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Journal Articles

Factor IX Expression within the Normal Range Prevents Spontaneous Bleeds Requiring Treatment Following FLT180a Gene Therapy in Patients with Severe Hemophilia B: Long-Term Follow-up Study of the B-Amaze Program

Pratima Chowdary, Susan Shapiro, Mike Makris, Gillian Evans, Sara Boyce, Kate Talks, Gerry Dolan, Ulrike Reiss, Mark Phillips, Anne Riddell, Maria Rita Peralta, Michelle Quaye, Ted Tuddenham, Alison Long, Julie Krop, Amit Nathwani

Blood (2021) 138 (Supplement 1): 3967.

https://doi.org/10.1182/blood-2021-146546

Published: 2021

Journal Articles

A hemophilia A mouse model for the in vivo assessment of emicizumab function

Stephen Ferrière, Ivan Peyron, Olivier D. Christophe, Charlotte Kawecki, Caterina Casari, Vincent Muczynski, Amit Nathwani, Alexandre Kauskot, Peter J. Lenting, Cécile V. Denis

Blood (2020) 136 (6): 740–748.

https://doi.org/10.1182/blood.2019004334

Published: 2020

Includes: Supplemental data

Journal Articles

Multicentre Retrospective Analysis of Chronic Lymphocytic Leukaemia Patients Treated with Idelalisib, "Real World" Data from the UK and Republic of Ireland - a Cohort of 68 Patients

Blood (2017) 130 (Supplement 1): 1733.

https://doi.org/10.1182/blood.V130.Suppl_1.1733.1733

Published: 2017

Journal Articles

A ROR1 Bispecific T Cell Engager for the Treatment of Chronic Lymphocytic Leukaemia Demonstrates Enhanced Function Following Ibrutinib Treatment

Satyen Gohil, BSc, MBBS, MRCP, FRCPath, Solange Rosa Paredes-Moscosso, Micaela Harrasser, Mohamed El-Kholy, Emma Morris, FRCPath, MA, MBBChir, PhD MRCP, Amit Nathwani, MD PhD, Marco Della Peruta, PhD

Blood (2017) 130 (Supplement 1): 4316.

https://doi.org/10.1182/blood.V130.Suppl_1.4316.4316

Published: 2017

Journal Articles

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

Ilenia Simeoni, Jonathan C. Stephens, Fengyuan Hu, Sri V. V. Deevi, Karyn Megy, Tadbir K. Bariana, Claire Lentaigne, Sol Schulman, Suthesh Sivapalaratnam, Minka J. A. Vries, Sarah K. Westbury, Daniel Greene, Sofia Papadia, Marie-Christine Alessi, Antony P. Attwood, Matthias Ballmaier, Gareth Baynam, Emilse Bermejo, Marta Bertoli, Paul F. Bray, Loredana Bury, Marco Cattaneo, Peter Collins, Louise C. Daugherty, Rémi Favier, Deborah L. French, Bruce Furie, Michael Gattens, Manuela Germeshausen, Cedric Ghevaert, Anne C. Goodeve, Jose A. Guerrero, Daniel J. Hampshire, Daniel P. Hart, Johan W. M. Heemskerk, Yvonne M. C. Henskens, Marian Hill, Nancy Hogg, Jennifer D. Jolley, Walter H. Kahr, Anne M. Kelly, Ron Kerr, Myrto Kostadima, Shinji Kunishima, Michele P. Lambert, Ri Liesner, José A. López, Rutendo P. Mapeta, Mary Mathias, Carolyn M. Millar, Amit Nathwani, Marguerite Neerman-Arbez, Alan T. Nurden, Paquita Nurden, Maha Othman, Kathelijne Peerlinck, David J. Perry, Pawan Poudel, Pieter Reitsma, Matthew T. Rondina, Peter A. Smethurst, William Stevenson, Artur Szkotak, Salih Tuna, Christel van Geet, Deborah Whitehorn, David A. Wilcox, Bin Zhang, Shoshana Revel-Vilk, Paolo Gresele, Daniel B. Bellissimo, Christopher J. Penkett, Michael A. Laffan, Andrew D. Mumford, Augusto Rendon, Keith Gomez, Kathleen Freson, Willem H. Ouwehand, Ernest Turro

Blood (2016) 127 (23): 2791–2803.

https://doi.org/10.1182/blood-2015-12-688267

Published: 2016

Includes: Supplemental data

Journal Articles

Cellular Immune Responses To Vector In a Gene Therapy Trial For Hemophilia B Using An AAV8 Self-Complementary Factor IX Vector

Etiena Basner-Tschakarjan, MD PhD, Federico Mingozzi, PhD, Yifeng Chen, MD, Amit Nathwani, MD, PhD, Edward Tuddenham, MD, Anne Riddell, BSc, Catherine Ng, MS, Pradip Rustagi, MD, Bertil Glader, MD, PhD, Mark Kay, MD, PhD, Ulrike M. Reiss, MD, Arthur W. Nienhuis, MD, Andrew Davidoff, MD, Katherine A. High, MD

Blood (2013) 122 (21): 717.

https://doi.org/10.1182/blood.V122.21.717.717

Published: 2013

Journal Articles

Assessing the Potential of Perinatal Gene Transfer Using Congenital Factor VII Deficiency as a Model System

Christopher J Binny, Jenny H McIntosh, Edward Tuddenham, MD, Simon Waddington, Suzanne Buckley, Adrian Thrasher, John T. Gray, PhD, Amit Nathwani, MD, PhD, Alice F Tarantal, PhD, Andrew Davidoff

Blood (2010) 116 (21): 247.

https://doi.org/10.1182/blood.V116.21.247.247

Published: 2010

Journal Articles

Early Clinical Trial Results Following Administration of a Low Dose of a Novel Self Complementary Adeno-Associated Viral Vector Encoding Human Factor IX In Two Subjects with Severe Hemophilia B

Amit Nathwani, MD, PhD, Edward Tuddenham, MD, Cecilia Rosales, Jenny McIntosh, Anne Riddell, Pradip Rustagi, Bertil Glader, Mark Kay, MD, PhD, James Allay, PhD, John Coleman, Susan Sleep, Katherine A. High, MD, Federico Mingozzi, PhD., John T. Gray, PhD, Ulrike M. Reiss, MD, Arthur W. Nienhuis, MD, Andrew Davidoff

Blood (2010) 116 (21): 248.

https://doi.org/10.1182/blood.V116.21.248.248

Published: 2010

Journal Articles

B-Cell Chronic Lymphocytic Leukemia (B-CLL) Cells Unresponsive to CD180 Ligation Fail to Respond to Anti-IgM Stimulation as Well

Nino Porakishvili, PhD, Peter Lydyard, PhD, Anna Bremser, Ketki Vispute, Azka Memon, Nina Kulikova, Edward Clarke, Kanti R Rai, MD, Amit Nathwani, MD, PhD, Rajendra N Damle, PhD, Nicholas Chiorazzi

Blood (2010) 116 (21): 3582.

https://doi.org/10.1182/blood.V116.21.3582.3582

Published: 2010

Journal Articles

Rituximab Plus Chlorambucil In Patients with CD20-Positive B-Cell Chronic Lymphocytic Leukemia (CLL): Final Response Analysis of An Open-Label Phase II Study

Peter Hillmen, MB, ChB, PhD, John G. Gribben, MD, DSc, George A. Follows, Donald Milligan, MD, MBChB, Hazem A. Sayala, MBChB, MRCP, Paul Moreton, David G. Oscier, Claire E. Dearden, MD, Daniel B. Kennedy, Andrew R. Pettitt, PhD, MRCPath, Amit Nathwani, MD, PhD, Dena Cohen, Andy Rawstron, PhD, Christopher F.E. Pocock, MD, PhD

Blood (2010) 116 (21): 697.

https://doi.org/10.1182/blood.V116.21.697.697

Published: 2010

Journal Articles

Inter-Laboratory Assessment of Minimal Residual Disease In Chronic Lymphocytic Leukemia – Evaluation of the Novel CD160FCA Assay

Timothy Farren, BSc(HONS), MIBMS, Fengting Liu, MD, PhD, Claire Stephens, MSc, Marion Macey, PhD, FRCPath, Michael Jenner, MD, PhD, FRCPath, Archie Prentice, MB, FRCP, FRCPath, Amit Nathwani, MBChB, FRCP, FRCPath, Samir Agrawal, MD, PhD, FRCPath

Blood (2010) 116 (21): 2723.

https://doi.org/10.1182/blood.V116.21.2723.2723

Published: 2010

Journal Articles

Stable High Level Coagulation Factor VIII Expression In Vivo Following Gene Transfer Using a Novel Expression Cassette Encoding a More Potent FVIII Variant

Jenny McIntosh, Peter J Lenting, Edward Tuddenham, MD, Motunrayo Sotannde, Simon Waddington, John T. Gray, PhD, Andrew Davidoff, Amit Nathwani, MD, PhD

Blood (2010) 116 (21): 250.

https://doi.org/10.1182/blood.V116.21.250.250

Published: 2010

Journal Articles

An Open-Label Phase II Study to Investigate the Safety and Efficacy of Rituximab Plus Chlorambucil in Previously Untreated Patients with CD20-Positive B-Cell Chronic Lymphocytic Leukaemia (CLL).

Peter Hillmen, MB, ChB, PhD, John G. Gribben, MD, DSc, George A Follows, Donald W. Milligan, MD, MBChB, Hazem A. Sayala, MBChB, MRCP, Paul Moreton, David Oscier, MD, Claire E. Dearden, MD, Daniel B. Kennedy, Andrew R. Pettitt, PhD, MRCPath, Amit Nathwani, MD, PhD, Dena Cohen, Walter M Gregory, Andy C. Rawstron, PhD, Colin R.W. Hayward, MBBS, Christopher Pocock

Blood (2009) 114 (22): 3428.

https://doi.org/10.1182/blood.V114.22.3428.3428

Published: 2009

Journal Articles

Rituximab in Combination with High-Dose Steroids in Advanced, Refractory Chronic Lymphocytic Leukaemia.

John Quinn, Sajir Mohamedbhai, Marilyn Treacey, Shirley D’Sa, Amit Nathwani

Blood (2007) 110 (11): 4719.

https://doi.org/10.1182/blood.V110.11.4719.4719

Published: 2007

Journal Articles

Factors Influencing Short Term In Vivo Biodistribution of Human Bone Marrow Derived Mesenchymal Stem Cells (hMSCs) in a Xenogeneic Animal Model.

Charalampia Kyriakou, MD, Neil Rabin, MD, Amit Nathwani, MD,PhD, Arnold Pizzey, David C. Linch, MD,PhD, Kwee Yong, MD,PhD

Blood (2006) 108 (11): 3182.

https://doi.org/10.1182/blood.V108.11.3182.3182

Published: 2006

Journal Articles

Gene Modified Human Mesenchymal Stem Cells Expressing Osteoprotegerin Inhibit Osteoclast Activation and Increase Trabecular Bone Area in a Xenogeneic Murine Model of Myeloma.

Neil Rabin, MD, Chara Kyriakou, MD, Reuben Benjamin, MD, Arnold Pizzey, Orla Gallagher, BSc, Nalini Singh, Clive Buckle, PhD, Peter Croucher, PhD, Amit Nathwani, PhD, Kwee Yong, PhD

Blood (2006) 108 (11): 505.

https://doi.org/10.1182/blood.V108.11.505.505

Published: 2006

Journal Articles

Comparison of Viral Vectors for Gene Transfer into CLL Cells: Efficient Transduction with Adeno-Associated Virus-8 (AAV-8).

Andrew P. Jewell, PhD, Melanie Cochrane, PhD, Jenny McIntosh, PhD, Reuben Benjamin, MD, Amit Nathwani, PhD

Blood (2005) 106 (11): 2985.

https://doi.org/10.1182/blood.V106.11.2985.2985

Published: 2005

Journal Articles

CD4 + Perforin + T Cells in B-CLL: MHC Class II Restriction and Anti-Cytomegalovirus Reactivity.

James Walton, BSc, Keirissa Lawson, BSc, Maria S. Manoussaka, PhD, Amit Nathwani, MD, Vincent Emory, PhD, Peter M. Lydyard, PhD, Nino Porakishvili, PhD

Blood (2005) 106 (11): 4979.

https://doi.org/10.1182/blood.V106.11.4979.4979

Published: 2005

Journal Articles

Toll like Receptors (TLRs) in B Cell Chronic Lymphocytic Leukemia (B-CLL).

Maria S. Manoussaka, PhD, Azka Memon, MSc, Amit Nathwani, MD, Nino Porakishvili, PhD, Edward Clark, PhD, Peter M. Lydyard, PhD

Blood (2005) 106 (11): 4980.

https://doi.org/10.1182/blood.V106.11.4980.4980

Published: 2005

Journal Articles

Activation and Proliferation of B Cell Chronic Lymphocytic Leukaemia (B-CLL) Cells through Anti-CD180, Anti-CD40 and IL-4.

Nino Porakishvili, PhD, Maria Manoussaka, PhD, Nino Kulikova, PhD, James Walton, BSc, Amit Nathwani, MD, Andrew P. Jewell, PhD, Freda Stevenson, PhD, Ed Clark, PhD, Peter M. Lydyard, PhD

Blood (2004) 104 (11): 4775.

https://doi.org/10.1182/blood.V104.11.4775.4775

Published: 2004

NARROW

Factor IX Expression within the Normal Range Prevents Spontaneous Bleeds Requiring Treatment Following FLT180a Gene Therapy in Patients with Severe Hemophilia B: Long-Term Follow-up Study of the B-Amaze Program

A hemophilia A mouse model for the in vivo assessment of emicizumab function

Multicentre Retrospective Analysis of Chronic Lymphocytic Leukaemia Patients Treated with Idelalisib, "Real World" Data from the UK and Republic of Ireland - a Cohort of 68 Patients

A ROR1 Bispecific T Cell Engager for the Treatment of Chronic Lymphocytic Leukaemia Demonstrates Enhanced Function Following Ibrutinib Treatment

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

Cellular Immune Responses To Vector In a Gene Therapy Trial For Hemophilia B Using An AAV8 Self-Complementary Factor IX Vector

Assessing the Potential of Perinatal Gene Transfer Using Congenital Factor VII Deficiency as a Model System

Early Clinical Trial Results Following Administration of a Low Dose of a Novel Self Complementary Adeno-Associated Viral Vector Encoding Human Factor IX In Two Subjects with Severe Hemophilia B

B-Cell Chronic Lymphocytic Leukemia (B-CLL) Cells Unresponsive to CD180 Ligation Fail to Respond to Anti-IgM Stimulation as Well

Rituximab Plus Chlorambucil In Patients with CD20-Positive B-Cell Chronic Lymphocytic Leukemia (CLL): Final Response Analysis of An Open-Label Phase II Study

Inter-Laboratory Assessment of Minimal Residual Disease In Chronic Lymphocytic Leukemia – Evaluation of the Novel CD160FCA Assay

Stable High Level Coagulation Factor VIII Expression In Vivo Following Gene Transfer Using a Novel Expression Cassette Encoding a More Potent FVIII Variant

An Open-Label Phase II Study to Investigate the Safety and Efficacy of Rituximab Plus Chlorambucil in Previously Untreated Patients with CD20-Positive B-Cell Chronic Lymphocytic Leukaemia (CLL).

Rituximab in Combination with High-Dose Steroids in Advanced, Refractory Chronic Lymphocytic Leukaemia.

Factors Influencing Short Term In Vivo Biodistribution of Human Bone Marrow Derived Mesenchymal Stem Cells (hMSCs) in a Xenogeneic Animal Model.

Gene Modified Human Mesenchymal Stem Cells Expressing Osteoprotegerin Inhibit Osteoclast Activation and Increase Trabecular Bone Area in a Xenogeneic Murine Model of Myeloma.

Comparison of Viral Vectors for Gene Transfer into CLL Cells: Efficient Transduction with Adeno-Associated Virus-8 (AAV-8).

CD4 + Perforin + T Cells in B-CLL: MHC Class II Restriction and Anti-Cytomegalovirus Reactivity.

Toll like Receptors (TLRs) in B Cell Chronic Lymphocytic Leukemia (B-CLL).

Activation and Proliferation of B Cell Chronic Lymphocytic Leukaemia (B-CLL) Cells through Anti-CD180, Anti-CD40 and IL-4.

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American Society of Hematology

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American Society of Hematology

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