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Lisa S. Chen
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Journal Articles

Pharmacological Profiling of Cells from Patients with Chronic Lymphocytic Leukemia (CLL) Treated with Pirtobrutinib

Shady I. Tantawy, Burcu Aslan, Lisa S Chen, Lakesla Iles, Philip A. Thompson, Nitin Jain, William G. Wierda, Varsha Gandhi
Journal: Blood
Blood (2022) 140 (Supplement 1): 501–502.
https://doi.org/10.1182/blood-2022-171119
Published: 2022
Journal Articles

Venetoclax Synergizes with the RNA-Directed Nucleoside Analog 8-Chloro-Adenosine in Acute Myeloid Leukemia in Vitro and In Vivo

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Corey James Morales, BA, BS, Lisa S Chen, PhD, Timothy Synold, PhD, Dinh Hoa Hoang, BS, Bin Amber Zhang, PhD, Lucy Ghoda, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-143240
Published: 2020
Journal Articles

Antileukemic Activity of 8-Chloro-Adenosine (8-Cl-Ado) Is Mediated By Mir-155 Degradation and ErbB3 Binding Protein (Ebp1)-Dependent p53 Activation: A Novel Therapeutic Approach for FLT3-ITD Acute Myeloid Leukemia (AML)

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Bijender Kumar, PhD, Corey James Morales, BA, BS, Chao Liu, PhD, Lisa S Chen, PhD, Tea Pemovska, PhD, Ryan Thompson, BS, Ling Li, PhD, Dinh Hoa Hoang, BS, Bin Zhang, PhD, Lucy Ghoda, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Krister Wennerberg, PhD, Calum Leitch, PhD, Xiaochun Yu, MD PhD, Ching-Cheng Chen, PhD, David Horne, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, Steven T Rosen
Journal: Blood
Blood (2018) 132 (Supplement 1): 3938.
https://doi.org/10.1182/blood-2018-99-119880
Published: 2018
Journal Articles

A pilot study of lower doses of ibrutinib in patients with chronic lymphocytic leukemia

Clinical Trials & Observations
Lisa S. Chen, Prithviraj Bose, Nichole D. Cruz, Yongying Jiang, Qi Wu, Philip A. Thompson, Shuju Feng, Michael H. Kroll, Wei Qiao, Xuelin Huang, Nitin Jain, William G. Wierda, Michael J. Keating, Varsha Gandhi
Journal: Blood
Blood (2018) 132 (21): 2249–2259.
https://doi.org/10.1182/blood-2018-06-860593
Published: 2018
Includes: Supplemental data
Journal Articles

8-Chloro-Adenosine Inhibits Molecular Poor-Risk Acute Myeloid Leukemia (AML) and Leukemic Stem Cells (LSC) Growth and Synergizes with the BCL-2 Inhibitor Venetoclax (ABT-199)

Ralf Buettner, PhD, Ching-Cheng Chen, PhD, Bijender Kumar, PhD, Corey Morales, BA, BS, Lisa S Chen, PhD, Krister Wennerberg, PhD, Ryan Thompson, MS, Tea Pemovska, MSc, Ling Li, PhD, Bin Zhang, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Calum Leitch, MD, David Horne, PhD, Joycelynne Palmer, PhD, Varsha Gandhi, PhD, Guido Marcucci, MD, Vinod Pullarkat, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2016) 128 (22): 2758.
https://doi.org/10.1182/blood.V128.22.2758.2758
Published: 2016
Journal Articles

8-Chloro-Adenosine Inhibits Molecular Poor-Risk Acute Myeloid Leukemia (AML) and Leukemic Stem Cells (LSC) Growth Via Novel RNA- and ATP-Directed Mechanisms: A Novel Therapeutic Approach for AML

Ralf Buettner, PhD, Ching-Cheng Chen, PhD, Bijender Kumar, PhD, Lisa S Chen, PhD, Krister Wennerberg, PhD, Ryan Thompson, MS, Tea Pemovska, MSc, Ling Li, PhD, Varsha Gandhi, PhD, Guido Marcucci, MD, Vinod Pullarkat, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2015) 126 (23): 792.
https://doi.org/10.1182/blood.V126.23.792.792
Published: 2015
Journal Articles

Blood collection methods affect cellular protein integrity: implications for clinical trial biomarkers and ZAP-70 in CLL

Lisa S. Chen, Michael J. Keating, Varsha Gandhi
Journal: Blood
Blood (2014) 124 (7): 1192–1195.
https://doi.org/10.1182/blood-2014-04-565754
Published: 2014
Journal Articles

Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma

Qingshan Yang, Lisa S. Chen, Sattva S. Neelapu, Roberto N. Miranda, L. Jeffrey Medeiros, Varsha Gandhi
Journal: Blood
Blood (2012) 120 (17): 3491–3500.
https://doi.org/10.1182/blood-2012-02-412643
Published: 2012
Includes: Supplemental data
Journal Articles

Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

Lisa S. Chen, Sanjeev Redkar, Pietro Taverna, Jorge E. Cortes, Varsha Gandhi
Journal: Blood
Blood (2011) 118 (3): 693–702.
https://doi.org/10.1182/blood-2010-12-323022
Published: 2011
Includes: Supplemental data
Journal Articles

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

Lisa S. Chen, Sanjeev Redkar, David Bearss, William G. Wierda, Varsha Gandhi
Journal: Blood
Blood (2009) 114 (19): 4150–4157.
https://doi.org/10.1182/blood-2009-03-212852
Published: 2009
Includes: Supplemental data
Journal Articles

Pim Kinase Inhibitor, SGI-1776, Induces Apoptosis in CLL Lymphocytes

Lisa S Chen, Ph.D, William G Wierda, M.D., Ph.D, Sanjeev Redkar, Ph.D, David J. Bearss, PhD, Varsha Gandhi, Ph.D
Journal: Blood
Blood (2008) 112 (11): 4199.
https://doi.org/10.1182/blood.V112.11.4199.4199
Published: 2008
Journal Articles

Mcl-1: the 1 in CLL

Varsha Gandhi, Kumudha Balakrishnan, Lisa S. Chen
Journal: Blood
Blood (2008) 112 (9): 3538–3540.
https://doi.org/10.1182/blood-2008-07-170241
Published: 2008