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Manfred Jung
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Journal Articles

Phase I Study of the LSD1 Inhibitor Tranylcypromine (TCP) in Combination with All- Trans Retinoic Acid (ATRA) and Low-Dose Cytarabine (LDAC) in Elderly, Medically Non-Fit Patients with AML or High-Risk MDS (TRANSATRA trial)

Michael Lübbert, Claudia Schmoor, Tobias Berg, Michael Kruszewski, Marcus Matthias Schittenhelm, Katharina Götze, Caroline Pabst, Andrea Kündgen, Tobias Ma, Anna Frey, Kevin Moschallski, Usama-Ur Rehman, Johannes Jung, Justus Duyster, Manfred Jung, Roland Schüle, Ralph Wäsch, Olga Grishina
Journal: Blood
Blood (2022) 140 (Supplement 1): 9087–9088.
https://doi.org/10.1182/blood-2022-159471
Published: 2022
Journal Articles

Epigenetic Modifications of the Bone Marrow (BM) Niche in Multiple Myeloma (MM) - a Three-Dimensional (3D) in Vitro Approach

Stefan J. Müller, PharmD, Dagmar Wider, Andreas R. Thomsen, MD, Marie Follo, PhD, Johannes M. Waldschmidt, MD, Gabriele Ihorst, Sandra M. Dold, MSc, Julia Felthaus, Johanna Senger, PhD, Julia Schüler, DVM, Justus Duyster, Abdel Kareem Azab, PhD, Martin J. Hug, PhD, Manfred Jung, PhD, Ralph Wäsch, MD, Monika Engelhardt
Journal: Blood
Blood (2017) 130 (Supplement 1): 1793.
https://doi.org/10.1182/blood.V130.Suppl_1.1793.1793
Published: 2017
Journal Articles

LSD1 Inhibition Leads to Differentiation in Hoxa9/Meis1- but Not in MN1-Induced Acute Myeloid Leukemia

Jessica Barth, Anna-Maria Scheder, Sebastian Mohr, Johannes Schulz-Fincke, Martin Schmitt, PhD, Alexandra Walter, Milica Tosic, Eric Metzger, Gesine Bug, MD, Michael Lübbert, Manfred Jung, PhD, Hubert Serve, Roland Schüle, PhD, Tobias Berg, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1246.
https://doi.org/10.1182/blood.V130.Suppl_1.1246.1246
Published: 2017
Journal Articles

LSD1 Inhibition Induces Differentiation and Reduces the Frequency of Leukemia-Initiating Cells in Hoxa9/Meis1-Induced Acute Myeloid Leukemia

Jessica Barth, Anna-Maria Scheder, Sebastian Mohr, Schulz-Fincke Johannes, Martin Schmitt, Alexandra Walter, Milica Tosic, Eric Metzger, Michael Lübbert, MD, Manfred Jung, PhD, Hubert Serve, MD, Roland Schüle, Tobias Berg, MD
Journal: Blood
Blood (2016) 128 (22): 3935.
https://doi.org/10.1182/blood.V128.22.3935.3935
Published: 2016
Journal Articles

Testing Novel Anti - Multiple Myeloma (MM) Agents in a Suitable Three-Dimensional (3D) Co-Culture Platform

Stefan J. Müller, Dipl.-Pharm., Johannes M. Waldschmidt, MD, Johanna Senger, PhD, Dagmar Wider, Andreas R. Thomsen, MD, Gabriele Ihorst, PhD, Justus Duyster, MD, Martin J. Hug, PhD, Manfred Jung, PhD, Ralph Wäsch, MD, Monika Engelhardt, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2109.
https://doi.org/10.1182/blood.V128.22.2109.2109
Published: 2016
Journal Articles

Results of an Open, Non-Comparative, Phase I/II Investigator Initiated Trial (IIT) in Relapsed or Refractory Multiple Myeloma Patients Using Vorinostat, Bortezomib, Doxorubicin and Dexamethasone (VBDD)

Alexander Keller, MD, Johannes M. Waldschmidt, MD, Dagmar Wider, Dorothee Jakobs, Mandy Möller, Heike Reinhardt, Milena Pantic, PhD, Olga Grishina, MD, Gabriele Ihorst, PhD, Annette M May, MD, Anna Frey, MD, Ulrike Kohlweyer, PhD, Justus Duyster, MD PhD, Manfred Jung, PhD, Monika Engelhardt, MD PhD, Ralph Wäsch, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4260.
https://doi.org/10.1182/blood.V126.23.4260.4260
Published: 2015
Journal Articles

Vorinostat (V) In Combination With Bortezomib (B), Doxorubicin (D) and Dexamethasone (D) (VBDD) In Patients With Refractory Or Relapsed Multiple Myeloma: An Interim Phase I/II Analysis

Martina Kleber, Dagmar Wider, Kristina Keller, Barbara Groß, Heike Reinhardt, Dorothee Jakobs, Mandy-Deborah Moeller, Manuela Burbeck, Milena Pantic, Annette May, Manfred Jung, PhD, Ralph Waesch, MD, Monika Engelhardt, MD
Journal: Blood
Blood (2013) 122 (21): 3202.
https://doi.org/10.1182/blood.V122.21.3202.3202
Published: 2013
Journal Articles

Drug-Drug Interactions in the Hematology and Oncology Department: A Real-Life Assessment of Frequency and Severity

Barbara Metzke, Martin J Hug, PhD, Geertje Fink, MD, Stefanie Hieke, Manfred Jung, PhD, Monika Engelhardt
Journal: Blood
Blood (2012) 120 (21): 4250.
https://doi.org/10.1182/blood.V120.21.4250.4250
Published: 2012
Journal Articles

Systemic Antifungal Drugs in the Hematology and Oncology Setting: A Real-Life Analysis in Consecutive Leukemia Patients of Patterns of Usage and Associated Problems,

Barbara Metzke, Stefanie Hieke, Manfred Jung, PhD, Ralph Waesch, MD, Monika Engelhardt, MD
Journal: Blood
Blood (2011) 118 (21): 4198.
https://doi.org/10.1182/blood.V118.21.4198.4198
Published: 2011
Journal Articles

Use of Systemic Antifungal Agents In Patients with Acute Leukemia: a Prospective Analysis Covering Clinical Parameters, Side Effects, Drug Interactions and Costs

Barbara Metzke, Stefanie Hieke, Werner Neubauer, PhD, Hartmut Bertz, PhD, Klaus Kümmerer, PhD, Manfred Jung, PhD, Monika Engelhardt, PhD
Journal: Blood
Blood (2010) 116 (21): 2568.
https://doi.org/10.1182/blood.V116.21.2568.2568
Published: 2010
Journal Articles

Selective HDAC6 Inhibition and Antileukemic Activity of the Novel HDAC Inhibitor ST80 in Myeloid Leukemia Cell Lines.

Bjorn W. Hackanson, MD, Leander Rimmele, Manfred Jung, PhD, Michael Lübbert, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 4808.
https://doi.org/10.1182/blood.V114.22.4808.4808
Published: 2009
Journal Articles

Hydroxamic Acids Derivatives Induce γ Globin Gene Expression in Vivo.

Hua Cao, M.D., Ph.D., Manfred Jung, Ph.D., George Stamatoyannopoulos, M.D.
Journal: Blood
Blood (2004) 104 (11): 1224.
https://doi.org/10.1182/blood.V104.11.1224.1224
Published: 2004
Journal Articles

Induction of human γ globin gene expression by histone deacetylase inhibitors

Hua Cao, George Stamatoyannopoulos, Manfred Jung
Journal: Blood
Blood (2004) 103 (2): 701–709.
https://doi.org/10.1182/blood-2003-02-0478
Published: 2004