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Radoslaw P. Nowak
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Journal Articles

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A -r and NPM1c AML

Wallace Bourgeois, Jevon A. Cutler, Brandon J. Aubrey, Daniela V. Wenge, Florian Perner, Cynthia Martucci, Jill A. Henrich, Kelly Klega, Radosław P. Nowak, Katherine A. Donovan, Meaghan Boileau, Yanhe Wen, Charlie Hatton, Athina A. Apazidis, Sarah Naomi Olsen, Nadia Kirmani, Yana Pikman, Jessica A. Pollard, Jennifer A. Perry, Adam S. Sperling, Benjamin L. Ebert, Gerard M. McGeehan, Brian D. Crompton, Eric S. Fischer, Scott A. Armstrong
Journal: Blood
Blood (2024) 143 (15): 1513–1527.
https://doi.org/10.1182/blood.2023021105
Published: 2024
Includes: Supplemental data
Journal Articles

Large-Scale Characterization and Functional Assessment of Adaptive Immunity in Patients with MGUS and SMM Reveals Significant Defects

Michelle P. Aranha, Romanos Sklavenitis-Pistofidis, Yoshinobu Konishi, Ting Wu, Hong Yue, Elizabeth D. Lightbody, Mahshid Rahmat, Michael Timonian, Daniel L. Mallory, Michael P. Agius, Shohreh Varmeh, Nang Kham Su, Jacqueline Perry, Erica M. Horowitz, Maya Davis, Anna Justis, Radosław P. Nowak, Mark Hamilton, Daniel Auclair, Catherine R. Marinac, Eric Fischer, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2023) 142 (Supplement 1): 2548.
https://doi.org/10.1182/blood-2023-178062
Published: 2023
Journal Articles

Dysregulated Humoral and Cellular Response to Sars-Cov-2 Vaccination in Patients with MGUS and SMM

Yoshinobu Konishi, Romanos Sklavenitis-Pistofidis, Michelle P. Aranha, Ting Wu, Hong Yue, Elizabeth D. Lightbody, Mahshid Rahmat, Michael Timonian, Shohreh Varmeh, Daniel Heilpern-Mallory, Michael P. Agius, Nang Kham Su, Jacqueline Perry, Erica Horowitz, Maya I. Davis, Anna V. Justis, Radoslaw P. Nowak, Mark Hamilton, Daniel Auclair, Catherine R. Marinac, Eric S. Fischer, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 7158–7159.
https://doi.org/10.1182/blood-2022-167212
Published: 2022
Journal Articles

Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1

Wenchao Wu, Geoffrey M. Nelson, Raphael Koch, Katherine A. Donovan, Radosław P. Nowak, Tayla B. Heavican-Foral, Ajit J. Nirmal, Huiyun Liu, Lei Yang, Jessica Duffy, Foster Powers, Kristen E. Stevenson, Marcus Kenneth Jones, Samuel Y. Ng, Gongwei Wu, Salvia Jain, Ran Xu, Sam Amaka, Christopher Trevisani, Nicholas L. Donaldson, Patrick R. Hagner, Laurence de Leval, Philippe Gaulard, Javeed Iqbal, Anjan Thakurta, Eric S. Fischer, Karen Adelman, David M. Weinstock
Journal: Blood
Blood (2022) 139 (13): 2024–2037.
https://doi.org/10.1182/blood.2021014701
Published: 2022
Includes: Supplemental data
Journal Articles

Potent Ikaros Degradation By the Cereblon E3 Ligase Modulator CC-92480 Is Effective in Combination with Menin-MLL1 Inhibition in MLL1 -Rearranged and NPM1 -Mutant AML

Wallace Bourgeois, Brandon J. Aubrey, Jevon A. Cutler, Katherine A. Donovan, Charles Hatton, Alexandra C. P. Theall, Radoslaw P. Nowak, Gerard M. McGeehan, Eric S. Fischer, Scott A. Armstrong
Journal: Blood
Blood (2021) 138 (Supplement 1): 208.
https://doi.org/10.1182/blood-2021-150971
Published: 2021
Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 406.
https://doi.org/10.1182/blood-2019-123573
Published: 2019
Journal Articles

Bruton tyrosine kinase degradation as a therapeutic strategy for cancer

Dennis Dobrovolsky, Eric S. Wang, Sara Morrow, Catharine Leahy, Tyler Faust, Radosław P. Nowak, Katherine A. Donovan, Guang Yang, Zhengnian Li, Eric S. Fischer, Steven P. Treon, David M. Weinstock, Nathanael S. Gray
Journal: Blood
Blood (2019) 133 (9): 952–961.
https://doi.org/10.1182/blood-2018-07-862953
Published: 2019
Includes: Supplemental data
Journal Articles

Triple Degradation of BTK, IKZF1 and IKZF3 in B-Cell Malignancies

Sara Morrow, BA, Dennis Dobrovolsky, PhD, Eric Wang, PhD, Radosław P. Nowak, PhD, Katherine Donovan, PhD, Tyler Faust, PhD, Guang Yang, PhD, Zhengnian Li, PhD, Eric Fischer, Steven P Treon, MD PhD FRCP, David M Weinstock, MD, Nathanael S. Gray, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 263.
https://doi.org/10.1182/blood-2018-99-116895
Published: 2018