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Journal Articles

Potent and Effective Targeting of AML with ‘Off-the-Shelf’ Engineered CD45-Targeting CAR T-Cells

Matthew Shaw, Aiyin Liao, Naeem Khan, Sylvie D Freeman, Thomas E. Whittaker, Adrian J. Thrasher, Martin Pule, Kerry Chester, Jenny Yeung, Persis Amrolia
Journal: Blood
Blood (2024) 144 (Supplement 1): 2024.
https://doi.org/10.1182/blood-2024-194359
Published: 2024
Journal Articles

The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients

Fadimana Kaya, Findlay Bewicke-Copley, Pedro Casado Izquierdo, Jiexin Zheng, Juho Jalmari Miettinen, Naeem Khan, Szilvia Krizsán, Joseph J Saad, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Josée Hébert, Janet Matthews, Marianne Grantham, Doriana Di Bella, Krister Wennerberg, Alun Parsons, John G. Gribben, James D. Cavenagh, Sylvie D Freeman, Csaba Bödör, Guy Sauvageau, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro R Cutillas, Kevin Rouault-Pierre, Jude Fitzgibbon, Ana Rio-Machin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4302.
https://doi.org/10.1182/blood-2023-174891
Published: 2023
Journal Articles

Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML

Ana Rio-Machin, Findlay Bewicke-Copley, Jiexin Zheng, Pedro Casado Izquierdo, Juho J. Miettinen, Naeem Khan, Jonas Demeulemeester, Szilvia Krizsán, Christopher Middleton, Sam Benkwitz-Bedford, Joseph Saad, Amaia Vilas-Zornoza, Teresa Ezponda, William Grey, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Farideh Miraki-Moud, Janet Matthews, Marianne Grantham, Ryan J Colm, Jonathan Bond, Doriana Di Bella, Krister Wennerberg, Alun Parsons, Andy G.X. Zeng, Hannah Armes, Karina Close, Fadimana Kaya, Kevin Rouault-Pierre, John G. Gribben, Felipe Prosper, James Cavenagh, John E. Dick, Sylvie D Freeman, Peter Van Loo, Csaba Bödör, Guy Sauvageau, Kimmo Porkka, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro Cutillas, Jude Fitzgibbon
Journal: Blood
Blood (2022) 140 (Supplement 1): 1030–1032.
https://doi.org/10.1182/blood-2022-159069
Published: 2022
Journal Articles

Post-Transplant MRD Status and T Cell Chimerism Predict Outcomes in Patients Allografted for AML/MDS-a Prospective Analysis from the UK NCRI Figaro Trial

(Justin) Ching Ting Loke, Nicholas McCarthy, Aimee E Jackson, Shamyla Siddique, Andrea Hodgkinson, John Mason, Charles Crawley, Maria H Gilleece, Andy Peniket, Rachel Elizabeth Protheroe, Rahuman Salim, Eleni Tholouli, Keith Wilson, Georgia M. Andrew, Richard Dillon, Naeem Khan, Victoria Potter, Pramila Krishnamurthy, Charles Craddock, Sylvie D Freeman
Journal: Blood
Blood (2021) 138 (Supplement 1): 415.
https://doi.org/10.1182/blood-2021-149269
Published: 2021
Journal Articles

Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia

Ana Rio-Machin, Pedro Casado-Izquierdo, Juho Miettinen, PhD, Findlay Bewicke-Copley, PhD MSc, BSc, Naeem Khan, PhD, Jonas Demeulemeester, Szilvia Krizsán, MD, Jiexin Zheng, Christopher Middleton, Wencheng Yin, William Grey, Farideh Miraki-Moud, PhD, Janet Matthews, Marianne Grantham, Kevin Rouault-Pierre, PhD, Krister Wennerberg, Alun Parsons, Hannah Armes, Karina EM Close, Doriana Di Bella, James Cavenagh, Sylvie D Freeman, Peter Van Loo, Csaba Bödör, PhD, Kimmo Porkka, Caroline A Heckman, PhD, Jun Wang, PhD, David Taussig, Dominique Bonnet, PhD, Jean-Baptiste Cazier, PhD, Pedro Cutillas, PhD, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-141345
Published: 2020
Journal Articles

No evidence that CD33 splicing SNP impacts the response to GO in younger adults with AML treated on UK MRC/NCRI trials

Clinical Trials & Observations
Rosemary E. Gale, Teodora Popa, Melissa Wright, Naeem Khan, Sylvie D. Freeman, Alan K. Burnett, Nigel H. Russell, Robert K. Hills, David C. Linch
Journal: Blood
Blood (2018) 131 (4): 468–471.
https://doi.org/10.1182/blood-2017-08-802157
Published: 2018
Includes: Supplemental data
Journal Articles

Flow Cytometric Minimal Residual Disease As Risk Stratification Tool in Younger Adults with NPM1 Wild Type Standard Risk Acute Myeloid Leukemia

Sylvie D Freeman, MBChB, DPhil, Robert K. Hills, DPhil, Paul Virgo, Naeem Khan, PhD, Stephen Couzens, Richard James Dillon, MA, PhD MRCP, FRCPath, Laura Upton, Lars Kjeldsen, MD, Ian Thomas, David Grimwade, Alan K. Burnett, MD, Nigel H. Russell
Journal: Blood
Blood (2017) 130 (Supplement 1): 468.
https://doi.org/10.1182/blood.V130.Suppl_1.468.468
Published: 2017
Journal Articles

Chronic Lymphocytic Leukaemia Drives the Production of T Regulatory Cells From the CD4+ CD25- Compartment with a CD27high/CD127 Low Phenotype.

Karen Piper, Mamtha Karanth, Doctor, Andrew McLarnon, Emma Kalk, Naeem Khan, Jim A Murray, Guy Pratt, Paul Moss, MBBS, PhD, FRCP
Journal: Blood
Blood (2009) 114 (22): 2330.
https://doi.org/10.1182/blood.V114.22.2330.2330
Published: 2009
Journal Articles

Selective accumulation of virus-specific CD8 + T cells with unique homing phenotype within the human bone marrow

Umaimainthan Palendira, Rosanna Chinn, Wajid Raza, Karen Piper, Guy Pratt, Lee Machado, Andrew Bell, Naeem Khan, Andrew D. Hislop, Richard Steyn, Alan B. Rickinson, Christopher D. Buckley, Paul Moss
Journal: Blood
Blood (2008) 112 (8): 3293–3302.
https://doi.org/10.1182/blood-2008-02-138040
Published: 2008
Includes: Supplemental data
Journal Articles

CD4 + T cells specific for glycoprotein B from cytomegalovirus exhibit extreme conservation of T-cell receptor usage between different individuals

Laura Crompton, Naeem Khan, Rajiv Khanna, Laxman Nayak, Paul A. H. Moss
Journal: Blood
Blood (2008) 111 (4): 2053–2061.
https://doi.org/10.1182/blood-2007-04-079863
Published: 2008
Journal Articles

Cancer Germline Antigen-Specific T Cells Are Present and Functional in Many Patients with Multiple Myeloma and Paraproteinaemia.

Oliver Goodyear, PhD, Karen Piper, PhD, Naeem Khan, PhD, Jane Starczynski, PhD, Prem Mahendra, MD, Guy Pratt, MD, Paul Moss, PhD
Journal: Blood
Blood (2006) 108 (11): 3507.
https://doi.org/10.1182/blood.V108.11.3507.3507
Published: 2006
Journal Articles

CD8 + T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden

Oliver Goodyear, Karen Piper, Naeem Khan, Jane Starczynski, Prem Mahendra, Guy Pratt, Paul Moss
Journal: Blood
Blood (2005) 106 (13): 4217–4224.
https://doi.org/10.1182/blood-2005-02-0563
Published: 2005
Includes: Supplemental data
Journal Articles

CD8+ T Cells Specific for Cancer-Testis Antigens Are Found in Many Patients with Multiple Myeloma and Correlate with Disease Burden.

Oliver C. Goodyear, Karen Piper, Julie Arrazi, Naeem Khan, Premini Mahendra, Guy Pratt, Paul Moss
Journal: Blood
Blood (2004) 104 (11): 2460.
https://doi.org/10.1182/blood.V104.11.2460.2460
Published: 2004
Journal Articles

B cells immortalized by a mini–Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells

Andreas Moosmann, Naeem Khan, Mark Cobbold, Caroline Zentz, Henri-Jacques Delecluse, Gabi Hollweck, Andrew D. Hislop, Neil W. Blake, Debbie Croom-Carter, Barbara Wollenberg, Paul A. H. Moss, Reinhard Zeidler, Alan B. Rickinson, Wolfgang Hammerschmidt
Journal: Blood
Blood (2002) 100 (5): 1755–1764.
https://doi.org/10.1182/blood.V100.5.1755.h81702001755_1755_1764
Published: 2002