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Journal Articles

High-Density Lipoprotein Inhibits Microvascular and Arterial Thrombosis in Mice By Attenuating VWF Self-Association

Raymond Adili, Nicole Rhoads, Jeffrey Harris, Minhua Ling, Junmei Chen, Jose A. Lopez, Dominic W. Chung

Blood (2023) 142 (Supplement 1): 3936.

https://doi.org/10.1182/blood-2023-178884

Published: 2023

Journal Articles

Steady-State Von Willebrand Factor Antigen Levels Predict Low Platelet Counts and Risk for Complications in Hospitalizations for Painful Sickle Cell Vaso-Occlusive Episodes

Xu Zhang, Binal Shah, Jin Han, Jose A. Lopez, Dominic W. Chung, Junmei Chen, Victor R. Gordeuk, Santosh L. Saraf

Blood (2023) 142 (Supplement 1): 2483.

https://doi.org/10.1182/blood-2023-190297

Published: 2023

Journal Articles

Self-Association of Von Willebrand Factor (VWF) into Prothrombotic Fibers Is Most Potently Enhanced By the Highly Atherogenic Small, Dense Fraction of Low-Density Lipoprotein (sd-LDL)

Junmei Chen, Forrest Nussdorfer, Raymond Adili, Kimsey Platten, Nicole Rhoads, Richard Maldonado, Franklin Reed, Yi Wang, Minhua Ling, Sergio Fazio, Xiaoyun Fu, Nathalie Pamir, Jose A. Lopez, Dominic W. Chung

Blood (2023) 142 (Supplement 1): 504.

https://doi.org/10.1182/blood-2023-188325

Published: 2023

Journal Articles

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Reheman Adili, Nathalie Pamir, Forrest Nussdorfer, Alexander St. John, Minhua Ling, Jennie Le, Jeff Harris, Nicole Rhoads, Yi Wang, Xiaoyun Fu, Junmei Chen, Sergio Fazio, Jonathan R. Lindner, José A. López

Blood (2023) 142 (13): 1156–1166.

https://doi.org/10.1182/blood.2023019749

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Unfolded Von Willebrand Factor Interacts with Protein S and Limits Its Anticoagulant Activity

Martha MS Sim, Hammodah Alfar, Melissa Hollifield, Dominic W. Chung, Xiaoyun Fu, Meenakshi Banerjee, Chi Peng, Xian Li, Alice Thornton, James Z Porterfield, Jamie Sturgill, Gail A Sievert, Marietta Barton-Baxter, Kenneth S Campbell, Jerold G Woodward, José A. López, Sidney W Whiteheart, Beth A Garvy, Jeremy P Wood

Blood (2022) 140 (Supplement 1): 2710–2711.

https://doi.org/10.1182/blood-2022-162612

Published: 2022

Journal Articles

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Raymond Adili, Nathalie Pamir, Forrest D Nussdorfer, Alexander E St. John, Minhua Ling, Jennie Le, Jeff Harris, Junmei Chen, Sergio Fazio, Jonathan Lindner, José A. López

Blood (2022) 140 (Supplement 1): 1660–1661.

https://doi.org/10.1182/blood-2022-170092

Published: 2022

Journal Articles

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

Alexander E St. John, MD, Yi Wang, PhD, Junmei Chen, PhD, Warren Osborn, Xu Wang, MD, Esther Lim, BS, Dominic W. Chung, PhD, Susan Stern, MD, Nathan White, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MDBS

Blood (2020) 136 (Supplement 1): 9–10.

https://doi.org/10.1182/blood-2020-141361

Published: 2020

Journal Articles

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation

Ian Johnston, Amrita Sarkar, Vincent Hayes, Gavin T. Koma, Gowthami M. Arepally, Junmei Chen, Dominic W. Chung, José A. López, Douglas B. Cines, Lubica Rauova, Mortimer Poncz

Blood (2020) 135 (15): 1270–1280.

https://doi.org/10.1182/blood.2018881607

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Hairpin and allosteric regulation in ADAMTS13

Dominic W. Chung

Blood (2019) 133 (17): 1800–1801.

https://doi.org/10.1182/blood-2019-02-900563

Published: 2019

Journal Articles

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Warren Osborn, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Barbara A Konkle, José A. López, MD

Blood (2018) 132 (Supplement 1): 4911.

https://doi.org/10.1182/blood-2018-99-117087

Published: 2018

Journal Articles

Inflammation, von Willebrand factor, and ADAMTS13

Junmei Chen, Dominic W. Chung

Blood (2018) 132 (2): 141–147.

https://doi.org/10.1182/blood-2018-02-769000

Published: 2018

Journal Articles

Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after CD19 CAR-T Cell Immunotherapy

Cameron J. Turtle, MBBS, PhD, Kevin A. Hay, MD FRCPC, MSc, Laila-Aicha Hanafi, PhD, Juliane Gust, MDPhD, W. Conrad Liles, MDPhD, José A. López, MD, Junmei Chen, PhD, Dominic W. Chung, PhD, Mark M Wurfel, MDPhD, Susanna Harju-Baker, PhD, Hasan Ozpolat, MD, Daniel Li, PhD, David Myerson, MDPhD, Luis F. Gonzalez-Cuyar, MD, Cecilia Yeung, MD, Kathleen R. Fink, MD, Stanley R. Riddell, MD, David G. Maloney, MD PhD

Blood (2017) 130 (Supplement 1): 805.

https://doi.org/10.1182/blood.V130.Suppl_1.805.805

Published: 2017

Journal Articles

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

Hasan Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Melissa Dominguez, MA, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Jose A. Lopez, MD, Barbara Konkle, MD

Blood (2017) 130 (Supplement 1): 2238.

https://doi.org/10.1182/blood.V130.Suppl_1.2238.2238

Published: 2017

Journal Articles

LDL and HDL Have Opposing Effects on VWF Self-Association

Forrest D Nussdorfer, BS, Nikita Taparia, BS, Shirin Feghhi, Alexander E St. John, MD, José A. López, MD, Dominic W. Chung, PhD

Blood (2017) 130 (Supplement 1): 3601.

https://doi.org/10.1182/blood.V130.Suppl_1.3601.3601

Published: 2017

Journal Articles

Thrombosis and Von Willebrand Factor in Chuvash Polycythemia

Victor R. Gordeuk, MD, Dominic W. Chung, PhD, Binal N. Shah, PhD, Junmei Chen, PhD, Adelina Sergueeva, MD, Galina Miasnikova, MD, Josef T. Prchal, MD, José A. López, MD

Blood (2017) 130 (Supplement 1): 2377.

https://doi.org/10.1182/blood.V130.Suppl_1.2377.2377

Published: 2017

Journal Articles

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Shelby A Cate, BS, Jennie Le, BS, Minhua Ling, PhD, Colette Norby, MS, Dominic W Chung, PhD, Barbara A. Konkle, MD, Jose A. Lopez, MD

Blood (2016) 128 (22): 1299.

https://doi.org/10.1182/blood.V128.22.1299.1299

Published: 2016

Journal Articles

Potential Mechanisms for Enhanced Activity of Von Willebrand Factor in Patients with Sickle Cell Disease

Junmei Chen, PhD, Tahsin Özpolat, MD, Yi Wang, PhD, Colette Norby, MS, Minhua Ling, PhD, Dominic W Chung, PhD, Barbara Konkle, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MD

Blood (2016) 128 (22): 3716.

https://doi.org/10.1182/blood.V128.22.3716.3716

Published: 2016

Journal Articles

VWF Cleavage Products Inhibit Shear-Induced Self-Association

Shirin Feghhi, PhD, Alexander St. John, MD MS, Jeff Harris, Jennie Le, BS, Dominic W Chung, PhD, Junmei Chen, PhD, Jose A. Lopez, MD

Blood (2016) 128 (22): 3718.

https://doi.org/10.1182/blood.V128.22.3718.3718

Published: 2016

Journal Articles

High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion

Dominic W. Chung, Junmei Chen, Minhua Ling, Xiaoyun Fu, Teri Blevins, Scott Parsons, Jennie Le, Jeff Harris, Thomas R. Martin, Barbara A. Konkle, Ying Zheng, José A. López

Blood (2016) 127 (5): 637–645.

https://doi.org/10.1182/blood-2014-09-599530

Published: 2016

Includes: Supplemental data

Journal Articles

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

Junmei Chen, PhD, Tahsin Özpolat, MD, Colette Norby, MS, Jennie Le, BS, Minhua Ling, PhD, Shelby A Cate, BS, Dominic W Chung, PhD, Xiaoyun Fu, PhD, Barbara Konkle, MD, Jose A. Lopez, MD

Blood (2015) 126 (23): 239.

https://doi.org/10.1182/blood.V126.23.239.239

Published: 2015

NARROW

High-Density Lipoprotein Inhibits Microvascular and Arterial Thrombosis in Mice By Attenuating VWF Self-Association

Steady-State Von Willebrand Factor Antigen Levels Predict Low Platelet Counts and Risk for Complications in Hospitalizations for Painful Sickle Cell Vaso-Occlusive Episodes

Self-Association of Von Willebrand Factor (VWF) into Prothrombotic Fibers Is Most Potently Enhanced By the Highly Atherogenic Small, Dense Fraction of Low-Density Lipoprotein (sd-LDL)

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Unfolded Von Willebrand Factor Interacts with Protein S and Limits Its Anticoagulant Activity

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation

Hairpin and allosteric regulation in ADAMTS13

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Inflammation, von Willebrand factor, and ADAMTS13

Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after CD19 CAR-T Cell Immunotherapy

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

LDL and HDL Have Opposing Effects on VWF Self-Association

Thrombosis and Von Willebrand Factor in Chuvash Polycythemia

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Potential Mechanisms for Enhanced Activity of Von Willebrand Factor in Patients with Sickle Cell Disease

VWF Cleavage Products Inhibit Shear-Induced Self-Association

High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

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American Society of Hematology

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American Society of Hematology

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