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Journal Articles

Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia

Yun Chen, Liguang Chen, Jian Yu, Emanuela M. Ghia, Michael Y. Choi, Ling Zhang, Suping Zhang, Elsa Sanchez-Lopez, George F. Widhopf, II, Karen Messer, Laura Z. Rassenti, Catriona Jamieson, Thomas J. Kipps

Blood (2019) 134 (13): 1084–1094.

https://doi.org/10.1182/blood.2019001366

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Cirmtuzumab Inhibits Non-Canonical Wnt Signaling without Enhancing Canonical Wnt/β-Catenin Signaling in Chronic Lymphocytic Leukemia

Han Zhang, PhD, Suping Zhang, PhD, Emanuela M. Ghia, PhD, Michael Y. Choi, MD, Jieyu Zhang, MS, Liguang Chen, PhD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD

Blood (2018) 132 (Supplement 1): 2652.

https://doi.org/10.1182/blood-2018-99-119606

Published: 2018

Journal Articles

Cirmtuzumab Blocks Production of Proinflammatory Factors By Inhibiting Wnt5a/ROR1 Induced Activation of NF-Kappa B in Chronic Lymphocytic Leukemia

Yun Chen, PhD, Michael Y. Choi, MD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Emanuela M. Ghia, PhD, Elsa Sanchez-Lopez, PhD, George F. Widhopf II, PhD, Karen Messer, PhD, Laura Z. Rassenti, PhD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD PhD

Blood (2018) 132 (Supplement 1): 4415.

https://doi.org/10.1182/blood-2018-99-111996

Published: 2018

Journal Articles

Wnt5a Induces Association of ROR1 with Ca 2+ /Calmodulin-Dependent Protein Kinase II and ROR1-Dependent Calcium Influx in Chronic Lymphocytic Leukemia

Liguang Chen, PhD, Yun Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD

Blood (2018) 132 (Supplement 1): 1846.

https://doi.org/10.1182/blood-2018-99-119811

Published: 2018

Journal Articles

Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia

Md Kamrul Hasan, Jian Yu, George F. Widhopf, II, Laura Z. Rassenti, Liguang Chen, Zhouxin Shen, Steven P. Briggs, Donna S. Neuberg, Thomas J. Kipps

Blood (2018) 132 (2): 170–178.

https://doi.org/10.1182/blood-2017-12-819383

Published: 2018

Includes: Supplemental data

Journal Articles

Wnt5a Can Induce Activation of Rac1 and Proliferation in Mantle Cell Lymphoma Via a ROR1-Dependent, but BTK-Independent, Signaling Pathway

Jian Yu, PhD, Yun Chen, PhD, Liguang Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf II, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 4019.

https://doi.org/10.1182/blood.V130.Suppl_1.4019.4019

Published: 2017

Journal Articles

Wnt5a Induces Interleukin-6 Via a ROR1-Dependent Pathway in Chronic Lymphocytic Leukemia, Leading to Leukemia-Cell Activation of STAT3

Yun Chen, PhD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 4282.

https://doi.org/10.1182/blood.V130.Suppl_1.4282.4282

Published: 2017

Journal Articles

Durable and Specific Inhibition of ROR1 Signaling Associates with Prolonged Progression Free Survival in Patients with Chronic Lymphocytic Leukemia Treated with Cirmtuzumab

Michael Choi, MD, George F. Widhopf II, PhD, Jian Yu, PhD, Liguang Chen, PhD, Md. Kamrul Hasan, PhD, Laura Z. Rassenti, PhD, Emily Pittman, PhD, Karen Messer, PhD, Charlene Gutierrez, BS, Reilly Lilianna Kidwell, BSc, Charles E. Prussak, PharmD, PhD, Januario E Castro, MD, Catriona Jamieson, MD PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 829.

https://doi.org/10.1182/blood.V130.Suppl_1.829.829

Published: 2017

Journal Articles

Nurse-like Cells Express High-Levels of Wnt5a, Which Induces ROR1-Dependent Signaling That Promotes Migration and Survival of Neoplastic Cells in Chronic Lymphocytic Leukemia

Yun Chen, PhD, Liguang Chen, PhD, Jian Yu, PhD, Ling Zhang, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 3007.

https://doi.org/10.1182/blood.V130.Suppl_1.3007.3007

Published: 2017

Journal Articles

Wnt5a Induces ROR1 to Complex with DOCK2 and Promote Proliferation of Chronic Lymphocytic Leukemia Cells

Md Kamrul Hasan, PhD, Jian Yu, PhD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Liguang Chen, PhD, Zhouxin Shen, PhD, Steven P. Briggs, PhD, Thomas J. Kipps, MD

Blood (2017) 130 (Supplement 1): 388.

https://doi.org/10.1182/blood.V130.Suppl_1.388.388

Published: 2017

Journal Articles

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

Bing Cui, Emanuela M. Ghia, Liguang Chen, Laura Z. Rassenti, Christopher DeBoever, George F. Widhopf, II, Jian Yu, Donna S. Neuberg, William G. Wierda, Kanti R. Rai, Neil E. Kay, Jennifer R. Brown, Jeffrey A. Jones, John G. Gribben, Kelly A. Frazer, Thomas J. Kipps

Blood (2016) 128 (25): 2931–2940.

https://doi.org/10.1182/blood-2016-04-712562

Published: 2016

Includes: Supplemental data

Journal Articles

Wnt5a Induces Association of ROR1 with 14-3-3ζ to Enhance Chemotaxis and Proliferation in Chronic Lymphocytic Leukemia

Jian Yu, PhD, Liguang Chen, PhD, Yun Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf, II, PhD, Zhouxin Shen, PhD, Steven P. Briggs, PhD, Thomas J. Kipps, MD, PhD

Blood (2016) 128 (22): 349.

https://doi.org/10.1182/blood.V128.22.349.349

Published: 2016

Journal Articles

Cirmtuzumab Targets ROR1 to Inhibit Ibrutinib-Resistant, Wnt5a-Induced Rac1 Activation in Chronic Lymphocytic Leukemia

Jian Yu, PhD, Liguang Chen, PhD, Bing Cui, PhD, Christina Wu, PhD, Michael Y. Choi, MD, Yun Chen, PhD, Ling Zhang, Laura Z. Rassenti, PhD, George F. Widhopf, II, PhD, Thomas J. Kipps, MD, PhD

Blood (2016) 128 (22): 2034.

https://doi.org/10.1182/blood.V128.22.2034.2034

Published: 2016

Journal Articles

Wnt5a Induces ROR1 to Complex with HS1, Which Undergoes Tyrosine Phosphorylation and Contributes to Planar-Cell-Polarity Migration in Chronic Lymphocytic Leukemia

Md Kamrul Hasan, PhD, Jian Yu, PhD, Liguang Chen, PhD, Bing Cui, PhD, Zhouxin Shen, PhD, George F. Widhopf, II, PhD, Laura Z. Rassenti, PhD, Steven P. Briggs, PhD, Thomas J. Kipps, MD, PhD

Blood (2016) 128 (22): 301.

https://doi.org/10.1182/blood.V128.22.301.301

Published: 2016

Journal Articles

Structural Features of ROR1 Required for Complexing with ROR2 and Enhancing Chemokine-Induced Migration and Leukemia-Cell Proliferation, Which Can be Blocked By the Anti-ROR1 Mab Cirmtuzumab (UC-961)

Jian Yu, PhD, Liguang Chen, MD PhD, George F. Widhopf, II, PhD, Suping Zhang, PhD, Bing Cui, PhD, Rongrong Wu, PhD, Ling Zhang, PhD, Thomas J. Kipps, MD, PhD

Blood (2015) 126 (23): 1741.

https://doi.org/10.1182/blood.V126.23.1741.1741

Published: 2015

Journal Articles

High-Level Expression of ROR1 Associates with Early Disease Progression in Patients with Chronic Lymphocytic Leukemia

Bing Cui, PhD, Liguang Chen, MD PhD, Laura Z. Rassenti, PhD, Emanuela M. Ghia, PhD, Jian Yu, PhD, Ling Zhang, PhD, Donna S Neuberg, ScD, William Wierda, MD PhD, Michael Keating, MBBS, Kanti R. Rai, MD, Neil E. Kay, MD, Jennifer R. Brown, MD PhD, John C. Byrd, MD, John Gribben, MDDSc, Thomas J. Kipps, MD, PhD

Blood (2015) 126 (23): 1713.

https://doi.org/10.1182/blood.V126.23.1713.1713

Published: 2015

Journal Articles

ROR1 Negative Chronic Lymphocytic Leukemia (CLL) Have a Distinctive Gene Expression Signature and May Represent an Indolent-Disease Subtype

Emanuela M. Ghia, PhD, Laura Z. Rassenti, PhD, Liguang Chen, MD PhD, Bing Cui, PhD, Christopher Deboever, BS, Kelly A. Frazer, Thomas J. Kipps, MD, PhD

Blood (2015) 126 (23): 2932.

https://doi.org/10.1182/blood.V126.23.2932.2932

Published: 2015

Journal Articles

MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

Bing Cui, Liguang Chen, Suping Zhang, Marek Mraz, Jessie-F. Fecteau, Jian Yu, Emanuela M. Ghia, Ling Zhang, Lei Bao, Laura Z. Rassenti, Karen Messer, George A. Calin, Carlo M. Croce, Thomas J. Kipps

Blood (2014) 124 (4): 546–554.

https://doi.org/10.1182/blood-2014-03-559690

Published: 2014

Includes: Supplemental data

Journal Articles

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Marek Mraz, Liguang Chen, Laura Z. Rassenti, Emanuela M. Ghia, Hongying Li, Kristen Jepsen, Erin N. Smith, Karen Messer, Kelly A. Frazer, Thomas J. Kipps

Blood (2014) 124 (1): 84–95.

https://doi.org/10.1182/blood-2013-09-527234

Published: 2014

Includes: Supplemental data

Journal Articles

Preclinical Development Of ROR1 Peptide Based Vaccine With Activity Against Chronic Lymphocytic Leukemia In ROR1 Transgenic Mice

Jian Yu, PhD, Bing Cui, Ph.D., George F. Widhopf, II, PhD, Liguang Chen, MD, PhD, Laura Rassenti, PhD, Zhengran Wang, BS, Shuyu Ma, BS, Tomoko Hayashi, M.D., Ph.D., Dennis A. Carson, M.D., Thomas J. Kipps, MD, PhD

Blood (2013) 122 (21): 4174.

https://doi.org/10.1182/blood.V122.21.4174.4174

Published: 2013

NARROW

Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia

Cirmtuzumab Inhibits Non-Canonical Wnt Signaling without Enhancing Canonical Wnt/β-Catenin Signaling in Chronic Lymphocytic Leukemia

Cirmtuzumab Blocks Production of Proinflammatory Factors By Inhibiting Wnt5a/ROR1 Induced Activation of NF-Kappa B in Chronic Lymphocytic Leukemia

Wnt5a Induces Association of ROR1 with Ca 2+ /Calmodulin-Dependent Protein Kinase II and ROR1-Dependent Calcium Influx in Chronic Lymphocytic Leukemia

Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia

Wnt5a Can Induce Activation of Rac1 and Proliferation in Mantle Cell Lymphoma Via a ROR1-Dependent, but BTK-Independent, Signaling Pathway

Wnt5a Induces Interleukin-6 Via a ROR1-Dependent Pathway in Chronic Lymphocytic Leukemia, Leading to Leukemia-Cell Activation of STAT3

Durable and Specific Inhibition of ROR1 Signaling Associates with Prolonged Progression Free Survival in Patients with Chronic Lymphocytic Leukemia Treated with Cirmtuzumab

Nurse-like Cells Express High-Levels of Wnt5a, Which Induces ROR1-Dependent Signaling That Promotes Migration and Survival of Neoplastic Cells in Chronic Lymphocytic Leukemia

Wnt5a Induces ROR1 to Complex with DOCK2 and Promote Proliferation of Chronic Lymphocytic Leukemia Cells

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

Wnt5a Induces Association of ROR1 with 14-3-3ζ to Enhance Chemotaxis and Proliferation in Chronic Lymphocytic Leukemia

Cirmtuzumab Targets ROR1 to Inhibit Ibrutinib-Resistant, Wnt5a-Induced Rac1 Activation in Chronic Lymphocytic Leukemia

Wnt5a Induces ROR1 to Complex with HS1, Which Undergoes Tyrosine Phosphorylation and Contributes to Planar-Cell-Polarity Migration in Chronic Lymphocytic Leukemia

Structural Features of ROR1 Required for Complexing with ROR2 and Enhancing Chemokine-Induced Migration and Leukemia-Cell Proliferation, Which Can be Blocked By the Anti-ROR1 Mab Cirmtuzumab (UC-961)

High-Level Expression of ROR1 Associates with Early Disease Progression in Patients with Chronic Lymphocytic Leukemia

ROR1 Negative Chronic Lymphocytic Leukemia (CLL) Have a Distinctive Gene Expression Signature and May Represent an Indolent-Disease Subtype

MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1

Preclinical Development Of ROR1 Peptide Based Vaccine With Activity Against Chronic Lymphocytic Leukemia In ROR1 Transgenic Mice

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American Society of Hematology

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American Society of Hematology

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