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Journal Articles

Unraveling Clonal Evolution and Mechanisms of Treatment Resistance in Murine KMT2A -Rearranged Leukemia with Subclonal FLT3 N676K

Ton Falques-Costa, Mattias Pilheden, Andrea Hanel, Qirui Zhang, Louise Ahlgren, Helena Sturesson, Lars Ronnstrand, Julhash Uddin Kazi, Merja Heinäniemi, Axel Hyrenius Wittsten, Anna K. Hagstroem-Andersson

Blood (2023) 142 (Supplement 1): 5918.

https://doi.org/10.1182/blood-2023-180636

Published: 2023

Journal Articles

Genomic Determinants of Therapy Response in ETV6::RUNX1 Leukemia

Laura Oksa, Sanni Moisio, Khurram Maqbool, Hassan Foroughi-Asl, Roger Kramer, Atte Nikkilä, Kaisa Vepsäläinen, Jesus Duque-Afonso, Julia Hauer, Jessica Nordlund, Valtteri Wirta, Olli Lohi, Merja Heinäniemi

Blood (2023) 142 (Supplement 1): 2970.

https://doi.org/10.1182/blood-2023-188691

Published: 2023

Journal Articles

Pax5 Heterozygosity Affects B-Cell Differentiation and Generates a Deregulated Precursor Population in the Bone Marrow

Franziska Auer, Mina Morcos, Mikko Sipola, Sanni Moisio, Anna Viitasalo, Aleksandra Pandyra, Arndt Borkhardt, Merja Heinäniemi, Julia Hauer

Blood (2023) 142 (Supplement 1): 2768.

https://doi.org/10.1182/blood-2023-184384

Published: 2023

Journal Articles

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Blood (2023) 141 (13): 1610–1625.

https://doi.org/10.1182/blood.2021011094

Published: 2023

Includes: Supplemental data

Journal Articles

A Human iPSC Model Reveals Specific Upregulation of Linker Histone H1-0 in ETV6::RUNX1 + Preleukemia and B Cell Precursor Acute Lymphoblastic Leukemia

Vera H Jepsen, Daniel Hein, Daniel Picard, Tobias Lautwein, Rabea Wagener, Nan Qin, Annika Filip, Merja Heinäniemi, Arndt Borkhardt, Ute Fischer

Blood (2022) 140 (Supplement 1): 3469–3470.

https://doi.org/10.1182/blood-2022-163564

Published: 2022

Journal Articles

Single-Cell Functional Genomics of Natural Killer Cell Interaction with Blood Cancers

Blood (2022) 140 (Supplement 1): 8343–8344.

https://doi.org/10.1182/blood-2022-167535

Published: 2022

Journal Articles

Genetic and Pharmacological Inhibition of BTK Increases Dasatinib Sensitivity in Vitro and In Vivo Including CNS-Infiltrating E2A-PBX1 + /Pre-BCR + ALL Cells

Gaia Gentile, Teresa Poggio, Antonella Catalano, Minna Voutilainen, Marta Andrade-Martinez, Tobias Ma, Roman Sankowski, Lina Goncarenko, Stefan Tholen, Kyuho Han, David Morgens, Marco Prinz, Michael Luebbert, Peter Bronsert, Michael Bassik, Michael Cleary, Oliver Schilling, Merja Heinäniemi, Jesus Duque Afonso

Blood (2022) 140 (Supplement 1): 503–504.

https://doi.org/10.1182/blood-2022-162699

Published: 2022

Journal Articles

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Blood (2022) 140 (Supplement 1): 101–103.

https://doi.org/10.1182/blood-2022-158694

Published: 2022

Journal Articles

Identification and Interpretation of Clinically Relevant Somatic Variants from Whole-Genome Sequencing Data

Khurram Maqbool, Hassan Hassan Foroughi-Asl, Ashwini Ashwini Jeggari, Vadym Ivanchuk, Jesper Eisfeldt, Annick Renevey, Keyvan Elhami, Chiara Rasi, Daniel Nilsson, Merja Heinäniemi, Olli Lohi, Valtteri Wirta

Blood (2022) 140 (Supplement 1): 13003–13004.

https://doi.org/10.1182/blood-2022-163295

Published: 2022

Journal Articles

Mechanistic Study of Wee1 Kinase Inhibition with AZD1775 Exposes Drug Targetable Vulnerabilities in Acute B-Lymphoblastic Leukemia

Alena Malyukova, Mari Lahnalampi, Ton Falqués, Petri Pölönen, Mikko Sipola, Juha Mehtonen, Susanna Teppo, Johanna Viiliäinen, Olli Lohi, Anna Hagstroem-Andersson, Merja Heinäniemi, Olle Sangfelt

Blood (2022) 140 (Supplement 1): 11576.

https://doi.org/10.1182/blood-2022-168684

Published: 2022

Journal Articles

Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia

Blood (2022) 140 (17): 1891–1906.

https://doi.org/10.1182/blood.2021015106

Published: 2022

Includes: Supplemental data

Journal Articles

Recurrent Germline Variant in the Cohesin Complex Gene RAD21 Predisposes Children to Lymphoblastic Leukemia and Lymphoma

Blood (2021) 138 (Supplement 1): 3358.

https://doi.org/10.1182/blood-2021-150284

Published: 2021

Journal Articles

Pax5 Heterozygosity Delays BCR Expression in Preb-II Cells and Generates a Preleukemic Population

Franziska Auer, Juha Mehtonen, Mikko Sipola, Mina Morcos, Aleksandra Pandyra, Arndt Borkhardt, Merja Heinäniemi, Julia Hauer

Blood (2021) 138 (Supplement 1): 1140.

https://doi.org/10.1182/blood-2021-150144

Published: 2021

Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 3944.

https://doi.org/10.1182/blood-2019-130774

Published: 2019

Journal Articles

Immunogenomic Landscape of Hematological Malignancies

Olli Dufva, Petri Pölönen, MSc, Oscar Brück, MD, Mikko A Keränen, MD PhD, Juha Mehtonen, MSc, Sanna M. Siitonen, MD PhD, Suvi-Katri Leivonen, PhD, Leo Meriranta, MS, Sirpa Leppa, MD Prof, Matti Nykter, Olli Lohi, MD PhD, Merja Heinäniemi, PhD, Satu Mustjoki, MD PhD

Blood (2018) 132 (Supplement 1): 2596.

https://doi.org/10.1182/blood-2018-99-118335

Published: 2018

Journal Articles

Genome-Wide Analysis of the Regulatory Landscape in Different Pre-B-ALL Subtypes

Mari Lahnalampi, MSc, Juha Mehtonen, MSc, Susanna Teppo, MSc, Saara Laukkanen, MSc, Laura Oksa, MSc, Markus Muschen, MD, Olli Lohi, MD PhD, Merja Heinäniemi, PhD

Blood (2017) 130 (Supplement 1): 3807.

https://doi.org/10.1182/blood.V130.Suppl_1.3807.3807

Published: 2017

Journal Articles

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Zhengshan Chen, MDPhD, Lai N Chan, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Cheryl L. Willman, MD, Markus Muschen, MDPhD

Blood (2017) 130 (Supplement 1): 1440.

https://doi.org/10.1182/blood.V130.Suppl_1.1440.1440

Published: 2017

Journal Articles

Pan-Hematopoietic Cancer Gene Expression Analysis Identifies Immunologically Active Acute Myeloid Leukemia Subtypes

Olli Dufva, Petri Pölönen, Mikko A Keränen, MD PhD, Thomas Liuksiala, Jake Lin, Juha Mehtonen, MSc, Sergei Häyrynen, Kirsi Granberg, PhD, Matti Nykter, PhD, Olli Lohi, Merja Heinäniemi, PhD, Satu Mustjoki, MD PhD

Blood (2016) 128 (22): 1725.

https://doi.org/10.1182/blood.V128.22.1725.1725

Published: 2016

Journal Articles

In Silico and Ex Vivo Drug Screening Identifies Dasatinib as a Potential Targeted Therapy for T-ALL

Saara Laukkanen, Petri Pölönen, Toni Grönroos, Heikki Kuusanmäki, MSc, Caroline A Heckman, PhD, Mika Kontro, Merja Heinäniemi, Olli Lohi

Blood (2016) 128 (22): 4029.

https://doi.org/10.1182/blood.V128.22.4029.4029

Published: 2016

Journal Articles

Transcriptional Regulatory Landscape of TCF3-PBX1-Positive Leukemia and Novel Targeted Treatments

Susanna Teppo, MSc, Juha Mehtonen, MSc, Samuli Eldfors, MSc, Caroline A Heckman, PhD, Markus Müschen, MD PhD, Merja Heinäniemi, PhD, Olli Lohi

Blood (2016) 128 (22): 4077.

https://doi.org/10.1182/blood.V128.22.4077.4077

Published: 2016

NARROW

Unraveling Clonal Evolution and Mechanisms of Treatment Resistance in Murine KMT2A -Rearranged Leukemia with Subclonal FLT3 N676K

Genomic Determinants of Therapy Response in ETV6::RUNX1 Leukemia

Pax5 Heterozygosity Affects B-Cell Differentiation and Generates a Deregulated Precursor Population in the Bone Marrow

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

A Human iPSC Model Reveals Specific Upregulation of Linker Histone H1-0 in ETV6::RUNX1 + Preleukemia and B Cell Precursor Acute Lymphoblastic Leukemia

Single-Cell Functional Genomics of Natural Killer Cell Interaction with Blood Cancers

Genetic and Pharmacological Inhibition of BTK Increases Dasatinib Sensitivity in Vitro and In Vivo Including CNS-Infiltrating E2A-PBX1 + /Pre-BCR + ALL Cells

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Identification and Interpretation of Clinically Relevant Somatic Variants from Whole-Genome Sequencing Data

Mechanistic Study of Wee1 Kinase Inhibition with AZD1775 Exposes Drug Targetable Vulnerabilities in Acute B-Lymphoblastic Leukemia

Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia

Recurrent Germline Variant in the Cohesin Complex Gene RAD21 Predisposes Children to Lymphoblastic Leukemia and Lymphoma

Pax5 Heterozygosity Delays BCR Expression in Preb-II Cells and Generates a Preleukemic Population

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Immunogenomic Landscape of Hematological Malignancies

Genome-Wide Analysis of the Regulatory Landscape in Different Pre-B-ALL Subtypes

Stat5 Feedback Control Switches MYC- and BCL6-Dependent Cell Fates in Normal and Transformed B Cells

Pan-Hematopoietic Cancer Gene Expression Analysis Identifies Immunologically Active Acute Myeloid Leukemia Subtypes

In Silico and Ex Vivo Drug Screening Identifies Dasatinib as a Potential Targeted Therapy for T-ALL

Transcriptional Regulatory Landscape of TCF3-PBX1-Positive Leukemia and Novel Targeted Treatments

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American Society of Hematology

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ASH Publications

American Society of Hematology

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