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Cheng-Hock Toh
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Journal Articles

Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation

Jun Yong, Cheng-Hock Toh
Journal: Blood
Blood (2023) 142 (25): 2133–2145.
https://doi.org/10.1182/blood.2023021166
Published: 2023
Includes: Supplemental data
Journal Articles

Real-world experience with caplacizumab in the management of acute TTP

Clinical Trials & Observations
Tina Dutt, Rebecca J. Shaw, Matthew Stubbs, Jun Yong, Benjamin Bailiff, Tanya Cranfield, Maeve P. Crowley, Michael Desborough, Toby A. Eyre, Richard Gooding, John Grainger, John Hanley, Joanna Haughton, Joannes Hermans, Quentin Hill, Louise Humphrey, Gillian Lowe, Hamish Lyall, Muhammad Mohsin, Phillip L. R. Nicolson, Nicole Priddee, Alexandros Rampotas, Rachel Rayment, Susan Rhodes, Alice Taylor, William Thomas, Oliver Tomkins, Joost J. Van Veen, Steven Lane, Cheng-Hock Toh, Marie Scully
Journal: Blood
Blood (2021) 137 (13): 1731–1740.
https://doi.org/10.1182/blood.2020007599
Published: 2021
Includes: Supplemental data
Journal Articles

Assembly of alternative prothrombinase by extracellular histones initiates and disseminates intravascular coagulation

Simon T. Abrams, Dunhao Su, Yasmina Sahraoui, Ziqi Lin, Zhenxing Cheng, Kate Nesbitt, Yasir Alhamdi, Micaela Harrasser, Min Du, Jonathan H. Foley, David Lillicrap, Guozheng Wang, Cheng-Hock Toh
Journal: Blood
Blood (2021) 137 (1): 103–114.
https://doi.org/10.1182/blood.2019002973
Published: 2021
Includes: Supplemental data
Journal Articles

Circulating Histone Levels Correlate with the Severity of COVID-19 and the Extent of Coagulation Activation and Inflammation

Rebecca Jane Shaw, MBChB (Hons), James Austin, PhD, Joseph Taylor, Tina Dutt, PhD, Guozheng Wang, MD PhD, Simon Timothy Abrams, PhD BSc, Cheng Hock Toh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 19.
https://doi.org/10.1182/blood-2020-142344
Published: 2020
Journal Articles

A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies

Simon Timothy Abrams, PhD BSc, Ben Morton, MBChB, MD, Yasir Alhamdi, MBChB, PhD, Mohmad Alsabani, Zhenxing Cheng, Steven Lane, PhD, Ingeborg Welters, PhD, Guozheng Wang, MD PhD, Cheng-Hock Toh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 440.
https://doi.org/10.1182/blood-2019-128493
Published: 2019
Journal Articles

Histones Bind Prothrombin to Generate Alternative Prothrombinase Complexes That Can Disseminate Intravascular Coagulation

Simon Timothy Abrams, PhD, Dunhao Su, PhD, Yasmina Sahraoui, MRes, Yasir Alhamdi, MBChB, PhD, Guozheng Wang, MD PhD, Cheng Hock Toh, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 218.
https://doi.org/10.1182/blood-2018-99-116117
Published: 2018
Journal Articles

Histone-Induced Lung Injury and Coagulation Activation Are Reduced By C-Reactive Protein In The Acute Phase Response

Simon Timothy Abrams, Nan Zhang, Guozheng Wang, Cheng-Hock Toh
Journal: Blood
Blood (2013) 122 (21): 457.
https://doi.org/10.1182/blood.V122.21.457.457
Published: 2013
Journal Articles

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

Christopher A. Moxon, Samuel C. Wassmer, Danny A. Milner, Jr, Ngawina V. Chisala, Terrie E. Taylor, Karl B. Seydel, Malcolm E. Molyneux, Brian Faragher, Charles T. Esmon, Colin Downey, Cheng-Hock Toh, Alister G. Craig, Robert S. Heyderman
Journal: Blood
Blood (2013) 122 (5): 842–851.
https://doi.org/10.1182/blood-2013-03-490219
Published: 2013
Includes: Supplemental data
Journal Articles

Activated protein C induces the release of microparticle-associated endothelial protein C receptor

Margarita Pérez-Casal, Colin Downey, Kenji Fukudome, Gernot Marx, Cheng Hock Toh
Journal: Blood
Blood (2005) 105 (4): 1515–1522.
https://doi.org/10.1182/blood-2004-05-1896
Published: 2005
Journal Articles

A New Functional Coagulation Assay for Measurement of Total Factor V Activity in Human Plasma and Its Application to Samples from Patients with Disseminated Intravascular Coagulation.

John A. Samis, PhD, Kenneth A. Stewart, Cheng Hock Toh, MD, Colin Downey, Michael E. Nesheim, PhD
Journal: Blood
Blood (2004) 104 (11): 2983.
https://doi.org/10.1182/blood.V104.11.2983.2983
Published: 2004
Journal Articles

A Novel Mechanism of Endothelial Protein C Receptor Release, in Microparticulate Form, by Activated Protein C.

Margarita Perez-Casal, PhD, Kenji Fukudome, PhD, Cheng Hock Toh, MD
Journal: Blood
Blood (2004) 104 (11): 1923.
https://doi.org/10.1182/blood.V104.11.1923.1923
Published: 2004
Journal Articles

Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca ++ -dependent complex of C-reactive protein with very-low–density lipoprotein and is a novel marker of impending disseminated intravascular coagulation

Clinical Trials & Observations
Cheng Hock Toh, John Samis, Colin Downey, John Walker, Lev Becker, Nicole Brufatto, Liliana Tejidor, Greg Jones, Wim Houdijk, Alan Giles, Marlys Koschinsky, Larry O. Ticknor, Ray Paton, Richard Wenstone, Michael Nesheim
Journal: Blood
Blood (2002) 100 (7): 2522–2529.
https://doi.org/10.1182/blood.V100.7.2522
Published: 2002
Journal Articles

Aberrant dimerization of von Willebrand factor as the result of mutations in the carboxy-terminal region: identification of 3 mutations in members of 3 different families with type 2A (phenotype IID) von Willebrand disease

M. Said Enayat, Andrea M. Guilliatt, Gurcharan K. Surdhar, P. Vincent Jenkins, K. John Pasi, Cheng Hock Toh, Michael D. Williams, Frank G. H. Hill
Journal: Blood
Blood (2001) 98 (3): 674–680.
https://doi.org/10.1182/blood.V98.3.674
Published: 2001