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Guangyao Kong
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Journal Articles

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation

Xiaona You, Fabao Liu, Moritz Binder, Alexis Vedder, Terra Lasho, Zhi Wen, Xin Gao, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy Finke, Abhishek Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie Droin, Anthony M. Hunter, Sergey Nikolaev, Maria Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M. Patnaik, Jing Zhang
Journal: Blood
Blood (2022) 139 (7): 1066–1079.
https://doi.org/10.1182/blood.2021012519
Published: 2022
Includes: Supplemental data
Journal Articles

A Risk Scoring System for Prognosis of Multiple Myeloma

Yachun Jia, Guangyao Kong, Aili He
Journal: Blood
Blood (2021) 138 (Supplement 1): 4748.
https://doi.org/10.1182/blood-2021-144586
Published: 2021
Journal Articles

Nras Q61R/+ and Kras −/− cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors

Zhi Wen, Grant Yun, Alexander Hebert, Guangyao Kong, Erik A. Ranheim, Remington Finn, Adhithi Rajagoplan, Shuyi Li, Yun Zhou, Mei Yu, Alisa Damnernsawad, Jeroen P. Roose, Joshua J. Coon, Renren Wen, Demin Wang, Jing Zhang
Journal: Blood
Blood (2021) 137 (23): 3259–3271.
https://doi.org/10.1182/blood.2020009082
Published: 2021
Includes: Supplemental data
Journal Articles

Loss of Asxl1 Cooperates with Oncogenic Nras to Drive CMML Progression

Xiaona You, PhD, Zhi Wen, PhD, Guangyao Kong, Adhithi Rajagopalan, BS, Erik A. Ranheim, MD PhD, Yun Zhou, MS, Mrinal M Patnaik, MDMBBS, Jing Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3790.
https://doi.org/10.1182/blood-2019-131347
Published: 2019
Journal Articles

Unique dependence on Sos1 in Kras G12D -induced leukemogenesis

Brief Report
Xiaona You, Guangyao Kong, Erik A. Ranheim, David Yang, Yun Zhou, Jing Zhang
Journal: Blood
Blood (2018) 132 (24): 2575–2579.
https://doi.org/10.1182/blood-2018-09-874107
Published: 2018
Includes: Supplemental data
Journal Articles

Canonical Notch Signaling Is Required for Kras G12D -Induced Myeloproliferative Neoplasm

Xiaona You, PhD, Guangyao Kong, Zhi Wen, Yuan-I Chang, Erik A. Ranheim, MD PhD, Eric Padron, MD, Jing Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1220.
https://doi.org/10.1182/blood.V130.Suppl_1.1220.1220
Published: 2017
Journal Articles

Molecular Determinants for Polycomb Group Protein YY1 Control of Hematopoietic Stem Cell Quiescence

Zhanping Lu, PhD, Courtney Hong, Guangyao Kong, PhD, Anna L F. V. Assumpção, Irene Ong, Emery H Bresnick, PhD, Jing Zhang, PhD, Xuan Pan, PhD DVM
Journal: Blood
Blood (2017) 130 (Supplement 1): 1140.
https://doi.org/10.1182/blood.V130.Suppl_1.1140.1140
Published: 2017
Journal Articles

p53 −/− synergizes with enhanced Nras G12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia

Jingfang Zhang, Guangyao Kong, Adhithi Rajagopalan, Li Lu, Jingming Song, Mohamed Hussaini, Xinmin Zhang, Erik A. Ranheim, Yangang Liu, Jinyong Wang, Xin Gao, Yuan-I Chang, Kirby D. Johnson, Yun Zhou, David Yang, Bhavana Bhatnagar, David M. Lucas, Emery H. Bresnick, Xuehua Zhong, Eric Padron, Jing Zhang
Journal: Blood
Blood (2017) 129 (3): 358–370.
https://doi.org/10.1182/blood-2016-06-719237
Published: 2017
Includes: Supplemental data
Journal Articles

Dnmt3a Haploisufficiency Cooperates with Oncogenic Kras to Promote an Early-Onset T-Cell Leukemia

Yuan-I Chang, PhD, Guangyao Kong, PhD, Jing Zhang, PhD, Erik A. Ranheim, MD
Journal: Blood
Blood (2016) 128 (22): 2729.
https://doi.org/10.1182/blood.V128.22.2729.2729
Published: 2016
Journal Articles

Loss of Sos1 Inhibits Oncogenic Kras-Induced Hyperactivation of Wild-Type Ras during Leukemogenesis

Xiaona You, PhD, Guangyao Kong, PhD, Erik A. Ranheim, MD, Yun Zhou, Jing Zhang
Journal: Blood
Blood (2016) 128 (22): 1543.
https://doi.org/10.1182/blood.V128.22.1543.1543
Published: 2016
Journal Articles

Downregulating Notch Counteracts Kras G12D -Induced ERK Activation and Oxidative Phosphorylation in Myeloproliferative Neoplasm

Guangyao Kong, PhD, Yuan-I Chang, PhD, Jingfang Zhang, PhD, Erik A. Ranheim, MD, Xinmin Zhang, Yun Zhou, Yangang Liu, Lan Zhou, MD PhD, Warren S. Pear, MD PhD, Jing Zhang, PhD
Journal: Blood
Blood (2016) 128 (22): 1565.
https://doi.org/10.1182/blood.V128.22.1565.1565
Published: 2016
Journal Articles

Downregulating Notch Signaling in Kras G12D/+ Mice Inhibits Both T-Cell Leukemia and Myeloproliferative Neoplasm in a Cell-Autonomous Manner

Guangyao Kong, PhD, Yuan-I Chang, PhD, Erik A. Ranheim, MD, Yun Zhou, Yangang Liu, Paul Lambert, PhD, Lan Zhou, MD PhD, Pamela Stanley, PhD, Warren S. Pear, MD PhD, Jing Zhang, PhD
Journal: Blood
Blood (2014) 124 (21): 261.
https://doi.org/10.1182/blood.V124.21.261.261
Published: 2014
Journal Articles

Kras Plays An Important Role In Generating Differentiated Blood Cells

Alisa Damnernsawad, Guangyao Kong, PhD, Yangang Liu, Yuan-I Chang, PhD, Jingfang Zhang, Qiang Chang, Jing Zhang, PhD
Journal: Blood
Blood (2013) 122 (21): 2451.
https://doi.org/10.1182/blood.V122.21.2451.2451
Published: 2013
Journal Articles

Loss Of p53 Promotes Transformation Of Oncogenic Nras-Induced Chronic Myelomonocytic Leukemia To An Acute Phase

Jingfang Zhang, Yangang Liu, Guangyao Kong, PhD, Yuan-I Chang, PhD, Erik A. Ranheim, MD, Jinyong Wang, PhD, Juan Du, PhD, Alisa Damnernsawad, Jing Zhang, PhD
Journal: Blood
Blood (2013) 122 (21): 3790.
https://doi.org/10.1182/blood.V122.21.3790.3790
Published: 2013
Journal Articles

Nras G12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions

Brief Report
Jinyong Wang, Guangyao Kong, Yangang Liu, Juan Du, Yuan-I Chang, Sin Ruow Tey, Xinmin Zhang, Erik A. Ranheim, Marc K. Saba-El-Leil, Sylvain Meloche, Alisa Damnernsawad, Jingfang Zhang, Jing Zhang
Journal: Blood
Blood (2013) 121 (26): 5203–5207.
https://doi.org/10.1182/blood-2012-12-475863
Published: 2013
Includes: Supplemental data
Journal Articles

Endogenous Nras G12D/+ and G12D/G12D Distinctly Regulate Self-Renewal and Differentiation of Haematopoietic Stem Cells

Guangyao Kong, Jinyong Wang, PhD, Yangang Liu, Juan Du, Alisa Damnernsawad, Erik A. Ranheim, MD, Myung-Jeom Ryu, PhD, Jing Zhang, PhD
Journal: Blood
Blood (2012) 120 (21): 4086.
https://doi.org/10.1182/blood.V120.21.4086.4086
Published: 2012