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Thomas Melchardt
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Journal Articles

Phase II frontline chemolight R-pola-glo trial induces high and durable response rates in elderly and medically unfit/frail patients with aggressive B-cell lymphoma

Free
Björn Chapuy, Rebecca Wurm-Kuczera, Ralph Michael, Meng Wang, Petra Pichler, Angela Huster, Andrea Kerkhoff, Michael Panny, Roland Schroers, Anna Ossami Saidy, Fabian Müller, Frederik Damm, Manuel Orlinger, Philipp Staber, Carsten Schwaenen, Luisa Wohn, Clemens Schmitt, Martin Hoffmann, Mathias Hänel, Johannes Duell, Simone Heyn, Stephanie Mayer, Thomas Weber, Peter Reimer, Natalia Magdalena Rotter, Ulf Schnetzke, Bastian von Tresckow, Gabriel Kammerer, Julia Rasvina, Barbara Lehner, Thomas Mika, David Böckle, Corinna Leng, Anna Lena Illert, Bettina Altmann, Birte Friedrichs, Ella Willenbacher, Dimitrios Mougiakakos, Christiane Pott, Salah-Eddin Al-Batran, Andreas Rosenwald, Dirk Hellwig, Sascha Dietrich, Bertram Glass, Georg Lenz, Ulrich Keller, Marita Ziepert, Thomas Melchardt, Richard Greil
Journal: Blood
Blood (2025) 146 (Supplement 1): 61.
https://doi.org/10.1182/blood-2025-61
Published: 2025
Journal Articles

Time-dependent long short-term memory neural cox regression in 2,690 patients with myeloid neoplasias treated with diverse therapies identifies bone marrow related information to be less important than expected in the context of other available clinical parameters: Insights from the AML-001 trial (NCT01074047) and the austrian myeloid registry (NCT04438889) of the AGMT study group

Free
Lisa Pleyer, Xu Zhang, Manuel Drost, Julia Oberlechner, Hubert Angermann, Michael Pfeilstöcker, Verena Petzer, Sonja Heibl, Jennifer Moritz, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Angelika Pichler, Bernd Hartmann, Gregor Aschauer, Clemens Schmitt, Sonia Vallet, Szilvia Boros, Petra Pichler, Andrea Hammerl-Steiner, Johannes Andel, Daniel Lopes de Menezes, Thomas Prebet, Amer Zeidan, Nadja Zaborsky, Richard Greil, Thomas Melchardt, Lona Gaugler, Jan Hasenauer, Marc Vaisband
Journal: Blood
Blood (2025) 146 (Supplement 1): 48.
https://doi.org/10.1182/blood-2025-48
Published: 2025
Journal Articles

Multivariable-adjusted validation of IWG23-defined peripheral blood complete remission (PB-CR) and IWG23 response criteria in 2,042 patients with MDS, CMML or AML treated with diverse first-line therapies: Insights from the AML-001 trial (NCT01074047) and the ‘austrian myeloid registry’ (NCT04438889) of the AGMT study group

Free
Lisa Pleyer, Xu Zhang, Manuel Drost, Hubert Angermann, Julia Oberlechner, Michael Pfeilstöcker, Verena Petzer, Sonja Heibl, Jennifer Moritz, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Angelika Pichler, Bernd Hartmann, Gregor Aschauer, Clemens Schmitt, Sonia Vallet, Szilvia Boros, Petra Pichler, Andrea Hammerl-Steiner, Johannes Andel, Jan Philipp Bewersdorf, Amer Zeidan, Daniel Lopes de Menezes, Thomas Prebet, Thomas Melchardt, Richard Greil, Lona Gaugler
Journal: Blood
Blood (2025) 146 (Supplement 1): 3859.
https://doi.org/10.1182/blood-2025-3859
Published: 2025
Journal Articles

Comparative analysis of ide-cel and cilta-cel in patients with Relapsed/Refractory multiple myeloma: A nationwide, retrospective, real-world analysis across Austria

Free
Irene Strassl, Alexander Nikoloudis, Lina Zoe Ruesing, Thomas Melchardt, Michael Leisch, Eduard Schulz, Annkristin Heine, Peter Neumeister, Normann Steiner, Dominik Wolf, Wolfgang Willenbacher, Petra Pichler, Theresa Lentner, Johannes Clausen, Veronika Buxhofer-Ausch, Sigrid Machherndl-Spandl, Olga Saini, Dagmar Wipplinger, Holger Rumpold, Nina Worel, Hermine Agis, Krauth Maria-Theresa
Journal: Blood
Blood (2025) 146 (Supplement 1): 4584.
https://doi.org/10.1182/blood-2025-4584
Published: 2025
Journal Articles

Randomized comparison between isatuximab-rd versus rd induction, followed by isa-R versus R maintenance in very elderly patients with NDMM: Efficacy data on MRD after induction (AGMT-MM04 Trial)

Free
Heinz Ludwig, Thomas Melchardt, Evangelos Terpos, Jelena Bila, Martin Schreder, Sarah Bernhard, Klaus Podar, Eirini Katodrytou, Thamer Sliwa, Predrag Djurdjevic, Sosana Delimpasi, Michael Leisch, Marko Mitrovic, Maria Gavriatopoulou, Ioannis Ntanasis-Stathopoulos, Eva Maria Autzinger, August Zabernigg, Michael Fillitz, Ewald Wöll, Petra Pichler, Irene Manrique, Bruno Paiva, Richard Greil
Journal: Blood
Blood (2025) 146 (Supplement 1): 2258.
https://doi.org/10.1182/blood-2025-2258
Published: 2025
Journal Articles

Efficacy and safety of vipor (P) in relapsed or refractory large B-cell lymphoma

Free
Thomas Oellerich, Rebecca Wurm-Kuczera, Shashwat Sahay, Meng Wang, Salaheddine Ali, Nazli Serin, Khouloud Kouidri, Donika Tahiri, Sebastian Scheich, Uta Brunnberg, David Winkler, Samixa Pudasaini, Zoi Saxonis, Atef Abdelhafez, Tatiana Borodina, Ulrike Krueger, David Böckle, Corinna Leng, Joseph Kauer, Isabelle Krämer, Konstantinos Christofyllakis, Marcel Teichert, Niklas Gebauer, Ulf Schnetzke, Thomas Weber, Lukas Frenzel, Anna-Carina Hund, Evgenii Shumilov, Thomas Melchardt, Florian Eisele, Mirjeta Berisha, Jakob Rudzki, Christian Scholz, Martin Schmidt-Hieber, Dimitrios Mougiakakos, Johannes Duell, Gerald Wulf, Christian Schmidt, Georg Lenz, Bastian von Tresckow, Hans Christian Reinhardt, Richard Greil, Lorenz Thurner, Peter Dreger, Martin Dreyling, Christiane Pott, Martina Rudelius, Oliver Weigert, Phillipp Strubel, Roland Eils, Antonia Busse, Ulrich Keller, Naveed Ishaque, Björn Chapuy
Journal: Blood
Blood (2025) 146 (Supplement 1): 3688.
https://doi.org/10.1182/blood-2025-3688
Published: 2025
Journal Articles

Validation of Recent Response Criteria (ELN-22, IWG-23 and PB-CR) in 1634 MDS/CMML/AML Patients Treated with HMA or HMA-Ven Using CPH Models and a CPH Deep Neural Network - Can or Should Response Criteria be Harmonized for Similarly Treated Patients?

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Lisa Pleyer, Marc Vaisband, Patrick Klammer, Manuel Drost, Hubert Angermann, Felix Keil, Verena Petzer, Sonja Heibl, Jennifer Moritz, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Angelika Pichler, Bernd L. Hartmann, Gregor Aschauer, Clemens Schmitt, Sonia Vallet, Szilvia Boros, Petra Pichler, Andrea Hammerl-Steiner, Felix Renneberg, Dilyan Majjiga, Gudrun Russ, Alexander Egle, Michael Leisch, Thomas Melchardt, Nadja Zaborsky, Viktoria Faber, Jan Philipp Bewersdorf, Amer M. Zeidan, Jan Hasenauer, Richard Greil
Journal: Blood
Blood (2024) 144 (Supplement 1): 7511.
https://doi.org/10.1182/blood-2024-208073
Published: 2024
Journal Articles

Real-World Comparison of Outcomes of Patients Treated with HMA Monotherapy Versus HMA-Ven - Insights from 1634 Patients Included within the Austrian Myeloid Registry of the AGMT Study Group

Free
Lisa Pleyer, Patrick Klammer, Manuel Drost, Hubert Angermann, Felix Keil, Verena Petzer, Sonja Heibl, Jennifer Moritz, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Angelika Pichler, Bernd L. Hartmann, Gregor Aschauer, Clemens Schmitt, Sonia Vallet, Szilvia Boros, Petra Pichler, Andrea Hammerl-Steiner, Felix Renneberg, Susanne Schnabel, Dilyan Majjiga, Thomas Melchardt, Alexander Egle, Michael Leisch, Richard Greil
Journal: Blood
Blood (2024) 144 (Supplement 1): 3793.
https://doi.org/10.1182/blood-2024-207230
Published: 2024
Journal Articles

Time of CAR-T Failure Is a Strong Predictor of Outcome for Bispecific Antibody Therapy in Relapsed/Refractory Large B-Cell Lymphoma

Free
Evgenii Shumilov, Rebecca Wurm-Kuczera, Vladan Vucinic, Maximilian Seib, Udo Holtick, Paolo Mazzeo, Julia Katharina Scholz, Hristo Boyadzhiev, Thomas Melchardt, Alexander Hölscher, Christian R Schultze-Florey, Giuliano Filippini Velazquez, Anna Ossami Saidy, Vadim Lesan, Ulf Schnetzke, Andrea Kerkhoff, Ulrike Bacher, Susanne Ghandili, Enver Aydilek, Niklas Gebauer, Thomas Weber, Gerald Wulf, Bertram Glass, Lorenz Thurner, Florian Heidel, Christoph Schmid, Andreas Viardot, Mathias Hänel, Sascha Dietrich, Thomas Pabst, Francis A. Ayuk, Bastian von Tresckow, Björn Chapuy, Christiane Pott, Fabian Mueller, Georg Lenz
Journal: Blood
Blood (2024) 144 (Supplement 1): 114.
https://doi.org/10.1182/blood-2024-198883
Published: 2024
Journal Articles

Using Different Vaf Cut-Offs, Myeloid NGS Analysis of 924 Paired Peripheral Blood/Bone Marrow Samples Yielding 6944 Result Pairs Reveal Peripheral Blood As Safe Alternative Sample to Bone Marrow, Irrespective of the Degree of Neutropenia or Circulating Blast Counts

Free
Lisa Pleyer, Manuel Drost, Jakob Wagner, Bettina Jansko-Gadermeir, Franz F Gassner, Nadja Zaborsky, Thomas Dillinger, Sonja Hutter, Viktoria Faber, Thomas Melchardt, Richard Greil
Journal: Blood
Blood (2024) 144 (Supplement 1): 6145.
https://doi.org/10.1182/blood-2024-209613
Published: 2024
Journal Articles

Outcomes of Tagraxofusp in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): A Multicenter Real-World Analysis

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Philipp Berning, David Baden, Philipp Faustmann, Snjezana Janjetovic, Hanna Katharina Zieger, Jan Christian Schroeder, Giuliano Filippini Velazquez, Anna Ossami Saidy, Hristo Boyadzhiev, Tim Sauer, Jan-Henrik Mikesch, Niklas Gebauer, Susanne Ghandili, Paul J. Bröckelmann, Friederike Hildebrand, Veit L. Buecklein, Rebecca Wurm-Kuczera, Ulrich Keller, Georg Lenz, Thomas Pabst, Thomas Melchardt, Claudia Lengerke, Maher Hanoun, Evgenii Shumilov, Ulrike Bacher
Journal: Blood
Blood (2024) 144 (Supplement 1): 3818.
https://doi.org/10.1182/blood-2024-211227
Published: 2024
Journal Articles

Feasibility and Safety of the First-in-Human Chemotherapy-Light Combination of Rituximab, Polatuzumab Vedotin and Glofitamab in Previously Untreated Aggressive B-Cell Lymphoma Patients Above 60 Years of Age Ineligible for a Fully Dosed R-CHOP - R-Pola-Glo/Ikf-t062, a Study of the Austrian Group for Medical Tumor Therapy (AGMT-NHL-16) and the German Lymphoma Alliance (GLA2022-10)

Free
Thomas Melchardt, Rebecca I Wurm-Kuczera, Bettina Altmann, Petra Pichler, Manuel Orlinger, Michael Panny, Luisa Wohn, Andreas Rosenwald, Dirk Hellwig, Sascha Dietrich, Bertram Glass, Georg Lenz, Ulrich Keller, Marita Ziepert, Richard Greil, Bjoern Chapuy
Journal: Blood
Blood (2023) 142 (Supplement 1): 1734.
https://doi.org/10.1182/blood-2023-188854
Published: 2023
Journal Articles

Tafasitamab and Lenalidomide in Relapsed/Refractory B-Cell Lymphoma: A Multicenter Retrospective Real-World-Study of Patients from Germany and Austria

Free
Anna Ruckdeschel, Koemm Sabrina, Max S. Topp, Richard Greil, Thomas Melchardt, Georg Lenz, Andrea Kerkhoff, Evgenii Shumilov, Georg Hess, Marta Baumgaertner, Lorenz Thurner, Igor Age Kos, Stephanie Mayer, Francis A. Ayuk, Rolf Krause, Marco Herling, Vladan Vucinic, Claudia Chapuy, Gerald Illerhaus, Markus Knott, Andreas Viardot, Alexander Grunenberg, Sascha Dietrich, Leandra Caille, Mareike C. Tometten, Hyunyee Rosa Cho, Julia Scholz, Fabian Mueller, Katharina Prochazka, Bjoern Chapuy, David Böckle, Bastian von Tresckow, Natalie Schub, Götz Gelbrich, Hermann Einsele, Johannes Duell
Journal: Blood
Blood (2023) 142 (Supplement 1): 1771.
https://doi.org/10.1182/blood-2023-185992
Published: 2023
Journal Articles

Randomized Comparison between Krd and Ktd Induction, Followed By K Maintenance or Control in Transplant Non-Eligible Patients with NDMM: Efficacy and Qol Data (AGMT-MM02 Trial)

Free
Heinz Ludwig, Thomas Melchardt, Siegfried Sormann, Niklas Zojer, Johannes Andel, Bernd L. Hartmann, Christoph Tinchon, Eberhard Gunsilius, Klaus Podar, Alexander Egle, Wolfgang Willenbacher, Ewald Wöll, Martin Schreder, Reinhard Ruckser, Boris Bozic, Maria-Theresa Krauth, Andreas Petzer, Clemens A. Schmitt, Sigrid Machherndl-Spandl, Hermine Agis, Michael Fillitz, Song-Yau Wang, Stefan Knop, Sarah Kainz, Bruno Paiva, Richard Greil
Journal: Blood
Blood (2022) 140 (Supplement 1): 10185–10188.
https://doi.org/10.1182/blood-2022-162336
Published: 2022
Journal Articles

Cox Proportional Hazards Deep Neural Network Identifies Peripheral Blood Complete Remission (PB-CR) to be at Least Equivalent to Morphologic CR in Predicting Outcomes of Patients Treated with Azacitidine - a Prospective Cohort Study By the AGMT

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Lisa Pleyer, Marc Vaisband, Michael Pfeilstocker, Reinhard Stauder, Sonja Heibl, Heinz Sill, Michael Girschikofsky, Margarete Stampfl-Mattersberger, Christoph Tinchon, Bernd L. Hartmann, Andreas Petzer, Martin Schreder, Clemens A. Schmitt, Sonia Vallet, Thomas Melchardt, Lukas Scagnetti, Armin Zebisch, Sigrid Machherndl-Spandl, Dominik Wolf, Felix Keil, Jan Hasenauer, Richard Greil
Journal: Blood
Blood (2022) 140 (Supplement 1): 1346–1349.
https://doi.org/10.1182/blood-2022-168521
Published: 2022
Journal Articles

The EQ-5D-5L Predicts Treatment Outcomes and Provides Added Value to the R-IPSS in Patients with MDS, CMML or AML Treated within the Austrian Azacitidine Registry - a Prospective Cohort Study By the AGMT Study Group

Free
Lisa Pleyer, Sonja Heibl, Christoph Tinchon, Sonja Vallet, Branka Petricevic, Michael Leisch, Alexander Egle, Thomas Melchardt, Gudrun Piringer, Dominik Wolf, Richard Beswick, Manuel Drost, Julian Larcher-Senn, Thomas Grochtdreis, Richard Greil, Reinhard Stauder
Journal: Blood
Blood (2021) 138 (Supplement 1): 64.
https://doi.org/10.1182/blood-2021-145281
Published: 2021
Journal Articles

Composition of the Immune Environment at Baseline Correlates with Time to Response and Treatment Outcome in Newly Diagnosed Transplant-Ineligible Multiple Myeloma (MM) Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Observation (AGMT_MM 02 Study)

Free
Irene Manrique, Richard Greil, Johannes Andel, Siegfried Sormann, Bernd L. Hartmann, Klaus Podar, Alexander Egle, Andreas Petzer, Niklas Zojer, Eberhard Gunsilius, Reinhard Ruckser, Boris Bozic, Clemens A. Schmitt, Sigrid Machherndl-Spandl, Hermine Agis, Martin Schreder, Song-Yau Wang, Wolfgang Willenbacher, Maria-Theresa Krauth, Christoph Tinchon, Michael Fillitz, Thomas Melchardt, Stefan Knop, Bruno Paiva, Heinz Ludwig
Journal: Blood
Blood (2021) 138 (Supplement 1): 1669.
https://doi.org/10.1182/blood-2021-150311
Published: 2021
Journal Articles

Peripheral Blood Complete Remission Provides Added Value to the Classical Definition of Morphologic Complete Remission - a Prospective Cohort Study of 1441 Patients with MDS, CMML and AML Treated within the Austrian Azacitidine Registry

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Lisa Pleyer, Michael Pfeilstocker, Reinhard Stauder, Sonja Heibl, Heinz Sill, Michael Girschikofsky, Margarete Stampfl-Mattesberger, Christoph Tinchon, Bernd Hartmann, Andreas Petzer, Branka Petricevic, Clemens A. Schmitt, Sonja Vallet, Klaus Geissler, Wolfgang R. Sperr, Michael Leisch, Alexander Egle, Thomas Melchardt, Gudrun Piringer, Armin Zebisch, Sigrid Machherndl-Spandl, Dominik Wolf, Felix Keil, Hubert Angermann, Manuel Drost, Julian Larcher-Senn, Richard Greil
Journal: Blood
Blood (2021) 138 (Supplement 1): 3387.
https://doi.org/10.1182/blood-2021-145401
Published: 2021
Journal Articles

Quality of Life in Newly Diagnosed Patients with Multiple Myeloma Randomized to Either Krd or Ktd Induction Therapy Followed By Carfilzomib Maintenance or Control (AGMT MM 02 trial)

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Heinz Ludwig, MD, Thomas Melchardt, MD PhD, Johannes Andel, MD, Eberhard Gunsilius, MD, Siegfried Sormann, MD, Axel Hinke, PhD, Bernd L. Hartmann, MD, Klaus Podar, MDPhD, Wolfgang Willenbacher, MD PhD, Alexander Egle, MD, Andreas Petzer, MD, Niklas Zojer, MD, Ewald Wöll, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Maria-Theresa Krauth, MD, Martin Schreder, MD, Hermine Agis, MD, Christoph Tinchon, MD, Michael Fillitz, MD, Richard Greil, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–29.
https://doi.org/10.1182/blood-2020-140701
Published: 2020
Journal Articles

Immunophenotyping of Baseline Bone Marrow Reveals a Specific Pattern of Immune Cells Associated with Greater Depth and Sustained Response in Newly Diagnosed Patients Randomized to Krd or Ktd Followed By Carfilzomib Maintenance or Control (AGMT MM 02 Study)

Free
Irene Manrique, PhD, Richard Greil, MD, Johannes Andel, MD, Siegfried Sormann, MD, Bernd L. Hartmann, MD, Klaus Podar, MDPhD, Alexander Egle, MD, Andreas Petzer, MD, Niklas Zojer, MD, Reinhard Ruckser, MD, Boris Bozic, MD, Clemens A. Schmitt, MD, Sigrid Machherndl-Spandl, MD, Hermine Agis, MD, Martin Schreder, MD, Maria-Theresa Krauth, MD, Christoph Tinchon, MD, Michael Fillitz, MD, Thomas Melchardt, MD PhD, Bruno Paiva, PhD, Heinz Ludwig, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-140918
Published: 2020