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Gerd Blobel
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Journal Articles

A novel LRF degrader induces fetal hemoglobin expression in adult erythroblasts

Free
Sisi Zheng, Abhirup Bagchi, Ke Li, Peng Huang, John Hines, Mackenzie Krone, Arseniy Butrin, Michael Bond, Belinda Giardine, Cheryl Keller, Zhuangzhuang Geng, Bailey Godfrey, Sarah Cotteta, Osheiza Abdulmalik, Ross Hardison, George Burslem, Eugene Khandros, Craig Crews, Gerd Blobel
Journal: Blood
Blood (2025) 146 (Supplement 1): 836.
https://doi.org/10.1182/blood-2025-836
Published: 2025
Journal Articles

LDB1-dependent enhancer networks drive high-risk transcriptional programs in T-cell acute lymphoblastic leukemia

Free
Rahul Bhansali, Juan Long, Petri Polonen, Shuo Zhang, Mariah Antopia, Siqing Wang, Nicholas Aboreden, Ahnaf Tausif, Zhuangzhuang Geng, Cheryl Keller, Belinda Giardine, Ross Hardison, Charles Mullighan, Gerd Blobel
Journal: Blood
Blood (2025) 146 (Supplement 1): 3251.
https://doi.org/10.1182/blood-2025-3251
Published: 2025
Journal Articles

Expansion of human hematopoietic stem cells by inhibiting translation

Free
Chenchen Li, Hanna Shin, Dheeraj Bhavanasi, Xiaolei Liu, Mai Liu, Yu Xiang, Scott Peslak, Friederike Herbst, Mohamad-Gabriel Alameh, Laura Breda, Stefano Rivella, Juan Alvarez-Dominguez, Gerd Blobel, Brian Gregory, Jian Huang, Peter Klein
Journal: Blood
Blood (2025) 146 (Supplement 1): 1379.
https://doi.org/10.1182/blood-2025-1379
Published: 2025
Journal Articles

Comparison of Fetal and Adult Erythroid Chromosomal Architectures Identifies a Novel Fetal Hemoglobin Regulatory Region

Free
Peng Huang, PhD, Cheryl A. Keller, PhD, Belinda Giardine, James O.J. Davies, Jim R. Hughes, Ross C Hardison, PhD, Gerd Blobel, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 774.
https://doi.org/10.1182/blood.V130.Suppl_1.774.774
Published: 2017
Journal Articles

Manipulating Higher Order Chromatin Structure of the β-Globin Locus by Targeted Tethering of a “looping” Factor

Free
Wulan Deng, Graduate, student, Philip D Gregory, PhD, Andreas Reik, PhD, Gerd Blobel, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 647.
https://doi.org/10.1182/blood.V116.21.647.647
Published: 2010
Journal Articles

Defective Production, Turnover, and Secretion of the Platelet α-Granule Protein P-Selectin In Mice with Disrupted FOG1-NuRD Interaction

Free
Yuhuan Wang, PhD, Ronghua Meng, PhD, Gerd Blobel, MD, PhD, Michael S. Marks, PhD, Mortimer Poncz, MD
Journal: Blood
Blood (2010) 116 (21): 547.
https://doi.org/10.1182/blood.V116.21.547.547
Published: 2010
Journal Articles

Acetylation-Dependent Interaction of GATA-1 with the Potential Mitotic “Bookmarking” Protein Brd3.

Free
Janine M Lamonica, Stephan Kadauke, Wulan Deng, Graduate, Gerd Blobel, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2598.
https://doi.org/10.1182/blood.V116.21.2598.2598
Published: 2010
Journal Articles

A Potential Epigenetic Bookmarking Function for the Hematopoietic Transcription Factor GATA-1.

Free
Stephan Kadauke, Janine M Lamonica, Alan Lau, PhD, Margaret Chou, Ph.D., Gerd Blobel, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2601.
https://doi.org/10.1182/blood.V116.21.2601.2601
Published: 2010
Journal Articles

SCL and Associated Proteins Distinguish Active from Repressive GATA Transcription Factor Complexes.

Free
Wulan Deng, Tamara Tripic, PhD, Yong Cheng, Ying Zhang, Christopher Vakoc, PhD, Ross Hardison, PhD, Gerd Blobel, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1379.
https://doi.org/10.1182/blood.V112.11.1379.1379
Published: 2008
Journal Articles

Graded Repression of PU.1 Expression by GATA Factors Influence Hematopoietic Progenitor Cell Fate

Free
Stella T. Chou, MD, Charles Bailey, M.D., Yu Yao, Zan Huang, PhD, Kim Nichols, MD, John Crispino, PhD, Ross Hardison, Ph.D., Gerd Blobel, MD, PhD, Chris Vakoc, MD, PhD, Mitchell J. Weiss, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 2469.
https://doi.org/10.1182/blood.V112.11.2469.2469
Published: 2008
Journal Articles

The GATA-1 Cofactor FOG-1 Recruits NuRD to Promote Normal Erythroid and Megakaryocyte Development and Maintain Lineage Fidelity by Restricting Mast Cell Gene Expression.

Free
Gregory D Gregory, Yuhuan Wang, Wei Hong, Annarita Miccio, Alexey Bersenev, Xiang Yu, Hongxin Wang, John Choi, Suresh Shelat, Wei Tong, Mortimer Poncz, Gerd Blobel
Journal: Blood
Blood (2008) 112 (11): 1373.
https://doi.org/10.1182/blood.V112.11.1373.1373
Published: 2008
Journal Articles

Cyclin D: CDK4/6 Kinase Activity, Regulated by GATA-1, Is Required for Megakaryocyte Polyploidization.

Free
Andrew G. Muntean, Liyan Pang, PhD, Mortimer Poncz, MD, Steve Dowdy, PhD, Gerd Blobel, MD/PhD, John Crispino, PhD
Journal: Blood
Blood (2006) 108 (11): 780.
https://doi.org/10.1182/blood.V108.11.780.780
Published: 2006
Journal Articles

Maturation Stage-Specific Regulation of Megakaryocytic Genes by Pointed-Domain Ets Proteins.

Free
Liyan Pang, Xun Wang, PhD, Yuhuan Wang, PhD, Gerd Blobel, PhD, MD, Mortimer Poncz, MD
Journal: Blood
Blood (2005) 106 (11): 1737.
https://doi.org/10.1182/blood.V106.11.1737.1737
Published: 2005
Journal Articles

Genetic Modeling of Chemical Antagonists: Genome Scale Validation of Hematopoietic Disease Drug Targets by In Vivo Functional Analysis.

Free
Tamas Oravecz, Ph.D., Alex Turner, Ph.D., Philip Brown, M.D., J.D., Brian Zambrowicz, Ph.D., Gerd Blobel, M.D., Ph.D.
Journal: Blood
Blood (2004) 104 (11): 2577.
https://doi.org/10.1182/blood.V104.11.2577.2577
Published: 2004