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Joan Bladé, MD
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Journal Articles

Immunoparesis Defined By Heavy/Light Chain Pair Suppression in Smoldering Multiple Myeloma Patients Shows Isotype Specificity

Ignacio Isola, MD, David Moreno, MD, Esther Moga, MD PhD, Mari-Pau Mena, PhD, Natalia Tovar, Luis Gerardo Rodríguez-Lobato, MD PhD, M. Teresa Cibeira, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, Carlos Fernandez de Larrea, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-139737
Published: 2020
Journal Articles

Clinical Significance and Biomarkers to Predict Unsustained Complete Remission in Transplant-Eligible Multiple Myeloma

Ana Jimenez-Ubieto, Bruno Paiva, PhD, Joaquin Martinez Lopez, María Teresa Cedena, MD, Noemi Puig, MD PhD, Albert Oriol, MD, Maria Jesús Blanchard, MD, Rafael Rios, MD PhD, Lucia Lopez-Anglada, PhD, Jesús Martín, Rafael Martínez, Anna Sureda Balari, MD PhD, Miguel Hernández, Javier de la Rubia, Isabel Krsnik, MD PhD, Valentin Cabañas, MD, Luis Palomera, MD PhD, Joan Bargay, MD, Jose Maria Moraleda, MD PhD, Laura Rosiñol, María-Victoria Mateos, MD PhD, Jesus F. San-Miguel, MD PhD, Joan Bladé, MD PhD, Juan-José Lahuerta, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136181
Published: 2020
Journal Articles

Discordances between Immunofixation (IFx) and Minimal Residual Disease (MRD) Assessment with Next-Generation Flow (NGF) and Sequencing (NGS) in Patients (Pts) with Multiple Myeloma (MM): Clinical and Pathogenic Significance

Sara Rodríguez, PhD, Ibai Goicoechea, PhD, Katerina Gemenetzi, Cirino Botta, MDPhD, Andreas Agathangelidis, PhD, Noemi Puig, MD PhD, María Teresa Cedena, MD, Alejandro Medina, MD, Rafael Valdés-Mas, Juan José Garcés, José J Pérez, Leire Burgos, María José Calasanz, PhD, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Sarvide Sarai, Felipe Prosper, MD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Ana Jiménez Ubieto, MDPhD, Joaquin Martinez Lopez, Juan Jose Lahuerta, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, María-Victoria Mateos, MD PhD, Anastasia Chatzidimitriou, Jesus F. San-Miguel, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136258
Published: 2020
Journal Articles

Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes

Cirino Botta, MD, Cristina Pérez Ruiz, Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Aintzane Zabaleta, PhD, Leire Burgos, Catarina Maia, Sara Rodríguez, PhD, Idoia Rodriguez, Sarai Sarvide, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Laura Rosinol Dachs, Albert Oriol, MD, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda, MD PhD, Rafael Martínez, Jesús Martín, Joan Bargay, MD PhD, Javier De La Rubia, Marco Rossi, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD, Massimo Gentile, Juana Merino, Felipe Prosper, MD PhD, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Juan-José Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 506.
https://doi.org/10.1182/blood-2019-123974
Published: 2019
Journal Articles

The Pathogenesis of Multiple Myeloma (MM) Is Preceded By Mutated Lymphopoiesis and B Cell Oligoclonality That Persist in Patients with Negative Minimal Residual Disease (MRD)

Sara Rodríguez, PhD, Noemi Puig, MD PhD, Katerina Gemenetzi, Ibai Goicoechea, PhD, Cirino Botta, MD, Andreas Agathangelidis, PhD, Rafael Valdés-Mas, Juan José Garcés, María Teresa Cedena, José J Pérez, Leire Burgos, Maria Jose Calasanz, PhD BSc, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Irene Aires, Idoia Rodriguez, Sarvide Sarai, Felipe Prosper, MD PhD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Juan-José Lahuerta, MD PhD, Laura Rosinol Dachs, Joan Bladé, MD, Maria-Victoria Mateos, Anastasia Hadzidimitriou, PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 509.
https://doi.org/10.1182/blood-2019-128049
Published: 2019
Journal Articles

Qip-Mass Spectrometry in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Residual Disease IMWG Response Assessment

Noemi Puig, MD PhD, Maria-Victoria Mateos, Teresa Contreras, Bruno Paiva, PhD, María Teresa Cedena, José J Pérez, Irene Aires, Cristina Agullo, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez De La Calle, MD PhD, Marta Sonia Gonzalez, MD, Albert Oriol, Norma C. Gutierrez, MD PhD, Rafael Rios, MD PhD, Laura Rosiñol, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Javier de la Rubia, MD PhD, Ana Isabel Teruel, MDcal Doctor, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel-Teodoro Hernández, Javier López, MD, Jesús Martín, Aránzazu García Mateo, PhD, Ramón García-Sanz, MD PhD, Enrique M. Ocio, Joan Bladé, MD PhD, Juan-José Lahuerta, MD PhD, Jesus F. San-Miguel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 581.
https://doi.org/10.1182/blood-2019-127717
Published: 2019
Journal Articles

Randomized Trial of Lenalidomide and Dexamethasone Versus Clarythromycin, Lenalidomide and Dexamethasone As First Line Treatment in Patients with Multiple Myeloma Not Candidates for Autologous Stem Cell Transplantation: Results of the GEM-Claridex Clinical Trial

Noemi Puig, MD PhD, Miguel T Hernández, Laura Rosinol Dachs, Esther González Garcia, MD, Felipe De Arriba, PhD, Albert Oriol, MD, Veronica Gonzalez-Calle, Fernando Escalante, MD, Javier De La Rubia, Mercedes Gironella Meda, Rafael Ríos Tamayo, Ricarda Belen Garcia Sanchez, José María Arguiñano Pérez, MD, Adrián Alegre Amor, MD, Jesús Martín, Norma C. Gutierrez, MD PhD, Maria Jose Calasanz, PhD BSc, Maria Luisa Martin-Ramos, María del Carmen Couto Caro, Maria Casanova, MD, Mario Arnao, MD, Ernesto Pérez Persona, Sebastián Garzón López, Marta Sonia Gonzalez, MD, Guillermo Martín Sánchez, MD, Adriana C. Rossi, MD MSc, Morton Coleman, MD, Cristina Encinas, Ana María Vale López, Ana Isabel Teruel, MDcal Doctor, Bruno Paiva, PhD, Maria Teresa Cedena Romero, MD PhD, Jesús San-Miguel, Juan Jose Lahuerta, MD PhD, Joan Bladé, MD, Ruben Niesvizky, MD, Maria-Victoria Mateos
Journal: Blood
Blood (2019) 134 (Supplement_1): 694.
https://doi.org/10.1182/blood-2019-123997
Published: 2019
Journal Articles

Tandem Autologous-Autologous Vs. Autologous-Allogeneic Transplantation for Newly Diagnosed Multiple Myeloma: Pooled Analysis of 1,338 Patients from Four Trials with Long-Term Follow up

Luciano J. Costa, MD PhD, Simona Iacobelli, Marcelo C. Pasquini, MD, Riddhi Modi, PhD, Luisa Giaccone, Joan Bladé, MD PhD, Stefan Schonland, Andrea Evangelista, Jose A. Perez-Simon, MD PhD, Parameswaran Hari, MBBS, MD, Elizabeth E. Brown, PhD MPH, Sergio A Giralt, MD, Francesca Patriarca, Edward A. Stadtmauer, MD FACP, Laura Rosinol, MD PhD, Amrita Y. Krishnan, MD, Goesta Gahrton, MD PhD, Benedetto Bruno, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 259.
https://doi.org/10.1182/blood-2019-121367
Published: 2019
Journal Articles

Flowct: A Semi-Automated Workflow for Deconvolution of Immunophenotypic Data and Objective Reporting on Large Datasets

Cirino Botta, MD, Catarina Maia, Cristina Pérez Ruiz, Irene Manrique, Juan José Garcés, Sara Rodríguez, PhD, Leire Burgos, Juana Merino, Aitziber Lopez Lopez, Noemi Puig, MD PhD, María Teresa Cedena, Artur Paiva, Marco Rossi, Pierosandro Tagliaferri, MD, Piefrancesco Tassone, MD, Massimo Gentile, MD, Ivan M. Borrello, MD, Laura Rosinol Dachs, Maria-Victoria Mateos, MD PhD, Juan-José Lahuerta, MD PhD, Joan Bladé, MD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4355.
https://doi.org/10.1182/blood-2019-122088
Published: 2019
Journal Articles

Validation and Improvement Opportunities of the Revised International Staging System for Multiple Myeloma: An Analysis on Mature Data from European Clinical Trials within the Harmony Big Data Platform

Mattia D'Agostino, MD, Anders Waage, MD PhD, Juan-José Lahuerta, MD PhD, Uta Bertsch, Elena Zamagni, MD, Lars Bullinger, Alessandra Larocca, Maria-Victoria Mateos, Niels W. C. J. Van De Donk, Hans Jürgen Salwender, MD, Joan Bladé, MD, Bronno van der Holt, PhD, Paola Tacchetti, Giovannino Ciccone, Sonja Zweegman, Hartmut Goldschmidt, Michele Cavo, Jesús San-Miguel, Pieter Sonneveld, Mario Boccadoro, Jesús María Hernández-Rivas, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1773.
https://doi.org/10.1182/blood-2019-124321
Published: 2019
Journal Articles

Randomized, Open-Label, Non-Inferiority, Phase 3 Study of Subcutaneous (SC) Versus Intravenous (IV) Daratumumab (DARA) Administration in Patients with Relapsed or Refractory Multiple Myeloma: Columba Update

Saad Z. Usmani, MD, Maria-Victoria Mateos, MD PhD, Hareth Nahi, MD PhD, Sebastian Grosicki, MD PhD, Vladimir I. Vorobyev, MD PhD, Ivan Spicka, MD PhD Prof, Vania T.M. Hungria, MD PhD, Sibirina Korenkova, Max Flogegard, Joan Bladé, MD PhD, Philippe Moreau, MD, Martin F. Kaiser, Shinsuke Iida, MD PhD, Jacob P. Laubach, MD, Tara Masterson, Kristen Anne Lantz, PhD, Lisa O'Rourke, MSN, RN, Christoph Heuck, Xiang Qin, Dolly A. Parasrampuria, PhD, Ming Qi, Nizar Bahlis, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1865.
https://doi.org/10.1182/blood-2019-122765
Published: 2019
Journal Articles

Final Analysis of a Phase 1b Study of Daratumumab in Combination with Carfilzomib and Dexamethasone for Relapsed or Refractory Multiple Myeloma (RRMM)

Ajai Chari, MD, Sagar Lonial, Joaquin Martinez-Lopez, MD PhD, Maria-Victoria Mateos, Joan Bladé, MD PhD, Lotfi Benboubker, MD, Albert Oriol, Paula Rodriguez Otero, Luis Pineiro, Andrzej Jakubowiak, MD PhD, Yunsi Olyslager, Jianping Wang, Ivo Nnane, Jon Ukropec, PhD, Martin Shreeve, Ming Qi, MD PhD, Philippe Moreau, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1876.
https://doi.org/10.1182/blood-2019-123539
Published: 2019
Journal Articles

Randomized, Open-Label, Non-Inferiority, Phase 3 Study of Subcutaneous (SC) Versus Intravenous (IV) Daratumumab (DARA) Administration in Patients (Pts) with Relapsed or Refractory Multiple Myeloma (RRMM): Body Weight Subgroup Analysis of Columba

Maria-Victoria Mateos, MD PhD, Saad Z. Usmani, MD, Sebastian Grosicki, MD PhD, Vladimir I. Vorobyev, MD PhD, Ivan Spicka, MD PhD Prof, Vania T.M. Hungria, MD PhD, Sibirina Korenkova, Nizar Bahlis, MD, Max Flogegard, Joan Bladé, MD PhD, Philippe Moreau, MD, Martin F. Kaiser, Shinsuke Iida, MD PhD, Jacob P. Laubach, MD, Tara Masterson, Kristen Anne Lantz, PhD, Lisa O'Rourke, MSN, RN, Xiang Qin, Dolly A. Parasrampuria, PhD, Christoph Heuck, Ming Qi, MD PhD, Hareth Nahi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1906.
https://doi.org/10.1182/blood-2019-122501
Published: 2019
Journal Articles

The Burden of Relapsed/Refractory Multiple Myeloma: An Indirect Comparison of Health-Related Quality of Life Burden across Different Types of Advanced Cancers at Baseline and after Treatment Based on HORIZON (OP-106) Study of Melflufen Plus Dexamethasone

Paul G. Richardson, MD, Alessandra Larocca, Xavier Leleu, MD PhD, Albert Oriol, MD, Agne Paner, MD, Paula Rodriguez Otero, Cyrille Touzeau, MD, Adrián Alegre Amor, MD, Christopher Maisel, MD, María-Victoria Mateos, MD PhD, Amitabha Mazumder, MD, Peter Strang, MD, Oskar Öhman, MSc, Johan Harmenberg, MD PhD, Stojan Zavisic, Joan Bladé, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3487.
https://doi.org/10.1182/blood-2019-124832
Published: 2019
Journal Articles

Heavy and Light Chain Monitoring in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Residual Disease IMWG Response Assessment

Noemi Puig, MD PhD, Teresa Contreras, Bruno Paiva, PhD, María Teresa Cedena, José J Pérez, Irene Aires, Cristina Agullo, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez De La Calle, MD PhD, Marta Sonia Gonzalez, MD, Albert Oriol, Norma C. Gutierrez, MD PhD, Rafael Rios, MD PhD, Laura Rosiñol, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Javier de la Rubia, MD PhD, Ana Isabel Teruel, MDcal Doctor, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel-Teodoro Hernández, Javier López, MD, Jesús Martín, Aránzazu García Mateo, PhD, Enrique M. Ocio, Ramón García-Sanz, MD PhD, Joan Bladé, MD PhD, Juan Jose Lahuerta, MD PhD, Jesus F. San-Miguel, MD, Maria-Victoria Mateos
Journal: Blood
Blood (2019) 134 (Supplement_1): 1852.
https://doi.org/10.1182/blood-2019-128655
Published: 2019
Journal Articles

Clinical Activity of Melflufen in Patients with Triple-Class Refractory Multiple Myeloma and Poor-Risk Features in an Updated Analysis of HORIZON (OP-106), a Phase 2 Study in Patients with Relapsed/Refractory Multiple Myeloma Refractory to Pomalidomide and/or Daratumumab

María-Victoria Mateos, MD PhD, Albert Oriol, MD, Alessandra Larocca, Paula Rodriguez Otero, Joan Bladé, MD, Michele Cavo, Hani Hassoun, MD, Xavier Leleu, MD PhD, Adrián Alegre Amor, MD, Christopher Maisel, MD, Agne Paner, MD, Johan Harmenberg, MD PhD, Catriona Byrne, RN, Sara Thuresson, MSc, Hanan Zubair, MSc, Paul G. Richardson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1883.
https://doi.org/10.1182/blood-2019-124825
Published: 2019
Journal Articles

Curative Strategy (GEM-CESAR) for High-Risk Smoldering Myeloma (SMM): Carfilzomib, Lenalidomide and Dexamethasone (KRd) As Induction Followed By HDT-ASCT, Consolidation with Krd and Maintenance with Rd

Maria-Victoria Mateos, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez-Calle, Marta Sonia Gonzalez, MD, Albert Oriol, MD, Norma C. Gutierrez, MD PhD, Bruno Paiva, PhD, Rafael Ríos Tamayo, Laura Rosinol Dachs, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre Amor, MD, Fernando Escalante, MD, Belén Iñigo, Noemi Puig, MD PhD, Javier De La Rubia, Ana Isabel Teruel, MDcal Doctor, Maria Teresa Cedena Romero, MD PhD, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel T Hernández, Javier Lopez Jimenez, MD, Jesús Martín, Aránzazu García Mateo, PhD, Enrique M. Ocio, Joan Bladé, MD, Juan Jose Lahuerta, MD PhD, Jesús San-Miguel
Journal: Blood
Blood (2019) 134 (Supplement_1): 781.
https://doi.org/10.1182/blood-2019-125204
Published: 2019
Journal Articles

Daratumumab Plus Bortezomib, Melphalan, and Prednisone Versus Bortezomib, Melphalan, and Prednisone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Overall Survival in Alcyone

Maria-Victoria Mateos, Michele Cavo, Joan Bladé, MD PhD, Meletios A. Dimopoulos, MD, Kenshi Suzuki, MD PhD, Andrzej Jakubowiak, MD PhD, Stefan Knop, Chantal Doyen, MD, Paulo Lucio, MD PhD, Zsolt Nagy, MD PhD, Ludek Pour, MD, Mark Cook, MBChB,PhD, Sebastian Grosicki, MD PhD, Andre H Crepaldi, MD, Anna Marina Liberati, Philip Campbell, MBBS, FRACP, FRCPA, Tatiana Shelekhova, Sung-Soo Yoon, MD PhD, Genadi Iosava, MD, Tomoaki Fujisaki, MD PhD, Mamta Garg, MD FRCP, FRCPath, Maria Krevvata, PhD, Jianping Wang, Anupa Kudva, MD, Jon Ukropec, PhD, Susan Wroblewski, PhD, Rachel Kobos, MD, Jesús San-Miguel
Journal: Blood
Blood (2019) 134 (Supplement_1): 859.
https://doi.org/10.1182/blood-2019-123401
Published: 2019
Journal Articles

Smoldering Multiple Myeloma: Usefulness of Serum Heavy/Light Chain Measurements for the Evaluation of Evolving Pattern

Carlos Fernandez de Larrea, MD PhD, Ignacio Isola, MD, Esther Moga, Maria Teresa Cibeira, MD PhD, Ester Lozano, PhD, Juan I. Arostegui, Montserrat Elena, Natalia Tovar, MD PhD, Jordi Yague, Laura Rosinol, MD PhD, Joan Bladé, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4514.
https://doi.org/10.1182/blood-2018-99-117385
Published: 2018
Journal Articles

Detailed Phenotypic, Molecular and Functional Profiling of Myeloid Derived Suppressor Cells (MDSCs) in the Tumor Immune Microenvironment (TIME) of Multiple Myeloma (MM)

Cristina Pérez Ruiz, Aintzane Zabaleta, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Juana Merino, Diego Alignani, PhD, Sonia Garate, Ibai Goicoechea, PhD, David Lara-Astiaso, PhD, Sarai Sarvide, Cirino Botta, MD, Joaquin Martinez Lopez, MD PhD, Albert Oriol, MD, Rafael Rios, MD PhD, Laura Rosinol, MD PhD, Maria-Victoria Mateos, MD PhD, Juan-José Lahuerta, MD PhD, Joan Bladé, MD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4436.
https://doi.org/10.1182/blood-2018-99-111102
Published: 2018