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Journal Articles

Multi-Antigen Targeting By Novel Combination of CAR-T Cells and hnCD16 Transgene, Yields in Complete Tumor Clearance Via Antibody Dependent Cellular Cytotoxicity

Soheila Shirinbak, Joy Grant, Wen-I Yeh, Angela Gentile, Bishwas Shrestha, Bi-Huei Yang, Mochtar Pribadi, Shohreh Sikaroodi, Amit Mehta, Amanda D Yzaguirre, Yijia Pan, Chia-Wei Chang, Tom Lee, Layton Smith, Jianming Wu, Bruce Walcheck, Martin Hosking, Bahram Valamehr

Blood (2022) 140 (Supplement 1): 10253–10254.

https://doi.org/10.1182/blood-2022-169462

Published: 2022

Journal Articles

Clinical Manufacture of FT819: Use of a Clonal Multiplexed-Engineered Master Induced Pluripotent Stem Cell Line to Mass Produce Off-the-Shelf CAR T-Cell Therapy

Blood (2021) 138 (Supplement 1): 1766.

https://doi.org/10.1182/blood-2021-152985

Published: 2021

Journal Articles

Dual Chimeric Antigen Receptor Approach Combining Novel Tumor Targeting Strategies Circumvents Antigen Escape in Multiple Myeloma

John Reiser, Ketan Mathavan, Sajid Mahmood, Yijia Pan, Bryan Hancock, Robert Blum, Wen-I Yeh, Andrew Houk, Chia-Wei Chang, Tom Lee, Uta Hopken, John Goulding, Armin Rehm, Kai W. Wucherpfennig, Jode P Goodridge, Ryan Bjordahl, Bahram Valamehr

Blood (2021) 138 (Supplement 1): 1718.

https://doi.org/10.1182/blood-2021-154025

Published: 2021

Journal Articles

Combination of Three Unique Anti-Tumor Modalities Engineered into iPSC-Derived T Cells Demonstrate a Synergistic Effect in Overcoming Tumor Heterogeneity and Cancer Escape

Bi-Huei Yang, Yu-Sheng Eason Lin, Soheila Shirinbak, Wen-I Yeh, Mochtar Pribadi, Hui-Yi Chu, Alma Gutierrez, Amit Mehta, Earl Avramis, Roseanna Petrovic, Benjamin Whitlock, Jason ORourke, Sjoukje van der Stegen, Tom Lee, Alec Witty, Eigen Peralta, Martin Hosking, Chia-Wei Chang, Bahram Valamehr

Blood (2021) 138 (Supplement 1): 2793.

https://doi.org/10.1182/blood-2021-153268

Published: 2021

Journal Articles

Multiplexed Engineered, Off-the-Shelf T Cells Carrying Three Tumor-Associated Antigen-Targeting Modalities: CAR + Pan-Tumor Targeting TCR + CD16 Fc Receptor

Cokey Nguyen, PhD, Eigen Peralta, PhD, Chia-Wei Chang, Wen-I Yeh, PhD, Yijia Pan, PhD, Dan Lu, PhD, May Sumi, Mochtar Pribadi, PhD, Bi-Huei Yang, PhD, Eric Sung, Alec Witty, PhD, Tom Lee, PhD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-141507

Published: 2020

Journal Articles

First-in-Human Study of Abbv-621, a TRAIL Receptor Agonist Fusion Protein, in Patients (Pts) with Relapsed/Refractory (RR) Acute Myeloid Leukemia (AML) and Diffuse Large B-Cell Lymphoma (DLBCL)

Maja J.A. de Jonge, MD, Benedito A. Carneiro, MD, Lot Devriese, MD PhD, Toshihiko Doi, MD PhD, Sudhir Penugonda, MD MPH, Adam M. Petrich, MD, Silpa Nuthalapati, PhD, Monica Motwani, PhD, Dimple A. Modi, PhD, Yu-Wei Chang, PhD, Emiliano Calvo, MD PhD, Victor Moreno, MD PhD

Blood (2019) 134 (Supplement_1): 3924.

https://doi.org/10.1182/blood-2019-129783

Published: 2019

Journal Articles

Pluripotent Cell-Derived Off-the-Shelf TCR-Less CAR-Targeted Cytotoxic T Cell Therapeutic for the Allogeneic Treatment of B Cell Malignancies

Blood (2018) 132 (Supplement 1): 4546.

https://doi.org/10.1182/blood-2018-99-116843

Published: 2018

Journal Articles

Generation of Clonal Antigen Specific CD8αβ + Cytotoxic T Lymphocytes from Renewable Pluripotent Stem Cells for Off-the-Shelf T Cell Therapeutics

Sjoukje Van Der Stegen, PhD, Raedun Clarke, PhD, Jorge Mansilla - Soto, PhD, Edwin Ortiz, Chia-Wei Chang, Jeff Sasaki, Tom Lee, PhD, Weijie Lan, PhD, Daniel Shoemaker, PhD, Isabelle Riviere, PhD, Bahram Valamehr, PhD, Michel Sadelain, MD PhD

Blood (2017) 130 (Supplement 1): 163.

https://doi.org/10.1182/blood.V130.Suppl_1.163.163

Published: 2017

Journal Articles

Modified IPS Cells for Hemoglobinopathies

Tim M. Townes, PhD, Lei Ding, Chia-Wei Chang, Yi-Shin Lai, Joe Sun, Kevin Pawlik

Blood (2015) 126 (23): SCI-17.

https://doi.org/10.1182/blood.V126.23.SCI-17.SCI-17

Published: 2015

Journal Articles

The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells

Zhenhua Yang, Jonathan Augustin, Chenbei Chang, Jing Hu, Kushani Shah, Chia-Wei Chang, Tim Townes, Hao Jiang

Blood (2014) 124 (13): 2025–2033.

https://doi.org/10.1182/blood-2014-01-549220

Published: 2014

Includes: Multimedia, Supplemental data

Journal Articles

Role Of Dpy30/MLL Complexes In Regulating Hematopoietic Progenitor Cell Maintenance and Differentiation

Zhenhua Yang, PhD, Jonathan Augustin, BA, Jing Hu, PhD, Chia-Wei Chang, PhD, Tim M. Townes, PhD, Hao Jiang, PhD

Blood (2013) 122 (21): 2424.

https://doi.org/10.1182/blood.V122.21.2424.2424

Published: 2013

Journal Articles

Defining the Malignant Epigenome in Non-Hodgkin Lymphoma

Jacqueline E. Payton, MD, PhD, Olivia I. Koues, PhD, Rodney Kowalewski, BS, Jennifer A. Schmidt, MS, Li-Wei Chang, PhD, Amanda Cashen, MD, Nancy L. Bartlett, MD, Eugene M. Oltz, PhD

Blood (2012) 120 (21): 524.

https://doi.org/10.1182/blood.V120.21.524.524

Published: 2012

Journal Articles

ER71 specifies Flk-1 + hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling

Fang Liu, Inyoung Kang, Changwon Park, Li-Wei Chang, Wei Wang, Dongjun Lee, Dae-Sik Lim, Daniel Vittet, Jeanne M. Nerbonne, Kyunghee Choi

Blood (2012) 119 (14): 3295–3305.

https://doi.org/10.1182/blood-2012-01-403766

Published: 2012

Includes: Supplemental data

Journal Articles

Distinct classes of c-Kit–activating mutations differ in their ability to promote RUNX1-ETO–associated acute myeloid leukemia

Heidi J. Nick, Hyung-Gyoon Kim, Chia-Wei Chang, Kevin W. Harris, Vishnu Reddy, Christopher A. Klug

Blood (2012) 119 (6): 1522–1531.

https://doi.org/10.1182/blood-2011-02-338228

Published: 2012

Includes: Supplemental data

Journal Articles

Complete characterization of the microRNAome in a patient with acute myeloid leukemia

Giridharan Ramsingh, Daniel C. Koboldt, Maria Trissal, Katherine B. Chiappinelli, Todd Wylie, Sunita Koul, Li-Wei Chang, Rakesh Nagarajan, Todd A. Fehniger, Paul Goodfellow, Vincent Magrini, Richard K. Wilson, Li Ding, Timothy J. Ley, Elaine R. Mardis, Daniel C. Link

Blood (2010) 116 (24): 5316–5326.

https://doi.org/10.1182/blood-2010-05-285395

Published: 2010

Includes: Supplemental data

Journal Articles

Chromatin Immunoprecipitation of GFP-Tagged PML-Rara Coupled to High-Throughput Next Generation Sequencing.

Nicole R. Grieselhuber, Jahangheer S. Shaik, PhD, Li-Wei Chang, PhD, Sean McGrath, Lukas D. Wartman, MD, Rakesh Nagarajan, MD, PhD, Richard K. Wilson, PhD, Elaine Mardis, PhD, Timothy J. Ley, MD

Blood (2009) 114 (22): 1276.

https://doi.org/10.1182/blood.V114.22.1276.1276

Published: 2009

Journal Articles

Comprehensive Evaluation of MicroRNA Genes and Gene Expression Using Next Generation Sequencing in a Patient with Acute Myelogenous Leukemia.

Giridharan Ramsingh, MD, Dan C Koboldt, M.S, Todd A Fehniger, MD, PhD, Todd Wylie, B.S, Vincent Magrini, Ph.D, Maria Trissal, B.S, Sunita Koul, MCA, Li-Wei Chang, PhD, Rakesh Nagarajan, MD, PhD, Timothy J. Ley, MD, Elaine Mardis, PhD, Daniel C. Link, MD

Blood (2009) 114 (22): 271.

https://doi.org/10.1182/blood.V114.22.271.271

Published: 2009

Journal Articles

The Expression Signature of M3 AML Suggests Direct and Indirect Effects of PML-RARA on Target Genes.

Jacqueline E. Payton, MD, PhD, Nicole R. Grieselhuber, BS, Li-Wei Chang, PhD, Mark A. Murakami, MS, Wenlin Yuan, PhD, Daniel C. Link, MD, Rakesh Nagarajan, MD, PhD, Mark A. Watson, MD, PhD, Timothy J. Ley, MD

Blood (2007) 110 (11): 719.

https://doi.org/10.1182/blood.V110.11.719.719

Published: 2007

Journal Articles

Gfi-1 Is Overexpressed on Chronic Myeloid Leukemic Cells.

Hui Cheng, M.D., Wei Chang, M.D., Ming Huang, M.D., Ying Sun, M.D., Yicheng Zhang, MD, MS

Blood (2007) 110 (11): 2928.

https://doi.org/10.1182/blood.V110.11.2928.2928

Published: 2007

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Multi-Antigen Targeting By Novel Combination of CAR-T Cells and hnCD16 Transgene, Yields in Complete Tumor Clearance Via Antibody Dependent Cellular Cytotoxicity

Clinical Manufacture of FT819: Use of a Clonal Multiplexed-Engineered Master Induced Pluripotent Stem Cell Line to Mass Produce Off-the-Shelf CAR T-Cell Therapy

Dual Chimeric Antigen Receptor Approach Combining Novel Tumor Targeting Strategies Circumvents Antigen Escape in Multiple Myeloma

Combination of Three Unique Anti-Tumor Modalities Engineered into iPSC-Derived T Cells Demonstrate a Synergistic Effect in Overcoming Tumor Heterogeneity and Cancer Escape

Multiplexed Engineered, Off-the-Shelf T Cells Carrying Three Tumor-Associated Antigen-Targeting Modalities: CAR + Pan-Tumor Targeting TCR + CD16 Fc Receptor

First-in-Human Study of Abbv-621, a TRAIL Receptor Agonist Fusion Protein, in Patients (Pts) with Relapsed/Refractory (RR) Acute Myeloid Leukemia (AML) and Diffuse Large B-Cell Lymphoma (DLBCL)

Pluripotent Cell-Derived Off-the-Shelf TCR-Less CAR-Targeted Cytotoxic T Cell Therapeutic for the Allogeneic Treatment of B Cell Malignancies

Generation of Clonal Antigen Specific CD8αβ + Cytotoxic T Lymphocytes from Renewable Pluripotent Stem Cells for Off-the-Shelf T Cell Therapeutics

Modified IPS Cells for Hemoglobinopathies

The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells

Role Of Dpy30/MLL Complexes In Regulating Hematopoietic Progenitor Cell Maintenance and Differentiation

Defining the Malignant Epigenome in Non-Hodgkin Lymphoma

ER71 specifies Flk-1 + hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling

Distinct classes of c-Kit–activating mutations differ in their ability to promote RUNX1-ETO–associated acute myeloid leukemia

Complete characterization of the microRNAome in a patient with acute myeloid leukemia

Chromatin Immunoprecipitation of GFP-Tagged PML-Rara Coupled to High-Throughput Next Generation Sequencing.

Comprehensive Evaluation of MicroRNA Genes and Gene Expression Using Next Generation Sequencing in a Patient with Acute Myelogenous Leukemia.

The Expression Signature of M3 AML Suggests Direct and Indirect Effects of PML-RARA on Target Genes.

Gfi-1 Is Overexpressed on Chronic Myeloid Leukemic Cells.

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American Society of Hematology

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