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Journal Articles

Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow

Vasilios A. Morikis, Shannon Chase, Ted Wun, Elliot L. Chaikof, John L. Magnani, Scott I. Simon

Blood (2017) 130 (19): 2101–2110.

https://doi.org/10.1182/blood-2017-05-783027

Published: 2017

Includes: Multimedia, Supplemental data

Journal Articles

Rivipansel (GMI-1070) Inhibits E-Selectin Recognition of Sialyl Lewis X Expressed on CD62L (L-selectin) and Blocks Integrin Activation and Arrest of Human Neutrophils

Scott I Simon, PhD, Vasilios A Morikis, PhD, Shannon Chase, PhD, John L Magnani, PhD

Blood (2016) 128 (22): 2509.

https://doi.org/10.1182/blood.V128.22.2509.2509

Published: 2016

Journal Articles

Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo

Helena Block, Anika Stadtmann, Daniel Riad, Jan Rossaint, Charlotte Sohlbach, Giulia Germena, Dianqing Wu, Scott I. Simon, Klaus Ley, Alexander Zarbock

Blood (2016) 127 (3): 314–324.

https://doi.org/10.1182/blood-2015-06-651034

Published: 2016

Includes: Supplemental data

Journal Articles

You’ve got to be kindlin!

Scott I. Simon

Blood (2015) 125 (12): 1855–1856.

https://doi.org/10.1182/blood-2015-02-623843

Published: 2015

Journal Articles

Hematopoietic Stem and Progenitor Cells Locally Produce Neutrophils Necessary To Resolve S. Aureus -Infected Wounds

Patrick C Falahee, M.S., Jennifer L Granick, DVM PhD, Delsheen Dahmubed, Scott I Simon, PhD

Blood (2013) 122 (21): 4710.

https://doi.org/10.1182/blood.V122.21.4710.4710

Published: 2013

Journal Articles

Staphylococcus aureus recognition by hematopoietic stem and progenitor cells via TLR2/MyD88/PGE 2 stimulates granulopoiesis in wounds

Jennifer L. Granick, Patrick C. Falahee, Delsheen Dahmubed, Dori L. Borjesson, Lloyd S. Miller, Scott I. Simon

Blood (2013) 122 (10): 1770–1778.

https://doi.org/10.1182/blood-2012-11-466268

Published: 2013

Includes: Supplemental data

Journal Articles

Gimme a brake: HPK1 regulates LFA-1 and neutrophil traction

Scott I. Simon

Blood (2013) 121 (20): 4017–4018.

https://doi.org/10.1182/blood-2013-03-489856

Published: 2013

Journal Articles

Inhibition of E-Selectin Inflammatory Function by the Glycomimetic GMI-1070

Scott I Simon, Shannon Chase, Helen Thackray, John L. Magnani, Ted Wun

Blood (2011) 118 (21): 851.

https://doi.org/10.1182/blood.V118.21.851.851

Published: 2011

Journal Articles

Neutrophil survival and c-kit + -progenitor proliferation in Staphylococcus aureus –infected skin wounds promote resolution

Min-Ho Kim, Jennifer L. Granick, Cindy Kwok, Naomi J. Walker, Dori L. Borjesson, Fitz-Roy E. Curry, Lloyd S. Miller, Scott I. Simon

Blood (2011) 117 (12): 3343–3352.

https://doi.org/10.1182/blood-2010-07-296970

Published: 2011

Includes: Supplemental data

Journal Articles

Effects of GMI-1070, a Pan-Selectin Inhibitor, on Leukocyte Adhesion In Sickle Cell Disease: Results From a Phase 1/2 Study

Ted Wun, MD, Laura M. De Castro, MD, Lori Styles, MD, Anthony Cheung, MD, Shannon Chase, Scott I Simon, PhD, John L Magnani, PhD, Helen Thackray, MD

Blood (2010) 116 (21): 262.

https://doi.org/10.1182/blood.V116.21.262.262

Published: 2010

Journal Articles

Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes In Sickle Cell Patients Not In Crisis

Scott I Simon, PhD, Shannon Chase, Sandra K Larkin, Frans Kuypers, Ph.D., Lori Styles, MD, Ted Wun, MD, FACP, Helen Thackray, MD, John L Magnani, PhD

Blood (2010) 116 (21): 2672.

https://doi.org/10.1182/blood.V116.21.2672.2672

Published: 2010

Journal Articles

Mightier than the sickle cell

Scott I. Simon, Ted Wun

Blood (2010) 116 (10): 1633.

https://doi.org/10.1182/blood-2010-06-289876

Published: 2010

Journal Articles

A day (or 5) in a neutrophil's life

Scott I. Simon, Min-Ho Kim

Blood (2010) 116 (4): 511–512.

https://doi.org/10.1182/blood-2010-05-283184

Published: 2010

Journal Articles

Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow

Ulrich Y. Schaff, Neha Dixit, Emily Procyk, Itsukyo Yamayoshi, Tiffany Tse, Scott I. Simon

Blood (2010) 115 (3): 657–666.

https://doi.org/10.1182/blood-2009-05-224659

Published: 2010

Includes: Supplemental data

Journal Articles

E-selectin prefers fatty-sweet receptors on rolling neutrophils

Scott I. Simon

Blood (2008) 112 (9): 3537.

https://doi.org/10.1182/blood-2008-07-168161

Published: 2008

Journal Articles

Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium

Chad E. Green, Ulrich Y. Schaff, Melissa R. Sarantos, Aaron F. H. Lum, Donald E. Staunton, Scott I. Simon

Blood (2006) 107 (5): 2101–2111.

https://doi.org/10.1182/blood-2005-06-2303

Published: 2006

Includes: Supplemental data

Journal Articles

Roles of neutrophil β2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice

Dori L. Borjesson, Scott I. Simon, Emir Hodzic, Hilde E. V. DeCock, Christie M. Ballantyne, Stephen W. Barthold

Blood (2003) 101 (8): 3257–3264.

https://doi.org/10.1182/blood-2002-04-1019

Published: 2003

Journal Articles

Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule–1

Eric R. Hentzen, Sriram Neelamegham, Geoffrey S. Kansas, Jennifer A. Benanti, Larry V. McIntire, C. Wayne Smith, Scott I. Simon

Blood (2000) 95 (3): 911–920.

https://doi.org/10.1182/blood.V95.3.911.003k36_911_920

Published: 2000

Journal Articles

Hydrodynamic Shear Shows Distinct Roles for LFA-1 and Mac-1 in Neutrophil Adhesion to Intercellular Adhesion Molecule-1

Sriram Neelamegham, Andrew D. Taylor, Alan R. Burns, C. Wayne Smith, Scott I. Simon

Blood (1998) 92 (5): 1626–1638.

https://doi.org/10.1182/blood.V92.5.1626

Published: 1998

NARROW

Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow

Rivipansel (GMI-1070) Inhibits E-Selectin Recognition of Sialyl Lewis X Expressed on CD62L (L-selectin) and Blocks Integrin Activation and Arrest of Human Neutrophils

Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo

You’ve got to be kindlin!

Hematopoietic Stem and Progenitor Cells Locally Produce Neutrophils Necessary To Resolve S. Aureus -Infected Wounds

Staphylococcus aureus recognition by hematopoietic stem and progenitor cells via TLR2/MyD88/PGE 2 stimulates granulopoiesis in wounds

Gimme a brake: HPK1 regulates LFA-1 and neutrophil traction

Inhibition of E-Selectin Inflammatory Function by the Glycomimetic GMI-1070

Neutrophil survival and c-kit + -progenitor proliferation in Staphylococcus aureus –infected skin wounds promote resolution

Effects of GMI-1070, a Pan-Selectin Inhibitor, on Leukocyte Adhesion In Sickle Cell Disease: Results From a Phase 1/2 Study

Effects of Selectin Antagonist GMI-1070 on the Activation State of Leukocytes In Sickle Cell Patients Not In Crisis

Mightier than the sickle cell

A day (or 5) in a neutrophil's life

Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow

E-selectin prefers fatty-sweet receptors on rolling neutrophils

Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium

Roles of neutrophil β2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice

Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule–1

Hydrodynamic Shear Shows Distinct Roles for LFA-1 and Mac-1 in Neutrophil Adhesion to Intercellular Adhesion Molecule-1

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American Society of Hematology

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ASH Publications

American Society of Hematology

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