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Journal Articles

Combining the Allosteric ABL1 Inhibitor Asciminib (ABL001) with Ponatinib Suppresses Emergence of and Restores Efficacy Against Highly Resistant BCR-ABL1 Compound Mutants

Christopher A. Eide, Matthew S. Zabriskie, Samantha L. Savage, Orlando Antelope, Nadeem A. Vellore, Hein Than, Anna Reister Schultz, Phillip M. Clair, Amber D. Bowler, Anthony D. Pomicter, Dongqing Yan, Anna V. Senina, Qiang Wang, Todd W. Kelley, Philippe Szankasi, Michael C. Heinrich, Jeffrey W. Tyner, Delphine Rea, MD, Jean-Michel Cayuela, Dong-Wook Kim, Cristina E. Tognon, Thomas O'Hare, PhD, Brian J. Druker, Michael W. Deininger
Journal: Blood
Blood (2019) 134 (Supplement_1): 188.
https://doi.org/10.1182/blood-2019-131781
Published: 2019
Journal Articles

Molecular Alterations in Chronic Myelomonocytic Leukemia Monocytes: Transcriptional and Methylation Profiling

Anca Franzini, PhD, Jamshid S Khorashad, MD PhD, Hein Than, MD FRCPath, MRCP, Anthony D. Pomicter, MS, Dongqing Yan, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3889.
https://doi.org/10.1182/blood-2018-99-115077
Published: 2018
Journal Articles

Combining Dasatinib and AC220 Reduces Stroma-Based pSTAT5Y694 in FLT3-ITD+ AML and Overcomes FLT3 TKI Resistance

Ami B. Patel, MD, Anthony D. Pomicter, MS, Dongqing Yan, Anna M. Eiring, PhD, Anca Franzini, PhD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2641.
https://doi.org/10.1182/blood-2018-99-117276
Published: 2018
Journal Articles

SIRT5 As a Therapeutic Target in Acute Myeloid Leukemia

Dongqing Yan, Anthony D. Pomicter, MS, William L. Heaton, MS, Clint C. Mason, PhD, Jonathan Ahmann, BS, Anna Senina, MS, Anca Franzini, PhD, Brayden Halverson, Hein Than, MD FRCPath, MRCP, Phillip M. Clair, MS, Jamshid S Khorashad, MD PhD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 907.
https://doi.org/10.1182/blood-2018-99-115468
Published: 2018
Journal Articles

Genotypic Representation of Myelodysplastic/Myeloproliferative Neoplasms in Nrg, Nrg-3GS and Srg-W41 Mice with Transgenic Expression of Human Cytokines

Hein Than, MD FRCPath, MRCP, Naoto Nakamichi, MD PhD, Anthony D. Pomicter, MS, John O'Shea, PhD, Orlando Antelope, Thomas O'Hare, PhD, Connie J. Eaves, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2038.
https://doi.org/10.1182/blood-2018-99-111728
Published: 2018
Journal Articles

Inhibition of Nucleocytoplasmic Export Enhances Selective Elimination of Leukemic Stem Cells in Chronic Myeloid Leukemia

Hein Than, MD FRCPath, MRCP, Anthony D. Pomicter, MS, Clinton C. Mason, PhD, Anna M. Eiring, PhD, William L. Heaton, MS, Dongqing Yan, Anna Senina, MS, Phillip M. Clair, MS, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 42.
https://doi.org/10.1182/blood.V130.Suppl_1.42.42
Published: 2017
Journal Articles

Persistence of Somatic Mutation Spectrum and Clonal Architecture in Chronic Myelomonocytic Leukemia Treated with Hypomethylating Agents

Hein Than, MD FRCPath, MRCP, Yi Qiao, PhD, Xiaomeng Huang, PhD, Dongqing Yan, Jamshid Sorouri Khorashad, MD PhD FRCPath, Anthony D. Pomicter, MS, Anca Franzini, PhD, Tibor Kovacsovics, Thomas O'Hare, PhD, Gabor T. Marth, DSc, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2527.
https://doi.org/10.1182/blood.V130.Suppl_1.2527.2527
Published: 2017
Journal Articles

Loss of G0S2 in Kinase-Independent TKI Resistance and Blastic Transformation of CML

Anna M. Eiring, PhD, Jonathan Ahmann, Clinton C. Mason, PhD, Ethan Dmitrovsky, MD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4173.
https://doi.org/10.1182/blood.V130.Suppl_1.4173.4173
Published: 2017
Journal Articles

Selective Inhibition of Nucleocytoplasmic Transport Overcomes Ruxolitinib Resistance in Myelofibrosis

Dongqing Yan, Srinivas K. Tantravahi, MBBS, Anthony D. Pomicter, MS, Clinton C. Mason, PhD, Anna Senina, MS, Qiang Wang, PhD, Jamshid Sorouri Khorashad, MD PhD FRCPath, Hein Than, MD FRCPath, MRCP, Phillip M. Clair, MS, William L. Heaton, MS, Anna M. Eiring, PhD, Josef T. Prchal, MD, Sabina I. Swierczek, PhD, Erkan Baloglu, Sharon Shacham, PhD MBA, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1660.
https://doi.org/10.1182/blood.V130.Suppl_1.1660.1660
Published: 2017
Journal Articles

A Novel JAK2 Mutation Confers Cytokine-Independence in the Absence of a Type I Dimeric Cytokine Receptor

Ami B. Patel, MD, Anca Franzini, PhD, Emilie Leroy, PhD, Dongqing Yan, Anna M. Eiring, PhD, Stefan N. Constantinescu, MD PhD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4212.
https://doi.org/10.1182/blood.V130.Suppl_1.4212.4212
Published: 2017
Journal Articles

Characterization of the Genomic Landscape of BCR-ABL1 Kinase-Independent Mechanisms of Resistance to ABL1 Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

Christopher A. Eide, Daniel Bottomly, Samantha L. Savage, Libbey White, Beth Wilmot, Anna M. Reister Schultz, Kimberly A. Uchida, Anupriya Agarwal, Elie Traer, MD, Lan Beppu, Olga Sala-Torra, Jerald P. Radich, Garrett Eickelberg, Richard D. Press, Marc M. Loriaux, Srinivas K. Tantravahi, MD, Anthony D. Pomicter, MS, Matthew S. Zabriskie, Michael W. Deininger, MD PhD, Thomas O'Hare, PhD, Jeffrey W. Tyner, Shannon K. McWeeney, Cristina E. Tognon, Brian J. Druker
Journal: Blood
Blood (2016) 128 (22): 1119.
https://doi.org/10.1182/blood.V128.22.1119.1119
Published: 2016
Journal Articles

Stroma-Based Activation of pSTAT3 Y705 Confers Resistance to FLT3 Inhibitors in FLT3 ITD-Positive AML

Ami Patel, MD, Anthony D. Pomicter, MS, Anna M. Eiring, PhD, Than Hein, MBBS, William L. Heaton, MS, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2016) 128 (22): 34.
https://doi.org/10.1182/blood.V128.22.34.34
Published: 2016
Journal Articles

The Nitric Oxide-Generating Prodrug Js-K Is Selectively Toxic Towards AML Compared to Normal Human Hematopoietic Cells

Kristi J. Smock, MD, William L. Heaton, MS, Anthony D. Pomicter, MS, Ronda A Crist, MT, Ken M Kosak, BS, Kenneth M Boucher, PhD, George M. Rodgers, MD PhD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD, Paul J Shami, MD
Journal: Blood
Blood (2016) 128 (22): 5217.
https://doi.org/10.1182/blood.V128.22.5217.5217
Published: 2016
Journal Articles

Selective Inhibition of Nuclear Cytoplasmic Transport As a New Treatment Paradigm in Myelofibrosis

Dongqing Yan, PhD, Srinivas K. Tantravahi, MD, Anthony D. Pomicter, MS, Anna Senina, MS, Kevin C. Gantz, Hannah M. Redwine, Josef T. Prchal, MD, Sabina Swierczek, PhD, Phillip M. Clair, MS, Anna M. Eiring, PhD, Erkan Baloglu, PhD MBA, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2016) 128 (22): 636.
https://doi.org/10.1182/blood.V128.22.636.636
Published: 2016
Journal Articles

MS4A3: A New Player in Leukemic Stem Cell Survival in Chronic Myeloid Leukemia

Anna M. Eiring, PhD, Jamshid S. Khorashad, MD PhD, Anupriya Agarwal, PhD, Clinton C. Mason, PhD, Russell Bell, PhD, Anna Senina, MS, Anthony D. Pomicter, MS, Fan Yu, MD, Hannah M. Redwine, Amber D. Bowler, Phillip M. Clair, MS, Srinivas K. Tantravahi, MD, Shannon K. McWeeney, Brian J. Druker, MD, Derek L. Stirewalt, Vivian Oehler, MD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2016) 128 (22): 934.
https://doi.org/10.1182/blood.V128.22.934.934
Published: 2016
Journal Articles

TNFR2 Signaling Promotes Myeloproliferative Disease Progression: A Role for MAPK8?

William L. Heaton, MS, Anna Senina, MS, Anthony D. Pomicter, MS, James Marvin, Josef T. Prchal, MD, Thomas O'Hare, PhD, Michael W. Deininger, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1962.
https://doi.org/10.1182/blood.V128.22.1962.1962
Published: 2016
Journal Articles

Ponatinib in Chronic-Phase Chronic Myeloid Leukemia Patients: Final Report from a Phase 1 Trial

Michael J. Mauro, MD, Jorge E. Cortes, MD, Hagop M. Kantarjian, MD, Neil P. Shah, MD PhD, Dale L. Bixby, MD, Ian W. Flinn, MD PhD, Thomas O'Hare, PhD, Victor M. Rivera, PhD, Stephanie Lustgarten, PhD, Sergio Santillana, MD, Michael C. Heinrich, Brian J. Druker, MD, Michael W. Deininger, MD PhD, Moshe Talpaz, MD
Journal: Blood
Blood (2016) 128 (22): 3063.
https://doi.org/10.1182/blood.V128.22.3063.3063
Published: 2016
Journal Articles

Long-Term Follow-up of the Efficacy and Safety of Ponatinib in Philadelphia Chromosome-Positive Leukemia Patients with the T315I Mutation

Elias J. Jabbour, MD, Jorge E. Cortes, MD, Moshe Talpaz, MD, Michele Baccarani, MD, Michael J. Mauro, MD, Andreas Hochhaus, MD, Timothy P. Hughes, MD FRACP, FRCPA, MBBS, FAAHMS, Francois Guilhot, MD, Michael W. Deininger, MD PhD, Neil Shah, MD PhD, Dale L. Bixby, MD, Ian W. Flinn, MD PhD, Thomas O'Hare, PhD, Stephanie Lustgarten, PhD, Victor M. Rivera, PhD, Sergio Santillana, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2016) 128 (22): 3067.
https://doi.org/10.1182/blood.V128.22.3067.3067
Published: 2016
Journal Articles

MS4A3 Improves Imatinib Response and Survival in BCR-ABL1 Primary TKI Resistance and in Blastic Transformation of Chronic Myeloid Leukemia

Anna M. Eiring, PhD, Jamshid S. Khorashad, MD PhD, Anupriya Agarwal, PhD, Clinton C. Mason, PhD, Fan Yu, MD, Hannah M. Redwine, Amber D. Bowler, Kevin C. Gantz, Kimberly R. Reynolds, MS, Phillip M. Clair, MS, David J. Anderson, MBA, Srinivas K Tantravahi, Shannon K. McWeeney, PhD, Brian J. Druker, MD, Derek L. Stirewalt, MD, Vivian G. Oehler, MD, Thomas O'Hare, PhD, Michael W. Deininger
Journal: Blood
Blood (2015) 126 (23): 14.
https://doi.org/10.1182/blood.V126.23.14.14
Published: 2015
Journal Articles

Transition of Chronic Myeloid Leukemia to Chronic Myelomonocytic Leukemia As a Tool to Observe Development of Chronic Myelomonocytic Leukemia

Jamshid S Khorashad, MD PhD, Srinivas K Tantravahi, Dongqing Yan, PhD, Anna M. Eiring, PhD, Hannah M. Redwine, Amber D. Bowler, Kevin C. Gantz, Keith M Gligorich, PhD, Anthony D Pomicter, MS, Todd W Kelley, MD, Thomas O'Hare, PhD, Michael W Deininger, MD PhD
Journal: Blood
Blood (2015) 126 (23): 5223.
https://doi.org/10.1182/blood.V126.23.5223.5223
Published: 2015