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Journal Articles

A Novel Humanized Hemophilia-a Mouse Model to Facilitate Preclinical In Vivo Studies of Human Specific Fviiia-Mimetic Bispecific Antibodies

Wenjing Li, Jianxin Hu, PhD, Nina Leksa, PhD, Maria M Aleman, PhD, Robert Peters, PhD, Joe Salas, PhD, Arjan Van Der Flier, PhD

Blood (2018) 132 (Supplement 1): 2458.

https://doi.org/10.1182/blood-2018-99-119012

Published: 2018

Journal Articles

Phospholipid-Independent Activity of Fviiia Mimetic Bispecific Antibodies in Plasma

Maria M Aleman, PhD, Siddharth Jindal, MS, Nina Leksa, PhD, Robert Peters, PhD, Joe Salas, PhD

Blood (2018) 132 (Supplement 1): 2461.

https://doi.org/10.1182/blood-2018-99-119226

Published: 2018

Journal Articles

Liver-Directed Gene Therapy for Hemophilia B with Immune Stealth Lentiviral Vectors

Alessio Cantore, Michela Milani, Andrea Annoni, Tongyao Liu, Sara Bartolaccini, Mauro Biffi, Fabio Russo, Robert Peters, PhD, Angelo Lombardo, Timothy C. Nichols, MD, Eduard Ayuso, Luigi Naldini

Blood (2017) 130 (Supplement 1): 605.

https://doi.org/10.1182/blood.V130.Suppl_1.605.605

Published: 2017

Journal Articles

Extravascular Distribution of Conventional and Ehl FIX Products Using In Vivo SPECT Imaging Analysis in Hemophilia B Mice

Joe Salas, PhD, Arjan Van Der Flier, PhD, Vu P. Hong, PhD, Jennifer Dumont, PhD, Kelly D Orcutt, PhD, Apollina Goel, PhD, Robert Peters, PhD

Blood (2017) 130 (Supplement 1): 1061.

https://doi.org/10.1182/blood.V130.Suppl_1.1061.1061

Published: 2017

Journal Articles

Evaluation of Recombinant Fixfc-Xten Bleeding Efficacy in Hemophilia-B Mouse Models

Zhan Liu, MSc, Arjan van der Flier, PhD, Ayman Ismail, PhD, Allison Simpson, Lutfiye Kurt, Volker Schellenberger, PhD, Christine Loh, PhD, Robert Peters, PhD

Blood (2016) 128 (22): 3757.

https://doi.org/10.1182/blood.V128.22.3757.3757

Published: 2016

Journal Articles

Nrf2 Activation and Fetal Hemoglobin Induction in Sickle Cell Disease

Sriram Krishnamoorthy, Dipti Gupta, William E. Hobbs, MD PhD, Christine Loh, PhD, David R. Light, Robert Peters, PhD, Sarah Sturtevant, Betty Pace, MD, Yukio Nakamura, Brian Lucas, Benjamin F. Vieira

Blood (2016) 128 (22): 4840.

https://doi.org/10.1182/blood.V128.22.4840.4840

Published: 2016

Journal Articles

Recombinant FIX/X-Bp from the Japanese Habu Snake Is a Universal Ligand for Purification of Highly Carboxylated Factor IX Variants and Factor X

Oblaise Mercury, BS, Lucy Liu, PhD, Ayman Ismail, PhD, Ming Zhang, PhD, Qi Lu, PhD, Tom O Cameron, PhD, Allison Goodman, BS, Liz Culyba, PhD, Rahul Ravindran Nair, BS, MS, Amy M Holthaus, BS, MS, John Kulman, PhD, Robert Peters, PhD

Blood (2015) 126 (23): 1081.

https://doi.org/10.1182/blood.V126.23.1081.1081

Published: 2015

Journal Articles

Evaluation of Enhanced in Vitro Plasma Stability of a Novel Long Acting Recombinant FVIIIFc-VWF-XTEN Fusion Protein

Ekta Seth Chhabra, PhD, Nancy Moore, Chris Furcht, Amy M Holthaus, BS, MS, Jiayun Liu, MS, Tongyao Liu, Volker Schellenberger, PhD, John Kulman, PhD, Joe Salas, PhD, Robert Peters, PhD

Blood (2015) 126 (23): 2279.

https://doi.org/10.1182/blood.V126.23.2279.2279

Published: 2015

Journal Articles

Identification of Active Coagulation Factor IX Variants with Insertion or Fusion of Unstructured Polypeptide Xten

Zhiqian Lucy Liu, PhD, Arjan van der Flier, PhD, Sara Bardan, Sheng Ding, Volker Schellenberger, PhD, John Kulman, PhD, Robert Peters, PhD

Blood (2015) 126 (23): 2280.

https://doi.org/10.1182/blood.V126.23.2280.2280

Published: 2015

Journal Articles

Novel Approach to Study Biodistribution and Accumulation of Pegylated Recombinant Factor VIII in Haemophilia A Mice

Vu P. Hong, PhD, Ayman Ismail, PhD, Nancy Moore, Robert Peters, PhD, Joe Salas, PhD

Blood (2015) 126 (23): 3517.

https://doi.org/10.1182/blood.V126.23.3517.3517

Published: 2015

Journal Articles

Recombinant FVIIIFc-VWF-XTEN Demonstrates Significant Bioavailability Following Subcutaneous Administration in Hemophilia A Mice

Douglas Drager, Sue Patarroyo-White, Hoson Chao, Ayman Ismail, PhD, Jiayun Liu, Amy M Holthaus, BS, MS, Ekta Chhabra, John Kulman, PhD, Volker Schellenberger, PhD, Tongyao Liu, Robert Peters, PhD

Blood (2015) 126 (23): 3492.

https://doi.org/10.1182/blood.V126.23.3492.3492

Published: 2015

Journal Articles

Platelet-Targeted rFVIIa-Xten Improves Thrombin Generation and Fibrin Formation Compared to Recombinant FVIIa

Maria M. Aleman, PhD, Elena N. Kistanova, Nancy Moore, Volker Schellenberger, PhD, Robert Peters, PhD, Joe Salas, PhD

Blood (2015) 126 (23): 2269.

https://doi.org/10.1182/blood.V126.23.2269.2269

Published: 2015

Journal Articles

Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model

Arjan van der Flier, PhD, Zhiqian Lucy Liu, PhD, Zhan Liu, MSc, Oblaise Mercury, BS, Ayman Ismail, PhD, Ekta Seth-Chhabra, PhD, John Kulman, PhD, Volker Schellenberger, PhD, David R. Light, PhD, Robert Peters, PhD

Blood (2015) 126 (23): 2271.

https://doi.org/10.1182/blood.V126.23.2271.2271

Published: 2015

Journal Articles

Assessing Structure-Activity Relationships in FVIII By Integration of Structural, Biophysical, and Biochemical Data Obtained with Anti-FVIII Antibodies

Zhiqian Lucy Liu, PhD, George Bou-Assaf, PhD, Ming Zhang, PhD, Allison Goodman, Po-lin Chiu, PhD, Melissa Chambers, Thomas Walz, PhD, Robert Peters, PhD, John Kulman, PhD

Blood (2014) 124 (21): 4223.

https://doi.org/10.1182/blood.V124.21.4223.4223

Published: 2014

Journal Articles

Enhancing the Acute Hemostatic Efficacy in Cynomolgus Monkeys By Targeting Activated Coagulation Factor VII to Platelets

Siyuan Tan, PhD, Joe Salas, PhD, Kai Chen, Tamera Ashworth, Sarah Smith, Elena Kistanova, Nancy Moore, Marisol Acosta, Anxhela Kole, David R. Light, PhD, Robert Peters, PhD, Haiyan Jiang, PhD

Blood (2014) 124 (21): 1488.

https://doi.org/10.1182/blood.V124.21.1488.1488

Published: 2014

Journal Articles

Structural Comparability Between Recombinant FVIII-Fc and Its Isolated FVIII and Fc Constituents

John Kulman, Ph.D., Susan Tsutakawa, PhD, George Bou-Assaf, PhD, Steven Berkowitz, PhD, David R. Light, PhD, Adam Mezo, PhD, Deping Wang, PhD, Marc Whitlow, PhD, Liz Culyba, PhD, John Tainer, PhD, Robert Peters, PhD

Blood (2012) 120 (21): 1135.

https://doi.org/10.1182/blood.V120.21.1135.1135

Published: 2012

Journal Articles

A Novel Single Chain Recombinant Factor VIII Fc Fusion Protein Is Active In Vitro and Fully Efficacious in An In Vivo Hema Mouse Bleeding Model

Yang Buyue, PhD, Tongyao Liu, Thomas Reidy, Susannah Patarroyo-White, George D Kamphaus, PhD, Mark Slein, BS, Glenn F Pierce, M.D., PhD, Jurg M Sommer, PhD, Robert Peters, PhD

Blood (2011) 118 (21): 1192.

https://doi.org/10.1182/blood.V118.21.1192.1192

Published: 2011

Journal Articles

Pre-Clinical Characterization and Analysis of Long Lasting Recombinant Factor IXFc

John V Amari, PhD, Qi Lu, PhD, Mark Slein, BS, Robert Peters, PhD

Blood (2010) 116 (21): 4415.

https://doi.org/10.1182/blood.V116.21.4415.4415

Published: 2010

NARROW

A Novel Humanized Hemophilia-a Mouse Model to Facilitate Preclinical In Vivo Studies of Human Specific Fviiia-Mimetic Bispecific Antibodies

Phospholipid-Independent Activity of Fviiia Mimetic Bispecific Antibodies in Plasma

Liver-Directed Gene Therapy for Hemophilia B with Immune Stealth Lentiviral Vectors

Extravascular Distribution of Conventional and Ehl FIX Products Using In Vivo SPECT Imaging Analysis in Hemophilia B Mice

Evaluation of Recombinant Fixfc-Xten Bleeding Efficacy in Hemophilia-B Mouse Models

Nrf2 Activation and Fetal Hemoglobin Induction in Sickle Cell Disease

Recombinant FIX/X-Bp from the Japanese Habu Snake Is a Universal Ligand for Purification of Highly Carboxylated Factor IX Variants and Factor X

Evaluation of Enhanced in Vitro Plasma Stability of a Novel Long Acting Recombinant FVIIIFc-VWF-XTEN Fusion Protein

Identification of Active Coagulation Factor IX Variants with Insertion or Fusion of Unstructured Polypeptide Xten

Novel Approach to Study Biodistribution and Accumulation of Pegylated Recombinant Factor VIII in Haemophilia A Mice

Recombinant FVIIIFc-VWF-XTEN Demonstrates Significant Bioavailability Following Subcutaneous Administration in Hemophilia A Mice

Platelet-Targeted rFVIIa-Xten Improves Thrombin Generation and Fibrin Formation Compared to Recombinant FVIIa

Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model

Assessing Structure-Activity Relationships in FVIII By Integration of Structural, Biophysical, and Biochemical Data Obtained with Anti-FVIII Antibodies

Enhancing the Acute Hemostatic Efficacy in Cynomolgus Monkeys By Targeting Activated Coagulation Factor VII to Platelets

Structural Comparability Between Recombinant FVIII-Fc and Its Isolated FVIII and Fc Constituents

A Novel Single Chain Recombinant Factor VIII Fc Fusion Protein Is Active In Vitro and Fully Efficacious in An In Vivo Hema Mouse Bleeding Model

Pre-Clinical Characterization and Analysis of Long Lasting Recombinant Factor IXFc

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American Society of Hematology

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ASH Publications

American Society of Hematology

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