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Journal Articles

Platelet dysfunction reversal with cold-stored vs room temperature–stored platelet transfusions

Valery J. Kogler, Jeffrey A. Miles, Tahsin Özpolat, S. Lawrence Bailey, Daire A. Byrne, Morgan Bawcom-Randall, Yi Wang, Hannah J. Larsen, Franklin Reed, Xiaoyun Fu, Moritz Stolla
Journal: Blood
Blood (2024) 143 (20): 2073–2088.
https://doi.org/10.1182/blood.2023022593
Published: 2024
Includes: Supplemental data
Journal Articles

Self-Association of Von Willebrand Factor (VWF) into Prothrombotic Fibers Is Most Potently Enhanced By the Highly Atherogenic Small, Dense Fraction of Low-Density Lipoprotein (sd-LDL)

Junmei Chen, Forrest Nussdorfer, Raymond Adili, Kimsey Platten, Nicole Rhoads, Richard Maldonado, Franklin Reed, Yi Wang, Minhua Ling, Sergio Fazio, Xiaoyun Fu, Nathalie Pamir, Jose A. Lopez, Dominic W. Chung
Journal: Blood
Blood (2023) 142 (Supplement 1): 504.
https://doi.org/10.1182/blood-2023-188325
Published: 2023
Journal Articles

Bioactive Lipid Mediators Predict Platelet Function in Transfusion Recipients: A Phase 1 Randomized Clinical Trial in Healthy Humans

Valery J Kogler, Jeffrey Miles, Hasan Tahsin Ozpolat, Shawn Bailey, Daire Byrne, Morgan Bawcom-Randall, Yi Wang, Hannah Larsen, Franklin Reed, Xiaoyun Fu, Moritz Stolla
Journal: Blood
Blood (2023) 142 (Supplement 1): 1287.
https://doi.org/10.1182/blood-2023-180307
Published: 2023
Journal Articles

Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets

Hannah Larsen, Daire Byrne, Hasan Tahsin Ozpolat, Aastha Chauhan, Shawn Bailey, Nicole Rhoads, Franklin Reed, Massiel Chavez Stolla, Raymond Adili, Michael Holinstat, Xiaoyun Fu, Moritz Stolla
Journal: Blood
Blood (2023) 142 (Supplement 1): 2668.
https://doi.org/10.1182/blood-2023-190021
Published: 2023
Journal Articles

Low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand factor self-association

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Reheman Adili, Nathalie Pamir, Forrest Nussdorfer, Alexander St. John, Minhua Ling, Jennie Le, Jeff Harris, Nicole Rhoads, Yi Wang, Xiaoyun Fu, Junmei Chen, Sergio Fazio, Jonathan R. Lindner, José A. López
Journal: Blood
Blood (2023) 142 (13): 1156–1166.
https://doi.org/10.1182/blood.2023019749
Published: 2023
Includes: Multimedia, Supplemental data
Journal Articles

Unfolded Von Willebrand Factor Interacts with Protein S and Limits Its Anticoagulant Activity

Martha MS Sim, Hammodah Alfar, Melissa Hollifield, Dominic W. Chung, Xiaoyun Fu, Meenakshi Banerjee, Chi Peng, Xian Li, Alice Thornton, James Z Porterfield, Jamie Sturgill, Gail A Sievert, Marietta Barton-Baxter, Kenneth S Campbell, Jerold G Woodward, José A. López, Sidney W Whiteheart, Beth A Garvy, Jeremy P Wood
Journal: Blood
Blood (2022) 140 (Supplement 1): 2710–2711.
https://doi.org/10.1182/blood-2022-162612
Published: 2022
Journal Articles

Deletion of 12-Lipoxygenase Improves Platelet Function after Storage and Transfusion in Thrombocytopenic Mice

Moritz Stolla, Hannah Johnson, Massiel Chavez Stolla, Shawn Lawrence Bailey, Daire Byrne, Michael Holinstat, Xiaoyun Fu
Journal: Blood
Blood (2022) 140 (Supplement 1): 8552.
https://doi.org/10.1182/blood-2022-163781
Published: 2022
Journal Articles

Anticoagulation targeting membrane-bound anionic phospholipids improves outcomes of traumatic brain injury in mice

Xinlong Dong, Wei Liu, Yu Shen, Katie Houck, Mengchen Yang, Yuan Zhou, Zilong Zhao, Xiaoping Wu, Teri Blevins, Amanda L. Koehne, Tze-Chein Wun, Xiaoyun Fu, Min Li, Jianning Zhang, Jing-fei Dong
Journal: Blood
Blood (2021) 138 (25): 2714–2726.
https://doi.org/10.1182/blood.2021011310
Published: 2021
Includes: Supplemental data
Journal Articles

Role of 12-LOX in the Platelet Storage Lesion

Hannah Johnson, Xiaoyun Fu, Shawn Lawrence Bailey, Daire Byrne, Michael Holinstat, Moritz Stolla
Journal: Blood
Blood (2021) 138 (Supplement 1): 3241.
https://doi.org/10.1182/blood-2021-150335
Published: 2021
Journal Articles

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

Alexander E St. John, MD, Yi Wang, PhD, Junmei Chen, PhD, Warren Osborn, Xu Wang, MD, Esther Lim, BS, Dominic W. Chung, PhD, Susan Stern, MD, Nathan White, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MDBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-141361
Published: 2020
Journal Articles

Human Platelets Stored at Room Temperature Demonstrate Diminished Resistance to Oxidative Stress Compared to Those Stored at 4°C

Xiaoyun Fu, PhD, Warren Osborn, Yu Shen, Yi Wang, PhD, Jeffrey Miles, Lydia Fang, M.S., Barbara Osborne, RN, Junmei Chen, PhD, José A. López, MDBS, Moritz Stolla, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24.
https://doi.org/10.1182/blood-2020-143190
Published: 2020
Journal Articles

Targeted Proteomics Reveals That the Dominant Mechanism of Gpibα Loss during Platelet Storage Depends on Temperature of Storage

Moritz Stolla, MD, Yi Wang, PhD, Jeffrey Miles, Barbara Osborne, RN, Yu Shen, Lydia Fang, M.S., Shawn Lawrence Bailey, BS, Warren Osborn, Junmei Chen, PhD, Jose A. Lopez, MDBS, Xiaoyun Fu, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-143077
Published: 2020
Journal Articles

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Tatsuro Yoshida, PhD, Angelo D'Alessandro, PhD, Xiaoyun Fu, PhD, Travis Nemkov, PhD, Davide Stefanoni, Michael Dioguardi, BS, Neeta Rugg, Shawnagay Nestheide, BS, William Iselin, BA, Andrew Dunham, PhD, James C. Zimring, MD PhD, Jose A Cancelas, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4994.
https://doi.org/10.1182/blood-2019-125961
Published: 2019
Journal Articles

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Angelo D'Alessandro, PhD, Travis Nemkov, Julie Reisz, PhD, Monika Dzieciatkowska, PhD, Rachel Culp-Hill, BS, Davide Stefanoni, Tatsuro Yoshida, PhD, Andrew Dunham, PhD, Tamir Kanias, PhD, Larry J. DuMont, PhD MBA, Michael Paul Busch, MD PhD, Elan Z Eisenmesser, Kirk C Hansen, Xiaoyun Fu, PhD, Tiffany Thomas, PhD, Matthew Karafin, MD, Eldad A. Hod, MD, Richard O Francis, MD PhD, Steven L Spitalnik, PhD, James C. Zimring, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2543.
https://doi.org/10.1182/blood-2018-99-119262
Published: 2018
Journal Articles

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Warren Osborn, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Barbara A Konkle, José A. López, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4911.
https://doi.org/10.1182/blood-2018-99-117087
Published: 2018
Journal Articles

Effects of Oral N -Acetylcysteine on Oxidative Stress in Patients with Sickle Cell Disease

Joep W.R. Sins, MDMSc, Xiaoyun Fu, PhD, Karin Fijnvandraat, MD PhD, Melissa Dominguez, MA, A. W. Rijneveld, Jean-Louis Kerkhoffs, MD PhD, A van Meurs, MD, M. R. De Groot, MD, H Heijboer, MD PhD, Erfan Nur, MD PhD, Brenda M Luken, PhD, Sacha S Zeerleder, MD PhD, Marie-Françoise Dresse, Phu-Quoc Le, MD, Philippe Hermans, MD PhD, Anna Vanderfaeillie, MD, Eric Van Den Neste, Fleur Samantha Benghiat, Rachel Kesse-Adu, MD, Andre Delannoy, MD, Andre Efira, MD, Marie-Agnes Azerad, MD, C A de Borgie, MD PhD, Junmei Chen, PhD, Jose A. Lopez, MD, Bart J. Biemond, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2244.
https://doi.org/10.1182/blood.V130.Suppl_1.2244.2244
Published: 2017
Journal Articles

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

Hasan Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Melissa Dominguez, MA, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Jose A. Lopez, MD, Barbara Konkle, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2238.
https://doi.org/10.1182/blood.V130.Suppl_1.2238.2238
Published: 2017
Journal Articles

A Quantitative Assay of In Vivo Cleavage of Von Willebrand Factor By ADAMTS13 Reveals Excessive Cleavage in Type 2B Von Willebrand Disease and Diminished Cleavage in Thrombotic Thrombocytopenic Purpura

Xiaoyun Fu, PhD, Mallory N. Pahl, Yi Wang, PhD, Barbara A. Konkle, MD, Junmei Chen, PhD, Jose A Lopez, MD
Journal: Blood
Blood (2016) 128 (22): 2532.
https://doi.org/10.1182/blood.V128.22.2532.2532
Published: 2016
Journal Articles

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Shelby A Cate, BS, Jennie Le, BS, Minhua Ling, PhD, Colette Norby, MS, Dominic W Chung, PhD, Barbara A. Konkle, MD, Jose A. Lopez, MD
Journal: Blood
Blood (2016) 128 (22): 1299.
https://doi.org/10.1182/blood.V128.22.1299.1299
Published: 2016
Journal Articles

Potential Mechanisms for Enhanced Activity of Von Willebrand Factor in Patients with Sickle Cell Disease

Junmei Chen, PhD, Tahsin Özpolat, MD, Yi Wang, PhD, Colette Norby, MS, Minhua Ling, PhD, Dominic W Chung, PhD, Barbara Konkle, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MD
Journal: Blood
Blood (2016) 128 (22): 3716.
https://doi.org/10.1182/blood.V128.22.3716.3716
Published: 2016