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David Fonseca-Arce
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Journal Articles

Identification of High-Efficiency β-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies

Kadriye Nehir Cosgun, Mark E Robinson, Nikol Agadzhanian, Zhangliang Cheng, Salim Oulghazi, Philipp Berning, David Fonseca-Arce, Kohei Kume, Jake Fontaine, Lai N Chan, Jaewoong Lee, Fang Yu, Zhijian Qian, Joo Y. Song, Wing Chung Chan, Jianjun Chen, Mark M Taketo, Hilde Schjerven, Markus Müschen
Journal: Blood
Blood (2024) 144 (Supplement 1): 4125.
https://doi.org/10.1182/blood-2024-208125
Published: 2024
Journal Articles

Targeting β-Catenin Protein Degradation in Refractory B-Cell Malignancies

Kadriye Nehir Cosgun, Mark E Robinson, Nikol Agadzhanian, Philipp Berning, David Fonseca-Arce, Etienne Leveille, Shalin Kothari, Matthew S. Davids, Julia Jellusova, Markus Müschen
Journal: Blood
Blood (2024) 144 (Supplement 1): 1412.
https://doi.org/10.1182/blood-2024-208598
Published: 2024
Journal Articles

STAT5-Feedback Controls Distinct Metabolic States for Dynamic Transitions between Cellular Activation and Quiescence in Acute Lymphoblastic Leukemia

Kohei Kume, Zhengshan Chen, Mark E Robinson, Lai N Chan, Etienne Leveille, Kadriye Nehir Cosgun, Zhangliang Cheng, David Fonseca Arce, Dhruv Khanduja, Thomas Graeber, Markus Müschen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2977.
https://doi.org/10.1182/blood-2023-191006
Published: 2023
Journal Articles

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

Kadriye Nehir Cosgun, Mark E Robinson, Salim Oulghazi, Liang Xu, Gang Xiao, Lai N Chan, Jaewoong Lee, Kohei Kume, Etienne Leveille, David Fonseca Arce, Dhruv Khanduja, Niklas Feldhahn, Joo Y. Song, Wing C. Chan, Jianjun Chen, M. Mark Taketo, Hilde Schjerven, Julia Jellusova, Shalin Kothari, Matthew S Davids, Markus Müschen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2818.
https://doi.org/10.1182/blood-2023-190522
Published: 2023
Journal Articles

Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies

Franz Ketzer, Lars Klemm, Mark E Robinson, Christian Loucks, David Fonseca Arce, Kadriye Nehir Cosgun, Shalin Kothari, Markus Müschen
Journal: Blood
Blood (2023) 142 (Supplement 1): 1396.
https://doi.org/10.1182/blood-2023-189221
Published: 2023
Journal Articles

Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies

Kohei Kume, Jaewoong Lee, Zhangliang Cheng, Mark E Robinson, Etienne Leveille, Kadriye Nehir Cosgun, Lai N Chan, Yanzhi Feng, David Fonseca Arce, Dhruv Khanduja, Derek Toomre, Markus Müschen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4138.
https://doi.org/10.1182/blood-2023-190926
Published: 2023
Journal Articles

Genetic Knockin Approaches to Reconstructing DLBCL-Subtypes from Human Germinal Center B-Cells

Dhruv Khanduja, Mark E Robinson, David Fonseca Arce, Lars Klemm, Etienne Leveille, Shalin Kothari, Rebecca Caeser, Daniel James Hodson, Markus Müschen
Journal: Blood
Blood (2023) 142 (Supplement 1): 1627.
https://doi.org/10.1182/blood-2023-190634
Published: 2023
Journal Articles

Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies

Kohei Kume, Zhengshan Chen, Lai N. Chan, Mark E. Robinson, Etienne Leveille, Jaewoong Lee, Kadriye Nehir Cosgun, David Fonseca Arce, Dhruv Khanduja, Lars Klemm, Markus Müschen
Journal: Blood
Blood (2022) 140 (Supplement 1): 5900–5901.
https://doi.org/10.1182/blood-2022-170396
Published: 2022
Journal Articles

IFITM3 Acts As a PIP 3 Scaffold in TCR-PI3K Signaling

Andrew Takeda, Jaewoong Lee, Tim Wartewig, Alberto Bigogno, David Fonseca Arce, Markus Müschen
Journal: Blood
Blood (2022) 140 (Supplement 1): 3030–3031.
https://doi.org/10.1182/blood-2022-170540
Published: 2022
Journal Articles

Repressive β-Catenin-Ikaros Complexes Are Essential to Prevent Clonal Evolution of Human Lymphopoiesis

Kadriye Nehir Cosgun, Wei Liu, Mark E. Robinson, David Fonseca Arce, Jennifer VanOudenhove, Alberto Bigogno, Richard Flavell, Stephanie Halene, Markus Müschen
Journal: Blood
Blood (2022) 140 (Supplement 1): 8744–8745.
https://doi.org/10.1182/blood-2022-170409
Published: 2022
Journal Articles

CD25 As Feedback Regulator of Oncogenic TCR Signaling in T-Cell Lymphoma

Ruifeng Sun, Jaewoong Lee, Tim Wartewig, Mark E. Robinson, Alberto Bigogno, David Fonseca Arce, Abu-Sayeef Mirza, Andrew Takeda, Lars Klemm, Vivasvan Vykunta, Brian Shy, Alexander Marson, Markus Müschen
Journal: Blood
Blood (2022) 140 (Supplement 1): 5975–5976.
https://doi.org/10.1182/blood-2022-170076
Published: 2022
Journal Articles

GSK3β Inhibition Is a Unique Vulnerability in Lymphoid Malignancies

Kadriye Nehir Cosgun, Huda Jumaa, Mark E. Robinson, Lai N. Chan, Jaewoong Lee, Kohei Kume, David Fonseca Arce, Julia Jellusova, Markus Müschen
Journal: Blood
Blood (2022) 140 (Supplement 1): 3114–3115.
https://doi.org/10.1182/blood-2022-169961
Published: 2022