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Journal Articles

Endogenous Ligands Selectively Stimulate Highly Avid Autoreactive Human Invariant Natural Killer T Cells with Distinctive T-Cell Receptor Vβ11 CDR3 Sequence Motifs

Osamu Imataki, Makito Tanaka, Alla Berezovskaya, Marcus O. Butler, Lee M. Nadler, Naoto Hirano

Blood (2011) 118 (21): 999.

https://doi.org/10.1182/blood.V118.21.999.999

Published: 2011

Journal Articles

Leuprolide Acetate (GnRH Agonist) to Enhance Immune Function Post-Autologous Hematopoietic Stem Cell Transplantation (HSCT)

Richard Champlin, Eva C. Guinan, MD, Lee M. Nadler, MD, Patricia McAdams, RN, Lisa Brennan, RN, Christine Barbon, MS, Ping Jiang, MS, Kristof Chwalisz, MD, PhD, Cynthia Mattia-Goldberg, Karim Sajwani, MS, Richard Boyd, MD, Peter F. Thall, PhD, Robertson Parkman, MD

Blood (2010) 116 (21): 4292.

https://doi.org/10.1182/blood.V116.21.4292.4292

Published: 2010

Journal Articles

A Series of Human Cell-Based Artificial APC Expands Long-Lived, Th1-Biased, Viral Antigen-Specific CD4 + T Cells with a Central/Effector Memory Phenotpype Restricted by Common HLA-DR Alleles

Marcus O. Butler, Sascha Ansén, Makito Tanaka, Osamu Imataki, Alla Berezovskaya, Mary M. Mooney, Genita Metzler, Matthew I. Milstein, Lee M. Nadler, Naoto Hirano

Blood (2010) 116 (21): 354.

https://doi.org/10.1182/blood.V116.21.354.354

Published: 2010

Journal Articles

CD8 Coreceptor-Independent T Cell Stimulation Induces High Avidity CTL In the Presence of IL-21

Osamu Imataki, Sascha Ansén, Makito Tanaka, Marcus O. Butler, Alla Berezovskaya, Kiyotaka Kuzushima, Lee M. Nadler, Naoto Hirano

Blood (2010) 116 (21): 2086.

https://doi.org/10.1182/blood.V116.21.2086.2086

Published: 2010

Journal Articles

Human CD4 + T Cells Help CD8 + T Cells Proliferate Ex Vivo by Secreting Both IL-2/IL-21 and Upregulating IL-21R

Marcus O. Butler, PhD, Osamu Imataki, Yoshihiro Yamashita, PhD, Makito Tanaka, Sascha Ansén, PhD, Alla Berezovskaya, PhD, Matthew I. Milstein, PhD, Genita Metzler, PhD, Mary M. Mooney, PhD, Andrew P. Murray, PhD, Hiroyuki Mano, Lee M. Nadler, Naoto Hirano

Blood (2010) 116 (21): 4284.

https://doi.org/10.1182/blood.V116.21.4284.4284

Published: 2010

Journal Articles

Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies

Jeff K. Davies, John G. Gribben, Lisa L. Brennan, Dongin Yuk, Lee M. Nadler, Eva C. Guinan

Blood (2008) 112 (6): 2232–2241.

https://doi.org/10.1182/blood-2008-03-143636

Published: 2008

Journal Articles

Long-Term Follow-Up of Autologous Bone Marrow Transplantation for Follicular Lymphoma in First Remission: Bone Marrow Involvement at Harvest and PCR Detectable Disease after Ex Vivo Purging Predict Relapse.

Jennifer R. Brown, MD, PhD, John G. Gribben, MD DPhil, Yang Feng, MS MPH, Donna Neuberg, DSc, Peter Mauch, MD, Lee M. Nadler, MD, Arnold S. Freedman, MD

Blood (2006) 108 (11): 3041.

https://doi.org/10.1182/blood.V108.11.3041.3041

Published: 2006

Journal Articles

Effective Control of Mismatched Alloreactivity Via Ex Vivo Alloantigen-Specific Co-Stimulatory Blockade Does Not Significantly Impact Pathogen-Specific Immunity.

Jeff K. Davies, BM, BCh, PhD, Gullu Gorgun, PhD, Lee M. Nadler, MD, Eva C. Guinan, MD

Blood (2006) 108 (11): 3177.

https://doi.org/10.1182/blood.V108.11.3177.3177

Published: 2006

Journal Articles

All Memory Lymphocytes Share a Common Differentiation Program.

W. Nicholas Haining, Benjamin Ebert, Aravind Subramanian, E. John Wherry, John Evans, Raymond Mak, Stephen Rivoli, Jill Angelosanto, Jennfer Pretz, Susan Kaech, Rafi Ahmed, Lee M. Nadler, Todd R. Golub

Blood (2006) 108 (11): 865.

https://doi.org/10.1182/blood.V108.11.865.865

Published: 2006

Journal Articles

Identification of an immunogenic CD8 + T-cell epitope derived from γ-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia

Naoto Hirano, Marcus O. Butler, Zhinan Xia, Alla Berezovskaya, Andrew P. Murray, Sascha Ansén, Seiji Kojima, Lee M. Nadler

Blood (2006) 108 (8): 2662–2668.

https://doi.org/10.1182/blood-2006-04-017566

Published: 2006

Journal Articles

CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants

Michael von Bergwelt-Baildon, Alexander Shimabukuro-Vornhagen, Alexey Popov, Nela Klein-Gonzalez, Francesca Fiore, Svenja Debey, Andreas Draube, Britta Maecker, Isaura Menezes, Lee M. Nadler, Joachim L. Schultze

Blood (2006) 107 (7): 2786–2789.

https://doi.org/10.1182/blood-2004-01-0113

Published: 2006

Includes: Supplemental data

Journal Articles

Engagement of CD83 ligand induces prolonged expansion of CD8 + T cells and preferential enrichment for antigen specificity

Naoto Hirano, Marcus O. Butler, Zhinan Xia, Sascha Ansén, Michael S. von Bergwelt-Baildon, Donna Neuberg, Gordon J. Freeman, Lee M. Nadler

Blood (2006) 107 (4): 1528–1536.

https://doi.org/10.1182/blood-2005-05-2073

Published: 2006

Journal Articles

Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-κB

Lara F. Costa, Mercedes Balcells, Elazer R. Edelman, Lee M. Nadler, Angelo A. Cardoso

Blood (2006) 107 (1): 285–292.

https://doi.org/10.1182/blood-2005-06-2208

Published: 2006

Journal Articles

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia

John G. Gribben, David Zahrieh, Katherine Stephans, Lini Bartlett-Pandite, Edwin P. Alyea, David C. Fisher, Arnold S. Freedman, Peter Mauch, Robert Schlossman, Lecia V. Sequist, Robert J. Soiffer, Blossom Marshall, Donna Neuberg, Jerome Ritz, Lee M. Nadler

Blood (2005) 106 (13): 4389–4396.

https://doi.org/10.1182/blood-2005-05-1778

Published: 2005

Journal Articles

Patients (Pts) Surviving Haploidentical Stem Cell Transplantation (SCT) after Ex Vivo Costimulatory Blockade To Induce Anergy Experience Few Long-Term Complications.

Eva C. Guinan, MD, John G. Gribben, MB, DSc, Lisa L. Brennan, RN, Lee M. Nadler, MD

Blood (2005) 106 (11): 599.

https://doi.org/10.1182/blood.V106.11.599.599

Published: 2005

Journal Articles

Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia

W. Nicholas Haining, Donna S. Neuberg, Heather L. Keczkemethy, John W. Evans, Stephen Rivoli, Rebecca Gelman, Howard M. Rosenblatt, William T. Shearer, Javier Guenaga, Daniel C. Douek, Lewis B. Silverman, Stephen E. Sallan, Eva C. Guinan, Lee M. Nadler

Blood (2005) 106 (5): 1749–1754.

https://doi.org/10.1182/blood-2005-03-1082

Published: 2005

Journal Articles

Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity

Jonathan W. Friedberg, Helen Kim, Mary McCauley, Edith M. Hessel, Paul Sims, David C. Fisher, Lee M. Nadler, Robert L. Coffman, Arnold S. Freedman

Blood (2005) 105 (2): 489–495.

https://doi.org/10.1182/blood-2004-06-2156

Published: 2005

Journal Articles

Aberrant Expression of BAFF System Molecules on B-Cell Precursor Leukemia Modulates Tumor Cell Survival: Novel Targets for Therapeutic Intervention.

Sara Maia, Sambasiva P. Rao, PhD, Stephen E. Sallan, MD, Lee M. Nadler, MD, Angelo A. Cardoso, MD, PhD

Blood (2004) 104 (11): 989.

https://doi.org/10.1182/blood.V104.11.989.989

Published: 2004

Journal Articles

γ-Globin, a Tumor-Associated Antigen for Juvenile Myelomonocytic Leukemia (JMML): A Cell-Based Approach To Identify Tumor Antigenic Epitopes That Are Naturally Processed and Presented.

Naoto Hirano, MD, PhD, Marcus O. Butler, MD, Zhinan Xia, PhD, Seiji Kojima, MD3, Lee M. Nadler, MD

Blood (2004) 104 (11): 3418.

https://doi.org/10.1182/blood.V104.11.3418.3418

Published: 2004

Journal Articles

4-1BB (CD137) or CD40 Signaling Fails To Improve the Expansion of Antigen Specific T Cells Demonstrated with Engagement of TCR, CD28 and CD83 Ligand.

Naoto Hirano, MD, PhD, Marcus O. Butler, MD, Lee M. Nadler, MD

Blood (2004) 104 (11): 2665.

https://doi.org/10.1182/blood.V104.11.2665.2665

Published: 2004

NARROW

Endogenous Ligands Selectively Stimulate Highly Avid Autoreactive Human Invariant Natural Killer T Cells with Distinctive T-Cell Receptor Vβ11 CDR3 Sequence Motifs

Leuprolide Acetate (GnRH Agonist) to Enhance Immune Function Post-Autologous Hematopoietic Stem Cell Transplantation (HSCT)

A Series of Human Cell-Based Artificial APC Expands Long-Lived, Th1-Biased, Viral Antigen-Specific CD4 + T Cells with a Central/Effector Memory Phenotpype Restricted by Common HLA-DR Alleles

CD8 Coreceptor-Independent T Cell Stimulation Induces High Avidity CTL In the Presence of IL-21

Human CD4 + T Cells Help CD8 + T Cells Proliferate Ex Vivo by Secreting Both IL-2/IL-21 and Upregulating IL-21R

Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies

Long-Term Follow-Up of Autologous Bone Marrow Transplantation for Follicular Lymphoma in First Remission: Bone Marrow Involvement at Harvest and PCR Detectable Disease after Ex Vivo Purging Predict Relapse.

Effective Control of Mismatched Alloreactivity Via Ex Vivo Alloantigen-Specific Co-Stimulatory Blockade Does Not Significantly Impact Pathogen-Specific Immunity.

All Memory Lymphocytes Share a Common Differentiation Program.

Identification of an immunogenic CD8 + T-cell epitope derived from γ-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia

CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants

Engagement of CD83 ligand induces prolonged expansion of CD8 + T cells and preferential enrichment for antigen specificity

Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-κB

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia

Patients (Pts) Surviving Haploidentical Stem Cell Transplantation (SCT) after Ex Vivo Costimulatory Blockade To Induce Anergy Experience Few Long-Term Complications.

Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia

Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity

Aberrant Expression of BAFF System Molecules on B-Cell Precursor Leukemia Modulates Tumor Cell Survival: Novel Targets for Therapeutic Intervention.

γ-Globin, a Tumor-Associated Antigen for Juvenile Myelomonocytic Leukemia (JMML): A Cell-Based Approach To Identify Tumor Antigenic Epitopes That Are Naturally Processed and Presented.

4-1BB (CD137) or CD40 Signaling Fails To Improve the Expansion of Antigen Specific T Cells Demonstrated with Engagement of TCR, CD28 and CD83 Ligand.

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American Society of Hematology

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American Society of Hematology

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