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Richard B Lock, PhD
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Journal Articles

A Novel Engineered Single-Chain Antibody Fragment for Targeting Pediatric Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

Sara M.A. Mohamed, Keith Sia, PhD, Karl-Heinz Friedrich, PhD, Andreas Wohlmann, Dr, Savvas Savvides, PhD, Peter Schofield, PhD, Daniel Christ, PhD, Maria Kavallaris, PhD, Richard B. Lock, PhD, Narges Bayat, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36.
https://doi.org/10.1182/blood-2020-138421
Published: 2020
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Jianping Li, MD, Catalina Troche, PhD, Julia Hlavka Zhang, BS, Jonathan Shrimp, PhD, Jacob S. Roth, PhD, Duohui Jing, PhD, Alok Swaroop, PhD, Marta Kulis, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Amin Sobn, PhD, Sharon Norton, MS, Richard Lynn Bennett, PhD, Min Shen, PhD, Matthew D. Hall, PhD, Richard B. Lock, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3758.
https://doi.org/10.1182/blood-2019-126910
Published: 2019
Journal Articles

Pediatric Preclinical Testing Consortium Evaluation of the Novel Anti-Microtubule Drug E7130 in Xenograft Models of Early T-Cell Precursor Acute Lymphoblastic Leukemia

Richard B. Lock, PhD, Kathryn Evans, Connor D Jones, Narimanne El-Zein, Katerina Bendak, PhD, Cara E Toscan, PhD, Chelsea Mayoh, Stephen W Erickson, PhD, Beverly A Teicher, PhD, Malcolm A Smith, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3875.
https://doi.org/10.1182/blood-2019-123867
Published: 2019
Journal Articles

A Single Mouse Trial Platform for Evaluation of Novel Agents in Acute Lymphoblastic Leukemia By the Pediatric Preclinical Testing Consortium

Richard B. Lock, PhD, Kathryn Evans, Tara Pritchard, Cara Toscan, Chelsea Mayoh, Beverly Teicher, Raushan T Kurmasheva, Peter J Houghton, Malcolm Smith, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4010.
https://doi.org/10.1182/blood-2018-99-113207
Published: 2018
Journal Articles

Comparison of MRD Levels and Gene Expression Patterns in MLL-R Versus Non-MLL Infant ALL

Rosemary Sutton, PhD, Tamara Law, BSc (Hons), Nicola C Venn, BSc (Hons), Carol Wadham, PhD, Emily VA Mould, PhD, Murray D Norris, PhD, Rishi S Kotecha, MB ChB FRACP PhD, Rolf Marschalek, PhD, Claus Meyer, PhD, Luciano Dalla-Pozza, MB BS FRACP, Glenn M Marshall, MBBS, MD FRACP, Richard B Lock, PhD, Toby N. Trahair, MBBS FRACP PhD
Journal: Blood
Blood (2016) 128 (22): 1740.
https://doi.org/10.1182/blood.V128.22.1740.1740
Published: 2016
Journal Articles

Investigation of a Novel Cyclin-Dependent-Kinase (CDK) Inhibitor Cdki-73 As an Effective Treatment Option for MLL-AML

Ka Leung Li, BSc (Hons), Sarah C Bray, PhD, Diana Iarossi, BSc (Hons), Julian Adams, PhD, Longjin Zhong, Ben Noll, BSc (Hons), Muhammed H Rahaman, BSc (Hons), Jennifer Richmond, BSc(Hons), Luen Bik To, MBBS, PhD, Ian D Lewis, MBBS, PhD FRACP, FRCPA, Richard B Lock, PhD, Shudong Wang, PhD, Richard J D'Andrea, PhD
Journal: Blood
Blood (2015) 126 (23): 1365.
https://doi.org/10.1182/blood.V126.23.1365.1365
Published: 2015
Journal Articles

Evaluation of Patient-Derived Xenografts for Modeling Outcome of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Abdulmohsen M Alruwetei, Msc, Hernan Carol, PhD, Rosemary Sutton, PhD, Glenn M Marshall, MBBS, MD FRACP, Richard B Lock, PhD
Journal: Blood
Blood (2015) 126 (23): 3759.
https://doi.org/10.1182/blood.V126.23.3759.3759
Published: 2015
Journal Articles

Efficacy of Focal Adhesion Kinase Inhibition in Combination with Dasatinib in BCR-ABL1 Acute Lymphoblastic Leukemia

Michelle L. Churchman, PhD, Luke Jones, BSc(Hons), Kathryn Evans, BSc(Hons), Jennifer Richmond, BSc(Hons), Irina M Shapiro, PhD, Jonathan A. Pachter, PhD, David T. Weaver, PhD, Peter J Houghton, PhD, Malcolm A. Smith, MD PhD, Richard B Lock, PhD, Charles G. Mullighan, MBBS, MSc, MD
Journal: Blood
Blood (2015) 126 (23): 3766.
https://doi.org/10.1182/blood.V126.23.3766.3766
Published: 2015
Journal Articles

Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)

Claudia Bruedigam, Frederik Otzen Bagger, Florian H Heidel, MD, Catherine Kuhn, Solene Guignes, Axia Song, Rebecca Austin, Therese Vu, Erwin M Lee, PhD, Andrew S. Moore, MBBS, FRACP, PhD, Richard B. Lock, PhD, Lars Bullinger, MD PhD, Geoff R Hill, MD, Steven W Lane, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2322.
https://doi.org/10.1182/blood.V124.21.2322.2322
Published: 2014
Journal Articles

Targeted Cancer Therapy in High-Risk Pediatric Leukemia Using Global Phosphotyrosine Profiling

Sibasish Dolai, PhD, Keith CS Sia, BSc(Hons), Alissa K Robbins, BSc(Hons), Ling Zhong, PhD, Sue Heatley, PhD, Tiffaney Vincent, BS, Falko Hochgräfe, PhD, Raushan T. Kurmasheva, PhD, Deborah L White, PhD FFSc (RCPA), Peter J. Houghton, PhD, Malcolm A. Smith, MD PhD, David T. Teachey, MD, Roger J Daly, PhD, Mark J Raftery, PhD, Richard B. Lock, PhD
Journal: Blood
Blood (2014) 124 (21): 969.
https://doi.org/10.1182/blood.V124.21.969.969
Published: 2014
Journal Articles

5-Aza-2'-Deoxycytidine Promotes Cytotoxic Effect of CART-Cells on Leukaemia Cells

Alla Dolnikov, PhD, Swapna Rossi, Ning Xu, PhD, Guy Klamer, PhD, Sylvie Shen, PhD, Kenneth P. Micklethwaite, MD PhD, Richard B Lock, PhD, Tracey O'Brien, MD
Journal: Blood
Blood (2014) 124 (21): 5812.
https://doi.org/10.1182/blood.V124.21.5812.5812
Published: 2014
Journal Articles

Identifying the Factors Modulating the Efficacy of CAR-T Cell Therapy

Alla Dolnikov, PhD, Guy Klamer, PhD, Arjanna Chitranjan, Ning Xu, PhD, Sylvie Shen, PhD, Kenneth P. Micklethwaite, MD PhD, Richard B. Lock, PhD, Tracey O'Brien, MD
Journal: Blood
Blood (2014) 124 (21): 5813.
https://doi.org/10.1182/blood.V124.21.5813.5813
Published: 2014
Journal Articles

Effective Targeting Of The P53/MDM2 Axis In Preclinical Models Of Infant MLL-Rearranged Acute Lymphoblastic Leukemia

Richard B Lock, PhD, Jennifer Richmond, BSc (Hons), Laura High, PhD, Hernan Carol, PhD, Kathryn Evans, BSc (Hons), Agnes M. Mendomo, MSc, Raushan T. Kurmasheva, PhD, Peter J. Houghton, PhD, Malcolm A. Smith, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 71.
https://doi.org/10.1182/blood.V122.21.71.71
Published: 2013
Journal Articles

Dual Inhibition of JAK/STAT and MAPK Pathways Results in Synergistic Cell Killing of JAK-Mutated Pediatric Acute Lymphoblastic Leukemia

Santi Suryani, PhD, Keith CS Sia, Lauryn Bracken, Hernan Carol, PhD, Kathryn Evans, Raushan Kurmasheva, PhD, Peter J. Houghton, PhD, Malcolm A. Smith, MD, PhD, Richard B. Lock, PhD
Journal: Blood
Blood (2012) 120 (21): 3562.
https://doi.org/10.1182/blood.V120.21.3562.3562
Published: 2012
Journal Articles

Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts That Express TNFα and Synergizes with TNFα in Vitro – A Report From the Pediatric Preclinical Testing Program (PPTP)

Malcolm A. Smith, MD, PhD, Hernan Carol, PhD, Kathryn Evans, Jennifer Richmond, Min Kang, PhD, C. Patrick Reynolds, MD, PhD, Srinivas Chunduru, PhD, Martin A. Graham, PhD, Brian Geier, M.Sc., Raushan Kurmasheva, PhD, Peter J. Houghton, PhD, Richard B. Lock, PhD
Journal: Blood
Blood (2012) 120 (21): 3565.
https://doi.org/10.1182/blood.V120.21.3565.3565
Published: 2012
Journal Articles

CSL362: A Monoclonal Antibody to Human Interleukin-3 Receptor (CD123), Optimized for NK Cell-Mediated Cytotoxicity of AML Stem Cells

Samantha J. Busfield, PhD, Mark Biondo, PhD, Mae Wong, PhD, Hayley S. Ramshaw, PhD, Erwin M Lee, PhD, Kirstee Martin, PhD, Souravi Ghosh, PhD, Hal Braley, Vesna Tomasetig, Con Panousis, PhD, Gino Vairo, PhD, Andrew W. Roberts, MBBS, PhD, Simon Z. He, MBBS, Naomi Sprigg, Daniel Thomas, MBBS, PhD, Mark DeWitte, VMD, Richard B. Lock, PhD, Angel F. Lopez, MBBS, PhD, Andrew Nash, PhD
Journal: Blood
Blood (2012) 120 (21): 3598.
https://doi.org/10.1182/blood.V120.21.3598.3598
Published: 2012
Journal Articles

A Neutralizing Antibody (CSL362) Against the Interleukin-3 Receptor α-Chain Augments the Efficacy of a Cytarabine/Daunorubicin Induction-Type Therapy in Preclinical Xenograft Models of Acute Myelogenous Leukemia

Erwin M Lee, PhD, Dean Yee, PhD, Samantha J Busfield, PhD, Gino Vairo, PhD, Richard B. Lock, PhD
Journal: Blood
Blood (2012) 120 (21): 3599.
https://doi.org/10.1182/blood.V120.21.3599.3599
Published: 2012
Journal Articles

Role of Connective Tissue Growth Factor (CTGF) in Survival and Chemosensitivity of Acute Lymphoblastic Leukemia

Hongbo Lu, MMSC, Venkata Lokesh Battula, Ph.D., Yuexi Shi, Richard B Lock, PhD, Suzanne Spong, Ph.D, Michael Andreeff, M.D., Ph.D., Marina Konopleva, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 2593.
https://doi.org/10.1182/blood.V118.21.2593.2593
Published: 2011
Journal Articles

Targeting the Leukemia-Associated Hypoxic Microenvironment with Hypoxia-Activated Prodrug PR-104

Juliana Benito, Ph.D., Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Bohem, Hongbo Lu, MMSC, Sergej Konoplev, MD, PhD, Wendy Fang, Steven M. Kornblau, MD, Patrick Zweidler-McKay, MD, PhD, William Wilson, PhD, Dario Campana, MD, PhD, Gautam Borthakur, MD, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, MD, Elizabeth J. Shpall, Deborah A Thomas, MD, Craig T. Jordan, PhD, Richard B Lock, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 868.
https://doi.org/10.1182/blood.V116.21.868.868
Published: 2010
Journal Articles

Targeting Connective Tissue Growth Factor (CTGF) In Acute Lymphoblastic Leukemia Pre-Clinical Models: Anti-CTGF Monoclonal Antibody Attenuates Tumor Growth In Mouse Models of ALL

Hongbo Lu, MMSC, Venkata Lokesh Battula, Ph.D., Borys Korchin, MD, Suzanne Spong, Ph.D, Martin Canizales, Ph.D, Richard B Lock, PhD, Michael Andreeff, MD, PhD, Marina Konopleva, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3257.
https://doi.org/10.1182/blood.V116.21.3257.3257
Published: 2010