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Dirk Heckl, PhD
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Journal Articles

Deconstructing the Clonal Advantage and Clonal Stability of 5q- Candidate Genes in Del(5q) MDS on a Single Cell Level

Ursula S.A. Stalmann, MD, Fabio Ticconi, MSc, Ronghui Li, MSc, Aaron B. Wong, PhD, Glenn Cowley, PhD, David E. Root, PhD, Dirk Heckl, PhD, Inge Snoeren, MSc, Sergio Martinez, PhDMSc, Tim H Brümmendorf, MD, Andreas Schuppert, PhD, Ivan Costa, PhD, Benjamin L. Ebert, MD PhD, Rebekka K. Schneider, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 559.
https://doi.org/10.1182/blood-2019-122588
Published: 2019
Journal Articles

Exome Sequencing of Relapsed Multiple Myeloma Combined with Pooled CRISPR/Cas9 Screens Identifies Gene Mutations Associated with Drug-Specific Resistance

Stephan Bohl, Laura K. Schmalbrock, MD, Imke Bauhuf, Anna Dolnik, Tamara J. Blätte, MSc, Stefanie Lindner, Dr., Tatjana Meyer, MSc, BSc, Sarah Knödler, Denise Miller, Miriam Kull, Christian Langer, MD, Hartmut Döhner, MD, Dirk Heckl, PhD, Lars Bullinger, Jan Krönke, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 809.
https://doi.org/10.1182/blood-2019-131245
Published: 2019
Journal Articles

Characterization of a Novel JAK1 Pseudokinase Mutation in the First Case of Trisomy 21-Independent GATA1-Mutated Transient Abnormal Myelopoiesis

Julius Lukes, Jr., MD, Petr Danek, MSc, Oriol Alejo, Eliska Potuckova, Ondrej Gahura, Dirk Heckl, PhD, Julia Starkova, PhD, Jan Zuna, Jan Stary, Prof., MD PhD, Jan Trka, Prof., MD PhD, Jan-Henning Klusmann, Marketa Zaliova, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4208.
https://doi.org/10.1182/blood-2019-122168
Published: 2019
Journal Articles

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Kathrin Krowiorz, Raj Bhayadia, Razan Jammal, Caroline Pabst, Nicole Pochert, MSc, Christoph Rueß, MSc, Christina Miller, Konstanze Döhner, MD, Tobias Maetzig, PhD, Hartmut Döhner, MD, Lars Bullinger, MD, Stephan Emmrich, PhD MSc, Dirk Heckl, PhD, Vera Martins, Reinhild Rösler, PhD, Sebastian Wiese, PhD, R. Keith Humphries, MD PhD, Arefeh Rouhi, PhD, Jan-Henning Klusmann, Florian Kuchenbauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2627.
https://doi.org/10.1182/blood-2018-99-116256
Published: 2018
Journal Articles

Modelling the Progression of a Preleukemic Stage to Overt Leukemia in Children with Down Syndrome

Maurice Labuhn, MSc, Kelly Perkins, PhD, Elli Papaemmanuil, PhD, Catherine Garnett, Soeren Matzk, Vyacheslav Amstislavskiy, Marlen Metzner, Alison Kennedy, Carina Scheer, Kenichi Yoshida, MD PhD, Adrian Schwarzer, MD PhD, John D. Crispino, PhD MBA, Jeffrey W. Taub, MD, Mitchell J. Weiss, MD PhD, Etsuro Ito, MDPhD, Seishi Ogawa, MD PhD, Dirk Reinhardt, Marie-Laure Yaspo, PhD, Peter J. Campbell, PhD, Dirk Heckl, PhD, Jan-Henning Klusmann, Paresh Vyas
Journal: Blood
Blood (2018) 132 (Supplement 1): 543.
https://doi.org/10.1182/blood-2018-99-116661
Published: 2018
Journal Articles

Serially Transplantable Patient-Derived Xenograft Model of Chronic Myelomonocytic Leukemia (CMML)

Arnold Kloos, PhD, Felicitas Thol, MD, Lina Winckler, Razif Gabdoulline, PhD, Konstantinos Mintzas, Nidhi Jyotsana, PhD, Renate Schottmann, Felix F. Adams, Adrian Schwarzer, MD PhD, Dirk Heckl, PhD, Suzan Imren, MD, R. Keith Humphries, Arnold Ganser, MD, Michael Heuser, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4236.
https://doi.org/10.1182/blood.V130.Suppl_1.4236.4236
Published: 2017
Journal Articles

The miRNA-193 Family Is a Potent Tumor-Suppressor and a Biomarker for Poor Prognosis in Acute Myeloid Leukemia

Razan Jammal, Kathrin Krowiorz, Nadine Haetscher, PhD, Stephan Emmrich, PhD MSc, Arefeh Rouhi, PhD, Michael Heuser, MD, Sabrina Bothur, Lars Bullinger, MD, Konstanze Döhner, Courteney Lai, Tobias Maetzig, Askar Obulkasim, Vera Martins, PhD, Medhanie A. Mulaw, Jun.-Prof. Dr., Jan Stary, MD D.Sc., Andre Baruchel, MD, Valerie De Haas, MD PhD, Dirk Reinhardt, MD PhD, Hartmut Döhner, MD, Jens Ruschmann, Michel Zwaan, Marry van den Heuvel-Eibrink, Dirk Heckl, PhD, Maarten Fornerod, PhD, R. Keith Humphries, MD PhD, Michael A Rieger, PhD, Florian Kuchenbauer, Jan-Henning Klusmann, MD
Journal: Blood
Blood (2016) 128 (22): 1534.
https://doi.org/10.1182/blood.V128.22.1534.1534
Published: 2016
Journal Articles

Crispr-Cas9 Mediated Disruption of Dnmt3a in JakV617F Hematopoietic Stem Cells Accelerates Disease Phenotype and Induces Lethal Myelofibrosis

Sebastien Jacquelin, PhD, Emma Dishington, Therese Vu, Axia Song, Matthew Heidecker, Solene Guignes, Claudia Bruedigam, PhD, Joanne Sutton, Geoffrey R Hill, MD PhD, Nicole Cloonan, PhD, Dirk Heckl, PhD, Steven W Lane, PhD
Journal: Blood
Blood (2016) 128 (22): 794.
https://doi.org/10.1182/blood.V128.22.794.794
Published: 2016
Journal Articles

Crispr-Cas9 Induced MLL-Rearrangements Cause Clonal Outgrowth in CD34+ Hematopoietic Stem Cells

Jana Reimer, Sabine Knoess, Maurice Labuhn, Emmanuelle Marie Charpentier, PhD, Jan-Henning Klusmann, MD, Dirk Heckl, PhD
Journal: Blood
Blood (2015) 126 (23): 165.
https://doi.org/10.1182/blood.V126.23.165.165
Published: 2015
Journal Articles

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

Kathrin Krowiorz, Razan Jammal, Stephan Emmrich, PhD MSc, Arefeh Rouhi, PhD, Michael Heuser, MD, Lars Bullinger, Konstanze Döhner, MD, Lai Courteney, Tobias Maetzig, PhD, Vera Martins, Medhanie Assmelash Mulaw, BSc,MSc,PhD, Dirk Heckl, PhD, Christian M. Zwaan, MD PhD, Jan Stary, Andre Baruchel, MD, Valerie De Haas, MD PhD, Dirk Reinhardt, MD, Maarten Fornerod, Hartmut Döhner, MD, Jens Ruschmann, Marry M van den Heuvel-Eibrink, MD PhD, R. Keith Humphries, MD PhD, Florian Kuchenbauer, MD PhD, Jan-Henning Klusmann, MD
Journal: Blood
Blood (2015) 126 (23): 1244.
https://doi.org/10.1182/blood.V126.23.1244.1244
Published: 2015
Journal Articles

GATA1-Centered Genetic Network on Chromosome 21 Drives Down Syndrome Acute Megakaryoblastic Leukemia

Lena Stachorski, Dirk Heckl, PhD, Veera Raghavan Thangapandi, Aliaksandra Maroz, PhD, Dirk Reinhardt, MD PhD, Jan-Henning Klusmann, MD
Journal: Blood
Blood (2014) 124 (21): 4310.
https://doi.org/10.1182/blood.V124.21.4310.4310
Published: 2014
Journal Articles

Critical Role Of Casein Kinase (Ck)1α Heterozygote Gene Inactivation In The Clonal Advantage Of Hematopoietic Stem Cells In Del(5q) MDS

Rebekka K. Schneider, MD, Dirk Heckl, PhD, Marcus Järås, PhD, Lisa Chu, McConkey Marie, PhD, Ann Mullally, MD, Benjamin L Ebert, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 98.
https://doi.org/10.1182/blood.V122.21.98.98
Published: 2013
Journal Articles

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Leukemia in a Murine Bone Marrow Transplantation Model

Dirk Heckl, PhD, Adrian Schwarzer, MD, Reinhard Haemmerle, Johann Meyer, PhD, Doris Steinemann, PhD, Cornelia Rudolph, PhD, Britta Skawran, PhD, Brigitte Schlegelberger, MD, Christopher Baum, MD, Ute Modlich, DVM, PhD
Journal: Blood
Blood (2011) 118 (21): 671.
https://doi.org/10.1182/blood.V118.21.671.671
Published: 2011
Journal Articles

Retroviral Ectopic Expression of a Signaling-Defective Thrombopoietin Receptor (Mpl) Induces a Systemic Loss of Hematopoietic Stem Cells in Mice,

Sabine Wintterle, MD, Dirk Heckl, PhD, Adrian Schwarzer, MD, Guntram Buesche, MD, Christopher Baum, MD, Ute Modlich, DVM, PhD
Journal: Blood
Blood (2011) 118 (21): 4175.
https://doi.org/10.1182/blood.V118.21.4175.4175
Published: 2011