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Journal Articles

How unique structural adaptations support and coordinate the complex function of von Willebrand factor

Peter J. Lenting, Cécile V. Denis, Olivier D. Christophe

Blood (2024) 144 (21): 2174–2184.

https://doi.org/10.1182/blood.2023023277

Published: 2024

Journal Articles

Fitusiran reduces bleeding in factor X–deficient mice

Sebastien Verhenne, Geneviève McCluskey, Hortense Maynadié, Frédéric Adam, Caterina Casari, Laurence Panicot-Dubois, Lydie Crescence, Christophe Dubois, Cécile V. Denis, Peter J. Lenting, Olivier D. Christophe

Blood (2024) 144 (2): 227–236.

https://doi.org/10.1182/blood.2023023404

Published: 2024

Includes: Multimedia, Supplemental data

Journal Articles

AAV-Mediated Expression of a Single-Chain FVIII Mimetic Antibody Efficiently Corrects Bleeding in Haemophilia a Mice

Vincent Muczynski, Eric Bun, Lewis Tanner, Jenny H. McIntosh, Olivier D. Christophe, Amit C. Nathwani

Blood (2023) 142 (Supplement 1): 482.

https://doi.org/10.1182/blood-2023-186285

Published: 2023

Journal Articles

Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models

Stéphanie Roullet, Norman Luc, Julie Rayes, Jean Solarz, Dante Disharoon, Andrew Ditto, Emily Gahagan, Christa Pawlowski, Thibaud Sefiane, Frédéric Adam, Caterina Casari, Olivier D. Christophe, Michael Bruckman, Peter J. Lenting, Anirban Sen Gupta, Cécile V. Denis

Blood (2023) 141 (23): 2891–2900.

https://doi.org/10.1182/blood.2022018956

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

Blood (2023) 141 (12): 1457–1468.

https://doi.org/10.1182/blood.2022017569

Published: 2023

Includes: Supplemental data

Journal Articles

A FVIII-Mimetic Bispecific Antibody with an Embedded Self-Regulation Mechanism Reduces the Risk of Prothrombotic Events for the Treatment of Haemophilia a

Vincent Muczynski, Angel Smith, Thibaud Sefiane, Olivier D. Christophe, Peter J. Lenting, David Granger, Kerry Chester, Amit C. Nathwani

Blood (2022) 140 (Supplement 1): 677–678.

https://doi.org/10.1182/blood-2022-169482

Published: 2022

Journal Articles

A hemophilia A mouse model for the in vivo assessment of emicizumab function

Stephen Ferrière, Ivan Peyron, Olivier D. Christophe, Charlotte Kawecki, Caterina Casari, Vincent Muczynski, Amit Nathwani, Alexandre Kauskot, Peter J. Lenting, Cécile V. Denis

Blood (2020) 136 (6): 740–748.

https://doi.org/10.1182/blood.2019004334

Published: 2020

Includes: Supplemental data

Journal Articles

Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia

Karen Aymonnier, Charlotte Kawecki, Laurence Venisse, Yacine Boulaftali, Olivier D. Christophe, Peter J. Lenting, Véronique Arocas, Emmanuelle de Raucourt, Cécile V. Denis, Marie-Christine Bouton

Blood (2019) 134 (19): 1632–1644.

https://doi.org/10.1182/blood.2019000281

Published: 2019

Includes: Supplemental data

Journal Articles

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski, Caterina Casari, François Moreau, Gabriel Aymé, Charlotte Kawecki, Paulette Legendre, Valerie Proulle, Olivier D. Christophe, Cécile V. Denis, Peter J. Lenting

Blood (2018) 132 (11): 1193–1197.

https://doi.org/10.1182/blood-2018-01-829523

Published: 2018

Includes: Supplemental data

Journal Articles

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

Peter J. Lenting, Cécile V. Denis, Olivier D. Christophe

Blood (2017) 130 (23): 2463–2468.

https://doi.org/10.1182/blood-2017-08-801662

Published: 2017

Journal Articles

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Vincent Muczynski, Gabriel Aymé, Véronique Regnault, Marc Vasse, Delphine Borgel, Paulette Legendre, Amine Bazaa, Amélie Harel, Cécile Loubière, Peter J. Lenting, Cécile V. Denis, Olivier D. Christophe

Blood (2017) 129 (17): 2443–2454.

https://doi.org/10.1182/blood-2016-06-724351

Published: 2017

Includes: Supplemental data

Journal Articles

Von Willebrand Factor Interaction with FVIII: Development of Long Acting FVIII Therapies

Peter J Lenting, PhD, Vincent Muczynski, PhD, Gabriel Aymé, PhD, Cecile V. Denis, PhD, Olivier D. Christophe, PhD

Blood (2016) 128 (22): SCI-8.

https://doi.org/10.1182/blood.V128.22.SCI-8.SCI-8

Published: 2016

Journal Articles

Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X

Vincent Muczynski, Amine Bazaa, Cécile Loubière, Amélie Harel, Ghislaine Cherel, Cécile V. Denis, Peter J. Lenting, Olivier D. Christophe

Blood (2016) 127 (6): 778–786.

https://doi.org/10.1182/blood-2015-05-647032

Published: 2016

Includes: Supplemental data

Journal Articles

Mechanisms and Therapeutic Modulation of the Bleeding Tendency in Genetically-Engineered Von Willebrand Disease Type 2B Mice

Fatoumata Tall, MD, Frederic Adam, PhD, Amine Bazaa, PhD, Olivier D. Christophe, PhD, Peter J. Lenting, PhD, Cecile V. Denis, PhD, Valerie Proulle, MD PhD

Blood (2015) 126 (23): 3516.

https://doi.org/10.1182/blood.V126.23.3516.3516

Published: 2015

Journal Articles

von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends

Peter J. Lenting, Olivier D. Christophe, Cécile V. Denis

Blood (2015) 125 (13): 2019–2028.

https://doi.org/10.1182/blood-2014-06-528406

Published: 2015

Journal Articles

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice

Yoko Morioka, Caterina Casari, Nikolett Wohner, Sungyun Cho, Sachiko Kurata, Ayumi Kitano, Olivier D. Christophe, Peter J. Lenting, Renhao Li, Cécile V. Denis, Nicolas Prévost

Blood (2014) 123 (21): 3344–3353.

https://doi.org/10.1182/blood-2013-10-531392

Published: 2014

Includes: Multimedia, Supplemental data

Journal Articles

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B–associated thrombocytopenia

Caterina Casari, Vivian Du, Ya-Ping Wu, Alexandre Kauskot, Philip G. de Groot, Olivier D. Christophe, Cécile V. Denis, Bas de Laat, Peter J. Lenting

Blood (2013) 122 (16): 2893–2902.

https://doi.org/10.1182/blood-2013-03-493312

Published: 2013

Includes: Supplemental data

Journal Articles

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

Blood (2013) 121 (17): 3335–3344.

https://doi.org/10.1182/blood-2012-10-462200

Published: 2013

Includes: Supplemental data

Journal Articles

Mutations in the A3 domain of Von Willebrand factor inducing combined qualitative and quantitative defects in the protein

Paulette Legendre, Ana-Maria Navarrete, Julie Rayes, Caterina Casari, Pierre Boisseau, Catherine Ternisien, Claudine Caron, Edith Fressinaud, Jenny Goudemand, Agnès Veyradier, Cécile V. Denis, Peter J. Lenting, Olivier D. Christophe

Blood (2013) 121 (11): 2135–2143.

https://doi.org/10.1182/blood-2012-09-456038

Published: 2013

Includes: Supplemental data

Journal Articles

Determinants of von Willebrand Factor Function

Cécile V. Denis, PhD, Olivier D. Christophe, PhD, Peter J. Lenting, PhD

Blood (2012) 120 (21): SCI-17.

https://doi.org/10.1182/blood.V120.21.SCI-17.SCI-17

Published: 2012

NARROW

How unique structural adaptations support and coordinate the complex function of von Willebrand factor

Fitusiran reduces bleeding in factor X–deficient mice

AAV-Mediated Expression of a Single-Chain FVIII Mimetic Antibody Efficiently Corrects Bleeding in Haemophilia a Mice

Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in von Willebrand disease murine models

A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

A FVIII-Mimetic Bispecific Antibody with an Embedded Self-Regulation Mechanism Reduces the Risk of Prothrombotic Events for the Treatment of Haemophilia a

A hemophilia A mouse model for the in vivo assessment of emicizumab function

Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Von Willebrand Factor Interaction with FVIII: Development of Long Acting FVIII Therapies

Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X

Mechanisms and Therapeutic Modulation of the Bleeding Tendency in Genetically-Engineered Von Willebrand Disease Type 2B Mice

von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B–associated thrombocytopenia

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

Mutations in the A3 domain of Von Willebrand factor inducing combined qualitative and quantitative defects in the protein

Determinants of von Willebrand Factor Function

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American Society of Hematology

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American Society of Hematology

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