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Journal Articles

High-Density Lipoprotein Inhibits Microvascular and Arterial Thrombosis in Mice By Attenuating VWF Self-Association

Raymond Adili, Nicole Rhoads, Jeffrey Harris, Minhua Ling, Junmei Chen, Jose A. Lopez, Dominic W. Chung

Blood (2023) 142 (Supplement 1): 3936.

https://doi.org/10.1182/blood-2023-178884

Published: 2023

Journal Articles

Self-Association of Von Willebrand Factor (VWF) into Prothrombotic Fibers Is Most Potently Enhanced By the Highly Atherogenic Small, Dense Fraction of Low-Density Lipoprotein (sd-LDL)

Junmei Chen, Forrest Nussdorfer, Raymond Adili, Kimsey Platten, Nicole Rhoads, Richard Maldonado, Franklin Reed, Yi Wang, Minhua Ling, Sergio Fazio, Xiaoyun Fu, Nathalie Pamir, Jose A. Lopez, Dominic W. Chung

Blood (2023) 142 (Supplement 1): 504.

https://doi.org/10.1182/blood-2023-188325

Published: 2023

Journal Articles

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Reheman Adili, Nathalie Pamir, Forrest Nussdorfer, Alexander St. John, Minhua Ling, Jennie Le, Jeff Harris, Nicole Rhoads, Yi Wang, Xiaoyun Fu, Junmei Chen, Sergio Fazio, Jonathan R. Lindner, José A. López

Blood (2023) 142 (13): 1156–1166.

https://doi.org/10.1182/blood.2023019749

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Raymond Adili, Nathalie Pamir, Forrest D Nussdorfer, Alexander E St. John, Minhua Ling, Jennie Le, Jeff Harris, Junmei Chen, Sergio Fazio, Jonathan Lindner, José A. López

Blood (2022) 140 (Supplement 1): 1660–1661.

https://doi.org/10.1182/blood-2022-170092

Published: 2022

Journal Articles

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Warren Osborn, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Barbara A Konkle, José A. López, MD

Blood (2018) 132 (Supplement 1): 4911.

https://doi.org/10.1182/blood-2018-99-117087

Published: 2018

Journal Articles

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

Hasan Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Melissa Dominguez, MA, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Jose A. Lopez, MD, Barbara Konkle, MD

Blood (2017) 130 (Supplement 1): 2238.

https://doi.org/10.1182/blood.V130.Suppl_1.2238.2238

Published: 2017

Journal Articles

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Shelby A Cate, BS, Jennie Le, BS, Minhua Ling, PhD, Colette Norby, MS, Dominic W Chung, PhD, Barbara A. Konkle, MD, Jose A. Lopez, MD

Blood (2016) 128 (22): 1299.

https://doi.org/10.1182/blood.V128.22.1299.1299

Published: 2016

Journal Articles

Potential Mechanisms for Enhanced Activity of Von Willebrand Factor in Patients with Sickle Cell Disease

Junmei Chen, PhD, Tahsin Özpolat, MD, Yi Wang, PhD, Colette Norby, MS, Minhua Ling, PhD, Dominic W Chung, PhD, Barbara Konkle, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MD

Blood (2016) 128 (22): 3716.

https://doi.org/10.1182/blood.V128.22.3716.3716

Published: 2016

Journal Articles

High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion

Dominic W. Chung, Junmei Chen, Minhua Ling, Xiaoyun Fu, Teri Blevins, Scott Parsons, Jennie Le, Jeff Harris, Thomas R. Martin, Barbara A. Konkle, Ying Zheng, José A. López

Blood (2016) 127 (5): 637–645.

https://doi.org/10.1182/blood-2014-09-599530

Published: 2016

Includes: Supplemental data

Journal Articles

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

Junmei Chen, PhD, Tahsin Özpolat, MD, Colette Norby, MS, Jennie Le, BS, Minhua Ling, PhD, Shelby A Cate, BS, Dominic W Chung, PhD, Xiaoyun Fu, PhD, Barbara Konkle, MD, Jose A. Lopez, MD

Blood (2015) 126 (23): 239.

https://doi.org/10.1182/blood.V126.23.239.239

Published: 2015

Journal Articles

ADAMTS13 Synergizes with HDL in Preventing Von Willebrand Factor Self-Association Under Shear Stress

Dominic W Chung, PhD, Junmei Chen, PhD, Minhua Ling, PhD, Taisha Doo, BS, Teri Blevens, Barbara A Konkle, MD, Jose A Lopez, MD

Blood (2015) 126 (23): 3451.

https://doi.org/10.1182/blood.V126.23.3451.3451

Published: 2015

Journal Articles

High Density Lipoprotein and Apolipoprotein A-I Bind Von Willebrand Factor and Prevent Its Self-Association Into Thick Fibers

Dominic W. Chung, PhD, Ying Zheng, Junmei Chen, PhD, Minhua Ling, Ph.D., Xiaoyun Fu, PhD, José A. López

Blood (2013) 122 (21): 194.

https://doi.org/10.1182/blood.V122.21.194.194

Published: 2013

Journal Articles

Oxidation of Key Methionine Residues in the N-Terminal Domains of ADAMTS13 Correlates with Loss of Its Proteolytic Activity,

Yi Wang, Ph.D., Junmei Chen, Ph.D., Minhua Ling, Ph.D., José A. López, MD, Dominic W Chung, PhD, Xiaoyun Fu, Ph.D.

Blood (2011) 118 (21): 3276.

https://doi.org/10.1182/blood.V118.21.3276.3276

Published: 2011

Journal Articles

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13

Junmei Chen, Xiaoyun Fu, Yi Wang, Minhua Ling, Brad McMullen, John Kulman, Dominic W. Chung, José A. López

Blood (2010) 115 (3): 706–712.

https://doi.org/10.1182/blood-2009-03-213967

Published: 2010

Journal Articles

Oxidative Modification of Von Willebrand Factor Inhibits Its Cleavage by ADAMTS13

Junmei Chen, PhD, Xiaoyun Fu, Ph.D, Minhua Ling, PhD, Brad McMullen, John Kulman, PhD, Dominic Chung, PhD, Jose A Lopez, MD

Blood (2008) 112 (11): 3921.

https://doi.org/10.1182/blood.V112.11.3921.3921

Published: 2008

NARROW

High-Density Lipoprotein Inhibits Microvascular and Arterial Thrombosis in Mice By Attenuating VWF Self-Association

Self-Association of Von Willebrand Factor (VWF) into Prothrombotic Fibers Is Most Potently Enhanced By the Highly Atherogenic Small, Dense Fraction of Low-Density Lipoprotein (sd-LDL)

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Potential Mechanisms for Enhanced Activity of Von Willebrand Factor in Patients with Sickle Cell Disease

High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

ADAMTS13 Synergizes with HDL in Preventing Von Willebrand Factor Self-Association Under Shear Stress

High Density Lipoprotein and Apolipoprotein A-I Bind Von Willebrand Factor and Prevent Its Self-Association Into Thick Fibers

Oxidation of Key Methionine Residues in the N-Terminal Domains of ADAMTS13 Correlates with Loss of Its Proteolytic Activity,

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13

Oxidative Modification of Von Willebrand Factor Inhibits Its Cleavage by ADAMTS13

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American Society of Hematology

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American Society of Hematology

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