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Journal Articles

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Reheman Adili, Nathalie Pamir, Forrest Nussdorfer, Alexander St. John, Minhua Ling, Jennie Le, Jeff Harris, Nicole Rhoads, Yi Wang, Xiaoyun Fu, Junmei Chen, Sergio Fazio, Jonathan R. Lindner, José A. López

Blood (2023) 142 (13): 1156–1166.

https://doi.org/10.1182/blood.2023019749

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Raymond Adili, Nathalie Pamir, Forrest D Nussdorfer, Alexander E St. John, Minhua Ling, Jennie Le, Jeff Harris, Junmei Chen, Sergio Fazio, Jonathan Lindner, José A. López

Blood (2022) 140 (Supplement 1): 1660–1661.

https://doi.org/10.1182/blood-2022-170092

Published: 2022

Journal Articles

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Warren Osborn, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Barbara A Konkle, José A. López, MD

Blood (2018) 132 (Supplement 1): 4911.

https://doi.org/10.1182/blood-2018-99-117087

Published: 2018

Journal Articles

Ultra-Low Von Willebrand Factor (VWF) Adsorption Under Shear with a Polymer Coating for Blood-Contacting Devices

Wei Yang, PhD, Junmei Chen, PhD, Jennie Le, BS, José A. López, MD

Blood (2017) 130 (Supplement 1): 1024.

https://doi.org/10.1182/blood.V130.Suppl_1.1024.1024

Published: 2017

Journal Articles

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

Hasan Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Melissa Dominguez, MA, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Jose A. Lopez, MD, Barbara Konkle, MD

Blood (2017) 130 (Supplement 1): 2238.

https://doi.org/10.1182/blood.V130.Suppl_1.2238.2238

Published: 2017

Journal Articles

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Shelby A Cate, BS, Jennie Le, BS, Minhua Ling, PhD, Colette Norby, MS, Dominic W Chung, PhD, Barbara A. Konkle, MD, Jose A. Lopez, MD

Blood (2016) 128 (22): 1299.

https://doi.org/10.1182/blood.V128.22.1299.1299

Published: 2016

Journal Articles

VWF Cleavage Products Inhibit Shear-Induced Self-Association

Shirin Feghhi, PhD, Alexander St. John, MD MS, Jeff Harris, Jennie Le, BS, Dominic W Chung, PhD, Junmei Chen, PhD, Jose A. Lopez, MD

Blood (2016) 128 (22): 3718.

https://doi.org/10.1182/blood.V128.22.3718.3718

Published: 2016

Journal Articles

Pursuing Ultra-Low VWF Adsorption for Blood-Contacting Devices Under Shear

Wei Yang, PhD, Junmei Chen, PhD, Jennie Le, BS, Jose A. Lopez, MD

Blood (2016) 128 (22): 2539.

https://doi.org/10.1182/blood.V128.22.2539.2539

Published: 2016

Journal Articles

High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion

Dominic W. Chung, Junmei Chen, Minhua Ling, Xiaoyun Fu, Teri Blevins, Scott Parsons, Jennie Le, Jeff Harris, Thomas R. Martin, Barbara A. Konkle, Ying Zheng, José A. López

Blood (2016) 127 (5): 637–645.

https://doi.org/10.1182/blood-2014-09-599530

Published: 2016

Includes: Supplemental data

Journal Articles

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

Junmei Chen, PhD, Tahsin Özpolat, MD, Colette Norby, MS, Jennie Le, BS, Minhua Ling, PhD, Shelby A Cate, BS, Dominic W Chung, PhD, Xiaoyun Fu, PhD, Barbara Konkle, MD, Jose A. Lopez, MD

Blood (2015) 126 (23): 239.

https://doi.org/10.1182/blood.V126.23.239.239

Published: 2015

Journal Articles

Effects of N-Acetylcysteine in Patients with Sickle Cell Disease

Tahsin Özpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Shelby A Cate, BS, Jennie Le, BS, Colette Norby, MS, Barbara A. Konkle, MD, Jose A. Lopez, MD

Blood (2014) 124 (21): 4173.

https://doi.org/10.1182/blood.V124.21.4173.4173

Published: 2014

Journal Articles

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma

Junmei Chen, William E. Hobbs, Jennie Le, Peter J. Lenting, Philip G. de Groot, José A. López

Blood (2011) 117 (13): 3680–3683.

https://doi.org/10.1182/blood-2010-08-302539

Published: 2011

Includes: Supplemental data

Journal Articles

Normal Cleavage of Von Willebrand Factor by ADAMTS13 In the Absence of Factor VIII In Patients with Severe Hemophilia A

Junmei Chen, Ph.D., Dominic W. Chung, Ph.D., Jennie Le, B.S., Barbara A. Konkle, M.D., José A. López, M.D.

Blood (2010) 116 (21): 2114.

https://doi.org/10.1182/blood.V116.21.2114.2114

Published: 2010

Journal Articles

Active Von Willebrand Factor (VWF) in Plasma of Sickle Cell Patients Is An Indicator of Disease Severity.

Junmei Chen, PhD, William Hobbs, MD, PhD, Jennie Le, Peter J Lenting, PhD, Philip G De Groot, PhD, Jose A. Lopez, MD

Blood (2009) 114 (22): 2552.

https://doi.org/10.1182/blood.V114.22.2552.2552

Published: 2009

Journal Articles

Active Von Willebrand Factor in Plasma of Sickle Cell Patients Is An Indicator for Severity of Sickle Cell Anemia

Junmei Chen, PhD, William Hobbs, MD, PhD, Jennie Le, Peter J Lenting, PhD, Jose A Lopez, MD

Blood (2008) 112 (11): 5445.

https://doi.org/10.1182/blood.V112.11.5445.5445

Published: 2008

NARROW

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Ultra-Low Von Willebrand Factor (VWF) Adsorption Under Shear with a Polymer Coating for Blood-Contacting Devices

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

VWF Cleavage Products Inhibit Shear-Induced Self-Association

Pursuing Ultra-Low VWF Adsorption for Blood-Contacting Devices Under Shear

High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

Effects of N-Acetylcysteine in Patients with Sickle Cell Disease

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma

Normal Cleavage of Von Willebrand Factor by ADAMTS13 In the Absence of Factor VIII In Patients with Severe Hemophilia A

Active Von Willebrand Factor (VWF) in Plasma of Sickle Cell Patients Is An Indicator of Disease Severity.

Active Von Willebrand Factor in Plasma of Sickle Cell Patients Is An Indicator for Severity of Sickle Cell Anemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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