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Journal Articles

Enhancing Cytogenetic Diagnostics: Incorporating Optical Genome Mapping in the Laboratory Routine

Álvaro Díaz-González, Cristian García-Ruiz, Gayane Avetisyan, Gloria Llorens, José Vicente Gil, Elvira Mora, Santiago Furió, Empar Mayordomo, Carolina López-Benet, Marina Suárez-Terrón, Mireya Morote-Faubel, Marta Santiago, Samuel Romero, Marta Llop, Eva Barragán, Lourdes Cordón, Alessandro Liquori, Dolores Linares, Irene Luna, Ana Vicente, Rafael Andreu, Amparo Sempere, Leonor Senent, José Cervera, Guillermo Sanz, Javier De La Rubia, Esperanza Such
Journal: Blood
Blood (2023) 142 (Supplement 1): 5024.
https://doi.org/10.1182/blood-2023-180691
Published: 2023
Journal Articles

Definition and Clinical Significance of the MGUS-like Phenotype: A Study in 5,114 Patients (Pts) with Monoclonal Gammopathies

Leire Burgos, Luis Esteban Tamariz-Amador, Noemí Puig, María Teresa Cedena, Tomas Jelinek, Sarah K Johnson, Paolo Milani, Lourdes Cordon, José J Pérez, Marta Lasa, Rosalinda Termini, Albert Oriol, Miguel-Teodoro Hernández, Luis Palomera, Rafael Martinez Martinez, Javier de la Rubia, Felipe De Arriba, Rafael Rios, Maria Esther González, Mercedes Gironella, Valentin Cabañas, Maria Casanova, Isabel Krsnik, Albert Pérez, Veronica Gonzalez De La Calle, Paula Rodríguez-Otero, Vladimir Maisnar, Roman Hajek, Frits van Rhee, Victor H Jimenez-Zepeda, Giovanni Palladini, Paolo Milani, Alberto Orfao, Laura Rosinol, Joan Bladé Creixenti, Joaquín Martínez-López, Juan-José Lahuerta, Maria-Victoria Mateos, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 138 (Supplement 1): 541.
https://doi.org/10.1182/blood-2021-150092
Published: 2021
Journal Articles

Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

Clinical Trials & Observations
Ibai Goicoechea, Noemi Puig, Maria-Teresa Cedena, Leire Burgos, Lourdes Cordón, María-Belén Vidriales, Juan Flores-Montero, Norma C. Gutierrez, Maria-Jose Calasanz, Maria-Luisa Martin Ramos, David Lara-Astiaso, Amaia Vilas-Zornoza, Diego Alignani, Idoia Rodriguez, Sarai Sarvide, Daniel Alameda, Juan José Garcés, Sara Rodriguez, Vicente Fresquet, Jon Celay, Ramón Garcia-Sanz, Joaquin Martinez-Lopez, Albert Oriol, Rafael Rios, Jesus Martin-Sanchez, Rafael Martinez-Martinez, Josep Sarra, Miguel-Teodoro Hernandez, Javier de la Rubia, Isabel Krsnik, Jose-Maria Moraleda, Luis Palomera, Joan Bargay, Jose-Angel Martinez-Climent, Alberto Orfao, Laura Rosiñol, Maria-Victoria Mateos, Juan-José Lahuerta, Joan Blade, Jesús San Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 137 (1): 49–60.
https://doi.org/10.1182/blood.2020006731
Published: 2021
Includes: Supplemental data
Journal Articles

Impact of Measurable Residual Disease (MRD) By Multiparameter Flow Cytometry (MFC): A Real-World Study in 1,076 Patients with Acute Myeloid Leukemia (AML)

Bruno Paiva, PhD, María Belén Vidriales, Maria Desamparados Sampere Talens, Fabian Tarin, Enrique Colado, Celina Benavente, María Teresa Cedena, MD, Joaquin Sanchez, MD, Teresa Caballero-Velázquez, MD PhD, Lourdes Cordon, David Martínez-Cuadron, MD, Teresa Bernal del Castillo, MD PhD, Carmen Botella, Sofia Grille, MDPhD, Josefina Serrano, MD, Carlos Rodriguez, Jesús Lorenzo Algarra, Juan Manuel Alonso Dominguez, MD PhD MSc, Maria Luz Amigo, MD, Manuel BARRIOS García, MDPhD, Raimundo García-Boyero, MD, Mercedes Colorado, MD, Jaime Perez De Oteyza, MDPhD, Manuel Perez Encinas, MD, Lissette Del Pilar Costilla, MD, Maria Jose Sayas, Olga Pérez-López, Marcos González, Jose A. Perez-Simon, MD PhD, Joaquin Martinez-Lopez, MD PhD, Claudia Lucia Sossa, Alberto Orfao, MD PhD, Jesús F. San-Miguel, Miguel Sanz, MD PhD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–15.
https://doi.org/10.1182/blood-2020-134349
Published: 2020
Journal Articles

Single-Cell Characterization of the Multiple Myeloma (MM) Immune Microenvironment Identifies CD27-Negative T Cells As Potential Source of Tumor-Reactive Lymphocytes

Cirino Botta, MD, Cristina Pérez Ruiz, Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Aintzane Zabaleta, PhD, Leire Burgos, Catarina Maia, Sara Rodríguez, PhD, Idoia Rodriguez, Sarai Sarvide, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Laura Rosinol Dachs, Albert Oriol, MD, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda, MD PhD, Rafael Martínez, Jesús Martín, Joan Bargay, MD PhD, Javier De La Rubia, Marco Rossi, MD, Pierosandro Tagliaferri, MD, Pierfrancesco Tassone, MD, Massimo Gentile, Juana Merino, Felipe Prosper, MD PhD, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Juan-José Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 506.
https://doi.org/10.1182/blood-2019-123974
Published: 2019
Journal Articles

Clinical Significance and Transcriptional Profiling of Persistent Minimal Residual Disease (MRD) in Multiple Myeloma (MM) Patients with Standard-Risk (SR) and High-Risk (HR) Cytogenetics

Ibai Goicoechea, PhD, Noemi Puig, MD PhD, María Teresa Cedena, Lourdes Cordon, Maria-Belen Vidriales, MD, Leire Burgos, Juan Flores-Montero, Norma C. Gutierrez, MD PhD, Maria Jose Calasanz, BSc, PhD, Maria Luisa Martin-Ramos, David Lara-Astiaso, PhD, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Idoia Rodriguez, Sarai Sarvide, Ramon Garcia-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Albert Oriol, MD, Rafael Rios, MD PhD, Jesús Martín, Rafael Martínez, Josep Sarra, Miguel T Hernández, MD PhD, Javier De La Rubia, MD, Isabel Krsnik, Jose Maria Moraleda, Luis Palomera, MD PhD, Joan Bargay, MD PhD, Alberto Orfao, MD PhD, Laura Rosiñol, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, MD PhD, Joan Bladé, MD PhD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 112.
https://doi.org/10.1182/blood-2018-99-113312
Published: 2018
Journal Articles

Impact of Next-Generation Flow (NGF) Minimal Residual Disease (MRD) Monitoring in Multiple Myeloma (MM): Results from the Pethema/GEM2012 Trial

Bruno Paiva, PhD, Noemi Puig, MD PhD, Maria Teresa Cedena, Lourdes Cordon, Maria-Belen Vidriales, Leire Burgos, Juan Flores-Montero, Lucía Lopez-Anglada, Norma Gutierrez, MD PhD, Maria Jose Calasanz, BSc, PhD, Maria Luisa Martin-Ramos, Ramon Garcia-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Albert Oriol, MD, M Jesús Blanchard, Rafael Rios, Jesús Martín, Rafael Martínez, Josep Sarra, Miguel T Hernández, Javier de la Rubia, Isabel Krsnik, Jose M Moraleda, Luis Palomera, Juan Bargay, Alberto Orfao, MD PhD, Laura Rosinol, MD PhD, Maria-Victoria Mateos, MD, Juan-José Lahuerta, Joan Bladé, MD PhD, Jesus F. San Miguel, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 905.
https://doi.org/10.1182/blood.V130.Suppl_1.905.905
Published: 2017
Journal Articles

Infusion of Haploidentical Stem Cell after Consolidation in Younger Patients with Acute Myeloid Leukemia: Preliminary Results of a Phase I-II Study

Blanca Boluda, MD, Pau Montesinos, MD PhD, Rebeca Rodríguez-Veiga, MD, David Martínez-Cuadrón, MD PhD, Jaime Sanz, MDPhD, Amparo Sempere, MDPhD, Leonor Senent, MD, Pilar Solves, MD, Ines Gómez-Seguí, MD PhD, Lourdes Cordon, MD PhD, Mariam Ibáñez, PhD, Juan Montoro, Sr., MD, Anabel Regadera, MD, Dolores Planelles, Guillermo Sanz, MD, Antonio Torres, MD PhD, Miguel A. Sanz, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1614.
https://doi.org/10.1182/blood.V128.22.1614.1614
Published: 2016
Journal Articles

Clonal Hematopoiesis Landscape in Patients with De Novo Acute Myeloid Leukemia By Deep Sequencing

Mariam Ibáñez, PhD, Alexander Neef, PhD, Carmen Martínez-Losada, Esperanza Such, PhD, Desiree Company, Marta Llop, PhD, Josefina Serrano, MD, Eva Barragan, PhD, Beatricce de Matteo, José Esteban, María Cervera, Fernanda Martinez, Rafa Hernani, Carlos Carretero, Lourdes Cordon, MDPhD, Rafael Andreu, MD, Leonor Senent, MD PhD, Pau Montesinos, MD PhD, Joaquín Sanchez, Miguel A. Sanz, MD PhD, Jose Cervera, MD PhD
Journal: Blood
Blood (2016) 128 (22): 598.
https://doi.org/10.1182/blood.V128.22.598.598
Published: 2016
Journal Articles

Minimal residual disease monitoring and immune profiling in multiple myeloma in elderly patients

Clinical Trials & Observations
Bruno Paiva, Maria-Teresa Cedena, Noemi Puig, Paula Arana, Maria-Belen Vidriales, Lourdes Cordon, Juan Flores-Montero, Norma C. Gutierrez, María-Luisa Martín-Ramos, Joaquin Martinez-Lopez, Enrique M. Ocio, Miguel T. Hernandez, Ana-Isabel Teruel, Laura Rosiñol, María-Asunción Echeveste, Rafael Martinez, Mercedes Gironella, Albert Oriol, Carmen Cabrera, Jesus Martin, Joan Bargay, Cristina Encinas, Yolanda Gonzalez, Jacques J. M. Van Dongen, Alberto Orfao, Joan Bladé, Maria-Victoria Mateos, Juan José Lahuerta, Jesús F. San Miguel
Journal: Blood
Blood (2016) 127 (25): 3165–3174.
https://doi.org/10.1182/blood-2016-03-705319
Published: 2016
Includes: Supplemental data
Journal Articles

Prognostic Value of Immune Profiling Multiple Myeloma Patients during Minimal Residual Disease Monitoring in the Pethema/GEM2010MAS65 Study

Paula Arana, Bruno Paiva, PhD, Noemi Puig, MD PhD, Teresa Cedena, Lourdes Cordon, Maria Belen Vidriales, MD PhD, Joaquin Martinez-López, MDPhD, Enrique M. Ocio, MD PhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Rafael Martinez, MDPhD, Albert Oriol, MDPhD, Joan Blade, MDPhD, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 721.
https://doi.org/10.1182/blood.V126.23.721.721
Published: 2015
Journal Articles

What Is the Frequency of Transplant-Eligible Multiple Myeloma Patients Being Cured? the Impact of an MGUS-like Signature at Diagnosis and MRD-Negativity

Bruno Paiva, PhD, Maria Belen Vidriales, MD PhD, Noemi Puig, MD PhD, Teresa Cedena, Lourdes Cordon, Maria-Victoria Mateos, Joaquin Martinez-López, MDPhD, Laura Rosiñol, MDPhD, Alfonso Garcia de Coca, MD PhD, Natalia De Las Heras, MD, Josefina Galende, Jose Mariano Hernandez, MD, Luis Palomera, MDPhD, Javier De La Rubia, Joan Blade, MDPhD, Jesus San Miguel, MDPhD, Juan Jose Lahuerta
Journal: Blood
Blood (2015) 126 (23): 725.
https://doi.org/10.1182/blood.V126.23.725.725
Published: 2015
Journal Articles

Comparison Between First-Generation 4-Color Vs. Second-Generation 8-Color Multiparameter Flow Cytometry (MFC) to Monitor Minimal Residual Disease (MRD) in Multiple Myeloma (MM)

Paula Arana, Bruno Paiva, PhD, Maria Belen Vidriales, MD PhD, Juan A Flores-Montero, MD, Noemi Puig, MD PhD, Teresa Cedena, Lourdes Cordon, Joaquin Martinez-López, MDPhD, Enrique M. Ocio, MD PhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Joan Blade, MDPhD, Juan Jose Lahuerta, Jacques J.M. van Dongen, Alberto Orfao, MD PhD, Maria-Victoria Mateos, Jesus San Miguel, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2963.
https://doi.org/10.1182/blood.V126.23.2963.2963
Published: 2015
Journal Articles

The Relevance of Minimal Residual Disease (MRD) Monitoring in Elderly Multiple Myeloma (MM) Patients

Bruno Paiva, PhD, Teresa Cedena, Noemi Puig, MD PhD, Lourdes Cordon, Joaquin Martinez-López, MDPhD, Enrique M. Ocio, MD PhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Rafael Martinez, MD, Albert Oriol, MDPhD, Jesus Martin, Norma C Gutiérrez, Maria Belen Vidriales, MD PhD, Joan Blade, MDPhD, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 4181.
https://doi.org/10.1182/blood.V126.23.4181.4181
Published: 2015
Journal Articles

Prognostic Value of Antigen Expression in Multiple Myeloma (MM): A Large GEM/Pethema Study Based in Four Consecutive Clinical Trials

Bruno Paiva, PhD, Noemi Puig, MD PhD, Paula Arana, Teresa Cedena, Lourdes Cordon, Maria Belen Vidriales, MD PhD, Norma C Gutierrez, Joaquin Martinez-López, MDPhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Rafael Martinez, MD, Albert Oriol, MDPhD, Javier De La Rubia, Joan Blade, MDPhD, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 19.
https://doi.org/10.1182/blood.V126.23.19.19
Published: 2015
Journal Articles

Critical analysis of the stringent complete response in multiple myeloma: contribution of sFLC and bone marrow clonality

Clinical Trials & Observations Brief Report
Joaquín Martínez-López, Bruno Paiva, Lucía López-Anglada, María-Victoria Mateos, Teresa Cedena, María-Belén Vidríales, María Auxiliadora Sáez-Gómez, Teresa Contreras, Albert Oriol, Inmaculada Rapado, Ana-Isabel Teruel, Lourdes Cordón, María Jesús Blanchard, Enrique Bengoechea, Luis Palomera, Felipe de Arriba, Cecilia Cueto-Felgueroso, Alberto Orfao, Joan Bladé, Jesús F. San Miguel, Juan José Lahuerta
Journal: Blood
Blood (2015) 126 (7): 858–862.
https://doi.org/10.1182/blood-2015-04-638742
Published: 2015
Journal Articles

Clinical Significance of Sensitive Flow-MRD Monitoring in Elderly Multiple Myeloma Patients on the Pethema/GEM2010MAS65 Trial

Bruno Paiva, PhD, Maria Angeles Montalbán, Noemi Puig, MD PhD, Lourdes Cordon, Joaquin Martinez-Lopez, Enrique M Ocio, MD PhD, Miguel Hernandez, MD, Ana Isabel Teruel, Mercedes Gironella, MD, Maria Asunción Echeveste, Laura Rosiñol, MD PhD, Rafael Martinez, MD, Albert Oriol, MD, Jesus Martin, MD, Cristina Encinas, Norma Carmen Gutierrez, PhD MD, María-Belén Vidriales, MD PhD, Joan Blade, Juan José Lahuerta, MD PhD, Maria-Victoria Mateos, Jesus F. San Miguel
Journal: Blood
Blood (2014) 124 (21): 3390.
https://doi.org/10.1182/blood.V124.21.3390.3390
Published: 2014
Journal Articles

Whole Bone Marrow (BM) Immunophenotypic Profiling for the Identification of Newly Diagnosed Symptomatic Multiple Myeloma (MM) Patients with an MGUS-Like Signature Associated with Long-Term Disease Control (LTDC)

Bruno Paiva, María-Belén Vidriales, Jose J. Perez, María-Angeles Montalbán, Norma Gutierrez, Laura Rosiñol, MD, Joaquín Martínez-López, MD, María-Victoria Mateos, MD, PhD, Lourdes Cordon, Albert Oriol, Maria Jose Terol, MD, Maria Asuncion Echeveste, Raquel Paz, Felipe de Arriba, Luis Palomera, MD, Javier De La Rubia, MD, Joaquín Díaz-Mediavilla, Anna Sureda, MD, PhD, Ana Gorosquieta, Adrian Alegre, Alejandro Martín, Alberto Orfao, Juan-Jose Lahuerta, MD, Joan Blade, MD, Jesus F. San Miguel, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3949.
https://doi.org/10.1182/blood.V120.21.3949.3949
Published: 2012
Journal Articles

High-risk cytogenetics and persistent minimal residual disease by multiparameter flow cytometry predict unsustained complete response after autologous stem cell transplantation in multiple myeloma

Brief Report
Bruno Paiva, Norma C. Gutiérrez, Laura Rosiñol, María-Belén Vídriales, María-Ángeles Montalbán, Joaquín Martínez-López, María-Victoria Mateos, María-Teresa Cibeira, Lourdes Cordón, Albert Oriol, María-José Terol, María-Asunción Echeveste, Raquel de Paz, Felipe de Arriba, Luis Palomera, Javier de la Rubia, Joaquín Díaz-Mediavilla, Anna Sureda, Ana Gorosquieta, Adrian Alegre, Alejandro Martin, Miguel T. Hernández, Juan-José Lahuerta, Joan Bladé, Jesús F. San Miguel
Journal: Blood
Blood (2012) 119 (3): 687–691.
https://doi.org/10.1182/blood-2011-07-370460
Published: 2012
Includes: Supplemental data