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James E. Cox
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Journal Articles

Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease

Richa Sharma, Ada Antypiuk, S. Zebulon Vance, Deepa Manwani, Quentinn Pearce, James E. Cox, Xiuli An, Karina Yazdanbakhsh, Francesca Vinchi
Journal: Blood
Blood (2023) 141 (25): 3091–3108.
https://doi.org/10.1182/blood.2022018026
Published: 2023
Includes: Supplemental data
Journal Articles

Heme and Iron Aggravate Tissue Damage in Sickle Cell Disease By Driving Macrophage Functional Reprogramming through the Coordinated Suppression of Efferocytosis and Mitochondrial Metabolism

Richa Sharma, S. Zebulon Vance, Ada Antypiuk, Deepa Manwani, Quentinn Pearce, James E. Cox, Xiuli An, Karina Yazdanbakhsh, Francesca Vinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 2456–2457.
https://doi.org/10.1182/blood-2022-165364
Published: 2022
Journal Articles

Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis

Joseph S. Burch, Jason R. Marcero, John Alan Maschek, James E. Cox, Laurie K. Jackson, Amy E. Medlock, John D. Phillips, Harry A. Dailey, Jr
Journal: Blood
Blood (2018) 132 (10): 987–998.
https://doi.org/10.1182/blood-2018-01-829036
Published: 2018
Includes: Supplemental data
Journal Articles

The Role of TCA Cycle Compounds in Erythroid Heme Synthesis and Its Regulation During an Inflammatory Response

Jason R. Marcero, BS, Joseph S. Burch, PhD, John D. Phillips, PhD, James E. Cox, PhD, Laurie K. Jackson, PhD, Harry A. Dailey, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3473.
https://doi.org/10.1182/blood.V130.Suppl_1.3473.3473
Published: 2017
Journal Articles

Zebrafish screen identifies novel compound with selective toxicity against leukemia

Suzanne Ridges, Will L. Heaton, Deepa Joshi, Henry Choi, Anna Eiring, Lance Batchelor, Priya Choudhry, Elizabeth J. Manos, Hossein Sofla, Ali Sanati, Seth Welborn, Archana Agarwal, Gerald J. Spangrude, Rodney R. Miles, James E. Cox, J. Kimble Frazer, Michael Deininger, Kaveri Balan, Matthew Sigman, Markus Müschen, Tatiana Perova, Radia Johnson, Bertrand Montpellier, Cynthia J. Guidos, David A. Jones, Nikolaus S. Trede
Journal: Blood
Blood (2012) 119 (24): 5621–5631.
https://doi.org/10.1182/blood-2011-12-398818
Published: 2012
Includes: Supplemental data