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Journal Articles

Direct Visualization of Platelet Integrins Using ANTI-Transmembrane Domain Peptides Containing a BLUE Fluorescent Amino Acid

Karen Pei Yi Fong, PhD BS, Ismail A. Ahmed, PhD, Marco Mravic, B.S., M.S., Hyunil Jo, PhD, William F. DeGrado, PhD, Feng Gai, PhD, Joel S. Bennett, MD

Blood (2019) 134 (Supplement_1): 2344.

https://doi.org/10.1182/blood-2019-128363

Published: 2019

Journal Articles

Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton

Rustem I. Litvinov, Karen Pei Yi Fong, PhD BS, Oleg V. Kim, PhD, Kathleen I. Molnar, PhD, Paul C. Billings, PhD, Alex Sternisha, BS, James A. Wells, PhD, John W. Weisel, PhD, William F. DeGrado, PhD, Joel S. Bennett, MD

Blood (2018) 132 (Supplement 1): 1128.

https://doi.org/10.1182/blood-2018-99-113063

Published: 2018

Journal Articles

Unique Transmembrane Domain Interactions Differentially Modulate Platelet αIIbβ3 and αvβ3 Function

Rustem I. Litvinov, MD PhD, Marco Mravic, B.S., M.S., Hua Zhu, BS, John W. Weisel, PhD, William F. DeGrado, PhD, Joel S. Bennett, MD

Blood (2017) 130 (Supplement 1): 1019.

https://doi.org/10.1182/blood.V130.Suppl_1.1019.1019

Published: 2017

Journal Articles

Integrin αIIbβ3-Mediated c-Src Activation: Differential Binding to Inactive and Active c-Src

Lisa Span, Patrik Nygren, PhD, Yibing Wu, PhD, Hua Zhu, BS, David T. Moore, MD PhD, Hong Cheng, PhD, Heinrich Roder, PhD, William F. DeGrado, PhD, Joel S. Bennett, MD

Blood (2014) 124 (21): 4158.

https://doi.org/10.1182/blood.V124.21.4158.4158

Published: 2014

Journal Articles

Activating Individual αIIbβ3 Molecules Using An Anti-αIIb-Transmembrane Domain Peptide Causes αIIbβ3 Oligomerization and αIIbβ3-Mediated Outside-In Signaling

Hua Zhu, BS, David T. Moore, M.D, Ph.D, William F. DeGrado, Ph.D., Joel S. Bennett, MD

Blood (2013) 122 (21): 3506.

https://doi.org/10.1182/blood.V122.21.3506.3506

Published: 2013

Journal Articles

Analysis of β3 Binding to the c-Src SH3 Domain

Patrik Nygren, Ph.D., Lisa M. Span, David T. Moore, M.D, Ph.D, Hong Cheng, Ph.D., Heinrich Roder, PhD, William F. DeGrado, Ph.D., Joel S. Bennett, M.D.

Blood (2012) 120 (21): 383.

https://doi.org/10.1182/blood.V120.21.383.383

Published: 2012

Journal Articles

Kindlin-3 Undergoes Endoproteolysis in Stored Platelets and After Platelet Stimulation

Craig N. Streu, Ph.D., Patrik Nygren, Ph.D., Paul C. Billings, Ph.D., David T. Moore, B.S., M.S., Kathleen S. Molnar, B.S.E., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.

Blood (2011) 118 (21): 1255.

https://doi.org/10.1182/blood.V118.21.1255.1255

Published: 2011

Journal Articles

Assessing the Biochemistry of Kindlin-3 In Human Platelets

Craig N. Streu, Ph.D., David Thomas Moore, B.S., M.S., Paul C. Billings, Ph.D., Patrik Nygren, Ph.D., Karen P. Fong, Ph.D., Douglas G. Metcalf, Ph.D., Yibing Wu, Ph.D., William F. DeGrado, Ph.D., Joel S. Bennett, MD

Blood (2010) 116 (21): 2011.

https://doi.org/10.1182/blood.V116.21.2011.2011

Published: 2010

Journal Articles

Arylamides: Discovery of a Novel Class of Fully-Synthetic Small Molecule Heparin and LMWH Antagonists.

Richard W. Scott, Ph.D., Michael J. Costanzo, Ph.D., Katie B. Freeman, Ph.D., Robert W. Kavash, Ph.D., Trevor M. Young, William F. DeGrado, Ph.D., Walter Jeske, Ph.D.

Blood (2010) 116 (21): 1096.

https://doi.org/10.1182/blood.V116.21.1096.1096

Published: 2010

Journal Articles

Optimized Fully-Synthetic Salicylamide Heparin Antagonists Have Greater Efficacy Versus LMWHs and Display Improved Hemodynamic Responses as Compared to Protamine

Richard W. Scott, Ph.D., Michael J. Costanzo, Ph.D., Katie B. Freeman, Ph.D., Robert W. Kavash, Ph.D., Trevor M. Young, William F. DeGrado, Ph.D., Walter Jeske, Ph.D.

Blood (2010) 116 (21): 191.

https://doi.org/10.1182/blood.V116.21.191.191

Published: 2010

Journal Articles

Identification of Stalk Mutations That Stabilize the High Affinity Conformation of αIIbβ3 by Negative Design.

Jason E. Donald, PhD, Hua Zhu, BS, William F. DeGrado, PhD, Joel S. Bennett, MD

Blood (2009) 114 (22): 4017.

https://doi.org/10.1182/blood.V114.22.4017.4017

Published: 2009

Journal Articles

Protein-Protein and Protein-Lipid Interactions Modulate αIIbβ3 Inside-out Signaling.

David T. Moore, BA, MS, Patrik Nygren, PhD, Kathleen Molnar, BS, Kathleen Boesze-Battaglia, PhD, Joel S. Bennett, MD, William F. DeGrado, PhD

Blood (2009) 114 (22): 152.

https://doi.org/10.1182/blood.V114.22.152.152

Published: 2009

Journal Articles

Species differences in small molecule binding to αIIbβ3 are the result of sequence differences in 2 loops of the αIIb β propeller

Ramesh B. Basani, Hua Zhu, Michael A. Thornton, Cinque S. Soto, William F. DeGrado, M. Anna Kowalska, Joel S. Bennett, Mortimer Poncz

Blood (2009) 113 (4): 902–910.

https://doi.org/10.1182/blood-2008-09-177337

Published: 2009

Journal Articles

Characterization of the Weak Interaction of C-Src with the β3 Cytoplasmic Tail

Davi d T. Moore, Anjali Ganjiwale, Hong Cheng, Heinrich Roder, William F. DeGrado, Joel S. Bennett, MD

Blood (2008) 112 (11): 2856.

https://doi.org/10.1182/blood.V112.11.2856.2856

Published: 2008

Journal Articles

A Conserved Transmembrane Domain Interface Regulates Integrin Function

Bryan W Berger, Lisa M. Span, Daniel W Kulp, Paul C. Billings, William F. DeGrado, Joel S. Bennett, MD

Blood (2008) 112 (11): 2858.

https://doi.org/10.1182/blood.V112.11.2858.2858

Published: 2008

Journal Articles

NMR Structure of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer

Douglas G. Metcalf, Joseph M. Kielec, Kathleen G. Valentine, A. Joshua Wand, William F. DeGrado, Joel S. Bennett, MD

Blood (2008) 112 (11): 2866.

https://doi.org/10.1182/blood.V112.11.2866.2866

Published: 2008

Journal Articles

Factors That Influence the Homo- and Hetero-Oligomerization of the Leukocyte Integrin Transmembrane Domains

Lisa M. Span, Gevorg Grigoryan, Joel S. Bennett, MD, William F. DeGrado

Blood (2008) 112 (11): 3556.

https://doi.org/10.1182/blood.V112.11.3556.3556

Published: 2008

Journal Articles

Characterization of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer by NMR.

Douglas G. Metcalf, BS, Joseph M. Kielec, B.S., B.A., Kathleen G. Valentine, Ph.D., A. Joshua, Wand, Ph.D., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.

Blood (2007) 110 (11): 415.

https://doi.org/10.1182/blood.V110.11.415.415

Published: 2007

Journal Articles

Identification of Oligomerization Motifs in the β3 Transmembrane Domain.

Hua Zhu, BS, Douglas G. Metcalf, B.S., Wei Li, M.D., Roman Gorelik, B.S., Cinque Soto, Ph.D., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.

Blood (2007) 110 (11): 416.

https://doi.org/10.1182/blood.V110.11.416.416

Published: 2007

Journal Articles

The Design and Synthesis of Small Molecule Inhibitors of Collagen Binding to Integrin α2β1 as Antithrombotic Agents.

Meredith W. Miller, BS, Soni Basra, Ph.D., Paul C. Billings, Ph.D., Jamie Gewirtz, B.A., William F. DeGrado, Ph.D., Joel S. Bennett, M.D.

Blood (2007) 110 (11): 306.

https://doi.org/10.1182/blood.V110.11.306.306

Published: 2007

NARROW

Direct Visualization of Platelet Integrins Using ANTI-Transmembrane Domain Peptides Containing a BLUE Fluorescent Amino Acid

Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton

Unique Transmembrane Domain Interactions Differentially Modulate Platelet αIIbβ3 and αvβ3 Function

Integrin αIIbβ3-Mediated c-Src Activation: Differential Binding to Inactive and Active c-Src

Activating Individual αIIbβ3 Molecules Using An Anti-αIIb-Transmembrane Domain Peptide Causes αIIbβ3 Oligomerization and αIIbβ3-Mediated Outside-In Signaling

Analysis of β3 Binding to the c-Src SH3 Domain

Kindlin-3 Undergoes Endoproteolysis in Stored Platelets and After Platelet Stimulation

Assessing the Biochemistry of Kindlin-3 In Human Platelets

Arylamides: Discovery of a Novel Class of Fully-Synthetic Small Molecule Heparin and LMWH Antagonists.

Optimized Fully-Synthetic Salicylamide Heparin Antagonists Have Greater Efficacy Versus LMWHs and Display Improved Hemodynamic Responses as Compared to Protamine

Identification of Stalk Mutations That Stabilize the High Affinity Conformation of αIIbβ3 by Negative Design.

Protein-Protein and Protein-Lipid Interactions Modulate αIIbβ3 Inside-out Signaling.

Species differences in small molecule binding to αIIbβ3 are the result of sequence differences in 2 loops of the αIIb β propeller

Characterization of the Weak Interaction of C-Src with the β3 Cytoplasmic Tail

A Conserved Transmembrane Domain Interface Regulates Integrin Function

NMR Structure of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer

Factors That Influence the Homo- and Hetero-Oligomerization of the Leukocyte Integrin Transmembrane Domains

Characterization of a Disulfide-Crosslinked αIIbβ3 Cytoplasmic Domain Heterodimer by NMR.

Identification of Oligomerization Motifs in the β3 Transmembrane Domain.

The Design and Synthesis of Small Molecule Inhibitors of Collagen Binding to Integrin α2β1 as Antithrombotic Agents.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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