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Journal Articles

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Cristina Puy, Samantha A. Moellmer, Jiaqing Pang, Helen H. Vu, Alexander R. Melrose, Christina U. Lorentz, Erik I. Tucker, Joseph J. Shatzel, Ravi S. Keshari, Florea Lupu, David Gailani, Owen J. T. McCarty

Blood (2024) 144 (17): 1821–1833.

https://doi.org/10.1182/blood.2023022257

Published: 2024

Includes: Supplemental data

Journal Articles

Endogenous Protein C Activation with AB002 Improves Outcomes in a Rat Model of Acute Ischemic Stroke

Norah G. Verbout, Wenri Zhang, Erik I. Tucker, Andras Gruber

Blood (2023) 142 (Supplement 1): 3949.

https://doi.org/10.1182/blood-2023-187448

Published: 2023

Journal Articles

Antiplatelet Effects of Inhibiting Coagulation Factor XI in a Diet-Induced Obesity Model of Early Atherosclerosis

Tia CL Kohs, Iván Parra-Izquierdo, Helen Vu, Monica T Hinds, Joseph J Shatzel, Joseph E Aslan, Michael Wallisch, Erik I Tucker, Christina U Lorentz, Cristina Puy, David Gailani, Owen JT McCarty

Blood (2022) 140 (Supplement 1): 8437.

https://doi.org/10.1182/blood-2022-170472

Published: 2022

Journal Articles

Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Cancer Patients Undergoing Central Line Placement: A Phase 2 Clinical Trial

Michael A Pfeffer, Helen Vu, Tia CL Kohs, Jenny Wang, Christina U Lorentz, Erik I Tucker, Sven R Olson, Thomas G Deloughery, Monica T Hinds, Owen JT McCarty, Joseph J Shatzel

Blood (2022) 140 (Supplement 1): 1247–1249.

https://doi.org/10.1182/blood-2022-170429

Published: 2022

Journal Articles

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Christina U. Lorentz, Erik I. Tucker, Norah G. Verbout, Joseph J. Shatzel, Sven R. Olson, Brandon D. Markway, Michael Wallisch, Martina Ralle, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Jeffrey I. Weitz, András Gruber

Blood (2021) 138 (22): 2173–2184.

https://doi.org/10.1182/blood.2021011725

Published: 2021

Includes: Supplemental data

Journal Articles

A Phase 2 Trial of the Protein C Activator AB002 in End-Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, Christina U Lorentz, Brandon D Markway, Michael Wallisch, Joseph J Shatzel, Andras Gruber, Erik I Tucker

Blood (2021) 138 (Supplement 1): 669.

https://doi.org/10.1182/blood-2021-148208

Published: 2021

Journal Articles

Abelacimab Reduces Thrombus Propagation in a Baboon Model of Vascular Graft Thrombosis

Michael Wallisch, Yasser Khder, Monica T. Hinds, Erik I Tucker, Dan Bloomfield, Andras Gruber

Blood (2021) 138 (Supplement 1): 1027.

https://doi.org/10.1182/blood-2021-150535

Published: 2021

Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu

Blood (2021) 138 (2): 178–189.

https://doi.org/10.1182/blood.2020009345

Published: 2021

Includes: Supplemental data

Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139948

Published: 2020

Journal Articles

Crystalizing our view of the contact system

Erik I. Tucker

Blood (2020) 136 (14): 1576–1577.

https://doi.org/10.1182/blood.2020007084

Published: 2020

Journal Articles

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Erik I. Tucker, Norah G. Verbout, Brandon D. Markway, Michael Wallisch, Christina U. Lorentz, Monica T. Hinds, Joseph J. Shatzel, Leslie A. Pelc, David C. Wood, Owen J. T. McCarty, Enrico Di Cera, András Gruber

Blood (2020) 135 (9): 689–699.

https://doi.org/10.1182/blood.2019002771

Published: 2020

Includes: Supplemental data

Journal Articles

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

Norah G Verbout, PhD, Christina U Lorentz, PhD, Brandon D Markway, PhD, Joseph J Shatzel, MD, Erik I Tucker, PhD, Andras Gruber, MD

Blood (2019) 134 (Supplement_1): 2433.

https://doi.org/10.1182/blood-2019-124999

Published: 2019

Journal Articles

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

Michael Wallisch, PhD, Erik I Tucker, PhD, Christina U Lorentz, PhD, Jennifer Johnson, RLATG, Marschelle R Carris, BA, Owen JT McCarty, PhD, Monica T Hinds, PhD, András Gruber, MD

Blood (2017) 130 (Supplement 1): 236.

https://doi.org/10.1182/blood.V130.Suppl_1.236.236

Published: 2017

Journal Articles

E-WE Thrombin (ProCase) Inhibits Thrombin Mediated TAFI Activation and Accelerates TPA-Induced Thrombolysis

Erik I Tucker, PhD, Brandon Markway, PhD, Michael Wallisch, PhD, Norah Green Verbout, PhD, Christina Lorentz, PhD, Marschelle Carris, Owen J.T. McCarty, PhD, Andras Gruber, MD

Blood (2016) 128 (22): 1390.

https://doi.org/10.1182/blood.V128.22.1390.1390

Published: 2016

Journal Articles

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Cristina Puy, Erik I. Tucker, Anton Matafonov, Qiufang Cheng, Keith D. Zientek, Dave Gailani, András Gruber, Owen J. T. McCarty

Blood (2015) 125 (9): 1488–1496.

https://doi.org/10.1182/blood-2014-10-604587

Published: 2015

Includes: Supplemental data

Journal Articles

Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion

Christina U Lorentz, PhD, Norah G Verbout, PhD, Zhiping Cao, Helen Liu, Owen J.T. McCarty, PhD, Erik I. Tucker, PhD, Andras Gruber, MD, Donna Van Winkle, PhD

Blood (2014) 124 (21): 2873.

https://doi.org/10.1182/blood.V124.21.2873.2873

Published: 2014

Journal Articles

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Michael Wallisch, PhD, Greisel Jennifer, BS, Erik I Tucker, PhD, Owen J.T. McCarty, PhD, Monica T Hinds, PhD, Sue Murray, Jeff Crosby, PhD, Brett P. Monia, PhD, Andras Gruber, MD

Blood (2014) 124 (21): 1485.

https://doi.org/10.1182/blood.V124.21.1485.1485

Published: 2014

Journal Articles

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Anton Matafonov, Philberta Y. Leung, Adam E. Gailani, Stephanie L. Grach, Cristina Puy, Qiufang Cheng, Mao-fu Sun, Owen J. T. McCarty, Erik I. Tucker, Hiroaki Kataoka, Thomas Renné, James H. Morrissey, Andras Gruber, David Gailani

Blood (2014) 123 (11): 1739–1746.

https://doi.org/10.1182/blood-2013-04-499111

Published: 2014

Includes: Supplemental data

Journal Articles

Factor XI Deficiency Reduces The Inflammatory Response To Polymicrobial Sepsis In Mice

Charles E. Bane, jr., DVM, Kelli L. Boyd, DVM, Ph.D., Erik I. Tucker, Ph.D., Stephen T. Smiley, Ph.D., Andras Gruber, MD, David Gailani, MD

Blood (2013) 122 (21): 201.

https://doi.org/10.1182/blood.V122.21.201.201

Published: 2013

Journal Articles

Rapid Interruption Of Occlusive Thrombus Formation By The Protein C Activator Enzyme EWE Thrombin (ProCase) In Primates

Erik I Tucker, PhD, Michael Wallisch, PhD, Philberta Y Leung, PhD, Andras Gruber, MD, Enrico Di Cera, MD, Norah G Verbout, PhD

Blood (2013) 122 (21): 202.

https://doi.org/10.1182/blood.V122.21.202.202

Published: 2013

NARROW

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Endogenous Protein C Activation with AB002 Improves Outcomes in a Rat Model of Acute Ischemic Stroke

Antiplatelet Effects of Inhibiting Coagulation Factor XI in a Diet-Induced Obesity Model of Early Atherosclerosis

Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Cancer Patients Undergoing Central Line Placement: A Phase 2 Clinical Trial

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

A Phase 2 Trial of the Protein C Activator AB002 in End-Stage Renal Disease Patients on Chronic Hemodialysis

Abelacimab Reduces Thrombus Propagation in a Baboon Model of Vascular Graft Thrombosis

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Crystalizing our view of the contact system

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Safety and Antithrombotic Efficacy of the Recombinant Protein C Activator AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis

The Anti-Factor XII Antibody AB052 Is Antithrombotic without Hemostatic Impairment in a Primate Model of Extracorporeal Membrane Oxygenation

E-WE Thrombin (ProCase) Inhibits Thrombin Mediated TAFI Activation and Accelerates TPA-Induced Thrombolysis

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Factor XI Deficiency Reduces The Inflammatory Response To Polymicrobial Sepsis In Mice

Rapid Interruption Of Occlusive Thrombus Formation By The Protein C Activator Enzyme EWE Thrombin (ProCase) In Primates

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American Society of Hematology

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American Society of Hematology

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