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Timothy A. Graubert
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Journal Articles

Subclonal KIT D816V Mutations Are Prevalent in Chronic Myelomonocytic Leukemia and Correlate with Distinct Phenotypic Features

Anthony Hunter, Hannah Newman, Eric Solary, Klaus Geissler, Laura Palomo, Lurdes Zamora, Francesc Solé, Valeria Santini, Timothy A. Graubert, Swapna Thota, Elizabeth A. Griffiths, Lisa Pleyer, Felicitas R. Thol, Rafael Bejar, Luis E. Aguirre, David A. Sallman, Andrew Kuykendall, Rami S. Komrokji, Tracy I. George, Eric Padron
Journal: Blood
Blood (2022) 140 (Supplement 1): 9824–9827.
https://doi.org/10.1182/blood-2022-164816
Published: 2022
Journal Articles

Therapeutic Targeting of Spliceosome Mutant Myeloid Neoplasms Via PARP1 Inhibition

Sayantani Sinha, Zhiyan Silvia Liu, Maxwell Bannister, Erica Arriaga-Gomez, Axia Song, Dawei Zong, Martina Sarchi, Elizabeth Bonner, Victor Corral, Cassandra Leibson, Wannasiri Chiraphapphaiboon, Derek Stirewalt, Joachim Deeg, Sumit Rai, Matthew J Walter, Timothy A. Graubert, Sergei Doulatov, Dang Hai Nguyen, Stanley Chun-Wei Lee
Journal: Blood
Blood (2022) 140 (Supplement 1): 217–219.
https://doi.org/10.1182/blood-2022-170574
Published: 2022
Journal Articles

A Phase 2 Randomized Study Comparing Venetoclax and Azacitidine to Conventional Induction Chemotherapy for Newly Diagnosed Fit Adults with Acute Myeloid Leukemia

Amir T. Fathi, Geoffrey G Fell, Areej El-Jawahri, Alexander E. Perl, Brian A. Jonas, Ajoy L. Dias, Alice S. Mims, Uma Borate, Brittany Knick Ragon, Michael R. Grunwald, Mary Linton B. Peters, Timothy A. Graubert, Philip C. Amrein, Hanno R. Hock, Andrew M. Brunner, Gabriela S. Hobbs, Rupa Narayan, Donna S. Neuberg, Ibrahim Aldoss
Journal: Blood
Blood (2022) 140 (Supplement 1): 3284–3286.
https://doi.org/10.1182/blood-2022-162525
Published: 2022
Journal Articles

Mutant Srsf2 Diminishes Jak2 V617F -Induced Erythrocytosis in Mice and Is Associated with Lower Hemoglobin in Patients with Chronic Phase JAK2 -Mutant MPN

Anna E Marneth, Jonas S. Jutzi, Chulwoo J. Kim, Charles Laurore, Anastasia Tishena, Frederike Kramer, Azucena V. Rocha, Mohammed Wazir, Lachelle D. Weeks, Joan How, Maximilian F. Stahl, Marlise R. Luskin, R. Coleman Lindsley, Olga Pozdnyakova, Timothy A. Graubert, Ann Mullally
Journal: Blood
Blood (2022) 140 (Supplement 1): 1089–1090.
https://doi.org/10.1182/blood-2022-158823
Published: 2022
Journal Articles

Spliceosome Mutant Myeloid Malignancies Are Preferentially Sensitive to PARP Inhibition

Dang Hai Nguyen, Zhiyan Silvia Liu, Sayantani Sinha, Maxwell Bannister, Erica Arriaga-Gomez, Axia Song, Dawei Zong, Victor Corral, Cassandra Leibson, Sumit Rai, Timothy A. Graubert, Stanley C Lee
Journal: Blood
Blood (2021) 138 (Supplement 1): 322.
https://doi.org/10.1182/blood-2021-149688
Published: 2021
Journal Articles

Inhibition of ATR with AZD6738 (Ceralasertib) for the Treatment of Progressive or Relapsed Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: Safety and Preliminary Activity from a Phase Ib/II Study

Andrew M. Brunner, Yiwen Liu, Lourdes M. Mendez, Jacqueline S. Garcia, Philip C. Amrein, Donna S. Neuberg, Emma Dean, Simon Smith, Richard M. Stone, Amir T. Fathi, Matthew J. Walter, Timothy A. Graubert, Meagan A. Jacoby
Journal: Blood
Blood (2021) 138 (Supplement 1): 1521.
https://doi.org/10.1182/blood-2021-147301
Published: 2021
Journal Articles

ATR/CHK1/WEE1 Dependency in SRSF2 -Mutated MDS/AML

Samuli Eldfors, Sumit Rai, Vineet Sharma, Angelique N Gilbert, Kimmo Porkka, Timothy A. Graubert
Journal: Blood
Blood (2021) 138 (Supplement 1): 3661.
https://doi.org/10.1182/blood-2021-147960
Published: 2021
Journal Articles

Phase I Study of Ixazomib Added to Chemotherapy in the Treatment of Acute Lymphoblastic Leukemia in Older Adults

Philip C. Amrein, MD, Karen K. Ballen, MD, Kristen E. Stevenson, MS, Traci M. Blonquist, MS, Andrew M. Brunner, Gabriela S. Hobbs, MD, Hanno R. Hock, MD PhD, Steven L. McAfee, MD, Jenna A. Moran, NP, Meghan Bergeron, NP, Julia E. Foster, NP, Christina Bertoli, NP, Kristin McGregor, Molly Macrae, Meghan Burke, Tanya T. Behnan, BS, Tina T. Som, RN, Aura Y. Ramos, RN, Megan K. Vartanian, RN, Jennifer Lombardi Story, Christine Connolly, Timothy A. Graubert, MD, Donna S. Neuberg, ScD, Amir T. Fathi
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-139661
Published: 2020
Journal Articles

SF3B1 -mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS

Clinical Trials & Observations
Luca Malcovati, Kristen Stevenson, Elli Papaemmanuil, Donna Neuberg, Rafael Bejar, Jacqueline Boultwood, David T. Bowen, Peter J. Campbell, Benjamin L. Ebert, Pierre Fenaux, Torsten Haferlach, Michael Heuser, Joop H. Jansen, Rami S. Komrokji, Jaroslaw P. Maciejewski, Matthew J. Walter, Michaela Fontenay, Guillermo Garcia-Manero, Timothy A. Graubert, Aly Karsan, Manja Meggendorfer, Andrea Pellagatti, David A. Sallman, Michael R. Savona, Mikkael A. Sekeres, David P. Steensma, Sudhir Tauro, Felicitas Thol, Paresh Vyas, Arjan A. Van de Loosdrecht, Detlef Haase, Heinz Tüchler, Peter L. Greenberg, Seishi Ogawa, Eva Hellstrom-Lindberg, Mario Cazzola
Journal: Blood
Blood (2020) 136 (2): 157–170.
https://doi.org/10.1182/blood.2020004850
Published: 2020
Journal Articles

Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia

Robert P. Hasserjian, David P. Steensma, Timothy A. Graubert, Benjamin L. Ebert
Journal: Blood
Blood (2020) 135 (20): 1729–1738.
https://doi.org/10.1182/blood.2019004770
Published: 2020
Journal Articles

Redirecting T-Cells Against AML in a Multidimensional Targeting Space Using T-Cell Engaging Antibody Circuits (TEAC)

Eleanor Minogue, BSc, David Millar, PhD, Yan Chuan, PhD, Songfa Zhang, MD PhD, Korneel Grauwet, PhD, Mei Guo, Adam Langenbucher, Cyril H Benes, James Heather, PhD, Jeremy Minshull, PhD, Michael S. Lawrence, PhD, Rupa Narayan, David M. Langenau, PhD, Timothy A. Graubert, MD, Mark Cobbold
Journal: Blood
Blood (2019) 134 (Supplement_1): 2653.
https://doi.org/10.1182/blood-2019-127634
Published: 2019
Journal Articles

Potential Barriers to Clinical Trials of New Therapeutics for Myelodysplastic Syndromes: Wide Variation in Risk Definitions and Trial Enrollment Criteria

Andrew M. Brunner, MD, Jacqueline S. Garcia, R. Coleman Lindsley, MD, PhD, Gregory A. Abel, MD MPH, Donna S Neuberg, ScD, Richard M. Stone, MD, Timothy A. Graubert, MD, David P. Steensma, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4378.
https://doi.org/10.1182/blood-2018-99-114356
Published: 2018
Journal Articles

Clinical Outcomes Following Frontline Chemotherapy for Patients with Myeloid Malignancies Harboring Splicing Factor Mutations

Evan C. Chen, MD, Gabriela S. Hobbs, MD, Philip C. Amrein, MD, Timothy A. Graubert, MD, Amir T. Fathi, MD, Andrew M. Brunner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4364.
https://doi.org/10.1182/blood-2018-99-111982
Published: 2018
Journal Articles

Single-Cell RNA-Seq Reveals AML Cellular Hierarchies Relevant to Clinical Outcomes and Immunity

Peter Van Galen, PhD, Volker Hovestadt, PhD, Marc Wadsworth II, Travis Hughes, Gabriel Kenneth Griffin, MD, Julia A. Verga, Jason Stephansky, Timothy J. Pastika, Jennifer Lombardi Story, Geraldine S. Pinkus, MD, Olga Pozdnyakova, MD PhD, Ilene Galinsky, Richard M. Stone, MD, Timothy A. Graubert, MD, Alex K. Shalek, PhD, Jon C. Aster, MD PhD, Andrew A. Lane, MD PhD, Bradley E. Bernstein, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 542.
https://doi.org/10.1182/blood-2018-99-113502
Published: 2018
Journal Articles

Phase II Clinical Trial of Alisertib, an Aurora a Kinase Inhibitor, in Combination with Induction Chemotherapy in High-Risk, Untreated Patients with Acute Myeloid Leukemia

Andrew M. Brunner, MD, Traci M. Blonquist, MS, Daniel J. DeAngelo, MD, Malgorzata McMasters, MD, Eric S. Winer, MD, Gabriela S. Hobbs, MD, Philip C. Amrein, MD, Hanno Hock, MD PhD, David P. Steensma, Jacqueline S. Garcia, Marlise R. Luskin, MD, Richard M. Stone, MD, Karen K. Ballen, MD, Jacalyn Rosenblatt, MD, David E. Avigan, MD, Steven L McAfee, MD, Jenna A. Moran, NP, Meghan Bergeron, Julia Foster, ANP, Christina Bertoli, Kristin McGregor, Kaitlyn Fishman, Molly Macrae, Meghan Burke, Tanya T. Behnan, BS, Tina T. Som, RN, Aura Y. Ramos, Megan K. Vartanian, RN, Nicole Nelson, Emma Logan, Jennifer Lombardi Story, Christine Connolly, Donna S Neuberg, ScD, Yi-Bin Chen, MD, Timothy A. Graubert, MD, Amir T. Fathi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 766.
https://doi.org/10.1182/blood-2018-99-115145
Published: 2018
Journal Articles

High NPM1 -mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

Clinical Trials & Observations
Sanjay S. Patel, Frank C. Kuo, Christopher J. Gibson, David P. Steensma, Robert J. Soiffer, Edwin P. Alyea, III, Yi-Bin A. Chen, Amir T. Fathi, Timothy A. Graubert, Andrew M. Brunner, Martha Wadleigh, Richard M. Stone, Daniel J. DeAngelo, Valentina Nardi, Robert P. Hasserjian, Olga K. Weinberg
Journal: Blood
Blood (2018) 131 (25): 2816–2825.
https://doi.org/10.1182/blood-2018-01-828467
Published: 2018
Includes: Supplemental data
Journal Articles

Expression of B Cell Maturation Antigen (BCMA) and Transmembrane Activator and Caml Interactor (TACI) Are Correlated and Can be Targeted at Multiple Points during the Course of Multiple Myeloma

Allison O. Taylor, Matthew J. Frigault, MD, Felipe Bedoya, PhD, Michelle E. DeLelys, Alexandra J. Shay, Rachel T. Nicholson, Noopur Raje, MD, Fredric I. Preffer, PhD, Timothy A. Graubert, MD, Marcela V. Maus, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5363.
https://doi.org/10.1182/blood.V130.Suppl_1.5363.5363
Published: 2017
Journal Articles

Spliceosomal Mutations Induce R Loop-Associated ATR Signaling

Wan Yee Leong, PhD, Hai Dang Nguyen, PhD, Weiling Li, PhD, Matthew J. Walter, MD, Lee Zou, PhD, Timothy A. Graubert, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 116.
https://doi.org/10.1182/blood.V130.Suppl_1.116.116
Published: 2017
Journal Articles

Cellular Stressors Contribute to the Expansion of Multiple Hematopoietic Clones of Varying Leukemic Potential

Terrence N Wong, MD PhD, Christopher A Miller, PhD, Matthew RM Jotte, Nusayba Bagegni, MD, Jack D Baty, Amy E Schmidt, MDPhD, Amanda F Cashen, MD, Eric J. Duncavage, MD, Nichole M Helton, Mark A. Fiala, BS, Robert S Fulton, Sharon E Heath, Megan Janke, PhD, Kierstin Luber, Peter Westervelt, MDPhD, Ravi Vij, MDMBA, John F DiPersio, MD PhD, John S. Welch, MD PhD, Timothy A. Graubert, MD, Matthew J. Walter, MD, Timothy James J Ley, MD, Daniel C. Link, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 469.
https://doi.org/10.1182/blood.V130.Suppl_1.469.469
Published: 2017
Journal Articles

Preclinical Rationale for the Use of Regorafenib in Myeloid Malignancies

Gabriela S. Hobbs, MD, Andrew M. Brunner, MD, Timothy A. Graubert, MD, Cyril H Benes, Gabriel Daniel Duda, DMD, PhD, Yi-Bin Chen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2643.
https://doi.org/10.1182/blood.V130.Suppl_1.2643.2643
Published: 2017