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Robert Silasi
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Journal Articles

Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice

Huiping Shi, Liang Gao, Nicole Kirby, Bojing Shao, Xindi Shan, Mariko Kudo, Robert Silasi, John Michael McDaniel, Meixiang Zhou, Samuel McGee, Wei Jing, Florea Lupu, Audrey Cleuren, James N. George, Lijun Xia
Journal: Blood
Blood (2024) 143 (13): 1293–1309.
https://doi.org/10.1182/blood.2023021583
Published: 2024
Includes: Supplemental data
Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu
Journal: Blood
Blood (2021) 138 (2): 178–189.
https://doi.org/10.1182/blood.2020009345
Published: 2021
Includes: Supplemental data
Journal Articles

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

Narcis I. Popescu, Robert Silasi, Ravi S. Keshari, Alanson Girton, Tarea Burgett, Sacha S. Zeerleder, David Gailani, Andras Gruber, Florea Lupu, K. Mark Coggeshall
Journal: Blood
Blood (2018) 132 (8): 849–860.
https://doi.org/10.1182/blood-2017-10-813618
Published: 2018
Includes: Supplemental data
Journal Articles

In vivo–generated thrombin and plasmin do not activate the complement system in baboons

Brief Report
Ravi S. Keshari, Robert Silasi, Cristina Lupu, Fletcher B. Taylor, Jr, Florea Lupu
Journal: Blood
Blood (2017) 130 (24): 2678–2681.
https://doi.org/10.1182/blood-2017-06-788216
Published: 2017
Includes: Supplemental data
Journal Articles

Synthetic Pentasaccharide Fondaparinux (Arixtra ® ) Reduces Sepsis Induced Coagulopathy and Promotes Survival in the Baboon Model of E. coli Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi, PhD, Narcis Ioan Popescu, PhD, Cristina Lupu, PhD, Charles Esmon, PhD, Florea Lupu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2375.
https://doi.org/10.1182/blood.V130.Suppl_1.2375.2375
Published: 2017
Journal Articles

Bacteremia, Not Coagulation Proteases Contribute to In Vivo Complement Activation in Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Cristina Lupu, PhD, Fletcher B. Taylor, Jr., MD, Florea Lupu, PhD
Journal: Blood
Blood (2016) 128 (22): 275.
https://doi.org/10.1182/blood.V128.22.275.275
Published: 2016
Journal Articles

Role of Androgen Dependent TFPI-Regulating Protein (ADTRP) in Vascular Development and Function

Maulin Mukeshchandra Patel, Robert Silasi-Mansat, PhD, Ravi Shankar Keshari, PhD, Christopher L. Sansam, PhD, David A. Jones, PhD, Cristina Lupu, PhD, Florea Lupu, PhD
Journal: Blood
Blood (2016) 128 (22): 556.
https://doi.org/10.1182/blood.V128.22.556.556
Published: 2016
Journal Articles

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Marybeth Langer, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Mark K. Coggeshall, Steven DeMarco, PhD, Florea Lupu, PhD
Journal: Blood
Blood (2015) 126 (23): 765.
https://doi.org/10.1182/blood.V126.23.765.765
Published: 2015
Journal Articles

Inter-α inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury

Hala Chaaban, Ravi S. Keshari, Robert Silasi-Mansat, Narcis I. Popescu, Padmaja Mehta-D’Souza, Yow-Pin Lim, Florea Lupu
Journal: Blood
Blood (2015) 125 (14): 2286–2296.
https://doi.org/10.1182/blood-2014-06-582759
Published: 2015
Includes: Supplemental data
Journal Articles

A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis

Ravi Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Steven J DeMarco, PhD, Florea Lupu, PhD
Journal: Blood
Blood (2014) 124 (21): 112.
https://doi.org/10.1182/blood.V124.21.112.112
Published: 2014
Journal Articles

Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice

Longbiao Yao, Tadayuki Yago, Bojing Shao, Zhenghui Liu, Robert Silasi-Mansat, Hendra Setiadi, Florea Lupu, Rodger P. McEver
Journal: Blood
Blood (2013) 122 (23): 3832–3842.
https://doi.org/10.1182/blood-2012-12-473835
Published: 2013
Includes: Multimedia, Supplemental data
Journal Articles

Protective Mechanisms Of Inter-Alpha Inhibitor Protein On Extracellular Histone Toxicity

Hala Chaaban, MD, Ravi Keshari, PhD, Padmaja Mehta-D'Souza, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Florea Lupu, PhD
Journal: Blood
Blood (2013) 122 (21): 19.
https://doi.org/10.1182/blood.V122.21.19.19
Published: 2013
Journal Articles

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

Robert Silasi-Mansat, Hua Zhu, Narcis I. Popescu, Glenn Peer, Georgia Sfyroera, Paola Magotti, Lacramioara Ivanciu, Cristina Lupu, Tom E. Mollnes, Fletcher B. Taylor, Gary Kinasewitz, John D. Lambris, Florea Lupu
Journal: Blood
Blood (2010) 116 (6): 1002–1010.
https://doi.org/10.1182/blood-2010-02-269746
Published: 2010
Includes: Supplemental data