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Christina U Lorentz
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Journal Articles

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Cristina Puy, Samantha A. Moellmer, Jiaqing Pang, Helen H. Vu, Alexander R. Melrose, Christina U. Lorentz, Erik I. Tucker, Joseph J. Shatzel, Ravi S. Keshari, Florea Lupu, David Gailani, Owen J. T. McCarty
Journal: Blood
Blood (2024) 144 (17): 1821–1833.
https://doi.org/10.1182/blood.2023022257
Published: 2024
Includes: Supplemental data
Journal Articles

Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Cancer Patients Undergoing Central Line Placement: A Phase 2 Clinical Trial

Michael A Pfeffer, Helen Vu, Tia CL Kohs, Jenny Wang, Christina U Lorentz, Erik I Tucker, Sven R Olson, Thomas G Deloughery, Monica T Hinds, Owen JT McCarty, Joseph J Shatzel
Journal: Blood
Blood (2022) 140 (Supplement 1): 1247–1249.
https://doi.org/10.1182/blood-2022-170429
Published: 2022
Journal Articles

Antiplatelet Effects of Inhibiting Coagulation Factor XI in a Diet-Induced Obesity Model of Early Atherosclerosis

Tia CL Kohs, Iván Parra-Izquierdo, Helen Vu, Monica T Hinds, Joseph J Shatzel, Joseph E Aslan, Michael Wallisch, Erik I Tucker, Christina U Lorentz, Cristina Puy, David Gailani, Owen JT McCarty
Journal: Blood
Blood (2022) 140 (Supplement 1): 8437.
https://doi.org/10.1182/blood-2022-170472
Published: 2022
Journal Articles

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Clinical Trials & Observations
Christina U. Lorentz, Erik I. Tucker, Norah G. Verbout, Joseph J. Shatzel, Sven R. Olson, Brandon D. Markway, Michael Wallisch, Martina Ralle, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Jeffrey I. Weitz, András Gruber
Journal: Blood
Blood (2021) 138 (22): 2173–2184.
https://doi.org/10.1182/blood.2021011725
Published: 2021
Includes: Supplemental data
Journal Articles

A Phase 2 Trial of the Protein C Activator AB002 in End-Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, Christina U Lorentz, Brandon D Markway, Michael Wallisch, Joseph J Shatzel, Andras Gruber, Erik I Tucker
Journal: Blood
Blood (2021) 138 (Supplement 1): 669.
https://doi.org/10.1182/blood-2021-148208
Published: 2021
Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu
Journal: Blood
Blood (2021) 138 (2): 178–189.
https://doi.org/10.1182/blood.2020009345
Published: 2021
Includes: Supplemental data
Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
https://doi.org/10.1182/blood-2020-139948
Published: 2020
Journal Articles

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Clinical Trials & Observations
Erik I. Tucker, Norah G. Verbout, Brandon D. Markway, Michael Wallisch, Christina U. Lorentz, Monica T. Hinds, Joseph J. Shatzel, Leslie A. Pelc, David C. Wood, Owen J. T. McCarty, Enrico Di Cera, András Gruber
Journal: Blood
Blood (2020) 135 (9): 689–699.
https://doi.org/10.1182/blood.2019002771
Published: 2020
Includes: Supplemental data
Journal Articles

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, PhD, Christina U Lorentz, PhD, Brandon D Markway, PhD, Joseph J Shatzel, MD, Erik I Tucker, PhD, Andras Gruber, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2433.
https://doi.org/10.1182/blood-2019-124999
Published: 2019
Journal Articles

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

Michael Wallisch, PhD, Erik I Tucker, PhD, Christina U Lorentz, PhD, Jennifer Johnson, RLATG, Marschelle R Carris, BA, Owen JT McCarty, PhD, Monica T Hinds, PhD, András Gruber, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 236.
https://doi.org/10.1182/blood.V130.Suppl_1.236.236
Published: 2017
Journal Articles

Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion

Christina U Lorentz, PhD, Norah G Verbout, PhD, Zhiping Cao, Helen Liu, Owen J.T. McCarty, PhD, Erik I. Tucker, PhD, Andras Gruber, MD, Donna Van Winkle, PhD
Journal: Blood
Blood (2014) 124 (21): 2873.
https://doi.org/10.1182/blood.V124.21.2873.2873
Published: 2014