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Journal Articles

Co-mutation of BCOR and BCORL1 was associated with favorable outcome in the adverse risk patients with Acute Myeloid Leukemia

Free
Shunjie Yu, Zongru Li, Lijuan Hu, Ya-Zhen Qin, Guorui Ruan, Yazhe Wang, Hao Jiang, Feifei Tang, Jinsong JIA, Jing Wang, Qiang Fu, Xiaohui Zhang, Lanping Xu, Yu Wang, Yuqian Sun, Yueyun Lai, Hong-Xia Shi, Xiaojun Huang, Qian Jiang
Journal: Blood
Blood (2025) 146 (Supplement 1): 3400.
https://doi.org/10.1182/blood-2025-3400
Published: 2025
Journal Articles

Overexpression of CD103 on regulatory T cells mitigates acute graft-versus-host disease via promotion of tolerogenic dendritic cell networks

Free
Mehrdad Hefazi Torghabeh, R. Leo Sakemura, Hong Xia, Brooke Kimball, Long Mai, Claudia Manriquez Roman, Afshin Shameli, Olivia Sirpilla, Carli Stewart, Taro Hitosugi, Grace DeFranco, Jennifer Feigin, Shuwen Zhang, Truc Huynh, Ismail Can, Abhishek Mangaonkar, Kun Yun, Ateka Saleh, Lionel Kankeu Fonkoua, Yoh Yamaguchi, Sara Foote, Sophia Goldberg, Omar Gutierrez Ruiz, Elizabeth Siegler, Bruce Blazar, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 587.
https://doi.org/10.1182/blood-2025-587
Published: 2025
Journal Articles

Remodeling the bone marrow tumor microenvironment with CART cell therapy to overcome resistance in multiple myeloma

Free
Jennifer Feigin, Omar Gutierrez Ruiz, Carli Stewart, Brooke Kimball, Kun Yun, Mehrdad Hefazi Torghabeh, Claudia Manriquez Roman, Wannakorn Khopanlert, Ismail Can, Long Mai, Truc Huynh, Sophia Goldberg, Sara Foote, Grace DeFranco, Olivia Sirpilla, Dominic Skeele, Ateka Saleh, Hong Xia, Matthew Schellenberg, Yi Lin, Diane Jelinek, P. Leif Bergsagel, Elizabeth Siegler, R. Leo Sakemura, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 1028.
https://doi.org/10.1182/blood-2025-1028
Published: 2025
Journal Articles

Live imaging of human xenogeneic CART cells in a clinical trial of companion dogs with lymphoma

Free
Elizabeth Siegler, Alex Abel, Wesley Wierson, Truc Huynh, Carli Stewart, Long Mai, Brooke Kimball, Jennifer Feigin, Kun Yun, Claudia Manriquez Roman, Ismail Can, Omar Gutierrez Ruiz, Hong Xia, Ekene Ogbodo, Olivia Sirpilla, Grace DeFranco, Sophia Goldberg, Ateka Saleh, Sara Foote, Dominic Skeele, Yoh Yamaguchi, Lionel Kankeu Fonkoua, Mehrdad Hefazi Torghabeh, R. Leo Sakemura, Jeffrey Bryan, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 4105.
https://doi.org/10.1182/blood-2025-4105
Published: 2025
Journal Articles

Targeting CSF1R to overcome myeloid cell suppression in CART therapy

Free
Grace DeFranco, Kun Yun, Claudia Manriquez Roman, Jennifer Feigin, Samuel Olivier, Mehrdad Hefazi Torghabeh, Carli Stewart, Brooke Kimball, Elizabeth Siegler, Truc Huynh, Justyna Gleba, Matthew Pawlush, Andrew Zakko, Michael Redig, Skyeler Klinge, Long Mai, Aylin Alasonyalilar Demirer, James Miller, Erin Miller, R. Leo Sakemura, Ismail Can, Olivia Sirpilla, Omar Gutierrez Ruiz, Dominic Skeele, Sophia Goldberg, Sara Foote, Ateka Saleh, Hong Xia, Ekene Ogbodo, Yushi Qiu, Robert Smallridge, Abba Zubair, Han Tun, John Copland, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 5883.
https://doi.org/10.1182/blood-2025-5883
Published: 2025
Journal Articles

Ibrutinib enhances 41BB-costimulated CART19 function and persistence through immune reprogramming: Insights from the phase 3 ECOG-ACRIN E1912 clinical Trial

Free
Truc Huynh, Victoria Wang, Jennifer Feigin, Elizabeth Siegler, Brooke Kimball, Carli Stewart, Kun Yun, Long Mai, Claudia Manriquez Roman, Hong Xia, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Olivia Sirpilla, Grace DeFranco, Sophia Goldberg, Ateka Saleh, Dominic Skeele, Sara Foote, Yoh Yamaguchi, Lionel Kankeu Fonkoua, Mehrdad Hefazi Torghabeh, Sameer Parikh, Vitoria Cantinho Pereira, Paul Buckley, Alan Ramsay, Tait Shanafelt, Neil Kay, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 2101.
https://doi.org/10.1182/blood-2025-2101
Published: 2025
Journal Articles

IL-4 epigenetically reprograms CART19-28ζ cells to drive dysfunction

Free
Carli Stewart, Mehrdad Hefazi Torghabeh, Makena Rodriguez, Grace DeFranco, Sara Foote, Brooke Kimball, Long Mai, Truc Huynh, Elizabeth Siegler, Jennifer Feigin, Kun Yun, Dominic Skeele, Sophia Goldberg, Ateka Saleh, Olivia Sirpilla, Ismail Can, Hong Xia, Omar Gutierrez Ruiz, Ekene Ogbodo, Sameer Parikh, Esteban Braggio, Neil Kay, R. Leo Sakemura, Saad Kenderian
Journal: Blood
Blood (2025) 146 (Supplement 1): 2338.
https://doi.org/10.1182/blood-2025-2338
Published: 2025
Journal Articles

Oral etoposide vs intravenous daunorubicin plus ATRA-RIF as induction therapy for low-risk acute promyelocytic leukemia: A phase II randomized controlled Trial

Free
Xiaolu Zhu, Zhao Ting, Wen-Bing Duan, Qi Chen, Jing Liu, Wen-Jing Yu, Xiaosu Zhao, Ya-Zhen Qin, Hong-Xia Shi, Ying-Jun Chang, Xiaojun Huang, Hao Jiang
Journal: Blood
Blood (2025) 146 (Supplement 1): 1671.
https://doi.org/10.1182/blood-2025-1671
Published: 2025
Journal Articles

The Efficacy and Safety of Selinexor in Combination with Ruxolitinib in Ruxolitinib-Treated Myelofibrosis Patients: The Interim Analysis of a Prospective, Open-Label, Multicenter, Parallel-Cohort, Phase 2 Study

Free
Minghui Duan, Lan Ma, Qiuling Wu, Hong Liang, Wei Wang, Lijun Mu, Hai Lin, Hebing Zhou, Hong-xia Shi, Jinghua Wang, Hongmei Jing
Journal: Blood
Blood (2024) 144 (Supplement 1): 1002.
https://doi.org/10.1182/blood-2024-201204
Published: 2024
Journal Articles

Identification of T Cell Senescence As a Cell Fate Limiting the Antitumor Activity of 41BB-Costimulated CART Cells

Free
Ismail Can, R. Leo Sakemura, Olivia L. Sirpilla, Claudia Manriquez Roman, Carli M. Stewart, Kun Yun, Truc Huynh, Ekene Ogbodo, Lionel A Kankeu Fonkoua, Jennifer M. Feigin, Omar Gutierrez Ruiz, Long K. Mai, Hong Xia, Brooke L. Kimball, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, H. Atakan Ekiz, Berke Alkan, Fatih Sezer, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 4808.
https://doi.org/10.1182/blood-2024-207818
Published: 2024
Journal Articles

Distinct Functional Impacts of Cytokine Receptor Blockade on CART Cells

Free
Kun Yun, Evandro Bezerra, R. Leo Sakemura, Emmanuel Contreras Guzman, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, Jennifer M. Feigin, Grace E. DeFranco, Sophia Y. Goldberg, Dominic A. Skeele, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 7166.
https://doi.org/10.1182/blood-2024-211119
Published: 2024
Journal Articles

Intrinsic Immunosuppressive Features of Monocytes Suppress CART19 through IL-1 Pathway Modulation in Mantle Cell Lymphoma

Free
Kun Yun, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Shuwen Zhang, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, James H. Girsch, Jennifer M. Feigin, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Fariborz Rakhshan Rohakhtar, Vernadette Simon, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 908.
https://doi.org/10.1182/blood-2024-205905
Published: 2024
Journal Articles

Caspase-1 Inhibition Ameliorates CAR T-Cell Apoptosis and Tumor Cell Pyroptosis to Enhance the Efficacy and Safety of CAR T-Cell Therapy

Free
Wannakorn Khopanlert, Truc Huynh, Brooke L. Kimball, Grace E. DeFranco, Sophia Y. Goldberg, Dominic A. Skeele, Jennifer M. Feigin, James H. Girsch, Olivia L. Sirpilla, Carli M. Stewart, Kun Yun, Claudia Manriquez Roman, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Long K. Mai, Hong Xia, Mehrdad Hefazi, Lionel Aurelien Kankeu Fonkoua, Michael W. Ruff, Elizabeth L. Siegler, Saad S. Kenderian, R. Leo Sakemura
Journal: Blood
Blood (2024) 144 (Supplement 1): 907.
https://doi.org/10.1182/blood-2024-202661
Published: 2024
Journal Articles

A Completely Oral Regimen Including Oral Etoposide As Cytoreductive Chemotherapy Combined with All Trans Retinoic Acid and Oral Arsenic for Induction Therapy in Patients with High-Risk APL：Comparable to Intravenous Cytoreductive Therapy

Free
Feifei Tang, Wen-Bing Duan, Xiao-Hong Liu, Sheng-Ye Lu, Xiao-Su Zhao, Ya-Zhen Qin, Jin-Song Jia, Jing Wang, Li-Zhong Gong, Qian Jiang, Zhao Ting, Hong-Xia Shi, Ying-Jun Chang, Xiao-Jun Huang, Hao Jiang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4288.
https://doi.org/10.1182/blood-2023-188657
Published: 2023
Journal Articles

Comparison of Safety and Efficacy between Venetoclax Combined with CAG (cytarabine, aclarubicin, G-CSF) Regimen and CAG Regimen Alone in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Free
Wen-Jing Yu, Ying Wu, Qi Chen, Xiaolu Zhu, Xu-Ying Pei, Jin-Song Jia, Jing Wang, Xiao-Su Zhao, Ying-Jun Chang, Yue-Yun Lai, Hong-Xia Shi, Guo-Rui Ruan, Ya-Zhen Qin, Xiao-Hong Liu, Xiao Jun Huang, Hao Jiang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1525.
https://doi.org/10.1182/blood-2023-184665
Published: 2023
Journal Articles

The Efficacy and Safety of Selinexor in Combination with Ruxolitinib in Ruxolitinib-Treated Myelofibrosis Patients： the Interim Analysis of a Prospective, Open-Label, Multicenter, Parallel-Cohort, Phase 2 Study

Free
Minghui Duan, Lan Ma, Qiuling Wu, Hong Liang, Wei Wang, Shaoling Wu, Lijun Mu, Hai Lin, Hebing Zhou, Hong-Xia Shi, Jinghua Wang, Hongmei Jing
Journal: Blood
Blood (2023) 142 (Supplement 1): 4578.
https://doi.org/10.1182/blood-2023-188037
Published: 2023
Journal Articles

Tacrolimus Plus High-Dose Dexamethasone Versus High-Dose Dexamethasone Alone As First-Line Treatment for Adult Immune Thrombocytopenia: The Phase 2, Open Label, Randomized Trial (TARGET 020)

Free
Zhuo-Yu An, Ye-Jun Wu, Yun He, Xiao-Lu Zhu, Hong-Xia Shi, Chen-Cong Wang, Hao Jiang, Jin Lu, Qian Jiang, Qiu-Sha Huang, Hai-Xia Fu, Feng-Rong Wang, Xiao-Dong Mo, Yu Wang, Xiang-Yu Zhao, Yuan-Yuan Zhang, Wei Han, Huan Chen, Yao Chen, Chen-Hua Yan, Jing-Zhi Wang, Ting-Ting Han, Yu-Hong Chen, Yi-Fei Cheng, Ying-Jun Chang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Xiaohui Zhang
Journal: Blood
Blood (2021) 138 (Supplement 1): 13.
https://doi.org/10.1182/blood-2021-152111
Published: 2021
Journal Articles

A Clinical Study of 15 Acute Leukemia Patients with Plasmacytoid Dendritic Cells Expansion

Free
Ya-Lan Zhou, Yan Wei, Xiaohong Liu, Jing Wang, Jinsong Jia, Hong-Xia Shi, Ying-Jun Chang, Xiao-Su Zhao, Yan-Rong Liu, Guo-Rui Ruan, Xiao-Jun Huang, Hao Jiang
Journal: Blood
Blood (2021) 138 (Supplement 1): 4468.
https://doi.org/10.1182/blood-2021-149623
Published: 2021
Journal Articles

Interferon May Help Control the Recurrence of Chronic Myeloid Leukemia after Discontinuation of Tyrosine Kinase Inhibitor

Free
Jun Kong, MD, Xiao-Hong Liu, Ya-Zhen Qin, Hong-Xia Shi, Yue-Yun Lai, Xiao-Jun Huang, Hao Jiang
Journal: Blood
Blood (2018) 132 (Supplement 1): 4270.
https://doi.org/10.1182/blood-2018-99-119063
Published: 2018
Journal Articles

Interim Results of a Multi-Center Observational Study of Current Treatment Patterns for Patients with Severe Aplastic Anemia (SAA), Very Severe Aplastic Anemia (VSAA) and Transfusion-Dependent Non-Severe Aplastic Anemia (TD-NSAA) in China

Free
Feng-Kui Zhang, Xiao-Fan Zhu, Hai-Long He, Shun-Qing Wang, Jing-Yan Tang, Dao-Bin Zhou, Dong-Hua Zhang, Yu-Hong Zhou, De-pei Wu, Wei Li, Ling-Hui Xia, Huan-Ling Zhu, Feng Liu, Hong-Xia Shi, Xi Zhang, Fang Zhou, Jian-Da Hu, Jian-Pei Fang, Xie-Qun Chen, Tie-Zhen Ye, Ying-Min Liang, Jie Jin
Journal: Blood
Blood (2015) 126 (23): 4505.
https://doi.org/10.1182/blood.V126.23.4505.4505
Published: 2015