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Journal Articles

What’s brewing for MALT1 in lymphoma?

Marcel Spaargaren

Blood (2023) 142 (23): 1939–1941.

https://doi.org/10.1182/blood.2023022058

Published: 2023

Journal Articles

High karyotypic complexity is an independent prognostic factor in patients with CLL treated with venetoclax combinations

Moritz Fürstenau, Yvonne J. Thus, Sandra Robrecht, Clemens H. M. Mellink, Anne-Marie van der Kevie-Kersemaekers, Julie Dubois, Julia von Tresckow, Michaela Patz, Michael Gregor, Patrick Thornton, Philipp B. Staber, Tamar Tadmor, Mark-David Levin, Caspar da Cunha-Bang, Christof Schneider, Christian Bjoern Poulsen, Thomas Illmer, Björn Schöttker, Ann Janssens, Ilse Christiansen, Thomas Nösslinger, Michael Baumann, Holger Hebart, Tobias Gaska, Josien C. Regelink, Ellen C. Dompeling, Vesa Lindström, Gunnar Juliusson, Anouk Widmer, Jeroen Goede, Neta Goldschmidt, Florian Simon, Nisha De Silva, Anna-Maria Fink, Kirsten Fischer, Clemens-Martin Wendtner, Matthias Ritgen, Monika Brüggemann, Eugen Tausch, Marcel Spaargaren, Eric Eldering, Stephan Stilgenbauer, Carsten U. Niemann, Michael Hallek, Barbara Eichhorst, Karl-Anton Kreuzer, Arnon P. Kater

Blood (2023) 142 (5): 446–459.

https://doi.org/10.1182/blood.2023019634

Published: 2023

Includes: Supplemental data

Journal Articles

Immune evasion in primary testicular and central nervous system lymphomas: HLA loss rather than 9p24.1/ PD-L1/PD-L2 alterations

Marthe Minderman, Avital Amir, Willem Kraan, Esther J. M. Schilder-Tol, Monique E. C. M. Oud, Cornelis G. Scheepstra, Arnold L. Noorduyn, Philip M. Kluin, Marie José Kersten, Marcel Spaargaren, Steven T. Pals

Blood (2021) 138 (13): 1194–1197.

https://doi.org/10.1182/blood.2021011366

Published: 2021

Includes: Supplemental data

Journal Articles

Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis

Zemin Ren, Marcel Spaargaren, Steven T. Pals

Blood (2021) 137 (13): 1713–1718.

https://doi.org/10.1182/blood.2020008188

Published: 2021

Journal Articles

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

Zemin Ren, Harmen van Andel, Wim de Lau, Robin B. Hartholt, Madelon M. Maurice, Hans Clevers, Marie José Kersten, Marcel Spaargaren, Steven T. Pals

Blood (2018) 131 (9): 982–994.

https://doi.org/10.1182/blood-2017-07-797050

Published: 2018

Includes: Supplemental data

Journal Articles

The forkhead transcription factor FOXP1 represses human plasma cell differentiation

Martine van Keimpema, Leonie J. Grüneberg, Michal Mokry, Ruben van Boxtel, Menno C. van Zelm, Paul Coffer, Steven T. Pals, Marcel Spaargaren

Blood (2015) 126 (18): 2098–2109.

https://doi.org/10.1182/blood-2015-02-626176

Published: 2015

Includes: Supplemental data

Journal Articles

Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy

Martin F. M. de Rooij, Annemieke Kuil, Arnon P. Kater, Marie José Kersten, Steven T. Pals, Marcel Spaargaren

Blood (2015) 125 (14): 2306–2309.

https://doi.org/10.1182/blood-2014-12-619163

Published: 2015

Includes: Supplemental data

Journal Articles

Combined Inhibition of Phosphatidylinositol 3-Kinase (PI3K) Isoform α and δ By the Pan-Class I PI3K Inhibitor SAR245409 (XL765) in Primary Chronic Lymphocytic Leukemia Cells Blocks Survival, Adhesion and Proliferation

Rachel Thijssen, Gregor van Bochove, Martin FM de Rooij, Johanna ter Burg, Marcel Spaargaren, PhD, Coumaran Egile, PhD, Marie Jose Kersten, MD PhD, Eric Eldering, PhD, Arnon P. Kater, MD PhD

Blood (2014) 124 (21): 4691.

https://doi.org/10.1182/blood.V124.21.4691.4691

Published: 2014

Journal Articles

Combined Inhibition of mTOR and DNA-PK Blocks Survival, Adhesion, Proliferation and Chemoresistance in Primary Chronic Lymphocytic Leukemia (CLL) Cells

Rachel Thijssen, Gregor van Bochove, Ingrid AM Derks, Johanna ter Burg, Martin FM de Rooij, Marcel Spaargaren, PhD, Marie Jose Kersten, MD PhD, Eric Eldering, PhD, Arnon P. Kater, MD PhD

Blood (2014) 124 (21): 1981.

https://doi.org/10.1182/blood.V124.21.1981.1981

Published: 2014

Journal Articles

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells

Martine van Keimpema, Leonie J. Grüneberg, Michal Mokry, Ruben van Boxtel, Jan Koster, Paul J. Coffer, Steven T. Pals, Marcel Spaargaren

Blood (2014) 124 (23): 3431–3440.

https://doi.org/10.1182/blood-2014-01-553412

Published: 2014

Includes: Supplemental data

Journal Articles

Possible Mechanisms Of Resistance To The Novel BH3-Mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk

Rachel Thijssen, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Katinka Weller, Hermen S Overkleeft, Marinus H.J. Van Oers, MD, PhD, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD, Eric Eldering, PhD

Blood (2013) 122 (21): 4188.

https://doi.org/10.1182/blood.V122.21.4188.4188

Published: 2013

Journal Articles

Egress of CD19 + CD5 + cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients

Betty Y. Chang, Michelle Francesco, Martin F. M. De Rooij, Padmaja Magadala, Susanne M. Steggerda, Min Mei Huang, Annemieke Kuil, Sarah E. M. Herman, Stella Chang, Steven T. Pals, Wyndham Wilson, Adrian Wiestner, Marcel Spaargaren, Joseph J. Buggy, Laurence Elias

Blood (2013) 122 (14): 2412–2424.

https://doi.org/10.1182/blood-2013-02-482125

Published: 2013

Includes: Supplemental data

Journal Articles

Mapping the Targets of Dasatinib in Chronic Lymphocytic Leukemia Reveals Distinct Roles for Abl and Btk in Drug Resistance and Adhesion, and Explains Clinical Effects On Lymph Node Reduction

Eric Eldering, PhD, Christian R Geest, Martin FM de Rooij, Nora Liu, Bogdan I Florea, Marinus H.J. Van Oers, MD, PhD, Hermen S Overkleeft, Marcel Spaargaren, PhD, Arnon P. Kater, MD PhD

Blood (2012) 120 (21): 3900.

https://doi.org/10.1182/blood.V120.21.3900.3900

Published: 2012

Journal Articles

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor– and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

Martin F. M. de Rooij, Annemieke Kuil, Christian R. Geest, Eric Eldering, Betty Y. Chang, Joseph J. Buggy, Steven T. Pals, Marcel Spaargaren

Blood (2012) 119 (11): 2590–2594.

https://doi.org/10.1182/blood-2011-11-390989

Published: 2012

Includes: Supplemental data

Journal Articles

Egress of CD19 + CD5 + Cells Into Peripheral Blood Following Treatment with the Bruton Tyrosine Kinase Inhibitor, PCI-32765, in Mantle Cell Lymphoma Patients

Betty Y Chang, PhD, Michelle Francesco, Padmaja Magadala, Min Mei Huang, PhD, Marcel Spaargaren, PhD, Joseph J. Buggy, PhD, Laurence Elias, MD

Blood (2011) 118 (21): 954.

https://doi.org/10.1182/blood.V118.21.954.954

Published: 2011

Journal Articles

Lymphoma spread? Target CD47-SIRPα!

Marcel Spaargaren

Blood (2011) 118 (18): 4762–4764.

https://doi.org/10.1182/blood-2011-09-375139

Published: 2011

Journal Articles

Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival

Rogier M. Reijmers, Richard W. J. Groen, Annemieke Kuil, Kees Weijer, Fiona C. Kimberley, Jan Paul Medema, Toin H. van Kuppevelt, Jin-Ping Li, Marcel Spaargaren, Steven T. Pals

Blood (2011) 117 (23): 6162–6171.

https://doi.org/10.1182/blood-2010-12-325522

Published: 2011

Journal Articles

Transcriptional Silencing of the Wnt-Antagonist Dickkopf-1 (DKK1) by Promoter Methylation Unleashes Aberrant Wnt Signaling In Advanced Multiple Myeloma

Kinga A Kocemba, MSc, Richard W Groen, PhD, Harmen van Andel, BSc, Karene Mahtouk, PhD, Marie Jose Kersten, MD, PhD, Marcel Spaargaren, PhD, Steven T Pals, MD, PhD

Blood (2010) 116 (21): 1919.

https://doi.org/10.1182/blood.V116.21.1919.1919

Published: 2010

Journal Articles

Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma

Rogier M. Reijmers, Richard W. J. Groen, Henk Rozemuller, Annemieke Kuil, Anneke de Haan-Kramer, Tamás Csikós, Anton C. M. Martens, Marcel Spaargaren, Steven T. Pals

Blood (2010) 115 (3): 601–604.

https://doi.org/10.1182/blood-2009-02-204396

Published: 2010

Includes: Supplemental data

Journal Articles

Targeting EXT-1 Reveals a Crucial Role of Heparan Sulfate in the Growth of Multiple Myeloma.

Rogier M Reijmers, Richard W.J. Groen, Henk Rozemuller, Annemieke Kuil, Anneke de Haan - Kramer, Tamas Csikos, Anton C.M. Martens, Marcel Spaargaren, Steven T Pals

Blood (2009) 114 (22): 1830.

https://doi.org/10.1182/blood.V114.22.1830.1830

Published: 2009

NARROW

What’s brewing for MALT1 in lymphoma?

High karyotypic complexity is an independent prognostic factor in patients with CLL treated with venetoclax combinations

Immune evasion in primary testicular and central nervous system lymphomas: HLA loss rather than 9p24.1/ PD-L1/PD-L2 alterations

Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

The forkhead transcription factor FOXP1 represses human plasma cell differentiation

Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy

Combined Inhibition of Phosphatidylinositol 3-Kinase (PI3K) Isoform α and δ By the Pan-Class I PI3K Inhibitor SAR245409 (XL765) in Primary Chronic Lymphocytic Leukemia Cells Blocks Survival, Adhesion and Proliferation

Combined Inhibition of mTOR and DNA-PK Blocks Survival, Adhesion, Proliferation and Chemoresistance in Primary Chronic Lymphocytic Leukemia (CLL) Cells

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells

Possible Mechanisms Of Resistance To The Novel BH3-Mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk

Egress of CD19 + CD5 + cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients

Mapping the Targets of Dasatinib in Chronic Lymphocytic Leukemia Reveals Distinct Roles for Abl and Btk in Drug Resistance and Adhesion, and Explains Clinical Effects On Lymph Node Reduction

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor– and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

Egress of CD19 + CD5 + Cells Into Peripheral Blood Following Treatment with the Bruton Tyrosine Kinase Inhibitor, PCI-32765, in Mantle Cell Lymphoma Patients

Lymphoma spread? Target CD47-SIRPα!

Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival

Transcriptional Silencing of the Wnt-Antagonist Dickkopf-1 (DKK1) by Promoter Methylation Unleashes Aberrant Wnt Signaling In Advanced Multiple Myeloma

Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma

Targeting EXT-1 Reveals a Crucial Role of Heparan Sulfate in the Growth of Multiple Myeloma.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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