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Journal Articles

Addition of Sorafenib to Cladribine, High-Dose Cytarabine, G-CSF, and Mitoxantrone (CLAG-M) in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) and High-Grade Myeloid Neoplasms Independent of FLT3-Mutation Status: Final Results of a Phase 1/2 Study

Anna B. Halpern, Eduardo P Rodríguez-Arbolí, Megan Othus, Kelsey-Leigh A Garcia, Mary-Elizabeth M. Percival, Ryan D. Cassaday, Vivian G. Oehler, Pamela S. Becker, Jacob S. Appelbaum, Janis L. Abkowitz, Johnnie J. Orozco, Sioban B. Keel, Paul C. Hendrie, Bart L. Scott, Cristina Ghiuzeli, Roland B. Walter, Elihu H. Estey

Blood (2022) 140 (Supplement 1): 8999–9001.

https://doi.org/10.1182/blood-2022-159882

Published: 2022

Journal Articles

Association of unbalanced translocation der(1;7) with germline GATA2 mutations

Blood (2021) 138 (23): 2441–2445.

https://doi.org/10.1182/blood.2021012781

Published: 2021

Includes: Supplemental data

Journal Articles

A Phase 1/2 Trial of Cladribine, High-Dose Cytarabine, G-CSF, and Dose-Escalated Mitoxantrone (CLAG-M) Plus Gemtuzumab Ozogamicin in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) or Other High-Grade Myeloid Neoplasm

Colin D. Godwin, Megan Othus, Mary-Elizabeth M. Percival, Paul C. Hendrie, Bart L. Scott, Jacob S. Appelbaum, Anna B. Halpern, Vivian G. Oehler, Johnnie J. Orozco, Sioban B. Keel, Janis L. Abkowitz, Jason P. Cooper, Ryan D. Cassaday, Kaysey F. Orlowski, Anise J. Marshall, Clarisa N. Brown, Elihu H. Estey, Roland B. Walter

Blood (2021) 138 (Supplement 1): 34.

https://doi.org/10.1182/blood-2021-151658

Published: 2021

Journal Articles

Loss of Lamin B1 in Myeloid Neoplasms with 5q Deletion Causes Myeloid-Biased Hematopoiesis and Pelger-Huet Nuclear Anomaly

Andreea Reilly, J. Philip Creamer, Massiel Chavez Stolla, Yuchuan Wang, Jing Du, Rachel Wellington, Stephanie Busch, Elihu H. Estey, Pamela S. Becker, Min Fang, Sioban B. Keel, Janis L. Abkowitz, Lorinda A. Soma, Jian Ma, Zhijun Duan, Sergei Doulatov

Blood (2021) 138 (Supplement 1): 502.

https://doi.org/10.1182/blood-2021-154121

Published: 2021

Journal Articles

Distinct Genetic Pathways Define Leukemia Predisposition Versus Adaptive Clonal Hematopoiesis in Shwachman-Diamond Syndrome

Alyssa L. Kennedy, MDPhD, Kasiani C. Myers, MD, James Bowman, PhD, Christopher J. Gibson, MD, Gwen M. Muscato, Robert Klein, Kaitlyn Ballotti, Nicholas Camarda, Elissa M. Furutani, MD, Chad E. Harris, MS, Shanshan Liu, PhD, Ashley Galvin, Maggie Malsch, MSN, RN, David C. Dale, MD, John M Gansner, MD PhD, Taizo A. Nakano, MD, Alison A. Bertuch, MD, Adrianna Vlachos, MD, Jeff H. Lipton, MD PhD, Paul Castillo, MD, James Connelly, John Edwards, MD, Nobuko Hijiya, MD, Richard Ho, MD, Inga Hofmann, MD, James N Huang, MD, Sioban B. Keel, MD, Adam J. Lamble, MD, Bonnie W Lau, MD PhD, Kelly J. Walkovich, MD, Maxim Norkin, MD, Wendy Stock, MD, Steffen Boettcher, Christian Brendel, PhD, Elliot Stieglitz, MD, Mark D. Fleming, MD DPhil, Stella M. Davies, PhD MBBS, MRCP, Edie A. Weller, Chris Bahl, PhD, Scott L. Carter, PhD, Akiko Shimamura, MD PhD, R. Coleman Lindsley, MD PhD

Blood (2020) 136 (Supplement 1): 35–36.

https://doi.org/10.1182/blood-2020-137125

Published: 2020

Journal Articles

Phase 1 Trial of Cladribine, High-Dose Cytarabine, G-CSF, and Dose-Escalated Mitoxantrone (CLAG-M) Plus Gemtuzumab Ozogamicin in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) or Other High-Grade Myeloid Neoplasm

Colin D. Godwin, MDMPhil, Megan Othus, PhD, Mary-Elizabeth M. Percival, MD, Bart L. Scott, MD, Pamela S. Becker, MD PhD, Kelda M. Gardner, PA-C, Sioban B. Keel, MD, Tejaswini M. Dhawale, MD, Vivian G. Oehler, MD, Janis L. Abkowitz, MD, Anna B. Halpern, MD, Paul C. Hendrie, MD PhD, Kaysey F. Orlowski, Alice Woo, Elihu H. Estey, MD, Roland B. Walter, MD PhD MS

Blood (2019) 134 (Supplement_1): 3892.

https://doi.org/10.1182/blood-2019-126009

Published: 2019

Journal Articles

Comparison of Outcomes after Early Hospital Discharge (EHD) Following Intensive Induction Vs. Post-Remission Chemotherapy for Adults with Acute Myeloid Leukemia (AML) and Other High-Grade Myeloid Neoplasms

Anna B. Halpern, MD, Nicholas P Howard, Megan Othus, PhD, Paul C. Hendrie, MD PhD, Nikita Vashi Baclig, MD MPH, Sarah A Buckley, MD, Mary-Elizabeth M. Percival, MD, Pamela S. Becker, MD PhD, Bart L. Scott, MD, Vivian G. Oehler, MD, Terry B. Gernsheimer, MD, Sioban B. Keel, MD, Johnnie Orozco, MD, Ryan D. Cassaday, MD, Andrei R Shustov, MD, Garrett Hartley, Verna L Welch, PhD MPH, Elihu H. Estey, MD, Roland B. Walter, MD PhD MS

Blood (2019) 134 (Supplement_1): 1317.

https://doi.org/10.1182/blood-2019-124586

Published: 2019

Journal Articles

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes

Jasper Hsu, Andreea Reilly, Brian J. Hayes, Courtnee A. Clough, Eric Q. Konnick, Beverly Torok-Storb, Suleyman Gulsuner, David Wu, Pamela S. Becker, Siobán B. Keel, Janis L. Abkowitz, Sergei Doulatov

Blood (2019) 134 (2): 186–198.

https://doi.org/10.1182/blood.2018884338

Published: 2019

Includes: Supplemental data

Journal Articles

Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation

Raymond T. Doty, Xiaowei Yan, Christopher Lausted, Adam D. Munday, Zhantao Yang, Danielle Yi, Neda Jabbari, Li Liu, Siobán B. Keel, Qiang Tian, Janis L. Abkowitz

Blood (2019) 133 (5): 457–469.

https://doi.org/10.1182/blood-2018-05-850412

Published: 2019

Includes: Supplemental data

Journal Articles

Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis

Edyta Glogowska, Eve R. Schneider, Yelena Maksimova, Vincent P. Schulz, Kimberly Lezon-Geyda, John Wu, Kottayam Radhakrishnan, Siobán B. Keel, Donald Mahoney, Alison M. Freidmann, Rachel A. Altura, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Theodosia A. Kalfa, Patrick G. Gallagher

Blood (2017) 130 (16): 1845–1856.

https://doi.org/10.1182/blood-2017-05-786004

Published: 2017

Includes: Multimedia, Supplemental data

Journal Articles

Germline and Somatic Genetic Characterization of Shwachman-Diamond Syndrome

Kasiani C. Myers, MD, Adam S. Nelson, MBBS, Brian Sheehan, Maggie Malsch, Gwendolyn Towers, Audrey Anna Bolyard, RN, BS, Joan Moore, Sara Loveless, Leann Mount, Stella M Davies, MBBS, PhD, Siobán B. Keel, MD, Rabi Hanna, MD, Mark D. Fleming, MD DPhil, David C. Dale, MD, Akiko Shimamura, MD PhD

Blood (2016) 128 (22): 2681.

https://doi.org/10.1182/blood.V128.22.2681.2681

Published: 2016

Journal Articles

Detection of Mutations in Inherited Bone Marrow Failure and Myelodysplastic Syndrome Genes Using Genomic Capture and Massively Parallel Sequencing in Clinical Diagnostics

Siobán B. Keel, MD, Tom Walsh, PhD, Colin Pritchard, MD, Akiko Shimamura, MD PhD, Mary-Claire King, PhD, David Wu, MD PhD

Blood (2016) 128 (22): 1507.

https://doi.org/10.1182/blood.V128.22.1507.1507

Published: 2016

Journal Articles

The Interplay of GATA1 with Heme Regulates an Erythroid Cell's Differentiation

Raymond T Doty, PhD, Xiaowei Yan, PhD, Christopher Lausted, MS, Zhantao Yang, MD, Li Liu, PhD, Neda Jabbari, PhD, Siobán B. Keel, MD, Qiang Tian, MD PhD, Janis L. Abkowitz, MD

Blood (2016) 128 (22): 541.

https://doi.org/10.1182/blood.V128.22.541.541

Published: 2016

Journal Articles

Pathophysiology of Macrocytic Anemia in Diamond Blackfan Anemia and Del(5q) Myelodysplastic Syndrome

Zhantao Yang, MD, Sioban B. Keel, MD, Brent L. Wood, MDPhD, Bart L. Scott, MD MS, Janis L. Abkowitz, MD

Blood (2015) 126 (23): 670.

https://doi.org/10.1182/blood.V126.23.670.670

Published: 2015

Journal Articles

Phase 2 Study Of Early Discharge and Outpatient Management Of Adult Patients Following Intensive Induction Chemotherapy For MDS and Non-APL AML

Jennifer E. Vaughn, MD, MSPH, Morgan A. Powell, BS, Kelda M. Gardner, PA-C, Megan Othus, PhD, Rajeev Rajendra, MD, PhD, Donnelle Rizutto, RN, Pamela S. Becker, MD, PhD, Paul C. Hendrie, MD, PhD, Andrei R. Shustov, MD, Siobán B. Keel, MD, Vivian G. Oehler, MD, Terry B. Gernsheimer, MD, Janis L. Abkowitz, MD, Elihu H. Estey, MD, Roland B. Walter, MD, PhD

Blood (2013) 122 (21): 2932.

https://doi.org/10.1182/blood.V122.21.2932.2932

Published: 2013

Journal Articles

FLVCR1a But Not FLVCR1b Is Required For Effective Erythropoiesis In Adult Mice

Raymond T Doty, PhD, Marilyn Sanchez-Bonilla, Siobán B. Keel, MD, Janis L. Abkowitz, MD

Blood (2013) 122 (21): 308.

https://doi.org/10.1182/blood.V122.21.308.308

Published: 2013

Journal Articles

Comprehensive Genomic Evaluation For Inherited Bone Marrow Failure/Myelodysplastic Syndromes

Michael Zhang, Siobán B. Keel, MD, Tom Walsh, PhD, Ming Lee, Pritchard Colin, MD, PhD, Michael Jeng, MD, Amanda Watts, Janis L. Abkowitz, MD, Mary-Claire King, PhD, Akiko Shimamura, MD, PhD

Blood (2013) 122 (21): 592.

https://doi.org/10.1182/blood.V122.21.592.592

Published: 2013

Journal Articles

Murine Terminal Erythroid Differentiation and Early B Development Require the Sodium-Dependent Phosphate Import Protein, PiT1.

Li Liu, Marilyn Sanchez-Bonilla, Matthew Crouthamel, Cecilia Giachelli, Sioban B Keel, MD

Blood (2012) 120 (21): 2307.

https://doi.org/10.1182/blood.V120.21.2307.2307

Published: 2012

Journal Articles

Heme Excess Impairs the Maturation of Proerythroblasts From Patients with Diamond Blackfan Anemia (DBA) and 5q- Myelodysplastic Syndrome (MDS)

Zhantao Yang, MD, Sioban B Keel, MD, Akiko Shimamura, MD, PhD, Aaron T. Gerds, MD, Bart L. Scott, MD, MS, Janis L. Abkowitz, MD

Blood (2012) 120 (21): 514.

https://doi.org/10.1182/blood.V120.21.514.514

Published: 2012

Journal Articles

Why Do Erythroid Cells Need to Export Heme?

Janis L. Abkowitz, MD, Sioban B Keel, MD, Mary Philip, MD PhD, John C Byon, MD PhD, Raymond T Doty, PhD

Blood (2011) 118 (21): SCI-24.

https://doi.org/10.1182/blood.V118.21.SCI-24.SCI-24

Published: 2011

NARROW

Addition of Sorafenib to Cladribine, High-Dose Cytarabine, G-CSF, and Mitoxantrone (CLAG-M) in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) and High-Grade Myeloid Neoplasms Independent of FLT3-Mutation Status: Final Results of a Phase 1/2 Study

Association of unbalanced translocation der(1;7) with germline GATA2 mutations

A Phase 1/2 Trial of Cladribine, High-Dose Cytarabine, G-CSF, and Dose-Escalated Mitoxantrone (CLAG-M) Plus Gemtuzumab Ozogamicin in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) or Other High-Grade Myeloid Neoplasm

Loss of Lamin B1 in Myeloid Neoplasms with 5q Deletion Causes Myeloid-Biased Hematopoiesis and Pelger-Huet Nuclear Anomaly

Distinct Genetic Pathways Define Leukemia Predisposition Versus Adaptive Clonal Hematopoiesis in Shwachman-Diamond Syndrome

Phase 1 Trial of Cladribine, High-Dose Cytarabine, G-CSF, and Dose-Escalated Mitoxantrone (CLAG-M) Plus Gemtuzumab Ozogamicin in Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) or Other High-Grade Myeloid Neoplasm

Comparison of Outcomes after Early Hospital Discharge (EHD) Following Intensive Induction Vs. Post-Remission Chemotherapy for Adults with Acute Myeloid Leukemia (AML) and Other High-Grade Myeloid Neoplasms

Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes

Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation

Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis

Germline and Somatic Genetic Characterization of Shwachman-Diamond Syndrome

Detection of Mutations in Inherited Bone Marrow Failure and Myelodysplastic Syndrome Genes Using Genomic Capture and Massively Parallel Sequencing in Clinical Diagnostics

The Interplay of GATA1 with Heme Regulates an Erythroid Cell's Differentiation

Pathophysiology of Macrocytic Anemia in Diamond Blackfan Anemia and Del(5q) Myelodysplastic Syndrome

Phase 2 Study Of Early Discharge and Outpatient Management Of Adult Patients Following Intensive Induction Chemotherapy For MDS and Non-APL AML

FLVCR1a But Not FLVCR1b Is Required For Effective Erythropoiesis In Adult Mice

Comprehensive Genomic Evaluation For Inherited Bone Marrow Failure/Myelodysplastic Syndromes

Murine Terminal Erythroid Differentiation and Early B Development Require the Sodium-Dependent Phosphate Import Protein, PiT1.

Heme Excess Impairs the Maturation of Proerythroblasts From Patients with Diamond Blackfan Anemia (DBA) and 5q- Myelodysplastic Syndrome (MDS)

Why Do Erythroid Cells Need to Export Heme?

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