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Journal Articles

Accumulation of DNA Damage and Alteration of the DNA Damage Response in Chronic Myeloid Leukemia

Henning D. Popp, Vanessa Kohl, MSc, Johanna Flach, PhD, Susanne Brendel, MTA, Helga Kleiner, MTA, Wolfgang Seifarth, PhD, Christel Weiss, PhD, Susanne Saussele, MD, Wolf-Karsten Hofmann, MD PhD, Alice Fabarius, PhD

Blood (2019) 134 (Supplement_1): 5364.

https://doi.org/10.1182/blood-2019-122698

Published: 2019

Journal Articles

Anti-Leukemic Efficacy of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies

Vanessa Kohl, MSc, Susanne Brendel, MTA, Johanna Flach, PhD, Helga Kleiner, MTA, Christel Weiss, PhD, Wolfgang Seifarth, PhD, Daniel Nowak, MD, Wolf-Karsten Hofmann, MD PhD, Alice Fabarius, PhD, Henning D. Popp

Blood (2019) 134 (Supplement_1): 5056.

https://doi.org/10.1182/blood-2019-122672

Published: 2019

Journal Articles

Comparison of Four Different Humanized Hematopoietic Niche Xenotransplantation Methods to Engraft Myelodysplastic Syndromes (MDS)

Blood (2019) 134 (Supplement_1): 4227.

https://doi.org/10.1182/blood-2019-128075

Published: 2019

Journal Articles

Comparison of RNA-Based Versus DNA-Based Quantitative KIT D816V Mutation Analysis Reveals Significant Disparity in Patients with Advanced Systemic Mastocytosis

Mohamad Jawhar, Nicole Naumann, Johannes Lübke, Juliana Schwaab, Oliver Hofmann, Thomas Kielsgaard Kristensen, Karl Sotlar, Verena Haselmann, Sven Schneider, Georgia Metzgeroth, Henning D. Popp, Alice Fabarius, PhD, Peter Bugert, Wolf-Karsten Hofmann, MD PhD, Andreas Reiter

Blood (2019) 134 (Supplement_1): 2955.

https://doi.org/10.1182/blood-2019-128811

Published: 2019

Journal Articles

An Increased Bone Mineral Density As an Adverse Prognostic Factor in Patients with Systemic Mastocytosis

Mohamad Jawhar, Juliana Schwaab, Nicole Naumann, Georgia Metzgeroth, Alice Fabarius, PhD, Stefan O Schoenberg, Wolf-Karsten Hofmann, MD PhD, Philipp Riffel, Andreas Reiter

Blood (2019) 134 (Supplement_1): 4185.

https://doi.org/10.1182/blood-2019-129798

Published: 2019

Journal Articles

R-Loops-Induced ATR Signaling As a Potential Therapeutic Target in Myelodysplastic Syndrome

Johann-Christoph Jann, Johanna Flach, PhD, Antje Knaflic, Eva Altrock, PhD, Nanni Schmitt, MSc, Alexander Streuer, Justine Danner, Franziska Hofmann, Verena Nowak, Nina Draeger, Julia Obländer, Iris Palme, Patrick Wuchter, MD, Ahmed Jawhar, MD, Georgia Metzgeroth, MD, Florian Nolte, MD, Wolf-Karsten Hofmann, MD PhD, Daniel Nowak, MD

Blood (2019) 134 (Supplement_1): 4218.

https://doi.org/10.1182/blood-2019-126431

Published: 2019

Journal Articles

Clinical Characteristics and Treatment Allocations in Patients with Myelodysplastic Syndromes and Monosomy 7: Results from an International Multicenter Study Suggest That Hypomethylating Agents Significantly Improve Overall- and AML-Free Survival in Patients Classified As Very High Risk By IPSS-R

Julie Schanz, MD PhD, Friederike Braulke, MD, Ghulam J. Mufti, MD PhD, Elena Crisà, Austin Kulasekararaj, Kathrin Nachtkamp, MD, Ulrich Germing, Stefan Schmitz, MD PhD, Peter Haas, MD, Michael Lübbert, Catharina Müller-Thomas, MD, Katharina Götze, Uwe Platzbecker, MD, Florian Nolte, Wolf-Karsten Hofmann, MD PhD, Detlef Haase

Blood (2014) 124 (21): 4656.

https://doi.org/10.1182/blood.V124.21.4656.4656

Published: 2014

Journal Articles

Next Generation RNA Sequencing of Acute Promyelocytic Leukemia (APL) Identifies Novel Long Non Coding RNAs Including New Variants of MIR181A1HG That Are Differentially Expressed during Myeloid Differentiation

Frederic Lammer, Marion Klaumuenzer, PhD, Maximilian Mossner, Johann Christoph Jann, Anna Hecht, MD, Verena Nowak, Stephanie Fey, Julia Oblaender, Jovita Pressler, Eva Lengfelder, MD, Wolf-Karsten Hofmann, MD PhD, Daniel Nowak, MD

Blood (2014) 124 (21): 1031.

https://doi.org/10.1182/blood.V124.21.1031.1031

Published: 2014

Journal Articles

The KIT D816V Allele Burden in Systemic Mastocytosis Is Strongly Associated with Disease Subtype.

Juliana Schwaab, MD, Philipp Erben, MD, Hans-Peter Horny, MD, Martina Teichmann, MD, Georgia Metzgeroth, MD, Thomas Ernst, MD, Karl Sotlar, MD, Martin C Mueller, MD, Alexander Marx, MD, Karin Hartmann, MD, Andreas Hochhaus, MD, Nicholas C.P. Cross, PhD, Wolf Karsten Hofmann, MD, PhD, Andreas Reiter, MD

Blood (2012) 120 (21): 2859.

https://doi.org/10.1182/blood.V120.21.2859.2859

Published: 2012

Journal Articles

Second Line Therapy with Second Generation TKI After Intolerance to Imatinib Based Treatments Showed High Overall Survival in Contrast to Second Line Therapy After Resistance; Results of the Randomized CML Study IV

Blood (2011) 118 (21): 781.

https://doi.org/10.1182/blood.V118.21.781.781

Published: 2011

Journal Articles

Critical Evaluation of Diverse Clinical, Laboratory, Radiological and Histological Parameters Indicating Gastrointestinal Involvement for Diagnosis of Indolent and Aggressive Systemic Mastocytosis

Georgia Metzgeroth, MD, Juliana Schwaab, MD, Martina Teichmann, MD, Alexander Marx, MD, Henrik J. Michaely, MD, Hans Peter Horny, MD, Nicholas C.P. Cross, PhD, Andreas Hochhaus, MD, Wolf Karsten Hofmann, MD, PhD, Andreas Reiter, MD

Blood (2011) 118 (21): 5159.

https://doi.org/10.1182/blood.V118.21.5159.5159

Published: 2011

Journal Articles

ERG Overexpression Induces Cell Adhesion Mediated Drug Resistance in Acute Leukemia

Liliana H. Mochmann, MS, Martin Neumann, Verena Nowak, Monika Dejewska, Jutta Ortiz-Tanchez, MS, Wolf Karsten Hofmann, MD, PhD, Eckhard Thiel, Claudia D Baldus, MD

Blood (2011) 118 (21): 1389.

https://doi.org/10.1182/blood.V118.21.1389.1389

Published: 2011

Journal Articles

Adjuvant CD49d Blockade Eradicates Chemoresistant ALL

Yao-Te Hsieh, Eugene Park, Enzi Jiang, MD, PhD, Katrin Dauber, Doreen Chudziak, Paul Schaefer, Lars Klemm, Carlton Scharman, Eun-Suk Kang, MD, PhD, Hong-Hoe Koo, MD, PhD, Mignon L. Loh, M.D., Wolf Karsten Hofmann, MD, PhD, Nora Heisterkamp, Markus Muschen, MD, Hiroyuki Shimada, MD, Halvard Bonig, MD, MA, Yong-Mi Kim, MD, MPH

Blood (2010) 116 (21): 869.

https://doi.org/10.1182/blood.V116.21.869.869

Published: 2010

Journal Articles

High Density SNP Array Analysis of Acute Promyelocytic Leukemia (APL) Detects New Common Genomic Copy Number Alterations as Possible Cooperating Lesions

Daniel Nowak, MD, Marion Klaumuenzer, Benjamin Hanfstein, MD, Maximilian Mossner, Florian Nolte, MD, Verena Nowak, Julia Oblaender, Seishi Ogawa, MD, PhD, Alexander Kohlmann, PhD, Wolfgang Seifarth, PhD, Alice Fabarius, PhD, Philipp Erben, MD, Susanne Saussele, MD, Martin C Mueller, MD, PhD, Eva Lengfelder, MD, PhD, Wolf Karsten Hofmann, MD, PhD

Blood (2010) 116 (21): 2721.

https://doi.org/10.1182/blood.V116.21.2721.2721

Published: 2010

Journal Articles

Overexpression of BAALC Indicates Drug Resistance and Inferior Survival in Adult B-Precursor Acute Lymphoblastic Leukemia.

Andrea Kühnl, Nicola Gökbuget, MD, Andrea Stroux, Thomas Burmeister, MD, Martin Neumann, Sandra Heesch, MS, Torsten Haferlach, MD, Dieter Hoelzer, MD, PhD, Wolf Karsten Hofmann, MD, PhD, Eckhard Thiel, MD, Claudia D Baldus, MD

Blood (2009) 114 (22): 1581.

https://doi.org/10.1182/blood.V114.22.1581.1581

Published: 2009

Journal Articles

The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines.

Daniel Nowak, MD, Norihiko Kawamata, MD, PhD, Birte Niebuhr, PhD, Verena Nowak, Maximilian Mossner, Rahul R Nahar, Nils Heinrich Thoennissen, MD, Gabriela B. Iwanski, MD, Carol Stocking, PhD, Martin Dugas, MD, PhD, Wolf Karsten Hofmann, MD, PhD, Markus Müschen, MD, PhD, Phillip H Koeffler, MD, PhD

Blood (2009) 114 (22): 1284.

https://doi.org/10.1182/blood.V114.22.1284.1284

Published: 2009

Journal Articles

Epigenetic Dysregulation of GATA1 but Not Downstream Notch Effectors is Involved in MDS Dyserythropoiesis.

Olaf Joachim Hopfer, MD, Martina Komor, PhD, Claudia Freitag, Maximilian Mossner, Dieter Hoelzer, MD, PhD, Eckhard Thiel, MD, PhD, Wolf-Karsten Hofmann, MD, PhD

Blood (2008) 112 (11): 1652.

https://doi.org/10.1182/blood.V112.11.1652.1652

Published: 2008

Journal Articles

High Density SNP Array Analysis of Tyrosine Kinase Inhibitor (TKI) Resistant Chronic Myeloid Leukemia (CML) Shows Secondary Genomic Alterations

Daniel Nowak, MD, Norihiko Kawamata, MD, Tadayuki Akagi, PhD, Ryoko Okamoto, PhD, Nils Thoennissen, MD, Wolf-Karsten Hofmann, MD, PhD, Motohiro Kato, PhD, Torsten Haferlach, MD, PhD, Seishi Ogawa, MD, PhD, H. Phillip Koeffler, MD, PhD

Blood (2008) 112 (11): 3182.

https://doi.org/10.1182/blood.V112.11.3182.3182

Published: 2008

Journal Articles

Analysis of Chromosomal Aberrations and DNA Mutations in Bone Marrow Mesenchymal Stroma Cells from Patients with Myelodysplastic Syndrome Amd Acute Myeloid Leukemia

Olga Blau, MD, PhD, Wolf-Karsten Hofmann, MD, PhD, Igor W. Blau, MD, PhD, Claudia D Baldus, MD, Florian Nolte, MD, Gundula Thiel, MD, PhD, Elke Schuemann, Ouidad Benlasfer, Eckhard Thiel, MD, PhD

Blood (2008) 112 (11): 4843.

https://doi.org/10.1182/blood.V112.11.4843.4843

Published: 2008

Journal Articles

GATA and BCLxl Downregulation in Erythropoiesis during In Vitro Lineage Specific Differentiation of MDS Hematopoietic Progenitor Cells Is Not Induced by Activated Notch Pathway.

Olaf J. Hopfer, MD, Martina Komor, PhD, Ina S.N. Koehler, Claudia Freitag, Dieter Hoelzer, MD,PhD, Eckhard Thiel, MD,PhD, Wolf-Karsten Hofmann, MD,PhD

Blood (2007) 110 (11): 4118.

https://doi.org/10.1182/blood.V110.11.4118.4118

Published: 2007

NARROW

Accumulation of DNA Damage and Alteration of the DNA Damage Response in Chronic Myeloid Leukemia

Anti-Leukemic Efficacy of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies

Comparison of Four Different Humanized Hematopoietic Niche Xenotransplantation Methods to Engraft Myelodysplastic Syndromes (MDS)

Comparison of RNA-Based Versus DNA-Based Quantitative KIT D816V Mutation Analysis Reveals Significant Disparity in Patients with Advanced Systemic Mastocytosis

An Increased Bone Mineral Density As an Adverse Prognostic Factor in Patients with Systemic Mastocytosis

R-Loops-Induced ATR Signaling As a Potential Therapeutic Target in Myelodysplastic Syndrome

Clinical Characteristics and Treatment Allocations in Patients with Myelodysplastic Syndromes and Monosomy 7: Results from an International Multicenter Study Suggest That Hypomethylating Agents Significantly Improve Overall- and AML-Free Survival in Patients Classified As Very High Risk By IPSS-R

Next Generation RNA Sequencing of Acute Promyelocytic Leukemia (APL) Identifies Novel Long Non Coding RNAs Including New Variants of MIR181A1HG That Are Differentially Expressed during Myeloid Differentiation

The KIT D816V Allele Burden in Systemic Mastocytosis Is Strongly Associated with Disease Subtype.

Second Line Therapy with Second Generation TKI After Intolerance to Imatinib Based Treatments Showed High Overall Survival in Contrast to Second Line Therapy After Resistance; Results of the Randomized CML Study IV

Critical Evaluation of Diverse Clinical, Laboratory, Radiological and Histological Parameters Indicating Gastrointestinal Involvement for Diagnosis of Indolent and Aggressive Systemic Mastocytosis

ERG Overexpression Induces Cell Adhesion Mediated Drug Resistance in Acute Leukemia

Adjuvant CD49d Blockade Eradicates Chemoresistant ALL

High Density SNP Array Analysis of Acute Promyelocytic Leukemia (APL) Detects New Common Genomic Copy Number Alterations as Possible Cooperating Lesions

Overexpression of BAALC Indicates Drug Resistance and Inferior Survival in Adult B-Precursor Acute Lymphoblastic Leukemia.

The Pax5 Fusion Product Pax5-C20orf112 Causes Downregulation of Pre-B Cell Receptor Genes and Induces Differential Proliferation Patterns in B-Lymphoblastic Cell Lines.

Epigenetic Dysregulation of GATA1 but Not Downstream Notch Effectors is Involved in MDS Dyserythropoiesis.

High Density SNP Array Analysis of Tyrosine Kinase Inhibitor (TKI) Resistant Chronic Myeloid Leukemia (CML) Shows Secondary Genomic Alterations

Analysis of Chromosomal Aberrations and DNA Mutations in Bone Marrow Mesenchymal Stroma Cells from Patients with Myelodysplastic Syndrome Amd Acute Myeloid Leukemia

GATA and BCLxl Downregulation in Erythropoiesis during In Vitro Lineage Specific Differentiation of MDS Hematopoietic Progenitor Cells Is Not Induced by Activated Notch Pathway.

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American Society of Hematology

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American Society of Hematology

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