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Journal Articles

Optimization of Lentiviral ß-Globin Vectors in a Forward Orientation to Enhance Therapeutic Effectiveness for Sickle Cell Disease

Jennifer Okalova, Jordan Shields Alexander, Christopher Chambliss, Zhongyu Zhu, Yanping Xie, Matthew Addington-Hall, Oxana Slessareva, Tony Luo, Beatrix Ferencz, Ibeawuchi Oparaocha, Naoya Uchida, John F. Tisdale, Boro Dropulic, H. Trent Spencer, Rimas J Orentas, David R Archer

Blood (2023) 142 (Supplement 1): 5002.

https://doi.org/10.1182/blood-2023-187506

Published: 2023

Journal Articles

Assessment of Transduction of CD34+ Human Hematopoietic Stem Cells from Patients with Severe Hemophilia-Α with Lentiviral Vector Carrying a High Expression FVIII Transgene (CD68-ET3-LV)

Gurbind Singh, Mohanashankar A M, Shaji R Velayudhan, Gabriela Denning, Abraham Sunder Singh, Anbu Jeba, Aby Abraham, Christopher B Doering, H Trent Spencer, Alok Srivastava

Blood (2023) 142 (Supplement 1): 481.

https://doi.org/10.1182/blood-2023-188513

Published: 2023

Journal Articles

Development of a Novel L-Asparaginase with Enhanced Properties Using Ancestral Sequence Reconstruction

Kristopher A Knight, Harrison C. Brown, Kinnede R. White, H. Trent Spencer, Christopher B Doering, Sunil S. Raikar

Blood (2023) 142 (Supplement 1): 4191.

https://doi.org/10.1182/blood-2023-190281

Published: 2023

Journal Articles

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen, Alexandra Waller, Aditi Sharma, Claudia L. Edgar, Vikas A. Gupta, Shanmuganathan Chandrakasan, Jaquelyn T. Zoine, Andrew Fedanov, Sunil S. Raikar, Jean L. Koff, Christopher R. Flowers, Silvia Coma, Jonathan A. Pachter, Sruthi Ravindranathan, H. Trent Spencer, Mala Shanmugam, Edmund K. Waller

Blood (2022) 139 (4): 523–537.

https://doi.org/10.1182/blood.2021011597

Published: 2022

Includes: Supplemental data

Journal Articles

In Utero Transplantation of FVIII-Expressing Human Placental Cells Upregulates Gene Pathways Associated with Immune Tolerance, Altering the Response to Postnatal FVIII Infusion

Martin Rodriguez, Brady Trevisan, Sunil George, Jordan E Shields, Jorge Figueroa, Diane Meares, John Owen, Anthony Atala, Christopher B Doering, H. Trent Spencer, Christopher D Porada, M. Graca Almeida-Porada

Blood (2021) 138 (Supplement 1): 1863.

https://doi.org/10.1182/blood-2021-153417

Published: 2021

Journal Articles

Administration of FVIII-Expressing Human Placental Cells to Juvenile Sheep Yields Multi-Organ Engraftment, Therapeutic Plasma FVIII Levels and Alter Immune Signaling Pathways to Evade FVIII Inhibitor Induction

Brady Trevisan, Martin Rodriguez, Jacqueline Dizon, Sunil George, Jordan E Shields, Shannon Lankford, Rebecca Combs, John Owen, Anthony Atala, Christopher B Doering, H. Trent Spencer, Christopher D Porada, M. Graca Almeida-Porada

Blood (2021) 138 (Supplement 1): 3966.

https://doi.org/10.1182/blood-2021-151207

Published: 2021

Journal Articles

SAXS Analysis of the Intrinsic Tenase Complex Bound to Lipid Nanodisc Highlights Intermolecular Contacts between Factors VIIIa/IXa

Kenneth C Childers, Shaun Peters, John S. Lollar, H. Trent Spencer, Christopher B Doering, Paul Clinton Spiegel

Blood (2021) 138 (Supplement 1): 2099.

https://doi.org/10.1182/blood-2021-147073

Published: 2021

Journal Articles

Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor

Joseph S. Gish, Lexi Jarvis, Kenneth C. Childers, Shaun C. Peters, Connor S. Garrels, Ian W. Smith, H. Trent Spencer, Christopher B. Doering, Pete Lollar, P. Clint Spiegel, Jr

Blood (2021) 137 (21): 2981–2986.

https://doi.org/10.1182/blood.2020008940

Published: 2021

Includes: Supplemental data

Journal Articles

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

Brady Trevisan, Martin Rodriguez, BSc, Sunil George, PhD, Shannon Lankford, Jordan E Shields, MS, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-140745

Published: 2020

Journal Articles

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Quan DM Pham, Martin Rodriguez, BSc, Ritu M Ramamurthy, Sunil George, PhD, Jorge Figueroa, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-140883

Published: 2020

Journal Articles

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Martin Rodriguez, BSc, Brady Trevisan, Sunil George, PhD, Ritu M Ramamurthy, Andrew Rabah, Jordan E Shields, MS, Denise Schwahn, DVM, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Michael Gautreaux, PhD, D.ABHI, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-140845

Published: 2020

Journal Articles

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

M. Graca Almeida-Porada, MD PhD, Sunil George, PhD, Alshaima Morsi, MD, Nadia El-Akabawy, MD, Jorge Figueroa, Jordan E Shields, MS, Diane Meares, Andrew M. Farland, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD

Blood (2017) 130 (Supplement 1): 361.

https://doi.org/10.1182/blood.V130.Suppl_1.361.361

Published: 2017

Journal Articles

Targeting T-Cell Malignancies with Chimeric Antigen Receptors Using Two Structurally Different Antigen Binding Domains Against CD5

Sunil S Raikar, MD, Lauren C Fleischer, Robert Moot, B.S., Na Yoon Paik, B.S., Kristopher Knight, B.S., Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2017) 130 (Supplement 1): 4462.

https://doi.org/10.1182/blood.V130.Suppl_1.4462.4462

Published: 2017

Journal Articles

Engineering CD5-Targeted Chimeric Antigen Receptors and Edited T Cells for the Treatment of T-Cell Leukemia

Lauren C Fleischer, Sunil S Raikar, MD, Robert Moot, B.S., Kristopher A Knight, B.S., Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2017) 130 (Supplement 1): 1914.

https://doi.org/10.1182/blood.V130.Suppl_1.1914.1914

Published: 2017

Journal Articles

Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a

Christopher B Doering, PhD, Gabriela Denning, PhD, Jordan E Shields, MS, William Swaney, Lilith Reeves, Punam Malik, MD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 4421.

https://doi.org/10.1182/blood.V126.23.4421.4421

Published: 2015

Journal Articles

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Reginald Tran, BS, David R Myers, PhD, Jordan E Shields, MS, Byungwook Ahn, PhD, Yongzhi Qiu, PhD, Caroline Hansen, BS, Yumiko Sakurai, MSc, Robert Moot, BS, H. Trent Spencer, PhD, Christopher B Doering, PhD, Wilbur A Lam, MD PhD

Blood (2015) 126 (23): 4415.

https://doi.org/10.1182/blood.V126.23.4415.4415

Published: 2015

Journal Articles

Expansion and Bioengineering of Peripheral Blood-Derived Anti-Cancer Gd T Cells in Serum Free Media

Kathryn S Sutton, MD BS, Anindya Dasgupta, PhD, David McCarty, Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 5553.

https://doi.org/10.1182/blood.V126.23.5553.5553

Published: 2015

Journal Articles

Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Philip Zakas, BS, Kristopher Knight, Ernest T Parker, BA, H. Trent Spencer, PhD, Eric Gaucher, PhD, Christopher B Doering, PhD

Blood (2015) 126 (23): 123.

https://doi.org/10.1182/blood.V126.23.123.123

Published: 2015

Journal Articles

Expanding the Ligand Binding Repertoire of Chimeric Antigen Receptors Using Lamprey Variable Lymphocyte Receptors

Robert Moot, BS, Sunil Raikar, MD, Lauren C Fleischer, BS, David McCarty, Melissa Querrey, Christopher B Doering, PhD, H. Trent Spencer, PhD

Blood (2015) 126 (23): 3244.

https://doi.org/10.1182/blood.V126.23.3244.3244

Published: 2015

Journal Articles

Bioengineered Coagulation Factor VIII Enables Long-Term Correction Of Murine Hemophilia A Following Liver-Directed Adeno-Associated Viral Vector Delivery

Harrison C. Brown, BBA, Jordan E Shields, Shangzhen Zhou, MD, J. Fraser Wright, PhD, H. Trent Spencer, PhD, Christopher B Doering, PhD

Blood (2013) 122 (21): 4210.

https://doi.org/10.1182/blood.V122.21.4210.4210

Published: 2013

NARROW

Optimization of Lentiviral ß-Globin Vectors in a Forward Orientation to Enhance Therapeutic Effectiveness for Sickle Cell Disease

Assessment of Transduction of CD34+ Human Hematopoietic Stem Cells from Patients with Severe Hemophilia-Α with Lentiviral Vector Carrying a High Expression FVIII Transgene (CD68-ET3-LV)

Development of a Novel L-Asparaginase with Enhanced Properties Using Ancestral Sequence Reconstruction

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

In Utero Transplantation of FVIII-Expressing Human Placental Cells Upregulates Gene Pathways Associated with Immune Tolerance, Altering the Response to Postnatal FVIII Infusion

Administration of FVIII-Expressing Human Placental Cells to Juvenile Sheep Yields Multi-Organ Engraftment, Therapeutic Plasma FVIII Levels and Alter Immune Signaling Pathways to Evade FVIII Inhibitor Induction

SAXS Analysis of the Intrinsic Tenase Complex Bound to Lipid Nanodisc Highlights Intermolecular Contacts between Factors VIIIa/IXa

Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

Targeting T-Cell Malignancies with Chimeric Antigen Receptors Using Two Structurally Different Antigen Binding Domains Against CD5

Engineering CD5-Targeted Chimeric Antigen Receptors and Edited T Cells for the Treatment of T-Cell Leukemia

Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Expansion and Bioengineering of Peripheral Blood-Derived Anti-Cancer Gd T Cells in Serum Free Media

Bioengineering Coagulation Factor VIII through Ancestral Protein Reconstruction

Expanding the Ligand Binding Repertoire of Chimeric Antigen Receptors Using Lamprey Variable Lymphocyte Receptors

Bioengineered Coagulation Factor VIII Enables Long-Term Correction Of Murine Hemophilia A Following Liver-Directed Adeno-Associated Viral Vector Delivery

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American Society of Hematology

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ASH Publications

American Society of Hematology

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