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Journal Articles

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Cristina Puy, Samantha A. Moellmer, Jiaqing Pang, Helen H. Vu, Alexander R. Melrose, Christina U. Lorentz, Erik I. Tucker, Joseph J. Shatzel, Ravi S. Keshari, Florea Lupu, David Gailani, Owen J. T. McCarty

Blood (2024) 144 (17): 1821–1833.

https://doi.org/10.1182/blood.2023022257

Published: 2024

Includes: Supplemental data

Journal Articles

Biology of factor XI

Samantha A. Moellmer, Cristina Puy, Owen J. T. McCarty

Blood (2024) 143 (15): 1445–1454.

https://doi.org/10.1182/blood.2023020719

Published: 2024

Journal Articles

Multimodality Quantification of Thrombus Deposition in Extracorporeal Membrane Oxygenation (ECMO); Correlating Oxygenator Computed Tomography Imaging, Electron Microscopy and Histology to Clinical Outcomes

Jenny Si Han Wang, Ari Lauthner, Helen H. Vu, Rick Mathews, Bishoy Zakhary, Owen J. T. McCarty, David Zonies, Ran Ran, Joseph J. Shatzel

Blood (2023) 142 (Supplement 1): 1285.

https://doi.org/10.1182/blood-2023-191092

Published: 2023

Journal Articles

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Christina U. Lorentz, Erik I. Tucker, Norah G. Verbout, Joseph J. Shatzel, Sven R. Olson, Brandon D. Markway, Michael Wallisch, Martina Ralle, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Jeffrey I. Weitz, András Gruber

Blood (2021) 138 (22): 2173–2184.

https://doi.org/10.1182/blood.2021011725

Published: 2021

Includes: Supplemental data

Journal Articles

Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin

Hiroshi Deguchi, Shravan Morla, Jevgenia Zilberman-Rudenko, Andras Gruber, Owen J T McCarty, Priyanka Srivastava, David Gailani, John H. Griffin

Blood (2021) 138 (Supplement 1): 441.

https://doi.org/10.1182/blood-2021-151372

Published: 2021

Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu

Blood (2021) 138 (2): 178–189.

https://doi.org/10.1182/blood.2020009345

Published: 2021

Includes: Supplemental data

Journal Articles

Aspirin and antiplatelet treatments in cancer

Derrick L. Tao, Samuel Tassi Yunga, Craig D. Williams, Owen J. T. McCarty

Blood (2021) 137 (23): 3201–3211.

https://doi.org/10.1182/blood.2019003977

Published: 2021

Journal Articles

Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs

Özgün Babur, Alexander R. Melrose, Jennifer M. Cunliffe, John Klimek, Jiaqing Pang, Anna-Liisa I. Sepp, Jevgenia Zilberman-Rudenko, Samuel Tassi Yunga, Tony Zheng, Iván Parra-Izquierdo, Jessica Minnier, Owen J. T. McCarty, Emek Demir, Ashok P. Reddy, Phillip A. Wilmarth, Larry L. David, Joseph E. Aslan

Blood (2020) 136 (20): 2346–2358.

https://doi.org/10.1182/blood.2020005496

Published: 2020

Includes: Supplemental data

Journal Articles

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

Christina U Lorentz, PhD, Norah G Verbout, PhD, Joseph J Shatzel, MD, Michael Wallisch, PhD, Brandon D Markway, PhD, Monica T Hinds, PhD, Owen J T McCarty, PhD, David Gailani, MD, Jeffrey I. Weitz, MDFRCPC, Erik I Tucker, PhD, András Gruber, MD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139948

Published: 2020

Journal Articles

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Erik I. Tucker, Norah G. Verbout, Brandon D. Markway, Michael Wallisch, Christina U. Lorentz, Monica T. Hinds, Joseph J. Shatzel, Leslie A. Pelc, David C. Wood, Owen J. T. McCarty, Enrico Di Cera, András Gruber

Blood (2020) 135 (9): 689–699.

https://doi.org/10.1182/blood.2019002771

Published: 2020

Includes: Supplemental data

Journal Articles

Tyrosine Kinase Inhibitors (TKIs) Targeting Syk and BTK Signaling Differentially Affect PI3K Signalosome Organization and Platelet Function

Tony Zheng, Elizabeth R Lofurno, Sarah Elgamal, Alexander R Melrose, Jiaqing Pang, Joseph J Shatzel, MD, Owen J T McCarty, PhD, Joseph Aslan, PhD

Blood (2019) 134 (Supplement_1): 2074.

https://doi.org/10.1182/blood-2019-129066

Published: 2019

Journal Articles

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Jevgenia Zilberman-Rudenko, Hiroshi Deguchi, MD PhD, Mohammed Hayat, Meenal Shukla, PhD, Jennifer Nagrampa Orje, Zihan Guo, Tine Wyseure, PhD, Laurent O Mosnier, Owen J T McCarty, PhD, Zaverio M. Ruggeri, MD, John H. Griffin, PhD

Blood (2019) 134 (Supplement_1): 3632.

https://doi.org/10.1182/blood-2019-129312

Published: 2019

Journal Articles

Contact system sends defensins to the rescue

Laura D. Healy, Owen J. T. McCarty

Blood (2019) 133 (5): 385–386.

https://doi.org/10.1182/blood-2018-12-887547

Published: 2019

Journal Articles

Ticagrelor breaks up the tumor-platelet party

Annachiara Mitrugno, Owen J. T. McCarty

Blood (2017) 130 (10): 1177–1178.

https://doi.org/10.1182/blood-2017-07-795898

Published: 2017

Journal Articles

Polyphosphate nanoparticles on the platelet surface trigger contact system activation

Johan J. F. Verhoef, Arjan D. Barendrecht, Katrin F. Nickel, Kim Dijkxhoorn, Ellinor Kenne, Linda Labberton, Owen J. T. McCarty, Raymond Schiffelers, Harry F. Heijnen, Antoni P. Hendrickx, Huub Schellekens, Marcel H. Fens, Steven de Maat, Thomas Renné, Coen Maas

Blood (2017) 129 (12): 1707–1717.

https://doi.org/10.1182/blood-2016-08-734988

Published: 2017

Includes: Multimedia, Supplemental data

Journal Articles

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va

Hiroshi Deguchi, Ranjeet K. Sinha, Patrizia Marchese, Zaverio M. Ruggeri, Jevgenia Zilberman-Rudenko, Owen J. T. McCarty, Mitchell J. Cohen, John H. Griffin

Blood (2016) 128 (14): 1870–1878.

https://doi.org/10.1182/blood-2016-03-707679

Published: 2016

Includes: Supplemental data

Journal Articles

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization

Rachelle E. Kosoff, Joseph E. Aslan, John C. Kostyak, Essel Dulaimi, Hoi Yee Chow, Tatiana Y. Prudnikova, Maria Radu, Satya P. Kunapuli, Owen J. T. McCarty, Jonathan Chernoff

Blood (2015) 125 (19): 2995–3005.

https://doi.org/10.1182/blood-2014-10-604504

Published: 2015

Includes: Supplemental data

Journal Articles

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Cristina Puy, Erik I. Tucker, Anton Matafonov, Qiufang Cheng, Keith D. Zientek, Dave Gailani, András Gruber, Owen J. T. McCarty

Blood (2015) 125 (9): 1488–1496.

https://doi.org/10.1182/blood-2014-10-604587

Published: 2015

Includes: Supplemental data

Journal Articles

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Anton Matafonov, Philberta Y. Leung, Adam E. Gailani, Stephanie L. Grach, Cristina Puy, Qiufang Cheng, Mao-fu Sun, Owen J. T. McCarty, Erik I. Tucker, Hiroaki Kataoka, Thomas Renné, James H. Morrissey, Andras Gruber, David Gailani

Blood (2014) 123 (11): 1739–1746.

https://doi.org/10.1182/blood-2013-04-499111

Published: 2014

Includes: Supplemental data

Journal Articles

Rac and Cdc42 team up for platelets

Joseph E. Aslan, Owen J. T. McCarty

Blood (2013) 122 (18): 3096–3097.

https://doi.org/10.1182/blood-2013-08-516906

Published: 2013

NARROW

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Biology of factor XI

Multimodality Quantification of Thrombus Deposition in Extracorporeal Membrane Oxygenation (ECMO); Correlating Oxygenator Computed Tomography Imaging, Electron Microscopy and Histology to Clinical Outcomes

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Aspirin and antiplatelet treatments in cancer

Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs

Safety and Efficacy of the Contact Activation Inhibitor AB023 in Patients with End-Stage Renal Disease on Chronic Hemodialysis: A Phase 2, Double-Blind, Randomized, Placebo-Controlled Trial

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Tyrosine Kinase Inhibitors (TKIs) Targeting Syk and BTK Signaling Differentially Affect PI3K Signalosome Organization and Platelet Function

Cardiac Myosin Acts Is a Potent Procoagulant in Vitro and In Vivo

Contact system sends defensins to the rescue

Ticagrelor breaks up the tumor-platelet party

Polyphosphate nanoparticles on the platelet surface trigger contact system activation

Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Rac and Cdc42 team up for platelets

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American Society of Hematology

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ASH Publications

American Society of Hematology

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