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John R. Mackey
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Journal Articles

Targeting N-Myristoylation for Adult Acute Myeloid Leukemia Therapy

Jay Gamma, Erwan Beauchamp, Qiang Liu, Aishwarya Iyer, Megan Yap, Zoulika Zak, Cassidy Ekstrom, Krista Vincent, Joseph Brandwein, Jean C.Y. Wang, Naveen Pemmaraju, Gautam Borthakur, John R. Mackey, Luc G. Berthiaume
Journal: Blood
Blood (2022) 140 (Supplement 1): 3088–3089.
https://doi.org/10.1182/blood-2022-170544
Published: 2022
Journal Articles

A First in Class, Open-Label, First-in-Human, Phase I Trial of Daily Oral Pclx-001

Randeep Sangha, Laurie H. Sehn, Rahima Jamal, Jennifer Spratlin, John Kuruvilla, Michael J. Weickert, Luc G. Berthiaume, John R. Mackey
Journal: Blood
Blood (2022) 140 (Supplement 1): 12057–12058.
https://doi.org/10.1182/blood-2022-168140
Published: 2022
Journal Articles

Validation of NMT1 and NMT2 As Novel Drug Targets in Adult Acute Myeloid Leukemia: Rationale for N-Myristoyltransferase Inhibition with Pclx-001 for Clinical Trials

Jay Gamma, Aishwarya Iyer, Megan Yap, Zoulika Zak, Krista Vincent, Cassidy Ekstrom, Erwan Beauchamp, Lynne Postovit, John R. Mackey, Naveen Pemmaraju, Gautam Borthakur, Joseph Brandwein, Luc G. Berthiaume
Journal: Blood
Blood (2021) 138 (Supplement 1): 4344.
https://doi.org/10.1182/blood-2021-154000
Published: 2021
Journal Articles

An Open-Label, First-in-Human, Phase I Trial of Daily Pclx-001

Randeep Sangha, John R. Mackey, Laurie H. Sehn, John Kuruvilla, Michael J. Weickert, Luc G. Berthiaume
Journal: Blood
Blood (2021) 138 (Supplement 1): 1364.
https://doi.org/10.1182/blood-2021-153613
Published: 2021
Journal Articles

Nonclinical Efficacy and Toxicity and Selection of a Safe Clinical Starting Dose for an NMT Inhibitor in Development for Hematological Malignancies

Michael J. Weickert, PhD, John Dillberger, DVM, PhD, Caren Brown, Francis Phaneuf, John R. Mackey, MD, Randeep Sangha, MD, Luc G. Berthiaume, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-141910
Published: 2020
Journal Articles

Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies

Michael Weickert, John Dillberger, John R. Mackey, Paul Wyatt, David Gray, Kevin Read, Christian Li, Audrey Parenteau, Luc G. Berthiaume
Journal: Blood
Blood (2019) 134 (Supplement_1): 3362.
https://doi.org/10.1182/blood-2019-124934
Published: 2019
Journal Articles

N-Myristoyltransferase 2 (NMT2) Protein Levels Predict Survival in Acute Myeloid Leukemia (AML): A Novel Prognostic Biomarker

Ryan J Stubbins, MDMSc, Zoulika Zak, Aishwarya Iyer, Megan Yap, Krista Vincent, Lynne M Postovit, MD, John R Mackey, MD, Artur J Szkotak, MD PhD, Lalit Saini, MD, Luc G Berthiaume, PhD, Joseph M. Brandwein, MD FRCPC
Journal: Blood
Blood (2017) 130 (Supplement 1): 3914.
https://doi.org/10.1182/blood.V130.Suppl_1.3914.3914
Published: 2017
Journal Articles

Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identification of fludarabine-sensitive and -insensitive populations

John R. Mackey, Carlos M. Galmarini, Kathryn A. Graham, Anil A. Joy, Alain Delmer, Laith Dabbagh, Darryl Glubrecht, Lawrence D. Jewell, Raymond Lai, Thack Lang, John Hanson, James D. Young, Helene Merle-Béral, Jacques L. Binet, Carol E. Cass, Charles Dumontet
Journal: Blood
Blood (2005) 105 (2): 767–774.
https://doi.org/10.1182/blood-2004-03-1046
Published: 2005
Journal Articles

Expression of high Km 5′-nucleotidase in leukemic blasts is an independent prognostic factor in adults with acute myeloid leukemia

Clinical Trials & Observations
Carlos M. Galmarini, Kathryn Graham, Xavier Thomas, Fabien Calvo, Philippe Rousselot, Assia El Jafaari, Emeline Cros, John R. Mackey, Charles Dumontet
Journal: Blood
Blood (2001) 98 (6): 1922–1926.
https://doi.org/10.1182/blood.V98.6.1922
Published: 2001