain Inhibitor, PLX51107, in B Cell Malignancies

Monica Mead, MD BS, Erika Von Euw, PhD BS, Dylan Conklin, Ben Powell, PhD BS, Kanthinh Manivong, BS, Eileen Do, Dennis J. Slamon, MDPhD, Sarah Larson, MD
Journal: Blood
Blood (2015) 126 (23): 3702.
https://doi.org/10.1182/blood.V126.23.3702.3702
Published: 2015