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Nicole S. Arellano
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Journal Articles

PROTACtion against BCL-xL in post-MPN AML

Free
Nicole S. Arellano, Shannon E. Elf
Journal: Blood
Blood (2025) 146 (3): 266–267.
https://doi.org/10.1182/blood.2025029273
Published: 2025
Journal Articles

Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms

Available to Purchase
Nicole S Arellano, William L Heaton, Mirielle C Nauman, Abigail E Runnels, Jacky Gomez-Villa, Daniele Vanni, Melissa Gaviria, Maihi Fujita, Nathan M Krah, Michele Ciboddo, Saveg Yadav, Callie T Brown, Parker D Bowden, Amy K Chen, Christopher Henning, Silvia Catricalà, Ilaria Carola Casetti, Oscar Borsani, Elisa Rumi, Daniela Pietra, Isabelle Plo, Caroline Marty, Marco Marchetti, Caner Saygin, Ami B Patel, Shannon E Elf
Journal: Blood
Blood blood.2024026940.
https://doi.org/10.1182/blood.2024026940
Published: 2025
Includes: Supplemental data
Journal Articles

Type 2 but Not Type 1 Calreticulin Mutants Exhibit Loss of Chaperone Function Due to C-Terminal Structural Interference, and Bind to Wild Type Calreticulin in a Dominant Negative Manner

Free
Nicole S Arellano, Jacqueline Gomez, Harrison S Greenbaum, Michele Ciboddo, Deborah Rodriguez, Amy K Chen, Lulu Allie, Alex Rosencrance, Shannon Elf
Journal: Blood
Blood (2022) 140 (Supplement 1): 1087–1088.
https://doi.org/10.1182/blood-2022-166506
Published: 2022
Journal Articles

Myeloproliferative Neoplasm-Associated Type 2 Calreticulin Mutations Differentially Activate and Depend on the ATF6 Pathway of the UPR

Free
Nicole S Arellano, Katarzyna Kurylowicz, Luke Maxwell, Harrison S Greenbaum, Juan Ibarra, Shannon Elf
Journal: Blood
Blood (2021) 138 (Supplement 1): 3588.
https://doi.org/10.1182/blood-2021-151632
Published: 2021
Journal Articles

Type I Calreticulin Mutations Result in Hyperactivation of Its Acetyltransferase Function and Iron Metabolism, Inducing a Susceptibility to Ferroptosis

Free
Harrison S Greenbaum, Maria Evers, Alex Rosencrance, Luke Maxwell, Katarzyna Kurylowicz, Nicole S Arellano, Michele Ciboddo, Jinjun Gao, Juan Ibarra, Shannon Elf
Journal: Blood
Blood (2021) 138 (Supplement 1): 3593.
https://doi.org/10.1182/blood-2021-153480
Published: 2021
Journal Articles

Type 1 Calreticulin Mutations Differentially Activate the IRE1α-XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms

Free
Juan Ibarra, Yassmin Elbanna, Katarzyna Kurylowicz, Harrison S Greenbaum, Maria Evers, Nicole S Arellano, Dongbo Yang, Althea Bock-Hughes, Chenyu Liu, Quinn Smith, Julian Lutze, Julian Baumeister, Milena Kalmer, Kathrin Olschok, Benjamin Nicholson, Diane Silva, Luke Maxwell, Jonathan Dowgielewicz, Michele Ciboddo, Elisa Rumi, Daniela Pietra, Steffen Koschmieder, Sandeep Gurbuxani, Rebekka K. Schneider, Scott Oakes, Shannon Elf
Journal: Blood
Blood (2021) 138 (Supplement 1): 628.
https://doi.org/10.1182/blood-2021-147859
Published: 2021