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Journal Articles

Targeting Notch and Hedgehog Embryonic Signaling Pathways Has Potent Anti-Tumor Activity in Myeloma and Is Effective in Myeloma Bone Disease.

Rolf Schwarzer, Nicole Schünemann, David M Wong, Bjarne Bogen, Kurt Bommert, Bernd Dörken, MD, Rudolf Manz, Franziska Jundt, MD

Blood (2012) 120 (21): 2938.

https://doi.org/10.1182/blood.V120.21.2938.2938

Published: 2012

Journal Articles

The Relevance of Phosphorylated YB-1 for Multiple Myeloma Cell Survival and Drug Resistance

Madlen Effenberger, Valentin Bruttel, Ralf C. Bargou, Kurt Bommert

Blood (2008) 112 (11): 734.

https://doi.org/10.1182/blood.V112.11.734.734

Published: 2008

Journal Articles

Novel, 2 ND Generation Histone Deacetylase (HDAC) Inhibitor JNJ-26481585 Exhibits Potent Antitumor Activity Against Chronic Lymphocytic Leukemia Cells In-Vitro and Ex-Vivo .

Kurt Bommert, PhD, Stefan Knop, MD, Janine Arts, PhD, Peter King, PhD, Martin Page, PhD, Eugen Leo, MD, PhD, Ralf Bargou, MD

Blood (2007) 110 (11): 4679.

https://doi.org/10.1182/blood.V110.11.4679.4679

Published: 2007

Journal Articles

Altered Expression and Signalling of Bone Morphogenetic Protein Receptor 1A (BMPR-1A) and Enhanced Hematopoietic Progenitor Cell Growth in Long-Term Stromal Culture Assays from Two Patients with a Myeloproliferative Syndrome and Pulmonary Hypertension.

Martin Hildebrandt, MD, Kurt Bommert, PhD, Kirstin Rautenberg, Wolf-Dieter Ludwig, MD

Blood (2006) 108 (11): 3640.

https://doi.org/10.1182/blood.V108.11.3640.3640

Published: 2006

Journal Articles

Role and Regulation of Heat Shock Proteins 90alpha and 90beta in Multiple Myeloma.

Manik Chatterjee, MD, Sarika Jain, Thorsten Stühmer, PhD, Mindaugas Andrulis, MD, Ute Ungethüm, MD, Ralf-Jurgen Kuban, PhD, Kurt Bommert, PhD, Max Topp, MD, Doris Krämer, MD, Hans K. Müller-Hermelink, MD, Herrmann Einsele, MD, Greiner Axel, MD, Ralf C. Bargou, MD

Blood (2006) 108 (11): 5029.

https://doi.org/10.1182/blood.V108.11.5029.5029

Published: 2006

Journal Articles

STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90α and β in multiple myeloma cells, which critically contribute to tumor-cell survival

Manik Chatterjee, Sarika Jain, Thorsten Stühmer, Mindaugas Andrulis, Ute Ungethüm, Ralf-Jürgen Kuban, Heike Lorentz, Kurt Bommert, Max Topp, Doris Krämer, Hans Konrad Müller-Hermelink, Hermann Einsele, Axel Greiner, Ralf C. Bargou

Blood (2006) 109 (2): 720–728.

https://doi.org/10.1182/blood-2006-05-024372

Published: 2006

Journal Articles

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells

Martin Janz, Michael Hummel, Matthias Truss, Brigitte Wollert-Wulf, Stephan Mathas, Korinna Jöhrens, Christian Hagemeier, Kurt Bommert, Harald Stein, Bernd Dörken, Ralf C. Bargou

Blood (2006) 107 (6): 2536–2539.

https://doi.org/10.1182/blood-2005-07-2694

Published: 2006

Includes: Supplemental data

Journal Articles

Elevated NF-κB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

Stephan Mathas, Korinna Jöhrens, Stefan Joos, Andreas Lietz, Franziska Hummel, Martin Janz, Franziska Jundt, Ioannis Anagnostopoulos, Kurt Bommert, Peter Lichter, Harald Stein, Claus Scheidereit, Bernd Dörken

Blood (2005) 106 (13): 4287–4293.

https://doi.org/10.1182/blood-2004-09-3620

Published: 2005

Journal Articles

Selective Induction of the p53-Pathway as Treatment for Multiple Myeloma.

Thorsten Stühmer, Angela Zöllinger, Manik Chatterjee, Kurt Bommert, Ralf C. Bargou

Blood (2005) 106 (11): 3382.

https://doi.org/10.1182/blood.V106.11.3382.3382

Published: 2005

Journal Articles

Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma

Thorsten Stühmer, Manik Chatterjee, Martin Hildebrandt, Pia Herrmann, Hella Gollasch, Christian Gerecke, Sebastian Theurich, Luisa Cigliano, Rudolf A. Manz, Peter T. Daniel, Kurt Bommert, Lyubomir T. Vassilev, Ralf C. Bargou

Blood (2005) 106 (10): 3609–3617.

https://doi.org/10.1182/blood-2005-04-1489

Published: 2005

Journal Articles

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells

Manik Chatterjee, Thorsten Stühmer, Pia Herrmann, Kurt Bommert, Bernd Dörken, Ralf C. Bargou

Blood (2004) 104 (12): 3712–3721.

https://doi.org/10.1182/blood-2004-04-1670

Published: 2004

Journal Articles

Combined Disruption of Both the MEK/ERK and the IL-6R/STAT3 Pathways Is Required To Induce Apoptosis of Multiple Myeloma Cells in the Presence of Bone Marrow Stromal Cells.

Manik Chatterjee, Thorsten Stuehmer, Pia Herrmann, Kurt Bommert, Bernd Dorken, Ralf C. Bargou

Blood (2004) 104 (11): 4839.

https://doi.org/10.1182/blood.V104.11.4839.4839

Published: 2004

Journal Articles

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

Stephan Mathas, Andreas Lietz, Martin Janz, Michael Hinz, Franziska Jundt, Claus Scheidereit, Kurt Bommert, Bernd Dörken

Blood (2003) 102 (3): 1028–1034.

https://doi.org/10.1182/blood-2002-04-1154

Published: 2003

Journal Articles

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway

Manik Chatterjee, Dirk Hönemann, Suzanne Lentzsch, Kurt Bommert, Christine Sers, Pia Herrmann, Stephan Mathas, Bernd Dörken, Ralf C. Bargou

Blood (2002) 100 (9): 3311–3318.

https://doi.org/10.1182/blood-2002-01-0102

Published: 2002

Journal Articles

Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils

Franziska Jundt, Ioannis Anagnostopoulos, Kurt Bommert, Florian Emmerich, Gerd Müller, Hans-Dieter Foss, Hans-Dieter Royer, Harald Stein, Bernd Dörken

Blood (1999) 94 (6): 2065–2071.

https://doi.org/10.1182/blood.V94.6.2065

Published: 1999

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Targeting Notch and Hedgehog Embryonic Signaling Pathways Has Potent Anti-Tumor Activity in Myeloma and Is Effective in Myeloma Bone Disease.

The Relevance of Phosphorylated YB-1 for Multiple Myeloma Cell Survival and Drug Resistance

Novel, 2 ND Generation Histone Deacetylase (HDAC) Inhibitor JNJ-26481585 Exhibits Potent Antitumor Activity Against Chronic Lymphocytic Leukemia Cells In-Vitro and Ex-Vivo .

Altered Expression and Signalling of Bone Morphogenetic Protein Receptor 1A (BMPR-1A) and Enhanced Hematopoietic Progenitor Cell Growth in Long-Term Stromal Culture Assays from Two Patients with a Myeloproliferative Syndrome and Pulmonary Hypertension.

Role and Regulation of Heat Shock Proteins 90alpha and 90beta in Multiple Myeloma.

STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90α and β in multiple myeloma cells, which critically contribute to tumor-cell survival

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells

Elevated NF-κB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas

Selective Induction of the p53-Pathway as Treatment for Multiple Myeloma.

Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells

Combined Disruption of Both the MEK/ERK and the IL-6R/STAT3 Pathways Is Required To Induce Apoptosis of Multiple Myeloma Cells in the Presence of Bone Marrow Stromal Cells.

Inhibition of NF-κB essentially contributes to arsenic-induced apoptosis

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway

Hodgkin/Reed-Sternberg Cells Induce Fibroblasts to Secrete Eotaxin, a Potent Chemoattractant for T Cells and Eosinophils

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