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Rachel Okabe
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Journal Articles

RON Kinase Is a Novel Therapeutic Target for Philadelphia-Negative Myeloproliferative Neoplasms

Free
Lindsay Meg Gurska, Rachel Okabe, Meng Maxine Tong, Daniel Choi, Kristina Ames, Shira Glushakow-Smith, Allison Montoya, Ellen Tein, Haiying Cheng, Swati Goel, Balazs Halmos, Kira Gritsman
Journal: Blood
Blood (2021) 138 (Supplement 1): 1462.
https://doi.org/10.1182/blood-2021-148192
Published: 2021
Journal Articles

PI3Kinase Alpha and Delta Promote Hematopoietic Stem Activation Under Stress

Free
Shayda Hemmati, PhD, Taneisha Sinclair, Meng Tong, Boris Bartholdy, PhD, Rachel Okabe, MD, Kristina Ames, PhD, Leanne Ostrodka, MD, Tamanna Haque, MD, Imit Kaur, PhD, Anupriya Agarwal, PhD, Jean Zhao, PhD, Thomas Roberts, PhD, Kira Gritsman, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 329.
https://doi.org/10.1182/blood-2018-99-114891
Published: 2018
Journal Articles

MSI2 Is Required for Maintaining the Activated Myelodysplastic Syndrome Stem Cell

Free
Tzu-Chieh Ho, PhD, James Taggart, BS, Elianna Amin, PhD, Haiming Xu, PhD, Trevor Barlowe, BA, Alexander R Perez, BS, Patrick Tivnan, BS, Rachel Okabe, BS, Christopher Lengner, PhD, Amit Verma, MD, Gail J Roboz, MD, Monica L. Guzman, PhD, Christina S Leslie, PhD, Stephen D. Nimer, MD, Michael G. Kharas, PhD
Journal: Blood
Blood (2015) 126 (23): 714.
https://doi.org/10.1182/blood.V126.23.714.714
Published: 2015
Journal Articles

Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress

Free
Nan Xiao, Kaushal Jani, Kelly Morgan, Rachel Okabe, Dana E. Cullen, Jonathan L. Jesneck, Glen D. Raffel
Journal: Blood
Blood (2012) 119 (21): 4898–4907.
https://doi.org/10.1182/blood-2012-01-403089
Published: 2012
Includes: Supplemental data
Journal Articles

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

Free
Michael G. Kharas, Rachel Okabe, Jared J. Ganis, Maricel Gozo, Tulasi Khandan, Mahnaz Paktinat, D. Gary Gilliland, Kira Gritsman
Journal: Blood
Blood (2010) 115 (7): 1406–1415.
https://doi.org/10.1182/blood-2009-06-229443
Published: 2010
Includes: Supplemental data
Journal Articles

The p110α Catalytic Isoform of PI3 Kinase Is Important for Erythropoiesis, but Has a Minimal Role in Hematopoietic Stem Cell Self-Renewal.

Free
Kira Gritsman, MD, PhD, Tulasi Khandan, Rachel Okabe, Maricel Gozo, Mahnaz Paktinat, D. Gary Gilliland, PhD, MD, Thomas M Roberts, PhD, Jean J. Zhao, PhD
Journal: Blood
Blood (2009) 114 (22): 3620.
https://doi.org/10.1182/blood.V114.22.3620.3620
Published: 2009
Journal Articles

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoiesis and Leukemogenesis.

Free
Inga Hofmann Zhang, MD, Elizabeth H. Stover, Dana E. Cullen, Junhao Mao, PhD, Kelly J. Morgan, PhD, Benjamin H. Lee, MD, PhD, Michael G. Kharas, PhD, Peter G. Miller, Rachel Okabe, Scott A. Armstrong, MD, PhD, Nico Ghilardi, PhD, Stephen Gould, PhD, Fred J. deSauvage, PhD, Andrew P. McMahon, PhD, D. Gary Gilliland, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1391.
https://doi.org/10.1182/blood.V112.11.1391.1391
Published: 2008
Journal Articles

Common Self-Renewal Pathways Contribute to the Induction of Acute Myeloid Leukemias Associated with Different Oncogenes

Free
Brynn T Kvinlaug, BSc, MSc, Wai-In Chan, PhD, Lars Bullinger, MD, Christopher Sears, Donna Paul, Rachel Okabe, BSc, Benjamin H Lee, MD, PhD, Inusha De Silva, PhD, Scott Armstrong, MD, PhD, Hartmut Dohner, MD, D. Gary Gilliland, Brian JP Huntly, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 505.
https://doi.org/10.1182/blood.V112.11.505.505
Published: 2008
Journal Articles

EXEL-8232, a Small Molecule JAK2 Inhibitor, Effectively Treats Thrombocytosis and Extramedullary Hematopoiesis in a Murine Model of Myeloproliferative Disease Induced by MPLW515L

Free
Gerlinde Wernig, Michael G. Kharas, Dena S. Leeman, Rachel Okabe, Maricel Gozo, Mahnaz Paktinat, Erika Haydu, Brian Ball, Tulasi Khandan, Douglas O. Clary, D Gary Gilliland
Journal: Blood
Blood (2008) 112 (11): 3741.
https://doi.org/10.1182/blood.V112.11.3741.3741
Published: 2008
Journal Articles

Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera.

Free
Gerlinde Wernig, MD, Michael G. Kharas, PhD, Rachel Okabe, Sandra A. Moore, Dena S. Leeman, Dana E. Cullen, Maricel Gozo, Elizabeth P. McDowell, Ross L. Levine, John Doukas, Chi Ching Mak, Glenn Noronha, Michael Martin, Yon D. Ko, Benjamin H. Lee, Richard Soll, Ayalew Tefferi, John D. Hood, D. Gary Gilliland
Journal: Blood
Blood (2007) 110 (11): 556.
https://doi.org/10.1182/blood.V110.11.556.556
Published: 2007
Journal Articles

Development of a Myeloproliferative Disease or a T Cell Lymphoblastic Leukemia in a Murine Bone Marrow Transplant Model of NUP214-ABL1.

Free
Jennifer L. Rocnik, Melanie Cornejo, Benjamin H. Lee, Rachel Okabe, Elizabeth McDowell, Maricel Gozo, Kim De Keersmaecker, Jan Cools, D. Gary Gilliland
Journal: Blood
Blood (2006) 108 (11): 618.
https://doi.org/10.1182/blood.V108.11.618.618
Published: 2006
Journal Articles

FLT3-ITD Cooperates with MOZ-TIF2 in Leukemogenesis in a Murine Bone Marrow Transplantation Model.

Free
Winnie F. Tam, PhD, Jennifer Rocnik, Ph.D., Sarah Wojiski, Ph.D., Kenji Deguchi, M.D., Rachel Okabe, B.S., Ben Lee, M.D. Ph.D., D. Gary Gilliland, Ph.D. M.D.
Journal: Blood
Blood (2006) 108 (11): 1427.
https://doi.org/10.1182/blood.V108.11.1427.1427
Published: 2006
Journal Articles

Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD

Free
Jennifer L. Rocnik, Rachel Okabe, Jin-Chen Yu, Benjamin H. Lee, Neill Giese, David P. Schenkein, D. Gary Gilliland
Journal: Blood
Blood (2006) 108 (4): 1339–1345.
https://doi.org/10.1182/blood-2005-11-011429
Published: 2006
Includes: Supplemental data
Journal Articles

Expression of Jak2V617F causes a polycythemia vera–like disease with associated myelofibrosis in a murine bone marrow transplant model

Free
Gerlinde Wernig, Thomas Mercher, Rachel Okabe, Ross L. Levine, Benjamin H. Lee, D. Gary Gilliland
Journal: Blood
Blood (2006) 107 (11): 4274–4281.
https://doi.org/10.1182/blood-2005-12-4824
Published: 2006
Includes: Supplemental data
Journal Articles

The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo

Free
Elizabeth H. Stover, Jing Chen, Benjamin H. Lee, Jan Cools, Elizabeth McDowell, Jennifer Adelsperger, Dana Cullen, Allison Coburn, Sandra A. Moore, Rachel Okabe, Doriano Fabbro, Paul W. Manley, James D. Griffin, D. Gary Gilliland
Journal: Blood
Blood (2005) 106 (9): 3206–3213.
https://doi.org/10.1182/blood-2005-05-1932
Published: 2005
Journal Articles

PKC412 Effectively Inhibits Constitutively Activated FGFR3 Mutants in Murine Leukemia Models and t(4;14) Myeloma Cell Lines.

Free
Jing Chen, Ph.D., Benjamin H. Lee, M.D., Ph.D., Ifor R. Williams, M.D., Ph.D., Jeffery L. Kutok, M.D., Ph.D., Nicole Duclos, Sarah Cohen, Jennifer Adelsperger, Rachel Okabe, Allison Coburn, Sandra Moore, Brian J.P. Huntly, M.D., Ph.D., Constantine S. Mitsiades, M.D., Kenneth C. Anderson, M.D., James D. Griffin, M.D., Doriano Fabbro, Ph.D., D. Gary Gilliland, M.D., Ph.D.
Journal: Blood
Blood (2004) 104 (11): 2448.
https://doi.org/10.1182/blood.V104.11.2448.2448
Published: 2004
Journal Articles

PKC412 Inhibits the ZNF198-FGFR1 Fusion Tyrosine Kinase and Is Efficacious in Treatment of t(8;13)(p11;q12) Associated Stem Cell Myeloproliferative Disease.

Free
Jing Chen, Ph.D., Daniel J. DeAngelo, M.D., Jeffery L. Kutok, M.D., Ph.D., Ifor R. Williams, M.D., Ph.D., Benjamin H. Lee, M.D., Ph.D., Martha Wadleigh, M.D., Nicole Duclos, Sarah Cohen, Jennifer Adelsperger, Rachel Okabe, Allison Coburn, Ilene Galinsky, Brian J.P. Huntly, M.D., Ph.D., Pamela Cohen, Ph.D., Thomas Meyer, Ph.D., Doriano Fabbro, Ph.D., Lolita Banerji, Ph.D., James D. Griffin, M.D., Sheng Xiao, M.D., Jonathan A. Fletcher, M.D., Richard M. Stone, M.D., D. Gary Gilliland, M.D., Ph.D.
Journal: Blood
Blood (2004) 104 (11): 2549.
https://doi.org/10.1182/blood.V104.11.2549.2549
Published: 2004