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Journal Articles

Clonal Architecture Analysis of TET2 Identified Distinct Origins in Myelodysplastic Syndromes

Zhongxun Shi, MD, Bing Li, MD, Tiejun Qin, MD, Zefeng Xu, MD, Lijuan Pan, MD, Shiqiang Qu, MD, Gang Huang, PhD, Zhijian Xiao, MD

Blood (2020) 136 (Supplement 1): 18.

https://doi.org/10.1182/blood-2020-139329

Published: 2020

Journal Articles

RUNX1 Mutation Leads to Megakaryocyte-Primed Hematopoietic Stem Cell Expansion and Familial Platelet Disorder

Chen Wang, MD, Weinan Wang, BS, Lei Huang, PhD, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2020) 136 (Supplement 1): 8–9.

https://doi.org/10.1182/blood-2020-140769

Published: 2020

Journal Articles

Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models

Asumi Yokota, PhD, Lulu Zhang, PhD, Jianhua Feng, Xiaomin Feng, MD PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD

Blood (2019) 134 (Supplement_1): 1696.

https://doi.org/10.1182/blood-2019-126799

Published: 2019

Journal Articles

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Bing Li, MD, Jinqin Liu, Tiejun Qin, Zefeng Xu, MD, Gang Huang, PhD, Zhijian Xiao, MD

Blood (2019) 134 (Supplement_1): 2979.

https://doi.org/10.1182/blood-2019-126346

Published: 2019

Journal Articles

Cell-Intrinsic Inflammation Drives Progression from Myelodysplastic Syndromes to Leukemia

Laura Barreyro, PhD, Avery Sampson, BSc, Kathleen Hueneman, Kwangmin Choi, PhD, Susanne Christie, BSc, Dehua Wang, MD, Gang Huang, PhD, Daniel T. Starczynowski, PhD

Blood (2019) 134 (Supplement_1): 2983.

https://doi.org/10.1182/blood-2019-127307

Published: 2019

Journal Articles

Comparable Leukemic Cells Reduction but Improved Normal Hematopoietic Regeneration with G-CSF Priming Plus Low Dose Chemotherapy Regimen Relative to Standard Chemotherapy in AML Mice Model

Ya Zhang, MS, Xiaomin Feng, MD PhD, Aili Chen, PhD, Shaoyan Hu, MD PhD, Qianfei Wang, PhD, Gang Huang, PhD

Blood (2019) 134 (Supplement_1): 1362.

https://doi.org/10.1182/blood-2019-129465

Published: 2019

Journal Articles

Identification, Isolation and Transcriptome Analyses of Mouse, Rat and Man Erythroblastic Island Central Macrophages

Wei Li, MD PhD, Yaomei Wang, MD PhD, Huizhi Zhao, Huan Zhang, Yuanlin Xu, Shihui Wang, Xinhua Guo, Yumin Huang, Xianfang Wu, Charles Rice, Gang Huang, PhD, Lixiang Chen, Xiuli An, MD PhD

Blood (2018) 132 (Supplement 1): 841.

https://doi.org/10.1182/blood-2018-99-114188

Published: 2018

Journal Articles

Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL

Chen Wang, PhDcandidate, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2018) 132 (Supplement 1): 1325.

https://doi.org/10.1182/blood-2018-99-116919

Published: 2018

Journal Articles

Myc Regulates the Development and Anti-Tumor Immunity of Natural Killer Cells

Yuting Tang, MD PhD, Xiaomei Yan, MD PhD, Di Zhan, PhD, Lijun Wen, MS, Rui Huang, MD PhD, Yue Zhang, MD PhD, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Jianfeng Zhou, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1113.

https://doi.org/10.1182/blood-2018-99-114180

Published: 2018

Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2018-99-112529

Published: 2018

Journal Articles

The Trithorax-Group Protein ASH1L Regulates Hematopoietic Stem Cell Homeostasis Independently of Its Histone Methyltransferase Activity

Gloria Jih, PhD, Jennifer Chase, PhD, Yile Zhou, MD PhD, Ann Friedman, BS, Xiaomin Feng, MD PhD, Manabu Nakayama, PhD, Haruhiko Koseki, PhD, Kenichi Nishioka, PhD, Gang Huang, PhD, Ivan Maillard, MD PhD

Blood (2018) 132 (Supplement 1): 1270.

https://doi.org/10.1182/blood-2018-99-117367

Published: 2018

Journal Articles

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Shailaja N Hegde, PhD, Mark J Althoff, BS, Ramesh C. Nayak, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Gang Huang, PhD, Yi Zheng, PhD, Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD

Blood (2018) 132 (Supplement 1): 551.

https://doi.org/10.1182/blood-2018-99-118919

Published: 2018

Journal Articles

Setd2-Mediated Epigenetic Regulation of Erythropoiesis and HSC Maintenance in Mouse Models

Xiaomin Feng, MD PhD, Yile Zhou, MD PhD, Asumi Yokota, PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 3823.

https://doi.org/10.1182/blood-2018-99-111735

Published: 2018

Journal Articles

HIF1A Is a Critical Downstream Mediator for Hemophagocytic Lymphohistiocytosis

Blood (2017) 130 (Supplement 1): 3565.

https://doi.org/10.1182/blood.V130.Suppl_1.3565.3565

Published: 2017

Journal Articles

Clinical Features and Biological Implications of U2AF1 Mutations in Myelodysplastic Syndromes

Bing Li, Jinqin Liu, Yujiao Jia, MD, Tiejun Qin, Zefeng Xu, MD, Yue Zhang, MD PhD, Gang Huang, PhD, Zhijian Xiao

Blood (2017) 130 (Supplement 1): 586.

https://doi.org/10.1182/blood.V130.Suppl_1.586.586

Published: 2017

Journal Articles

Essential Role of c-MYC for Natural Killer Cell Development, Proliferation and Anti-Tumor Activity

Yuting Tang, MD, Xiaomei Yan, Rui Huang, MD PhD, Yoshihiro Hayashi, MD PhD, Yue Zhang, Wang Qianfei, PhD, Jianfeng Zhou, MD PhD, Gang Huang, PhD

Blood (2017) 130 (Supplement 1): 786.

https://doi.org/10.1182/blood.V130.Suppl_1.786.786

Published: 2017

Journal Articles

Mutation Profiling Reveals Novel Epigenetics and Splicing Mutations in Chemorefractory Pediatric AML

Yingchi Zhang, PhD, Di Zhan, Peifang Xiao, MD, MIN Ruan, Jingliao Zhang, Gang Huang, PhD, Shaoyan Hu, MD PhD, Qianfei Wang, PhD, Xiaofan Zhu, MD

Blood (2017) 130 (Supplement 1): 3817.

https://doi.org/10.1182/blood.V130.Suppl_1.3817.3817

Published: 2017

Journal Articles

Monotcytes/Macrophages Are Involved in Erythrocytosis Caused By Both EPO-Dependent and -Independent Activation of EPOR

Asumi Yokota, PhD, Yoshihiro Hayashi, MD PhD, Jieyu Wang, MD PhD, Rui Huang, MD PhD, Xiaomei Yan, Yue Zhang, MD PhD, Gang Huang, PhD

Blood (2017) 130 (Supplement 1): 449.

https://doi.org/10.1182/blood.V130.Suppl_1.449.449

Published: 2017

Journal Articles

Global Crosstalk between Two Histone Modifications That Control Transcriptional Elongation in MLL Leukemia

Jiachen Bu, Aili Chen, PhD, Xiaomei Yan, Fuhong He, PhD, Yunzhu Dong, Yile Zhou, Jianlin He, Yoshihiro Hayashi, Di Zhan, Yanling Sun, Yue Zhang, Zhijian Xiao, Lee Grimes, Qianfei Wang, PhD, Gang Huang, PhD

Blood (2017) 130 (Supplement 1): 2495.

https://doi.org/10.1182/blood.V130.Suppl_1.2495.2495

Published: 2017

Journal Articles

The High NRF2 Expression Confers Chemotherapy Resistance through Upregulated DUSP1 in Myelodysplastic Syndromes

Peipei Lin, Yanling Ren, Xinping Zhou, Chen Mei, Chao Hu, Yingwan Luo, Yile Zhou, Xiaomei Yan, Gang Huang, PhD, Hongyan Tong, PhD

Blood (2017) 130 (Supplement 1): 2956.

https://doi.org/10.1182/blood.V130.Suppl_1.2956.2956

Published: 2017

NARROW

Clonal Architecture Analysis of TET2 Identified Distinct Origins in Myelodysplastic Syndromes

RUNX1 Mutation Leads to Megakaryocyte-Primed Hematopoietic Stem Cell Expansion and Familial Platelet Disorder

Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Cell-Intrinsic Inflammation Drives Progression from Myelodysplastic Syndromes to Leukemia

Comparable Leukemic Cells Reduction but Improved Normal Hematopoietic Regeneration with G-CSF Priming Plus Low Dose Chemotherapy Regimen Relative to Standard Chemotherapy in AML Mice Model

Identification, Isolation and Transcriptome Analyses of Mouse, Rat and Man Erythroblastic Island Central Macrophages

Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL

Myc Regulates the Development and Anti-Tumor Immunity of Natural Killer Cells

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

The Trithorax-Group Protein ASH1L Regulates Hematopoietic Stem Cell Homeostasis Independently of Its Histone Methyltransferase Activity

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Setd2-Mediated Epigenetic Regulation of Erythropoiesis and HSC Maintenance in Mouse Models

HIF1A Is a Critical Downstream Mediator for Hemophagocytic Lymphohistiocytosis

Clinical Features and Biological Implications of U2AF1 Mutations in Myelodysplastic Syndromes

Essential Role of c-MYC for Natural Killer Cell Development, Proliferation and Anti-Tumor Activity

Mutation Profiling Reveals Novel Epigenetics and Splicing Mutations in Chemorefractory Pediatric AML

Monotcytes/Macrophages Are Involved in Erythrocytosis Caused By Both EPO-Dependent and -Independent Activation of EPOR

Global Crosstalk between Two Histone Modifications That Control Transcriptional Elongation in MLL Leukemia

The High NRF2 Expression Confers Chemotherapy Resistance through Upregulated DUSP1 in Myelodysplastic Syndromes

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