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Journal Articles

Targeting MEK1/2 Signaling Cascade by AS703026, a Novel Selective MEK1/2 Inhibitor, Induces Pleiotropic Anti-Myeloma Activity in Vitro and In Vivo.

Yu-Tzu Tai, Ph.D., Kihyun Kim, M.D., Xian-Feng Li, M.S., Mariateresa Fulciniti, Ph.D., Weihua Song, M.D., Sabikun Nahar, B.S., Peter Burger, B.S., Mathew J. Rumizen, Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D, Teru Hideshima, M.D., Ph.D., Robert L Schlossman, M.D., Ph.D., Nikhil C. Munshi, Paul Richardson, M.D., Ph.D., Ann Clark, Ph.D., Janet Ogden, Ph.D., Goutopoulos Andreas, Ph.D., Luca Rastelli, Ph.D., Kenneth C. Anderson, MD

Blood (2009) 114 (22): 3848.

https://doi.org/10.1182/blood.V114.22.3848.3848

Published: 2009

Journal Articles

CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf–mediated interactions with bone marrow stromal cells

Yu-Tzu Tai, Ender Soydan, Weihua Song, Mariateresa Fulciniti, Kihyun Kim, Fangxin Hong, Xian-Feng Li, Peter Burger, Matthew J. Rumizen, Sabikun Nahar, Klaus Podar, Teru Hideshima, Nikhil C. Munshi, Giovanni Tonon, Ruben D. Carrasco, Daniel E. H. Afar, Kenneth C. Anderson

Blood (2009) 113 (18): 4309–4318.

https://doi.org/10.1182/blood-2008-10-183772

Published: 2009

Journal Articles

CS1 Promotes Multiple Myeloma Cell Adhesion, Clonogenic Growth, and Tumorigenicity Via C-Maf-Mediated Interactions with Bone Marrow Stromal Cells (BMSCs)

Yu-Tzu Tai, PhD, Ender Soydan, Mariateresa Fulciniti, Weihua Song, Xian-Feng Li, Peter Burger, Fangxin Hong, Giovanni Tonon, Kihyun Kim, Mathew J. Rumizen, Sabikun Nahar, Klaus Podar, Dharminder Chauhan, Teru Hideshima, Daniel R. Carrasco, Nikhil C Munshi, Daniel Afar, PhD, Kenneth C. Anderson

Blood (2008) 112 (11): 840.

https://doi.org/10.1182/blood.V112.11.840.840

Published: 2008

Journal Articles

Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu

Blood (2008) 112 (4): 1329–1337.

https://doi.org/10.1182/blood-2007-08-107292

Published: 2008

Includes: Supplemental data

Journal Articles

Low Levels of Circulating CS1, a Newly Identified Multiple Myeloma (MM) Antigen for a Novel Humanized HuLuc63 Monoclonal Antibody, Is Detected in MM Patient Sera and Correlates with Active Disease.

Yu-Tzu Tai, PhD, Audie G. Rice, Ph.D., Marav Leiba, M.D., Xian-Feng Li, M.S., Peter Burger, B.S., Weihua Song, M.D., Rao Prabhala, Ph.D., Myles Dillon, B.S., Edie Tolan, Ph.D., Xanling Xie, Ph.D., Teru Hideshima, M.D., Ph.D., Noopur Raje, M.D., Paul Richardson, M.D., Nihkil C. Munshi, M.D., Arnon Nagler, M.D., Herve Avet-Loiseau, M.D., Daniel E.H. Afar, Ph.D., Kenneth C. Anderson, M.D.

Blood (2007) 110 (11): 1509.

https://doi.org/10.1182/blood.V110.11.1509.1509

Published: 2007

Journal Articles

Identification of CS1 Peptides for Induction of Antigen-Specific CTLs in Multiple Myeloma.

Weihua Song, MD, Yu-Tzu Tai, PhD, Tetsuro Sasada, PhD, Peter Burger, BS, Mariateresa Fulciniti, PHD, Xianfeng Li, MS, Kenneth C. Anderdon, MD, Nikhil C. Munshi, MD

Blood (2007) 110 (11): 1611.

https://doi.org/10.1182/blood.V110.11.1611.1611

Published: 2007

Journal Articles

Activation of B-Cell Maturation Antigen (BCMA) on Human Multiple Myeloma Cells by a Proliferation-Inducing Ligand (APRIL) Promotes Myeloma Cell Function in the Bone Marrow Microenvironment.

Merav Leiba, M.D., Jiangchun Xu, M.D., Ph.D., Weihua Song, M.D., Xian-Feng Li, M.S., Peter Burger, B.S., Jennifer Kordich, M.S., Linda Cassiano, B.A., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Teru Hideshima, M.D., Ph.D., Nikhil C. Munshi, M.D., Paul Richardson, M.D., Kenneth C. Anderson, M.D., Yu-Tzu Tai, PhD

Blood (2007) 110 (11): 1503.

https://doi.org/10.1182/blood.V110.11.1503.1503

Published: 2007

Journal Articles

Acquisition of New In Vivo Genomic Change over Time in Multiple Myeloma.

Yu-Tzu Tai, PhD, Leutz Buon, M.S., Benjamin King, B.S., Cheng Li Cheng Li, Ph.D., Peter Burger Peter Burger, B.S., Xian-Feng Li, M.S., Weihua Song, M.D., Robert Schlossman, M.D., Paul Richardson, M.D., Kenneth C. Anderson, M.D., Nikhil Munshi, M.D.

Blood (2007) 110 (11): 2481.

https://doi.org/10.1182/blood.V110.11.2481.2481

Published: 2007

Journal Articles

Halofuginone, an Old Anticoccidosis Drug, Induces Apoptosisin Multiple Myeloma Cells, Associated with Down Regulation of MCL1.

Merav Leiba, MD, Yu-Tzu Tai, PHD, Teru Hideshima, MD, PHD, Jana Jakubikova, PHD, Ikeda Hiroshi, MD, PHD, Xian-Feng Li, MS, Peter Burger, BS, Paul Richardson, MD, Nikhil C. Munshi, MD, Arnon Nagler, MD, Kenneth C. Anderson, MD

Blood (2007) 110 (11): 4786.

https://doi.org/10.1182/blood.V110.11.4786.4786

Published: 2007

Journal Articles

CS1, a New Surface Target on Multiple Myeloma (MM) Cells, Protects Myeloma Cells from Apoptosis Via Regulation of ERK1/2, AKT and STAT3 Signaling Cascades.

Yu-Tzu Tai, PhD, Giovanni Tonon, M.D., Ph.D., Merav Leiba, M.D., Xian-Feng Li, M.S., Peter Burger, B.S., Weihua Song, M.D., Klaus Podar, M.D., Ph.D., Dharminder Chauhan, Ph.D., Nihkil Munshi, M.D., Kenneth C. Anderson, M.D.

Blood (2007) 110 (11): 109.

https://doi.org/10.1182/blood.V110.11.109.109

Published: 2007

Journal Articles

RETRACTED: Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

Yu-Tzu Tai, Mariateresa Fulciniti, Teru Hideshima, Weihua Song, Merav Leiba, Xian-Feng Li, Matthew Rumizen, Peter Burger, Aileen Morrison, Klaus Podar, Dharminder Chauhan, Pierfrancesco Tassone, Paul Richardson, Nikhil C. Munshi, Irene M. Ghobrial, Kenneth C. Anderson

Blood (2007) 110 (5): 1656–1663.

https://doi.org/10.1182/blood-2007-03-081240

Published: 2007

Journal Articles

Genomic Evolution of Multiple Myeloma In Vivo over Time.

Yu-Tzu Tai, PhD, Benjamin King, B.S., Cheng Li, Ph.D., XianFeng Li, M.S., Peter Burger, B.S., Weihua Song, M.D., Masood Shammas, Ph.D., Robert Schlossman, M.D., Paul Richardson, M.D., Kenneth C. Anderson, M.D., Nikhil C. Munshi, M.D.

Blood (2006) 108 (11): 3400.

https://doi.org/10.1182/blood.V108.11.3400.3400

Published: 2006

Journal Articles

Inhibition of ERK1/2 Activity by the MEK1/2 Inhibitor AZD6244 (ARRY-142886) Induces Human Multiple Myeloma Cell Apoptosis in the Bone Marrow Microenvironment: A New Therapeutic Strategy for MM.

Yu-Tzu Tai, PhD, Xian-Feng Li, M.S., Iris Breitkreutz, M.D., Weihua Song, M.D., Peter Burger, B.S., Matthew Rumizen, Teru Hideshima, M.D. Ph.D., Klaus Podar, M.D. Ph.D., Irene Ghobrial, M.D., Robert Schlossman, M.D., Paul Richardson, M.D., Nikhil C. Munshi, M.D., Kenneth C. Anderson, M.D.

Blood (2006) 108 (11): 3460.

https://doi.org/10.1182/blood.V108.11.3460.3460

Published: 2006

Journal Articles

The MEK1/2 Inhibitor AZD6244 (ARRY-142886) Downregulates Constitutive and Adhesion-Induced c- MAF Oncogene Expression and Its Downstream Targets in Human Multiple Myeloma.

Yu-Tzu Tai, PhD, Giovanni Tonon, Ph.D., Xian-Feng Li, M.S., Matthew Rumizen, Weihua Song, M.D., Aileen Morrison, B.S., Peter Burger, B.S., Nikhil C. Munshi, M.D., Kenneth C. Anderson, M.D.

Blood (2006) 108 (11): 3463.

https://doi.org/10.1182/blood.V108.11.3463.3463

Published: 2006

Journal Articles

Killing of Drug-Sensitive and Resistant Myeloma Cells and Disruption of Their Bone Marrow Stromal Interaction by HuLuc63, a Novel Humanized Anti-CS1 Monoclonal Antibody.

Yu-Tzu Tai, PhD, Weihua Song, M.D., Xian-Feng Li, M.S., Peter Burger, B.S., Robert Schlossman, M.D., Audie Rice, Ph.D., Anne van Abbema, Ph.D., Paul Richardson, M.D., Nikhil C. Munshi, M.D., Daniel Afar, Ph.D., Kenneth C. Anderson, M.D.

Blood (2006) 108 (11): 3470.

https://doi.org/10.1182/blood.V108.11.3470.3470

Published: 2006

NARROW

Targeting MEK1/2 Signaling Cascade by AS703026, a Novel Selective MEK1/2 Inhibitor, Induces Pleiotropic Anti-Myeloma Activity in Vitro and In Vivo.

CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf–mediated interactions with bone marrow stromal cells

CS1 Promotes Multiple Myeloma Cell Adhesion, Clonogenic Growth, and Tumorigenicity Via C-Maf-Mediated Interactions with Bone Marrow Stromal Cells (BMSCs)

Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu

Low Levels of Circulating CS1, a Newly Identified Multiple Myeloma (MM) Antigen for a Novel Humanized HuLuc63 Monoclonal Antibody, Is Detected in MM Patient Sera and Correlates with Active Disease.

Identification of CS1 Peptides for Induction of Antigen-Specific CTLs in Multiple Myeloma.

Activation of B-Cell Maturation Antigen (BCMA) on Human Multiple Myeloma Cells by a Proliferation-Inducing Ligand (APRIL) Promotes Myeloma Cell Function in the Bone Marrow Microenvironment.

Acquisition of New In Vivo Genomic Change over Time in Multiple Myeloma.

Halofuginone, an Old Anticoccidosis Drug, Induces Apoptosisin Multiple Myeloma Cells, Associated with Down Regulation of MCL1.

CS1, a New Surface Target on Multiple Myeloma (MM) Cells, Protects Myeloma Cells from Apoptosis Via Regulation of ERK1/2, AKT and STAT3 Signaling Cascades.

RETRACTED: Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

Genomic Evolution of Multiple Myeloma In Vivo over Time.

Inhibition of ERK1/2 Activity by the MEK1/2 Inhibitor AZD6244 (ARRY-142886) Induces Human Multiple Myeloma Cell Apoptosis in the Bone Marrow Microenvironment: A New Therapeutic Strategy for MM.

The MEK1/2 Inhibitor AZD6244 (ARRY-142886) Downregulates Constitutive and Adhesion-Induced c- MAF Oncogene Expression and Its Downstream Targets in Human Multiple Myeloma.

Killing of Drug-Sensitive and Resistant Myeloma Cells and Disruption of Their Bone Marrow Stromal Interaction by HuLuc63, a Novel Humanized Anti-CS1 Monoclonal Antibody.

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American Society of Hematology

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American Society of Hematology

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