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Varun Vijay Prabhu
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Journal Articles

Venetoclax Synergistically Enhances the Antileukemic Activity of Imipridone ONC213, a Novel Imipridone ONC201 Analog, in Acute Myeloid Leukemia

Yongwei Su, Xinyu Li, Holly Edwards, BS, Lisa Polin, PhD, Juiwanna Kushner, Sijana H Dzinic, PhD, Katie Hege, Yu Fukuda, John D. Schuetz, PhD, Joshua E. Allen, PhD, Martin Stogniew, Varun Vijay Prabhu, BPharm, MS, PhD, Jeffrey W. Taub, MD, Hai Lin, MD, Yubin Ge, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3936.
https://doi.org/10.1182/blood-2018-99-116997
Published: 2018
Journal Articles

Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the Integrated Stress Response Pathway

Varun Vijay Prabhu, BPharm, MS, PhD, Mala Kiran Talekar, MD, Amriti R Lulla, MS, C. Leah B Kline, Lanlan Zhou, Junior Hall, A. Pieter J Van den Heuvel, David T Dicker, Stephan A Grupp, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, MD, Wolfgang Oster, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry
Journal: Blood
Blood (2017) 130 (Supplement 1): 3842.
https://doi.org/10.1182/blood.V130.Suppl_1.3842.3842
Published: 2017
Journal Articles

ONC213, a Novel Second Generation Analog of ONC201, Shows Promising Anti-Leukemic Activity Against AML Cells In Vitro and In Vivo

Yongwei Su, Xinyu Li, Holly Edwards, Joshua E. Allen, PhD, Martin Stogniew, Varun Vijay Prabhu, BPharm, MS, PhD, Jeffrey W. Taub, MD, Hai Lin, Yubin Ge, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3822.
https://doi.org/10.1182/blood.V130.Suppl_1.3822.3822
Published: 2017
Journal Articles

The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Takenobu Nii, PhD, Jo Ishizawa, MD PhD, Varun Vijay Prabhu, BPharm, MS, PhD, Vivian Ruvolo, PhD, Neel Madhukar, Ran Zhao, Hong Mu, MD PhD, Lauren Heese, Kensuke Kojima, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Neil Charter, Sean Deacon, Olivier Elemento, PhD, Joshua E. Allen, PhD, Wolfgang Oster, MD, Martin Stogniew, Michael Andreeff, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2616.
https://doi.org/10.1182/blood.V130.Suppl_1.2616.2616
Published: 2017
Journal Articles

Integrated Stress Response and Immune Cell Infiltration in an Ibrutinib-Refractory Mantle Cell Lymphoma Patient Following ONC201 Treatment

Jorge Enrique Romaguera, Hun Ju Lee, MD, Rohinton Tarapore, PhD, Varun Vijay Prabhu, BPharm, MS, PhD, Joshua E. Allen, PhD, Lee Schalop, MD, Andrew Zloza, MD, Chi Young Ok, MD, Maria Badillo, Michael Wang, BS
Journal: Blood
Blood (2017) 130 (Supplement 1): 5163.
https://doi.org/10.1182/blood.V130.Suppl_1.5163.5163
Published: 2017
Journal Articles

ONC201 Depletes Cancer Stem Cells in Refractory Cancer Patient Samples

Varun Vijay Prabhu, Jo Ishizawa, MD PhD, Dan Zhao, MD PhD, Joshua E. Allen, PhD, Tracy T. Batchelor, MD, Andrew S. Chi, MD PhD, Michael Andreeff, MD PhD, Wafik S. El-Deiry, MD PhD F.A.C.P
Journal: Blood
Blood (2014) 124 (21): 5219.
https://doi.org/10.1182/blood.V124.21.5219.5219
Published: 2014
Journal Articles

Caspase-Dependent Anti-Tumor Effects of ONC201/TIC10 on Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM)

Amriti R. Lulla, Christina Leah B Kline, PhD, Liz J. Hernandez-Borrero, Varun Vijay Prabhu, Jessica M Wagner, David T. Dicker, Nathan G. Dolloff, PhD, Brian M Barth, PhD, Jeffrey J Pu, MD PhD, David F. Claxton, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry, MD PhD FACP
Journal: Blood
Blood (2014) 124 (21): 5224.
https://doi.org/10.1182/blood.V124.21.5224.5224
Published: 2014
Journal Articles

Screen of Small Molecule ONC201/TIC10 Identifies Single Agent Activity and Combinatorial Efficacy with Bortezomib, Rituximab or Dexamethasone in Killing of Acute Lymphoblastic Leukemia Cells

Jessica M Wagner, Varun Vijay Prabhu, Leah L. Kline, PhD, Amriti R. Lulla, Liz J. Hernandez-Borrero, Jeffrey J. Pu, MD PhD, David T. Dicker, Brian M Barth, PhD, David F. Claxton, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry, MD PhD FACP
Journal: Blood
Blood (2014) 124 (21): 5233.
https://doi.org/10.1182/blood.V124.21.5233.5233
Published: 2014
Journal Articles

Small Molecule ONC201/TIC10 Induces Caspase-Dependent Apoptosis in Acute Lymphoblastic Leukemia Cells Via Modulation of Bcl-2 and IAP Family Proteins

Varun Vijay Prabhu, Amriti R. Lulla, Jessica M Wagner, Liz J. Hernandez-Borrero, Mala K. Talekar, MD, Christina L. Kline, PhD, David T. Dicker, Brian M Barth, PhD, Jeffrey J. Pu, MD PhD, David F. Claxton, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry, MD PhD FACP
Journal: Blood
Blood (2014) 124 (21): 5237.
https://doi.org/10.1182/blood.V124.21.5237.5237
Published: 2014