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Journal Articles

Improved Vaccine Design For Adoptive Immunotherapy In Hematological Malignancies Through Chemically Modified Minor Histocompatibility Antigen Epitopes

Rimke Oostvogels, MD, Rieuwert Hoppes, Henk Lokhorst, Robbert M Spaapen, PhD, Huib Ovaa, PhD, Tuna Mutis, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 5435.
https://doi.org/10.1182/blood.V122.21.5435.5435
Published: 2013
Journal Articles

Bcr-Abl Positive Cells Display Increased Proteasome Activity and Greater Sensitivity to Proteasome Inhibition

Lisa Crawford, PhD, BSc, Philip Windrum, MD, MRCPath, Laura Magill, PhD, BSc, Junia V. Melo, MD, PhD, FRCPath, Lynn McCallum, PhD, BSc, MaryFrances McMullin, MD, Huib Ovaa, PhD, BSc, Brian Walker, PhD, BSc, Alexandra Irvine, PhD
Journal: Blood
Blood (2008) 112 (11): 3192.
https://doi.org/10.1182/blood.V112.11.3192.3192
Published: 2008
Journal Articles

CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib

Roberto Piva, Bruce Ruggeri, Michael Williams, Giulia Costa, Ilaria Tamagno, Dario Ferrero, Valentina Giai, Marta Coscia, Silvia Peola, Massimo Massaia, Gabriella Pezzoni, Cecilia Allievi, Nicoletta Pescalli, Mara Cassin, Stefano di Giovine, Paola Nicoli, Paola de Feudis, Ivan Strepponi, Ilaria Roato, Riccardo Ferracini, Benedetta Bussolati, Giovanni Camussi, Susan Jones-Bolin, Kathryn Hunter, Hugh Zhao, Antonino Neri, Antonio Palumbo, Celia Berkers, Huib Ovaa, Alberto Bernareggi, Giorgio Inghirami
Journal: Blood
Blood (2008) 111 (5): 2765–2775.
https://doi.org/10.1182/blood-2007-07-100651
Published: 2008
Journal Articles

Secondary Bortezomib-Resistance Is Characterized by Upregulation of Proteasomal Subunits and Their Insufficient Inhibition by Bortezomib, Which Can Be Overcome by Alternative Proteasome Inhibitors Combined with Induction of the ER Stress Response.

Thomas Ruckrich, Jeannette Gogel, Marianne Kraus, Huib Ovaa, Christoph Driessen
Journal: Blood
Blood (2006) 108 (11): 2583.
https://doi.org/10.1182/blood.V108.11.2583.2583
Published: 2006
Journal Articles

Distinct Dynamic Profiles for NPI-0052-And Bortezomib-Induced Apoptosis in Multiple Myeloma.

Dharminder Chauhan, PhD, Ajita Singh, Ph.D, Mugdha Velankar, M.S, Teru Hideshima, Ph.D, Huib Ovaa, Ph.D, Celia Berkers, M.S, Giada Bianchi, Ph.D, Roberto Sitia, M.D., Nikhil C. Munshi, M.D., Paul Richardson, M.D., Michael A. Palladino, Ph.D, Kenneth C. Anderson, M.D
Journal: Blood
Blood (2006) 108 (11): 3396.
https://doi.org/10.1182/blood.V108.11.3396.3396
Published: 2006
Journal Articles

Evaluation of the Specificity and Cytotoxicity of Three Proteasome Inhibitors.

Lisa J.A. Crawford, Huib Ovaa, Brian Walker, Dharminder Chauhan, Kenneth C. Anderson, Treen C.M. Morris, Alexandra E. Irvine
Journal: Blood
Blood (2005) 106 (11): 3366.
https://doi.org/10.1182/blood.V106.11.3366.3366
Published: 2005
Journal Articles

Acquired Bortezomib (Velcade®)-Resistance Is Accompanied by Downmodulation of Proteasome Activity and Upregulation of Tripeptidyl Peptidase II (TPPII) and a Ubiquitin-Specific Protease.

Christoph Driessen, Jeanette Gogel, Marianne Kraus, Huib Ovaa, Alexander Beck, Thomas Rückrich
Journal: Blood
Blood (2005) 106 (11): 3375.
https://doi.org/10.1182/blood.V106.11.3375.3375
Published: 2005
Journal Articles

In Vitro and In Vivo Proteasome Activity Profiles of Bortezomib and a Novel Proteasome Inhibitor NPI-0052.

Dharminder Chauhan, PhD, Ta-Hsiang Chao, Ph.D, Laurence Catley, M.D, Benjamin Nicholson, Ph.D, Mugdha Velanker, M.S, Teru Hideshima, Ph.D, Celia Berkers, Ph.D, Huib Ovaa, Ph.D, Saskia Neuteboom, Ph.D, Michael Palladino, Ph.D, Kenneth C. Anderson, M.D
Journal: Blood
Blood (2005) 106 (11): 3363.
https://doi.org/10.1182/blood.V106.11.3363.3363
Published: 2005
Journal Articles

Activity Profiling of Proteasome Subunits and Deubiquitinating Enzymes in Human Hematopoetic Malignancies.

Christoph Driessen, Marianne Kraus, Jeanette Gogel, Alexander Beck, Winfried Kammer, Huib Ovaa, Herman Overkleeft, Thomas Rückrich
Journal: Blood
Blood (2005) 106 (11): 617.
https://doi.org/10.1182/blood.V106.11.617.617
Published: 2005