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Journal Articles

Genetic iron overload aggravates and pharmacological iron restriction improves MDS pathophysiology in a preclinical study

Ada Antypiuk, Steven Vance, Richa Sharma, Sara T. Passos, Michela Asperti, Shobana Navaneethabalakrishnan, Franz Durrenberger, Vania Manolova, Francesca Vinchi, Prof.

Blood blood.2024026135.

https://doi.org/10.1182/blood.2024026135

Published: 2024

Includes: Supplemental data

Journal Articles

Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease

Yongshuai Han, Chengjie Gao, Yunfeng Liu, Huan Zhang, Shihui Wang, Huizhi Zhao, Weili Bao, Xinhua Guo, Francesca Vinchi, Cheryl Lobo, Patricia Shi, Avital Mendelson, Larry Luchsinger, Hui Zhong, Karina Yazdanbakhsh, Xiuli An

Blood (2024) 143 (11): 1018–1031.

https://doi.org/10.1182/blood.2023021658

Published: 2024

Includes: Supplemental data

Journal Articles

Myelodysplastic Syndromes Benefit from Iron-Restricted Bone Marrow Transplant in Preclinical Mouse Model

Ada Antypiuk, Alberto Martinez, Ute Schaeper, Uwe Platzbecker, Francesca Vinchi

Blood (2023) 142 (Supplement 1): 2462.

https://doi.org/10.1182/blood-2023-189794

Published: 2023

Journal Articles

Combination Therapy with Luspatercept and the Ferroportin Inhibitor Vamifeport Is Superior to Either Drug Alone in Improving Anemia and Reducing Myeloid Skewing in MDS

Ada Antypiuk, Steven Vance, Franz Dürrenberger, Vania Manolova, Francesca Vinchi

Blood (2023) 142 (Supplement 1): 3836.

https://doi.org/10.1182/blood-2023-190095

Published: 2023

Journal Articles

Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease

Richa Sharma, Ada Antypiuk, S. Zebulon Vance, Deepa Manwani, Quentinn Pearce, James E. Cox, Xiuli An, Karina Yazdanbakhsh, Francesca Vinchi

Blood (2023) 141 (25): 3091–3108.

https://doi.org/10.1182/blood.2022018026

Published: 2023

Includes: Supplemental data

Journal Articles

Genetic Iron Overload Aggravates and Pharmacological Iron Restriction Improves MDS Pathophysiology in a Preclinical Mouse Model

S. Zebulon Vance, Ada Antypiuk, Richa Sharma, Franz Dürrenberger, Vania Manolova, Francesca Vinchi

Blood (2022) 140 (Supplement 1): 5341–5342.

https://doi.org/10.1182/blood-2022-170164

Published: 2022

Journal Articles

Differential Recovery of Macrophage Iron Deficiency By Oral Iron Formulations Determines Cell Inflammatory Response in Conditions of Iron Deficiency Anemia

Ada Antypiuk, Richa Sharma, Elisa Brilli, Germano Tarantino, Francesca Vinchi

Blood (2022) 140 (Supplement 1): 5335–5336.

https://doi.org/10.1182/blood-2022-165292

Published: 2022

Journal Articles

Heme and Iron Aggravate Tissue Damage in Sickle Cell Disease By Driving Macrophage Functional Reprogramming through the Coordinated Suppression of Efferocytosis and Mitochondrial Metabolism

Richa Sharma, S. Zebulon Vance, Ada Antypiuk, Deepa Manwani, Quentinn Pearce, James E. Cox, Xiuli An, Karina Yazdanbakhsh, Francesca Vinchi

Blood (2022) 140 (Supplement 1): 2456–2457.

https://doi.org/10.1182/blood-2022-165364

Published: 2022

Journal Articles

Lack of IL6 Improves Recovery from Anemia of Inflammation Which Gets Hampered in Presence of Excess Iron

Sayantani Sinha, Ritama Gupta, Amaliris Guerra, Paige Mc Veigh, Sara Gardenghi, Carla Casu, Francesca Vinchi, Stefano Rivella

Blood (2021) 138 (Supplement 1): 3072.

https://doi.org/10.1182/blood-2021-153126

Published: 2021

Journal Articles

Nrf2 Plays a Key Role in Iron-Overload Cardiomyopathy

Enrica Federti, Francesca Vinchi, Iana Iatcenko, Alessandra Ghigo, Alessandro Mattè, Serge Cedrick, Angela Siciliano, Deborah Chiabrando, Emanuela Tolosano, S. Zebulon Vance, Veronica Riccardi, Immacolata Andolfo, Achille Iolascon, Lucia de Franceschi

Blood (2021) 138 (Supplement 1): 3068.

https://doi.org/10.1182/blood-2021-146157

Published: 2021

Journal Articles

Iron Handling by Macrophages

Francesca Vinchi, PhD

Blood (2020) 136 (Supplement 1): SCI6.

https://doi.org/10.1182/blood-2020-133057

Published: 2020

Journal Articles

Intravenous Iron Promotes Low-Grade Inflammation in Anemic Patients By Triggering Macrophage Activation

Francesca Vinchi, PhD, Annalisa Castagna, B.S., PhD, Milene Costa da Silva, Fabiana Busti, MD PhD, Giacomo Marchi, MD, Richard Sparla, Martina U. Muckenthaler, PhD, Domenico Girelli, MD, PhD

Blood (2019) 134 (Supplement_1): 957.

https://doi.org/10.1182/blood-2019-132235

Published: 2019

Journal Articles

Transfusion-Induced Impairment of Macrophage Responses Is Partially Restored By the Iron Chelator Deferasirox

Francesca Vinchi, PhD, Richard Sparla, Sara Passos, PhD, Heike Weidner, Martina Rauner, PhD, Uwe Platzbecker, Martina U. Muckenthaler, PhD

Blood (2018) 132 (Supplement 1): 3625.

https://doi.org/10.1182/blood-2018-99-113016

Published: 2018

Journal Articles

TET2 deficiency leads to stem cell factor–dependent clonal expansion of dysfunctional erythroid progenitors

Blood (2018) 132 (22): 2406–2417.

https://doi.org/10.1182/blood-2018-05-853291

Published: 2018

Includes: Supplemental data

Journal Articles

Red Blood Cell Transfusions Shape Macrophages Towards an Anti-Inflammatory Functional Phenotype and Impair the Immune Response to Infectious Cues

Francesca Vinchi, Milene Costa da Silva, Richard Sparla, Heike Weidner, Martina Rauner, Emanuela Tolosano, Uwe Platzbecker, MD, Martina U. Muckenthaler

Blood (2017) 130 (Supplement 1): 227.

https://doi.org/10.1182/blood.V130.Suppl_1.227.227

Published: 2017

Journal Articles

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

Francesca Vinchi, PhD, Gregory M Vercellotti, MD, John D. Belcher, PhD, Eitan Fibach, PhD, Hala Zreid, MD, Rushdy Rasras, Hussam Ghoti, MD, Martina U. Muckenthaler, PhD, Eliezer A. Rachmilewitz, MD

Blood (2016) 128 (22): 2469.

https://doi.org/10.1182/blood.V128.22.2469.2469

Published: 2016

Journal Articles

Low-Iron Diet and Chelation Therapy Rescue Severe Atherosclerosis Associated with High Circulating Iron Levels

Francesca Vinchi, PhD, Andreas Simmelbauer, Master student, Sandro Altamura, PhD, Sebastian Spaich, Richard Sparla, Bruno Galy, PhD, Matthias W. Hentze, MD, Martina U. Muckenthaler, PhD

Blood (2016) 128 (22): 199.

https://doi.org/10.1182/blood.V128.22.199.199

Published: 2016

Journal Articles

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

Francesca Vinchi, Milene Costa da Silva, Giada Ingoglia, Sara Petrillo, Nathan Brinkman, Adrian Zuercher, Adelheid Cerwenka, Emanuela Tolosano, Martina U. Muckenthaler

Blood (2016) 127 (4): 473–486.

https://doi.org/10.1182/blood-2015-08-663245

Published: 2016

Includes: Supplemental data

Journal Articles

High Circulating Iron Levels Are a Risk Factor for Cardiovascular Disease: Clinical Implications for Iron-Overload Conditions

Francesca Vinchi, PhD, Andreas Simmelbauer, Master student, Milene Costa da Silva, PhDstudent, Sandro Altamura, PhD, Bruno Galy, PhD, Matthias W. Hentze, MD, Martina U. Muckenthaler, PhD

Blood (2015) 126 (23): 1040.

https://doi.org/10.1182/blood.V126.23.1040.1040

Published: 2015

Journal Articles

The Heme Scavenger Hemopexin Reverts Heme-Driven Pro-Inflammatory Phenotypic Switching of Macrophages in Sickle Cell Disease

Francesca Vinchi, PhD, Milene Costa da Silva, PhDstudent, Giada Ingoglia, PhDstudent, Sara Petrillo, PhDstudent, Nathan Brinkman, Adrian Zuercher, Adelheid Cerwenka, PhD, Emanuela Tolosano, PhD, Martina U. Muckenthaler, PhD

Blood (2015) 126 (23): 2205.

https://doi.org/10.1182/blood.V126.23.2205.2205

Published: 2015

NARROW

Genetic iron overload aggravates and pharmacological iron restriction improves MDS pathophysiology in a preclinical study

Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease

Myelodysplastic Syndromes Benefit from Iron-Restricted Bone Marrow Transplant in Preclinical Mouse Model

Combination Therapy with Luspatercept and the Ferroportin Inhibitor Vamifeport Is Superior to Either Drug Alone in Improving Anemia and Reducing Myeloid Skewing in MDS

Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease

Genetic Iron Overload Aggravates and Pharmacological Iron Restriction Improves MDS Pathophysiology in a Preclinical Mouse Model

Differential Recovery of Macrophage Iron Deficiency By Oral Iron Formulations Determines Cell Inflammatory Response in Conditions of Iron Deficiency Anemia

Heme and Iron Aggravate Tissue Damage in Sickle Cell Disease By Driving Macrophage Functional Reprogramming through the Coordinated Suppression of Efferocytosis and Mitochondrial Metabolism

Lack of IL6 Improves Recovery from Anemia of Inflammation Which Gets Hampered in Presence of Excess Iron

Nrf2 Plays a Key Role in Iron-Overload Cardiomyopathy

Iron Handling by Macrophages

Intravenous Iron Promotes Low-Grade Inflammation in Anemic Patients By Triggering Macrophage Activation

Transfusion-Induced Impairment of Macrophage Responses Is Partially Restored By the Iron Chelator Deferasirox

TET2 deficiency leads to stem cell factor–dependent clonal expansion of dysfunctional erythroid progenitors

Red Blood Cell Transfusions Shape Macrophages Towards an Anti-Inflammatory Functional Phenotype and Impair the Immune Response to Infectious Cues

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

Low-Iron Diet and Chelation Therapy Rescue Severe Atherosclerosis Associated with High Circulating Iron Levels

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

High Circulating Iron Levels Are a Risk Factor for Cardiovascular Disease: Clinical Implications for Iron-Overload Conditions

The Heme Scavenger Hemopexin Reverts Heme-Driven Pro-Inflammatory Phenotypic Switching of Macrophages in Sickle Cell Disease

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American Society of Hematology

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American Society of Hematology

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