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Journal Articles

Allele-Specific Expression of Leukemia Genes Is Associated with Pathogenicity in Poor Risk AML

Jiexin Zheng, Findlay Bewicke-Copley, Carlo Vermeulen, Pedro Casado, Fadimana Kaya, Jonas Demeulemeester, Molly Guscott, Szilvia Krizsán, Sam Benkwitz-Bedford, Farideh Miraki-Moud, Janet Matthews, Marianne Grantham, Doriana Di Bella, John G. Gribben, James Cavenagh, Peter Van Loo, Sarah McClelland, Csaba Bödör, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro R Cutillas, Jun Wang, Jeroen De Ridder, Jude Fitzgibbon, Ana Rio-Machin
Journal: Blood
Blood (2023) 142 (Supplement 1): 1389.
https://doi.org/10.1182/blood-2023-184516
Published: 2023
Journal Articles

The XPO1-FOXC1-HOX Functional Axis Opens New Therapeutic Avenues to Treat DEK-NUP214 AML Patients

Fadimana Kaya, Findlay Bewicke-Copley, Pedro Casado Izquierdo, Jiexin Zheng, Juho Jalmari Miettinen, Naeem Khan, Szilvia Krizsán, Joseph J Saad, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Josée Hébert, Janet Matthews, Marianne Grantham, Doriana Di Bella, Krister Wennerberg, Alun Parsons, John G. Gribben, James D. Cavenagh, Sylvie D Freeman, Csaba Bödör, Guy Sauvageau, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro R Cutillas, Kevin Rouault-Pierre, Jude Fitzgibbon, Ana Rio-Machin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4302.
https://doi.org/10.1182/blood-2023-174891
Published: 2023
Journal Articles

Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML

Ana Rio-Machin, Findlay Bewicke-Copley, Jiexin Zheng, Pedro Casado Izquierdo, Juho J. Miettinen, Naeem Khan, Jonas Demeulemeester, Szilvia Krizsán, Christopher Middleton, Sam Benkwitz-Bedford, Joseph Saad, Amaia Vilas-Zornoza, Teresa Ezponda, William Grey, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Farideh Miraki-Moud, Janet Matthews, Marianne Grantham, Ryan J Colm, Jonathan Bond, Doriana Di Bella, Krister Wennerberg, Alun Parsons, Andy G.X. Zeng, Hannah Armes, Karina Close, Fadimana Kaya, Kevin Rouault-Pierre, John G. Gribben, Felipe Prosper, James Cavenagh, John E. Dick, Sylvie D Freeman, Peter Van Loo, Csaba Bödör, Guy Sauvageau, Kimmo Porkka, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro Cutillas, Jude Fitzgibbon
Journal: Blood
Blood (2022) 140 (Supplement 1): 1030–1032.
https://doi.org/10.1182/blood-2022-159069
Published: 2022
Journal Articles

Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia

Vilma Dembitz, Hannah Lawson, Celine Philippe, Richard J. Burt, Sophie James, Aoife S.M. Magee, Keith Woodley, Jozef Durko, Joana Campos, Michael James Austin, Ana Rio-Machin, Pedro Casado Izquierdo, Findlay Bewicke-Copley, Giovanny Rodriguez Blanco, Bela Patel, Lori Hazlehurst, Barrie Peck, Andrew Finch, Pedro Cutillas, Jude Fitzgibbon, Mariia Yuneva, Kevin Rouault-Pierre, John Copland, III, Kamil Kranc, Paolo Gallipoli
Journal: Blood
Blood (2022) 140 (Supplement 1): 3058–3060.
https://doi.org/10.1182/blood-2022-166811
Published: 2022
Journal Articles

Characterising Tumour and Microenvironmental Responses to R-CHOP in Immunocompetent Mouse Models of DLBCL

Bernard D Maybury, Findlay Bewicke-Copley, Peter Johnson, Jude Fitzgibbon, Dinis Pedro Calado
Journal: Blood
Blood (2021) 138 (Supplement 1): 2401.
https://doi.org/10.1182/blood-2021-152318
Published: 2021
Journal Articles

The Paradoxical Efficacy of KDM6 Inhibition in Germinal Centre B-Cell Lymphomas

Karina Close, Hannah Armes, Emil Kumar, Findlay Bewicke-Copley, Adam Cribbs, James Dunford, Martin Philpott, Udo Oppermann, James Heward, Jude Fitzgibbon
Journal: Blood
Blood (2021) 138 (Supplement 1): 3289.
https://doi.org/10.1182/blood-2021-146392
Published: 2021
Journal Articles

KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas

James Heward, Lola Koniali, Annalisa D’Avola, Karina Close, Alison Yeomans, Martin Philpott, James Dunford, Tahrima Rahim, Ahad F. Al Seraihi, Jun Wang, Koorosh Korfi, Shamzah Araf, Sameena Iqbal, Findlay Bewicke-Copley, Emil Kumar, Darko Barisic, Maria Calaminici, Andrew Clear, John Gribben, Peter Johnson, Richard Neve, Pedro Cutillas, Jessica Okosun, Udo Oppermann, Ari Melnick, Graham Packham, Jude Fitzgibbon
Journal: Blood
Blood (2021) 138 (5): 370–381.
https://doi.org/10.1182/blood.2020008743
Published: 2021
Includes: Supplemental data
Journal Articles

Integration of Deep Multi-Omics Profiling Veals New Insights into the Biology of Poor-Risk Acute Myeloid Leukemia

Ana Rio-Machin, Pedro Casado-Izquierdo, Juho Miettinen, PhD, Findlay Bewicke-Copley, PhD MSc, BSc, Naeem Khan, PhD, Jonas Demeulemeester, Szilvia Krizsán, MD, Jiexin Zheng, Christopher Middleton, Wencheng Yin, William Grey, Farideh Miraki-Moud, PhD, Janet Matthews, Marianne Grantham, Kevin Rouault-Pierre, PhD, Krister Wennerberg, Alun Parsons, Hannah Armes, Karina EM Close, Doriana Di Bella, James Cavenagh, Sylvie D Freeman, Peter Van Loo, Csaba Bödör, PhD, Kimmo Porkka, Caroline A Heckman, PhD, Jun Wang, PhD, David Taussig, Dominique Bonnet, PhD, Jean-Baptiste Cazier, PhD, Pedro Cutillas, PhD, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-141345
Published: 2020
Journal Articles

Systematic Evaluation of Somatic Cis -Regulatory Mutations in Follicular Lymphoma

Firat Uyulur, MSc, Findlay Bewicke-Copley, PhD MSc, BSc, Chinedu Anthony Anene, PhD, Matthias Schlesner, PhD, Icgc MMML-Seq Project, Reiner Siebert, Prof. Dr. MD, Jessica Okosun, MD PhD, Jude Fitzgibbon, PhD, Jun Wang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
https://doi.org/10.1182/blood-2020-142623
Published: 2020
Journal Articles

Longitudinal Analyses of Diagnostic-Relapse Biopsies of Diffuse Large B Cell Lymphoma Reveal a Poor Risk Subset of ABC Patients Based on the Expression of a 30 Gene Panel

Findlay Bewicke-Copley, PhD MSc, BSc, Koorosh Korfi, PhD BSc, Shamzah Araf, MRCP, MBBS, PhD, Emil Arjun Kumar, BCh,BM, Thomas E C Cummin, MRCP MBBCh BSc, Margaret Ashton-Key, MD, Sharon Barrans, Suzan Van Hoppe, Cathy Burton, Mohamed Elshiekh, Simon Rule, Nicola Crosbie, Andrew James Clear, BSc, Maria Calaminici, MD PhD, David W. Scott, MBChB, PhD, Lisa M. Rimsza, MD, Menon Geetha, Chulin Sha, Michael A Bentley, Ai Nagano, PhD, Andrew Davies, MD PhD, Daniel Painter, BSc, Alexandra Smith, PhD, John G. Gribben, MD DSc, Kikkeri Naresh, David R Westhead, Jessica Okosun, MD PhD, Peter Johnson, MDFRCP, Jun Wang, PhD, Jude Fitzgibbon, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2769.
https://doi.org/10.1182/blood-2019-124352
Published: 2019