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Journal Articles

Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs

Saskia van der Velden, Thijs L. J. van Osch, Amina Seghier, Arthur E. H. Bentlage, Juk Yee Mok, Dionne M. Geerdes, Wim J. E. van Esch, Richard B. Pouw, Mieke C. Brouwer, Ilse Jongerius, Masja de Haas, Leendert Porcelijn, C. Ellen van der Schoot, Gestur Vidarsson, Rick Kapur

Blood (2024) 143 (1): 79–91.

https://doi.org/10.1182/blood.2023020484

Published: 2024

Includes: Supplemental data

Journal Articles

ITGB1 -Expressing Effector Memory CD4 + T-Cell Response Associates with Clinical Recovery in Childhood Immune Thrombocytopenia

David E. Schmidt, Katja Heitink-Pollé, Benoit P Nicolet, Leendert Porcelijn, Marrie Bruin, C. Ellen Van der Schoot, Rick Kapur, Gestur Vidarsson, Masja De Haas

Blood (2023) 142 (Supplement 1): 3955.

https://doi.org/10.1182/blood-2023-188702

Published: 2023

Journal Articles

Fc-Mediated Complement Activation Is Associated with Macrophage Trafficking and Induction of Neutrophil Extracellular Traps in Transfusion-Related Acute Lung Injury

Saskia van der Velden, Thijs L.J. van Osch, Amina Seghier, Arthur Bentlage, Juk Yee Mok, Dionne M Geerdes, Wim J.E. van Esch, Masja De Haas, Leendert Porcelijn, C. Ellen van der Schoot, Gestur Vidarsson, Rick Kapur

Blood (2021) 138 (Supplement 1): 354.

https://doi.org/10.1182/blood-2021-153988

Published: 2021

Journal Articles

Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in a Preclinical Model By Monoclonal Anti-HPA-1a Antibody Prophylaxis: Structural and Functional Properties of Antibody Variant Isoforms

Trude Victoria Mørtberg, Huiying Zhi, Gestur Vidarsson, Stian Foss, Terje E Michaelsen, Bjørn Skogen, Tor Brynjar Stuge, Jan Terje Andersen, Peter J. Newman, Maria Therese Ahlen

Blood (2021) 138 (Supplement 1): 1011.

https://doi.org/10.1182/blood-2021-149196

Published: 2021

Journal Articles

Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets

Alexander P. Bye, Willianne Hoepel, Joanne L. Mitchell, Sophie Jégouic, Silvia Loureiro, Tanya Sage, Gestur Vidarsson, Jan Nouta, Manfred Wuhrer, Steven de Taeye, Marit van Gils, Neline Kriek, Nichola Cooper, Ian Jones, Jeroen den Dunnen, Jonathan M. Gibbins

Blood (2021) 138 (16): 1481–1489.

https://doi.org/10.1182/blood.2021011871

Published: 2021

Includes: Supplemental data

Journal Articles

A Clinical Prediction Score for Course of Disease in Newly Diagnosed Childhood Immune Thrombocytopenia

David Schmidt, MD MSc, Katja M.J. Heitink-Pollé, MD PhD, C. Ellen van der Schoot, MD PhD, Leendert Porcelijn, MD, Gestur Vidarsson, PhD, Marrie Bruin, MD PhD, Johanna G. van der Bom, MD PhD, Masja De Haas, MD PhD

Blood (2019) 134 (Supplement_1): 2376.

https://doi.org/10.1182/blood-2019-130391

Published: 2019

Journal Articles

Identification of Self-Limiting Pediatric Immune Thrombocytopenia at Diagnosis

David Schmidt, MD MSc, Katja Heitink-Pollé, MD PhD, Bart Mertens, PhD, Annemieke G. Laarhoven, MD PhD, Leendert Porcelijn, MD, Barbera Veldhuisen, PhD, C. Ellen van der Schoot, MD PhD, Gestur Vidarsson, PhD, Johanna G van der Bom, MD PhD, Marrie Bruin, MD PhD, Masja De Haas, MD PhD

Blood (2018) 132 (Supplement 1): 1145.

https://doi.org/10.1182/blood-2018-99-116591

Published: 2018

Journal Articles

Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia

Peter A. A. Norris, BSc, George B. Segel, MD, Ulrich J Sachs, MD PhD, Behnaz Bayat, PhD, Gestur Vidarsson, PhD, Rick Kapur, MDPhDMSc, Christine M. Cserti-Gazdewich, BSc, MD FRCPC, Jeannie Callum, MD, Yulia Lin, MD FRCPC, Richard Burack, MD PhD, John W Semple, PhD, Alan H Lazarus, PhD

Blood (2018) 132 (Supplement 1): 129.

https://doi.org/10.1182/blood-2018-99-117650

Published: 2018

Journal Articles

Intravenous immunoglobulin vs observation in childhood immune thrombocytopenia: a randomized controlled trial

Katja M. J. Heitink-Pollé, Cuno S. P. M. Uiterwaal, Leendert Porcelijn, Rienk Y. J. Tamminga, Frans J. Smiers, Nicole L. van Woerden, Judit Wesseling, Gestur Vidarsson, Annemieke G. Laarhoven, Masja de Haas, Marrie C. A. Bruin

Blood (2018) 132 (9): 883–891.

https://doi.org/10.1182/blood-2018-02-830844

Published: 2018

Includes: Supplemental data

Journal Articles

Anti-Platelet Antibodies Are Predominantly IgM in Childhood Immune Thrombocytopenia

David Schmidt, MD MSc, Katja M.J. Heitink-Pollé, Leendert Porcelijn, MD, C. Ellen Van der Schoot, MD PhD, Gestur Vidarsson, PhD, Marrie Bruin, MD PhD, Masja De Haas, MD PhD

Blood (2017) 130 (Supplement 1): 3641.

https://doi.org/10.1182/blood.V130.Suppl_1.3641.3641

Published: 2017

Journal Articles

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

Elina Ovchynnikova, Francesca Aglialoro, Arthur E. H. Bentlage, Gestur Vidarsson, Nichole D. Salinas, Marieke von Lindern, Niraj H. Tolia, Emile van den Akker

Blood (2017) 130 (12): 1441–1444.

https://doi.org/10.1182/blood-2017-03-774364

Published: 2017

Includes: Supplemental data

Journal Articles

RhIg-prophylaxis is not influenced by FCGR2/3 polymorphisms involved in red blood cell clearance

Tamara C. Stegmann, Barbera Veldhuisen, Sietse Q. Nagelkerke, Dian Winkelhorst, Henk Schonewille, Esther P. Verduin, Taco W. Kuijpers, Masja de Haas, Gestur Vidarsson, C. Ellen van der Schoot

Blood (2017) 129 (8): 1045–1048.

https://doi.org/10.1182/blood-2016-05-716365

Published: 2017

Includes: Supplemental data

Journal Articles

IgG Subtype Affects Immunomodulation through FcγRs, on Non-Macrophage Populations in a Murine Model - Mechanistic Implications for Anti-D

James C. Zimring, MD PhD, Hayley Waterman, Xiaohong Wang, PhD, Linda Kapp, Jenna Lebedev, Heather Howie, PhD, Ariel Hay, Tamara Carola Stegmann, MSc, Gestur Vidarsson, PhD, C. Ellen Van der Schoot, MD PhD Prof.

Blood (2016) 128 (22): 21.

https://doi.org/10.1182/blood.V128.22.21.21

Published: 2016

Journal Articles

Patients with Autoimmune Anti-Red Blood Cell IgG1 Have Different Total- and Autoantibody -IgG1 Glycosylation Compared to Healthy Controls

Myrthe E. Sonneveld, MD, Masja De Haas, MD PhD Prof., Carolien Koeleman, Peter Ligthart, Manfred Wuhrer, PhD Prof., C. Ellen Van der Schoot, MD PhD Prof., Gestur Vidarsson, PhD

Blood (2016) 128 (22): 93.

https://doi.org/10.1182/blood.V128.22.93.93

Published: 2016

Journal Articles

Fc-Gamma Receptor Polymorphisms Are Associated with Susceptibility to and Recovery from Pediatric Immune Thrombocytopenia

Katja M.J. Heitink-Polle, MD, Annemieke G. Laarhoven, MD PhD, Marrie C.A. Bruin, MD PhD, Barbera Veldhuisen, PhD, Sietse Q. Nagelkerke, MD PhD, Taco Kuijpers, MD PhD Prof., C. Ellen van der Schoot, MD PhD Prof., Gestur Vidarsson, PhD, Masja de Haas, MD PhD Prof.

Blood (2016) 128 (22): 867.

https://doi.org/10.1182/blood.V128.22.867.867

Published: 2016

Journal Articles

IgG Alloantibodies Against RBC Induced By Pregnancy or Transfusion Have Unique Glycosylation Patterns Which Correlate with Clinical Outcome of Hemolytic Disease of the Fetus or Newborn

Myrthe Elisabeth Sonneveld, MD, Rosina Plomp, Jon Admiraal, Carolien Koeleman, Agnes Hipgrave-Ederveen, Joke Koelewijn, PhD, Peter Ligthart, Masja De Haas, Prof, MD, Manfred Wuhrer, Prof, C. Ellen Van der Schoot, Prof, MD, Gestur Vidarsson, PhD

Blood (2015) 126 (23): 660.

https://doi.org/10.1182/blood.V126.23.660.660

Published: 2015

Journal Articles

C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia

Rick Kapur, Katja M. J. Heitink-Pollé, Leendert Porcelijn, Arthur E. H. Bentlage, Marrie C. A. Bruin, Remco Visser, Dirk Roos, Richard B. M. Schasfoort, Masja de Haas, C. Ellen van der Schoot, Gestur Vidarsson

Blood (2015) 125 (11): 1793–1802.

https://doi.org/10.1182/blood-2014-05-579110

Published: 2015

Includes: Supplemental data

Journal Articles

Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages

Sietse Q. Nagelkerke, Gillian Dekkers, Iwan Kustiawan, Fleur S. van de Bovenkamp, Judy Geissler, Rosina Plomp, Manfred Wuhrer, Gestur Vidarsson, Theo Rispens, Timo K. van den Berg, Taco W. Kuijpers

Blood (2014) 124 (25): 3709–3718.

https://doi.org/10.1182/blood-2014-05-576835

Published: 2014

Includes: Supplemental data

Journal Articles

RhD Immunization Despite Adequate Immunoprophylaxis: Role of Fc Gamma Receptor Gene Polymorphisms

Tamara C Stegmann, Sietse Q Nagelkerke, MD, Dian van Winkelhorst, MD, Taco W Kuijpers, MD PhD, Gestur Vidarsson, PhD, C. Ellen van der Schoot, MD PhD

Blood (2014) 124 (21): 759.

https://doi.org/10.1182/blood.V124.21.759.759

Published: 2014

Journal Articles

Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts

Esther R. van Bladel, Annemieke G. Laarhoven, Laila B. van der Heijden, Katja M. Heitink-Pollé, Leendert Porcelijn, C. Ellen van der Schoot, Masja de Haas, Mark Roest, Gestur Vidarsson, Philip G. de Groot, Marrie C. A. Bruin

Blood (2014) 123 (10): 1556–1563.

https://doi.org/10.1182/blood-2013-08-519686

Published: 2014

Includes: Supplemental data

NARROW

Complement activation drives antibody-mediated transfusion-related acute lung injury via macrophage trafficking and formation of NETs

ITGB1 -Expressing Effector Memory CD4 + T-Cell Response Associates with Clinical Recovery in Childhood Immune Thrombocytopenia

Fc-Mediated Complement Activation Is Associated with Macrophage Trafficking and Induction of Neutrophil Extracellular Traps in Transfusion-Related Acute Lung Injury

Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in a Preclinical Model By Monoclonal Anti-HPA-1a Antibody Prophylaxis: Structural and Functional Properties of Antibody Variant Isoforms

Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets

A Clinical Prediction Score for Course of Disease in Newly Diagnosed Childhood Immune Thrombocytopenia

Identification of Self-Limiting Pediatric Immune Thrombocytopenia at Diagnosis

Fcγ Receptors I and III on Splenic Macrophages Mediate GPIIb/IIIa Autoantibody-Dependent Phagocytosis of Platelets in Human Immune Thrombocytopenia

Intravenous immunoglobulin vs observation in childhood immune thrombocytopenia: a randomized controlled trial

Anti-Platelet Antibodies Are Predominantly IgM in Childhood Immune Thrombocytopenia

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

RhIg-prophylaxis is not influenced by FCGR2/3 polymorphisms involved in red blood cell clearance

IgG Subtype Affects Immunomodulation through FcγRs, on Non-Macrophage Populations in a Murine Model - Mechanistic Implications for Anti-D

Patients with Autoimmune Anti-Red Blood Cell IgG1 Have Different Total- and Autoantibody -IgG1 Glycosylation Compared to Healthy Controls

Fc-Gamma Receptor Polymorphisms Are Associated with Susceptibility to and Recovery from Pediatric Immune Thrombocytopenia

IgG Alloantibodies Against RBC Induced By Pregnancy or Transfusion Have Unique Glycosylation Patterns Which Correlate with Clinical Outcome of Hemolytic Disease of the Fetus or Newborn

C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia

Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages

RhD Immunization Despite Adequate Immunoprophylaxis: Role of Fc Gamma Receptor Gene Polymorphisms

Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts

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